scholarly journals Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaolei Wang ◽  
Smriti Mehra ◽  
Deepak Kaushal ◽  
Ronald S. Veazey ◽  
Huanbin Xu
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Infectious Diseases ◽  
Disease Progression ◽  
Immune Regulation ◽  
Neurological Disorders ◽  
Tryptophan Metabolism ◽  
Mycobacterium Tuberculosis Infection ◽  
Physiological Functions ◽  
Potential Impact ◽  
Host Metabolism

Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases. Here, we briefly highlight the recent advances regarding abnormal tryptophan metabolism in HIV and Mycobacterium tuberculosis infection and discuss its potential impact on immune regulation, disease progression, and neurological disorders. Finally, we also discuss the potential for metabolic tryptophan interventions toward these infectious diseases.

scholarly journals Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages

mBio ◽  
2021 ◽  
Author(s):  
Samantha L. Bell ◽  
Kayla L. Lopez ◽  
Jeffery S. Cox ◽  
Kristin L. Patrick ◽  
Robert O. Watson
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Infectious Diseases ◽  
Tuberculosis Infection ◽  
Harsh Environment ◽  
Intracellular Pathogens ◽  
First Line ◽  
Mycobacterium Tuberculosis Infection ◽  
Content Type ◽  
Selective Autophagy ◽  
Global Population

Mycobacterium tuberculosis (Mtb) infects one-quarter of the global population and causes one of the deadliest infectious diseases worldwide. Macrophages are the first line of defense against Mtb infection and are typically incredibly efficient at destroying intracellular pathogens, but Mtb has evolved to survive and replicate in this harsh environment.

scholarly journals Unraveling the Role of MicroRNAs in Mycobacterium tuberculosis Infection and Disease: Advances and Pitfalls

2019 ◽  
Vol 88 (3) ◽  
Author(s):  
Cinthya Ruiz-Tagle ◽  
Rodrigo Naves ◽  
María Elvira Balcells
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immune Regulation ◽  
Cell Type ◽  
Mycobacterium Tuberculosis Infection ◽  
Altered Expression ◽  
Content Type ◽  
Respiratory Droplets ◽  
Relevant Factors ◽  
Potential Biomarkers

ABSTRACT Tuberculosis (TB) is an infectious disease of extremely high epidemiological burden worldwide that is easily acquired through the inhalation of infected respiratory droplets. The complex pathogenesis of this infection spans from subjects never developing this disease despite intense exposure, to others in which immune containment fails catastrophically and severe or disseminated forms of disease ensue. In recent decades, microRNAs (miRNAs) have gained increasing attention due to their role as gene silencers and because of their altered expression in diverse human diseases, including some infections. Recent research regarding miRNAs and TB has revealed that the expression profile for particular miRNAs clearly changes upon Mycobacterium tuberculosis infection and also varies in the different stages of this disease. However, despite the growing number of studies—some of which have even proposed some miRNAs as potential biomarkers—methodological variations and key differences in relevant factors, such as sex and age, cell type analyzed, M. tuberculosis strain, and antimicrobial therapy status, strongly hinder the comparison of data. In this review, we summarize and discuss the literature and highlight the role of selected miRNAs that have specifically and more consistently been associated with M. tuberculosis infection, together with a discussion of the possible gene and immune regulation pathways involved.

Research Progress of Epigallocatechin-3-gallate (EGCG) on Anti-pathogenic Microbes and Immune Regulation

2021 ◽  
Author(s):  
Zijuan Zhao ◽  
Feng Meiyan ◽  
Wan Juan ◽  
Xin Zheng ◽  
Cuiqin Teng ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Mycobacterium Tuberculosis ◽  
Infectious Diseases ◽  
Immune Regulation ◽  
Hepatitis Virus ◽  
Research Progress ◽  
Pathogenic Microorganisms ◽  
Virus Spread ◽  
Virus Hepatitis ◽  
Pathogenic Microbes

At the end of 2019, the COVID-19 virus spread worldwide, infecting millions of people. Infectious diseases induced by pathogenic microorganisms such as influenza virus, hepatitis virus, and Mycobacterium tuberculosis are...

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