Case Report and Literature Analysis: Guillain-Barré Syndrome With Delayed Unilateral Facial Palsy

Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy in which most patients have cranial nerve involvement, with facial nerve involvement being the most common. However, delayed facial palsy (DFP) with asymmetric facial palsy is a rare manifestation of GBS, and the mechanism is unclear. We report a case of GBS combined with delayed unilateral facial palsy and review previously reported cases of GBS combined with DFP. A total of 28 cases of GBS with DFP, including the case in this report, were included in this study. The occurrence of DFP may be related to early subclinical demyelination of the facial nerve, the blood-nerve barrier of the facial nerve, facial movement, and descending reversible paralysis. The occurrence of unilateral facial palsy may be related to Campylobacter jejuni, specific anti-ganglioside antibodies, and the site of central nervous system anatomical involvement. There is no evidence that immunotherapy is related to the shortening of DFP course and improving patients' prognosis.

Download Full-text

Cranial Nerve Involvement and Dysautonomia in Post-COVID-19 Guillain-Barré Syndrome

Internal Medicine ◽

10.2169/internalmedicine.7355-21 ◽

2021 ◽

Author(s):

Toshiyuki Kakumoto ◽

Satoshi Kobayashi ◽

Hayato Yuuki ◽

Mitsuhiro Kainaga ◽

Yuichiro Shirota ◽

...

Keyword(s):

Cranial Nerve ◽

Guillain Barre Syndrome ◽

Cranial Nerve Involvement ◽

Nerve Involvement ◽

Guillain Barré Syndrome ◽

Guillain Barré

Download Full-text

Twelfth Cranial Nerve Involvement in Guillain-Barre Syndrome: A Case Report

Turkish Journal Of Neurology ◽

10.4274/tnd.2020.60948 ◽

2020 ◽

Vol 26 (4) ◽

pp. 353-356

Author(s):

Gizem Çifter ◽

Gholamreza Hoseinzadeh ◽

Elif Simin Issı ◽

Demet İlhan Algın ◽

Oğuz Osman Erdinç

Keyword(s):

Case Report ◽

Cranial Nerve ◽

Guillain Barre Syndrome ◽

Cranial Nerve Involvement ◽

Nerve Involvement ◽

Guillain Barré Syndrome ◽

Guillain Barré

Download Full-text

Unilateral Facial Palsy in an Adolescent with Guillain–Barré Syndrome

Journal of Pediatric Neurology ◽

10.1055/s-0040-1716911 ◽

2020 ◽

Author(s):

Emanuela Claudia Turco ◽

Benedetta Piccolo ◽

Francesco Pisani

Keyword(s):

Facial Palsy ◽

Pediatric Population ◽

Guillain Barre Syndrome ◽

Childhood Onset ◽

Peripheral Facial Palsy ◽

Nerve Involvement ◽

Guillain Barré Syndrome ◽

Potential Indicator ◽

Guillain Barré ◽

Work Up

AbstractGuillain–Barré syndrome (GBS) is the most common and most severe acute demyelinating polyneuropathy with ∼0.8 to 1.1/100,000 incidence in pediatric population. Unlike adult patients, incidence of facial nerve involvement in children with GBS has not yet been determined possibly because of rare use of magnetic resonance imaging in childhood-onset GBS. In the present study, we describe a girl with GBS who presented unilateral peripheral facial palsy, confirmed by neuroimaging and electrophysiological evaluation. We suggest that both neuroimaging and detailed electrophysiological evaluation should be integrated into the work-up of such patients. We also wish to highlight the importance of evaluating cranial nerve involvement as a potential indicator of severity of disease.

Download Full-text

Childhood Guillain-Barré Syndrome’s Subtypes and Outcome: A Single Centre Experience

İstanbul Kanuni Sultan Süleyman Tıp Dergisi ◽

10.5222/iksstd.2021.95867 ◽

2021 ◽

Author(s):

Özben Akıncı Göktaş ◽

Ömer Bektaş ◽

Merve Feyza Yüksel ◽

Süleyman Şahin ◽

Serap Teber

Keyword(s):

Cranial Nerve ◽

Ventilatory Support ◽

Guillain Barre Syndrome ◽

Clinical Scale ◽

Cranial Nerve Involvement ◽

Female Ratio ◽

Nerve Involvement ◽

Guillain Barré Syndrome ◽

Guillain Barré

INTRODUCTION: In this study, we aimed to revise the clinical, epidemiologic and prognostic features of childhood Guillain-Barré syndrome. METHODS: Thirty two children admitted to our hospital and diagnosed with Guillain-Barré syndrome between June 2007- November 2019 were enrolled in the study. We also administered clinical evaluation scale at onset, discharge, 1,3,6 and 12 months after discharge. RESULTS: The median age was 72.22 months (range from 6 to 202 months) with a male to female ratio of 1.46. Based on electrophysiological features; 22 patients were classified as acute inflammatory demyelinating polyradiculoneuropathy, 10 as acute motor axonal neuropathy. The incidence of cranial nerve involvement was 28.1 % and was related to lower clinical scale score at admission and discharge. Clinical scale scores were significantly different between axonal and demyelinating subgroups except for admission. At 12th month follow-up visit, 78.1% of patients were recovered without sequal. DISCUSSION AND CONCLUSION: We think that the most important predictor of morbidity is predicting the possible ventilatory support need during the follow up period. Short incubating period of antecedent infection and cranial nerve involvement will probably increase ventilatory support need. The prognosis was found to be significantly different between electrophysiological subtypes in our series, axonal forms being consistent with poor prognosis.

Download Full-text