scholarly journals Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning

2020 ◽  
Vol 14 ◽  
Author(s):  
Dejuan Wang ◽  
Yang Chen ◽  
Yiling Chen ◽  
Xiaowen Li ◽  
Penglai Liu ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Discrimination Learning ◽  
Granule Cells ◽  
Odor Discrimination

scholarly journals Dopaminergic modulation of olfactory bulb processing affects odor discrimination learning in rats.

2009 ◽  
Vol 123 (4) ◽  
pp. 828-833 ◽  
Author(s):  
Olga Escanilla ◽  
Courtney Yuhas ◽  
David Marzan ◽  
Christiane Linster
Keyword(s):  
Olfactory Bulb ◽  
Discrimination Learning ◽  
Odor Discrimination ◽  
Dopaminergic Modulation

scholarly journals Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

2015 ◽  
Vol 18 (10) ◽  
pp. 1474-1482 ◽  
Author(s):  
Olivier Gschwend ◽  
Nixon M Abraham ◽  
Samuel Lagier ◽  
Frédéric Begnaud ◽  
Ivan Rodriguez ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Discrimination Learning ◽  
Odor Discrimination ◽  
Pattern Separation

Group I Metabotropic Glutamate Receptors Are Differentially Expressed by Two Populations of Olfactory Bulb Granule Cells

2007 ◽  
Vol 97 (4) ◽  
pp. 3136-3141 ◽  
Author(s):  
Thomas Heinbockel ◽  
Kathryn A. Hamilton ◽  
Matthew Ennis
Keyword(s):  
Olfactory Bulb ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Granule Cells ◽  
Mitral Cell ◽  
Mitral Cells ◽  
Patch Clamp Recording ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Bath Application

In the main olfactory bulb, several populations of granule cells (GCs) can be distinguished based on the soma location either superficially, interspersed with mitral cells within the mitral cell layer (MCL), or deeper, within the GC layer (GCL). Little is known about the physiological properties of superficial GCs (sGCs) versus deep GCs (dGCs). Here, we used patch-clamp recording methods to explore the role of Group I metabotropic glutamate receptors (mGluRs) in regulating the activity of GCs in slices from wildtype and mGluR−/− mutant mice. In wildtype mice, bath application of the selective Group I mGluR agonist DHPG depolarized and increased the firing rate of both GC subtypes. In the presence of blockers of fast synaptic transmission (APV, CNQX, gabazine), DHPG directly depolarized both GC subtypes, although the two GC subtypes responded differentially to DHPG in mGluR1−/− and mGluR5−/− mice. DHPG depolarized sGCs in slices from mGluR5−/− mice, although it had no effect on sGCs in slices from mGluR1−/− mice. By contrast, DHPG depolarized dGCs in slices from mGluR1−/− mice but had no effect on dGCs in slices from mGluR5−/− mice. Previous studies showed that mitral cells express mGluR1 but not mGluR5. The present results therefore suggest that sGCs are more similar to mitral cells than dGCs in terms of mGluR expression.

scholarly journals Migration of bipolar subependymal cells, precursors of the granule cells of the rat olfactory bulb, with reference to the arrangement of the radial glial fibers.

1990 ◽  
Vol 53 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Kiyoshi KISHI ◽  
Jun Yun PENG ◽  
Sachiko KAKUTA ◽  
Kunio MURAKAMI ◽  
Masaru KURODA ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Granule Cells ◽  
Radial Glial

The Mitral and Short Axon Cells of the Olfactory Bulb

1970 ◽  
Vol 7 (3) ◽  
pp. 631-651
Author(s):  
J. L. PRICE ◽  
T. P. S. POWELL
Keyword(s):  
Electron Microscope ◽  
Olfactory Bulb ◽  
Granule Cells ◽  
Primary Dendrite ◽  
Plexiform Layer ◽  
Mitral Cell ◽  
Granule Cell Layer ◽  
Mitral Cells ◽  
Axon Initial Segments ◽  
Large Neurons

A description is given of the mitral and short axon cells of the olfactory bulb of the rat from Golgi material examined with the light microscope and from material examined with the electron microscope. The mitral cells are large neurons with primary and secondary dendrites which both extend into the overlying external plexiform layer, although only the primary dendrite enters the glomerular formations. No predominant antero-posterior orientation of the secondary dendrites has been found. Within the glomeruli the mitral cell dendrites are in synaptic contact with the olfactory nerves and also with the periglomerular cells, but elsewhere the only synapses on the mitral cells are the ‘reciprocal synapses’ with the granule cells. Synaptic-type vesicles are found in all parts of the mitral cells, including the axon initial segments; they appear to be especially concentrated in the distal portions of the dendrites. Several types of short axon cells have been found in the granule cell layer in Golgi-impregnated material. Their cell bodies can also be distinguished with the electron microscope, and from previous work it is probable that the axons of at least some of these cells form flattened-vesicle symmetrical synapses upon the granule cells.

scholarly journals Transient Activity Induces a Long-Lasting Increase in the Excitability of Olfactory Bulb Interneurons

2008 ◽  
Vol 99 (1) ◽  
pp. 187-199 ◽  
Author(s):  
Tsuyoshi Inoue ◽  
Ben W. Strowbridge
Keyword(s):  
Olfactory Bulb ◽  
Granule Cells ◽  
Receptor Activation ◽  
Brain Regions ◽  
Persistent Activity ◽  
Cellular Mechanisms ◽  
Calcium Dependent ◽  
Transient Activity ◽  
Olfactory Bulb Slices ◽  
Processing And Storage

Little is known about the cellular mechanisms that underlie the processing and storage of sensory in the mammalian olfactory system. Here we show that persistent spiking, an activity pattern associated with working memory in other brain regions, can be evoked in the olfactory bulb by stimuli that mimic physiological patterns of synaptic input. We find that brief discharges trigger persistent activity in individual interneurons that receive slow, subthreshold oscillatory input in acute rat olfactory bulb slices. A 2- to 5-Hz oscillatory input, which resembles the synaptic drive that the olfactory bulb receives during sniffing, is required to maintain persistent firing. Persistent activity depends on muscarinic receptor activation and results from interactions between calcium-dependent afterdepolarizations and low-threshold Ca spikes in granule cells. Computer simulations suggest that intrinsically generated persistent activity in granule cells can evoke correlated spiking in reciprocally connected mitral cells. The interaction between the intrinsic currents present in reciprocally connected olfactory bulb neurons constitutes a novel mechanism for synchronized firing in subpopulations of neurons during olfactory processing.

scholarly journals NMDA Receptor-Dependent Synaptic Activation of TRPC Channels in Olfactory Bulb Granule Cells

2012 ◽  
Vol 32 (17) ◽  
pp. 5737-5746 ◽  
Author(s):  
O. Stroh ◽  
M. Freichel ◽  
O. Kretz ◽  
L. Birnbaumer ◽  
J. Hartmann ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Olfactory Bulb ◽  
Granule Cells ◽  
Trpc Channels ◽  
Synaptic Activation

scholarly journals P1.1.21 Odor Discrimination by Mitral Cells in Rat Olfactory Bulb Using Microwire Array Recordinge

2012 ◽  
Author(s):  
Q. Dong ◽  
J. Zhou ◽  
L. J. Zhuang ◽  
D. Wang ◽  
P. Wang
Keyword(s):  
Olfactory Bulb ◽  
Odor Discrimination ◽  
Mitral Cells

scholarly journals The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the α3β4 subtype

2013 ◽  
Vol 109 (3) ◽  
pp. 867-872 ◽  
Author(s):  
Geeta Sharma
Keyword(s):  
Olfactory Bulb ◽  
Perceptual Learning ◽  
Progenitor Cells ◽  
Glutamate Release ◽  
Brain Regions ◽  
Odor Discrimination ◽  
Rostral Migratory Stream ◽  
Receptor Expression ◽  
Granule Cell Layer ◽  
Migratory Stream

Addition of newly generated neurons into mature neural circuits in the adult CNS responds to changes in neurotransmitter levels and is tightly coupled to the activity of specific brain regions. This postnatal neurogenesis contributes to plasticity of the olfactory bulb and hippocampus and is thought to play a role in learning and memory, context and odor discrimination, as well as perceptual learning. While acetylcholine plays an important role in odor discrimination and perceptual learning, its role in adult neurogenesis in the olfactory bulb has not been elucidated. In this study, I have examined the functional expression of nAChRs in progenitor cells of the rostral migratory stream (RMS) in the adult olfactory bulb of mice. I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Unlike in the hippocampus, the predominant functional nAChRs on progenitor cells are of α3β4 subtype. Interestingly, functional receptor expression is lost once progenitor cells mature, and are incorporated into the granule cell layer. Instead, nAChRs are now expressed on some presynaptic terminals and modulate glutamate release onto granule cells. My results imply that ACh is a part of the permissive niche and likely plays a role in development of progenitor cells.

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