scholarly journals Mother-to-Infant Bonding in Women With a Bipolar Spectrum Disorder

2021 ◽  
Vol 9 ◽  
Author(s):  
Myrthe G. B. M. Boekhorst ◽  
Annemerle Beerthuizen ◽  
Manon Hillegers ◽  
Victor J. M. Pop ◽  
Veerle Bergink
Keyword(s):  
Bipolar Disorder ◽  
Pregnant Women ◽  
Population Based ◽  
Spectrum Disorder ◽  
Control Group ◽  
Bipolar Spectrum ◽  
Bipolar Spectrum Disorder ◽  
Not Otherwise Specified ◽  
Increased Risk ◽  
History Of

Purpose: Offspring of mothers with a bipolar disorder are at high-risk for impaired developmental outcomes and psychopathology (e. g., mood, anxiety, sleep disorders) later in life. This increased risk of psychopathology is not only because of genetic vulnerability, but environmental factors may play an important role as well. The often long and debilitating mood episodes of mothers with bipolar disorder might hamper their qualities as a caregiver and may impact the child. We examined early mother-to-infant bonding 1 year postpartum in mothers with bipolar spectrum disorder as compared to mothers of the general population. The association between mother-to-infant bonding and the type of bipolar spectrum diagnosis (bipolar I, bipolar II, bipolar Not Otherwise Specified) as well as relapse within 12 months postpartum was also assessed.Methods: In total, 75 pregnant women with a bipolar spectrum disorder participated in the current study. The participants were included in a longitudinal cohort study of women with bipolar spectrum disorder and were prospectively followed from pregnancy until 1 year postpartum. Mother-to-infant bonding was assessed using the Pre- and Postnatal Bonding Scale. A longitudinal population-based cohort of 1,419 pregnant women served as the control group. Multiple linear regression analyses were used to assess the association between bipolar spectrum disorder and mother-to-infant bonding scores, controlling for several confounders.Results: Women with bipolar spectrum disorder perceived the bonding with their child as less positive compared to the control group. The type of bipolar spectrum disorder was not associated with poorer bonding scores. Relapse during the 1st year after delivery also did not affect bonding scores in women with bipolar spectrum disorder.Conclusions: Our findings could imply that women with bipolar spectrum disorder are more vulnerable to impairments in bonding due to the nature of their psychopathology, regardless of the occurrence of postpartum relapse. Careful follow-up including monitoring of mother-to-infant bonding of pregnant women with a history of bipolar spectrum disorder should be a standard to this vulnerable group of women. In addition, regardless of severity and mood episode relapse, an intervention to improve bonding could be beneficial for all mothers with bipolar spectrum disorder and their newborns.

scholarly journals A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder

2014 ◽  
Vol 23 (23) ◽  
pp. 6395-6406 ◽  
Author(s):  
Kevin A. Strauss ◽  
Sander Markx ◽  
Benjamin Georgi ◽  
Steven M. Paul ◽  
Robert N. Jinks ◽  
...  
Keyword(s):  
Population Based ◽  
Spectrum Disorder ◽  
Bipolar Spectrum ◽  
Population Based Study ◽  
Bipolar Spectrum Disorder

scholarly journals Perinatal and neonatal outcomes of pregestational diabetes mellitus: a retrospective study

2021 ◽  
Author(s):  
Giampiero Capobianco ◽  
Alessandra Gulotta ◽  
Giulio Tupponi ◽  
Francesco Dessole ◽  
Giuseppe Virdis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pregnant Women ◽  
Gestational Hypertension ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Growth Disorders ◽  
Pregestational Diabetes ◽  
Increased Risk ◽  
History Of

Abstract BackgroundThe aim of the study was to evaluate maternal-foetal and neonatal clinical outcomes in a group of patients with pregestational diabetes mellitus (PGDM) such as diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), and maturity onset diabetes of the young (MODY).MethodsOverall, 174 pregnant women, nulliparous and multiparous, with single pregnancy were enrolled. The selected patients were divided into two groups: PGDM (42 with DM1, 14 with DM2, and 2 with MODY); 116 patients with a negative pathological history of diabetes mellitus were the control.ResultsWe reported an incidence of preterm delivery of 55.2% in the PGDM group, of 59.5% in the DM1 group, and 42.9% in the DM2 group VS. 6% in the controls. Foetal growth disorders, such as intrauterine growth retardation, small for gestational age, and foetal macrosomia were found in 19% and 3.6% in the case and in the control group, respectively. A relationship between DM2 and gestational hypertension was found.Conclusionspatients with PGDM are at increased risk of perinatal and neonatal complications in comparison with pregnant women without PGDM.

scholarly journals Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

2017 ◽  
Vol 210 (6) ◽  
pp. 408-412 ◽  
Author(s):  
Lukas Propper ◽  
Jill Cumby ◽  
Victoria C. Patterson ◽  
Vladislav Drobinin ◽  
Jacqueline M. Glover ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Family History ◽  
Depressive Disorder ◽  
Control Group ◽  
Major Depressive ◽  
Disruptive Mood Dysregulation Disorder ◽  
Increased Risk ◽  
History Of ◽  
Mood Dysregulation

BackgroundIt has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established.AimsWe examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders.MethodWe established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6–18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring.ResultsDiagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder.ConclusionsOur results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

Aripiprazole in the Treatment of Pediatric Bipolar Disorder: A Systematic Chart Review

CNS Spectrums ◽  
2005 ◽  
Vol 10 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Joseph Biederman ◽  
Mary Ann McDonnell ◽  
Janet Wozniak ◽  
Thomas Spencer ◽  
Megan Aleardi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Global Impression ◽  
Chart Review ◽  
Spectrum Disorder ◽  
Pediatric Bipolar Disorder ◽  
Bipolar Spectrum ◽  
Manic Symptoms ◽  
Bipolar Spectrum Disorder ◽  
Daily Dose ◽  
Clinical Global Impression Improvement

ABSTRACTBackgroundPediatric bipolar diorder is a serious neuropsychiatric disorder asociated with high levels of morbidity and disabilty.ObjectiveThis is a systematic chart review of all outpatient youth with the diagnosis of bipolar disorder and bipolar spectrum disorder treated with aripiprazole either alone or as add-on to ongoing treatments.MethodMedical records were reviewed to identify all subjects with bipolar and bipolar spectrum disorder prescribed aripiprazole in our clinic. During the chart review, the Clinical Global Impression scale was completed by the treating clinicians to determine usefullness.ResultsForty-one youths (mean age±SD: 11.4±3.5 years) with bipolar spectrum disorder who had been treated with aripiprazole were identified. These children received a mean daily dose of aripiprazole 16.0±7.9 mg over an average of 4.6 months. Using a Clinical Global Impression-Improvement scale score of <2 (very much/much improved) to define robust improvement, 71% showed improvement in manic symptoms. Treatment with aripiprazole was well tolerated.ConclusionThis study suggests that aripiprazole may be a useful and well-tolerated treatment for youth with bipolar disorder and it supports the need for controlled clinical trials of this compound in juvenile mania.

Fecundity and bipolar spectrum disorder

2016 ◽  
Vol 33 (S1) ◽  
pp. S342-S343
Author(s):  
J. Vieira ◽  
M. Salta ◽  
B. Barata ◽  
J. Nogueira ◽  
R. Sousa ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Statistical Significance ◽  
Well Being ◽  
Spectrum Disorder ◽  
Psychiatric Disease ◽  
Bipolar Spectrum ◽  
Number Of Children ◽  
Marriage Rates ◽  
Bipolar Spectrum Disorder ◽  
Competing Interest

IntroductionFertility and fecundity are usually considered signs of social and emotional well-being. Bipolar disorder (BD) is a prevalent psychiatric disease that influences the individual's life style and behaviours. Some studies have addressed the issue of fecundity among women with bipolar disorder but few have focused on determining the differences between disease subtypes, which is expected, taking into account the studied differences in demographic measures.ObjectivesTo examine the fecundity of a population of women with bipolar disorder.AimThe aim of this study is to compare the fecundity among women diagnosed with subtypes I to IV of BD, according to Akiskal's bipolar spectrum disorder classification.MethodsA total of 108 female outpatients were divided into four groups. We analyzed number of offspring and demographic features between patients with different subtypes of BD using multivariate analyses.ResultsOur results showed a significantly higher average number of children for BD IV patients when compared with BD I patients. Although not reaching statistical significance, BD I patients had less offspring than BD II and BD III patients. BD I patients had lower marriage rates compared to the other groups.ConclusionsOur results suggest that the subtype of bipolar disorder influences fecundity and behaviours, as is expressed by the lower number of marriages seen in BD I patients. We found that fecundity is significantly impaired among BD I patients, which may imply that female with more severe disorders are less likely to become parents. Fecundity is higher among BD IV patients, which makes a way to speculate about the adaptive role of hyperthimic temperamental traits.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Bipolar Disorder During Childhood and Adolescence

2015 ◽  
pp. 286-298
Author(s):  
Mary Fristad ◽  
Elizabeth Nick
Keyword(s):  
Bipolar Disorder ◽  
Mood Stabilizers ◽  
Childhood And Adolescence ◽  
Bipolar Spectrum ◽  
Not Otherwise Specified ◽  
Bipolar Spectrum Disorders ◽  
Professional Interest ◽  
Evidence Based Treatments ◽  
History Of ◽  
Spectrum Disorders

This chapter reviews bipolar spectrum disorders (bipolar I, bipolar II, bipolar disorder not otherwise specified, and cyclothymic disorder) in childhood and adolescence. The history of the diagnosis in youth, including recent increased public and professional interest, and surrounding controversy is reviewed. Attention is given to prevalence, incidence, similarities and differences in presentation, course, and comorbidities among child, adolescent, and adult bipolar spectrum disorders. Assessment issues are reviewed, including longitudinal and multiinformant perspectives, instruments, strategies, tools, and assessment challenges with youth. Examples of symptom manifestation in youth are provided. Genetic, cognitive, neuroanatomical, psychosocial, and environmental risks for youth bipolar spectrum disorders are discussed. Evidence-based treatments reviewed include commonly prescribed mood stabilizers and atypical antipsychotics, alternative biological treatments, adjunctive psychotherapies, and complementary and alternative treatments. Finally, future directions for the study, assessment, monitoring, and treatment of youth bipolar spectrum disorders are discussed.

scholarly journals Efavirenz Is Not Associated with an Increased Risk of Depressive Disorders in Patients Living with HIV: An 11-Year Population-Based Study in Taiwan

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1625
Author(s):  
Chia-Wen Li ◽  
Yen-Chin Chen ◽  
Nan-Yao Lee ◽  
Po-Lin Chen ◽  
Ming-Chi Li ◽  
...  
Keyword(s):  
Depressive Disorders ◽  
Past History ◽  
Treated Group ◽  
Population Based ◽  
Insurance Premium ◽  
Control Group ◽  
Hazard Ratios ◽  
Increased Risk ◽  
History Of ◽  
Southern Taiwan

(1) Background: This study aimed to determine the association between the use of efavirenz and depressive disorders among human immunodeficiency virus (HIV)-infected patients. (2) Methods: A retrospective cohort study was conducted using Taiwan’s National Health Insurance Database. We identified patients receiving anti-retroviral therapy (ART) between 2000 and 2009; these patients were followed until 2010 for diagnoses of depressive disorders using the Cox proportional hazard model to estimate hazard ratios. (3) Results: After up to 11 years of follow-up, the incidence of depressive disorders for the efavirenz-treated group was estimated at 12.2/1000 person-years (PYs), and the control group was at 12.5/1000 PY (p = 0.822). The independent risk factors for depressive disorders included an insurance premium of less than NTD 17,820 (New Taiwan Dollars—NTD) (adjusted hazard ratio (aHR) 2.59, 95% confidence interval (CI), 1.79–3.76, p < 0.001), and between NTD 17,821 and NTD 26,400 (aHR 1.55, 95% CI, 1.04–2.31, p = 0.030), living in Southern Taiwan (aHR 1.49, 95% CI, 1.21–1.84, p = 0.002), and with a psychiatric history (excluding depressive disorders) (aHR 4.59, 95% CI, 3.51–6.01, p = 0.030). (4) Conclusions: This study concluded that ART-treated patients with a past history of psychiatric disorders, lower insurance premium, and living in Southern Taiwan have an increased risk of depressive disorders, which are not associated with the use of efavirenz.

scholarly journals Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study

2012 ◽  
Vol 201 (5) ◽  
pp. 352-359 ◽  
Author(s):  
Maria A. I. Åberg ◽  
Margda Waern ◽  
Jenny Nyberg ◽  
Nancy L. Pedersen ◽  
Ylva Bergh ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Population Based ◽  
Cardiovascular Fitness ◽  
National Hospital ◽  
Population Based Study ◽  
Hazard Ratios ◽  
Increased Risk ◽  
History Of ◽  
Future Risk ◽  
Swedish Cohort

BackgroundStudies suggest a role for cardiovascular fitness in the prevention of affective disorders.AimsTo determine whether cardiovascular fitness at age 18 is associated with future risk of serious affective illness.MethodPopulation-based Swedish cohort study of male conscripts (n = 1 117 292) born in 1950–1987 with no history of mental illness who were followed for 3–40 years. Data on cardiovascular fitness at conscription were linked with national hospital registers to calculate future risk of depression (requiring in-patient care) and bipolar disorder.ResultsIn fully adjusted models low cardiovascular fitness was associated with increased risk for serious depression (hazard ratios (HR)=1.96, 95%, CI 1.71–2.23). No such association could be shown for bipolar disorder (HR=1.11, 95% CI 0.84–1.47).ConclusionsLower cardiovascular fitness at age 18 was associated with increased risk of serious depression in adulthood. These results strengthen the theory of a cardiovascular contribution to the aetiology of depression.

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