scholarly journals Association Between Polymorphisms in Gastric Cancer Related Genes and Risk of Gastric Cancer: A Case-Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Yan Pu ◽  
Xu Wen ◽  
Zhangjun Jia ◽  
Yu Xie ◽  
Changxing Luan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
High Sensitivity ◽  
Case Control ◽  
Healthy Controls ◽  
Genotype Frequencies ◽  
Related Variant ◽  
Gastric Cancer Patients ◽  
Control Study

Gastric cancer has the second highest incidence among all the malignancies in China, just below lung cancer. Gastric cancer is likewise one of the main sources of cancer related passings. Gastric cancer therefore remains a huge threat to human health. The primary reason is absence of high sensitivity and specificity for early detection while the pathogenesis of GC is stayed muddled. During the last few decades, a lot of GC related genes have been identified. To find candidate GC related variant in these GC related genes, we conducted this case-control study. 29 tagSNPs located in 7 GC related genes were included. 228 gastric cancer patients and 299 healthy controls were enrolled. Significant differences were found between the genotype frequencies of EFNA1 rs4971066 polymorphism between gastric cancer patients and healthy controls. The result indicated that ephrin-A1 tagSNP rs4971066 GT/TT genotypes was significantly associated with reduced susceptibility of gastric cancer development.

scholarly journals Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study

2017 ◽  
Vol 24 (5) ◽  
pp. 1082-1089 ◽  
Author(s):  
Filippo Pietrantonio ◽  
Giovanni Fucà ◽  
Federica Morano ◽  
Annunziata Gloghini ◽  
Simona Corso ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Metastatic Gastric Cancer ◽  
Case Control ◽  
Her2 Positive ◽  
Primary Resistance ◽  
Gastric Cancer Patients ◽  
Control Study

scholarly journals Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167615 ◽  
Author(s):  
Hee Jung Park ◽  
Ji Yong Ahn ◽  
Hwoon-Yong Jung ◽  
Jeong Hoon Lee ◽  
Kee Wook Jung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Gastric Cancer Patients ◽  
Control Study

Clinical characteristics and outcomes for gastric cancer patients over age 80: A retrospective case-control study.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 30-30
Author(s):  
Hee-Jung Park ◽  
Ji Yong Ahn ◽  
Hwoon-Yong JUNG ◽  
Jeong Hoon Lee ◽  
Kwi-Sook Choi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Elderly Patients ◽  
Cancer Patients ◽  
Curative Resection ◽  
Case Control Study ◽  
Case Control ◽  
Asa Score ◽  
Gastric Cancer Patients ◽  
Control Study

30 Background: The average human life expectancy is increasing worldwide, thus proportion of elderly gastric cancer patients are also increasing. In this study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old through a case-control study. Methods: From January 2004 to December 2010, 291 patients aged over 81 years old (case group) were diagnosed and treated with gastric cancer at the Asan Medical Center. During the same period, 291 patients aged 18 to 80 years old were selected as control group. The clinical findings, histopathological parameters, and clinical outcomes of gastric cancer were reviewed retrospectively and compared between the two groups. Results: There were significant differences in overall 5-year survival rate between the two groups (30.9% vs 73.8%, P< 0.001). When analysis was confined to resectable elderly patients with favorable performance of American Society of Anesthesiologists (ASA) score 1 or 2, curative resection group showed significantly better overall 3- and 5-year survival rate than the conservative treatment group (73.7% and 58.8% vs 29.8% and 0%, respectively). In multivariate analysis, lower BMI and advanced TNM stage were found to be independent prognostic predictors for poorer survival. ASA score showed borderline significance for predictors for poorer survival (P=0.087). Conclusions: Although elderly patients showed advanced stage at diagnosis and poor prognosis compared to non-elderly patients, elderly patients with good performance could benefit from curative resection of gastric cancer, thus the clinical decision whether to undergo curative resection or conservative management should be made on individualized approach.

Impact of neoadjuvant chemotherapy on surgical and pathological results of gastric cancer patients: A case‐control study

2020 ◽  
Author(s):  
Amir Zeide Charruf ◽  
Marcus Fernando Kodama Pertille Ramos ◽  
Marina Alessandra Pereira ◽  
Andre Roncon Dias ◽  
Tiago Biachi Castria ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Gastric Cancer Patients ◽  
Control Study
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