scholarly journals Comparative Study Between Functional MR Urography and Renal Scintigraphy to Evaluate Drainage Curves and Split Renal Function in Children With Congenital Anomalies of Kidney and Urinary Tract (CAKUT)

2020 ◽  
Vol 7 ◽  
Author(s):  
Maria Beatrice Damasio ◽  
Monica Bodria ◽  
Michael Dolores ◽  
Emmanuel Durand ◽  
Fiammetta Sertorio ◽  
...  
Keyword(s):  
Renal Function ◽  
Urinary Tract ◽  
Comparative Study ◽  
Congenital Anomalies ◽  
Renal Scintigraphy ◽  
Mr Urography ◽  
Split Renal Function

scholarly journals Protocol and Baseline Data on Renal Autologous Cell Therapy Injection in Adults with Chronic Kidney Disease Secondary to Congenital Anomalies of the Kidney and Urinary Tract

2021 ◽  
pp. 1-6
Author(s):  
Joseph Stavas ◽  
Maria Diaz-Gonzalez de Ferris ◽  
Ashley Johns ◽  
Deepak Jain ◽  
Tim Bertram
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Urinary Tract ◽  
Kidney Disease ◽  
Cell Therapy ◽  
Congenital Anomalies ◽  
Preliminary Analysis ◽  
Autologous Cell ◽  
Tissue Acquisition ◽  
Autologous Cell Therapy

Background: Advanced cell therapies with autologous, homologous cells show promise to affect reparative and restorative changes in the chronic kidney disease (CKD) nephron. We present our protocol and preliminary analysis of an IRB-approved, phase I single-group, open-label trial that tests the safety and efficacy of Renal Autologous Cell Therapy (REACT; NCT 04115345) in adults with congenital anomalies of the kidney and urinary tract (CAKUT). Methods: Adults with surgically corrected CAKUT and CKD stages 3 and 4 signed an informed consent and served as their “own” baseline control. REACT is an active biological ingredient acquired from a percutaneous tissue acquisition from the patient’s kidney cortex. The specimen undergoes a GMP-compliant manufacturing process that harvests the selected renal cells composed of progenitors for renal repair, followed by image-guided locoregional reinjection into the patient’s renal cortex. Participants receive 2 doses at 6-month intervals. Primary outcomes are stable renal function and stable/improved quality of life. Additional exploratory endpoints include the impact of REACT on blood pressure, vitamin D levels, hemoglobin, hematocrit and kidney volume by MRI analysis. Results: Four men and 1 woman were enrolled and underwent 5 cell injections. Their characteristics were as follows: mean 52.8 years (SD 17.7 years), 1 Hispanic, 4 non-Hispanic, and 5 white. There were no renal tissue acquisition, cell injection, or cell product-related complications at baseline. Conclusion: REACT is demonstrating feasibility and patient safety in preliminary analysis. Autologous cell therapy treatment has the potential to stabilize or improve renal function in CAKUT-associated CKD to delay or avert dialysis. Patient enrollment and follow-up are underway.

Chronic Urinary Obstruction: Evaluation of Dynamic Contrast-enhanced MR Urography for Measurement of Split Renal Function

Radiology ◽  
2014 ◽  
Vol 273 (3) ◽  
pp. 801-812 ◽  
Author(s):  
Michel Claudon ◽  
Emmanuel Durand ◽  
Nicolas Grenier ◽  
Alain Prigent ◽  
Daniel Balvay ◽  
...  
Keyword(s):  
Renal Function ◽  
Urinary Obstruction ◽  
Mr Urography ◽  
Dynamic Contrast Enhanced ◽  
Split Renal Function ◽  
Contrast Enhanced

A22 Calculation of split renal function from contrast enhanced multidetector CT: comparison with renal scintigraphy

2006 ◽  
Vol 27 (12) ◽  
pp. 1019
Author(s):  
S.M. McDonald ◽  
F. Sebastian ◽  
N.J. Hayes ◽  
Z. Abubacker ◽  
J.C. Fowler
Keyword(s):  
Renal Function ◽  
Multidetector Ct ◽  
Renal Scintigraphy ◽  
Split Renal Function ◽  
Contrast Enhanced

Comprehensive Comparative Study of Computed Tomography–Based Estimates of Split Renal Function for Potential Renal Donors

2012 ◽  
Vol 36 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Shigeyoshi Soga ◽  
Scott Britz-Cunningham ◽  
Kanako Kunishima Kumamaru ◽  
Sayeed Khan Malek ◽  
Stefan G. Tullius ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Renal Function ◽  
Comparative Study ◽  
Split Renal Function
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