scholarly journals Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis

2019 ◽  
Vol 10 ◽  
Author(s):  
Philipp Schwenkenbecher ◽  
Ulrich Wurster ◽  
Franz Felix Konen ◽  
Stefan Gingele ◽  
Kurt-Wolfram Sühs ◽  
...  
MedChemComm ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 1803-1809 ◽  
Author(s):  
Marat F. Kasakin ◽  
Artem D. Rogachev ◽  
Elena V. Predtechenskaya ◽  
Vladimir J. Zaigraev ◽  
Vladimir V. Koval ◽  
...  

Relapsing–remitting multiple sclerosis markers determined (a) and multivariate models for early diagnosis were evaluated (b).


2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Fuentes S ◽  

Multiple sclerosis can often present with nonspecific symptoms leading to difficulty in establishing a diagnosis early in the disease process. Early diagnosis and treatment is of importance due to the associated decrease in disability for those that get treatment sooner. Here we present a case with a patient the presented with changes in vision and paresthesias. Her initial workup from the neurologist was negative and further workup was delayed until her symptoms worsened. After worsening symptoms, MRI revealed that multiple sclerosis was the cause of her symptoms.


2018 ◽  
Vol 25 (6) ◽  
pp. 879-882 ◽  
Author(s):  
Kevin R Patel ◽  
Amel Karaa ◽  
Farrah J Mateen

Evidence from genetic and pathologic studies suggests that mitochondrial dysfunction occurs in multiple sclerosis (MS). Furthermore, cases of MS have been reported in patients with mitochondrial disease. The phenotypic range of mitochondrial illness associating with MS is not yet well defined. In this report, we highlight two cases of patients with confirmed genetic mutations responsible for progressive external ophthalmoplegia who independently meet McDonald criteria for MS. Better characterization of the range of mitochondrial disease associated with MS may improve our understanding of MS disease pathophysiology.


2009 ◽  
Vol 26 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Genaro Gabriel Ortiz ◽  
Miguel Ángel Macías-Islas ◽  
Fermín P. Pacheco-Moisés ◽  
José A. Cruz-Ramos ◽  
Silvia Sustersik ◽  
...  

Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis.Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification.Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.


Author(s):  
Gabriel Pádua da Silva ◽  
Marcelo Palinkas ◽  
Robson F. Tosta Lopes ◽  
Saulo C. Vallin Fabrin ◽  
Bruno Ferreira ◽  
...  

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