scholarly journals Erythema Multiforme Major Associated With Community-Acquired Pneumonia: Lessons From a Case Report

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiaomei Fan ◽  
Yong Luo ◽  
Jieluan Lu ◽  
Jinji Xu ◽  
Qing Chen ◽  
...  
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
Clinical Symptoms ◽  
Specific Treatment ◽  
Human Leukocyte ◽  
Community Acquired Pneumonia ◽  
The Body ◽  
Drug Induced ◽  
Chemical Structures ◽  
Erythema Multiforme Major

Background: Erythema multiforme (EM) is an acute immune-mediated inflammatory mucinous skin disorder. The etiology of pediatric EM involves infections, medications, autoimmune diseases, and genetic factors.Case Report: An 8-year-old girl with Mycoplasma pneumoniae (MP) associated community-acquired pneumonia developed erythema target-like symptoms 1 week after azithromycin administration. The erythema quickly spread throughout the body involving the oral and ocular mucous membranes, the trunk, and the extremities, and eventually developed into erythema multiform major (EMM). Through drug withdrawal and specific treatment including systemic corticosteroids and supportive care, her clinical symptoms were improved. After 31 days, most of the mucocutaneous symptoms were relieved, except pigmentation. Human leukocyte antigen (HLA) gene sequencing was performed and 20 HLA genotypes were identified. The patient follow-up lasted for 18 months. Rashes appeared on her trunk when receiving azithromycin orally after discharge and then disappeared after azithromycin withdrawal.Conclusions: Pediatric EM is a rare disease and recognition of its etiology is important for EM management. In this case, azithromycin and HLA-DQB1*03:01 genotype may contribute to EMM.Lesson: For drug-induced EM, rapid identification and withdrawal of the causative drugs is critical. Re-exposure to the same drug or exposure to drugs with similar chemical structures should also be avoided. Patient education and rational use of medicines are essential for pediatric patients.

scholarly journals Recurrent Painful Ophthalmoplegic Neuropathy: Diagnostic Controversies. Single Case Report with a Systematic Review

2021 ◽  
Author(s):  
Raffaele Falsaperla ◽  
Santiago Presti ◽  
Manuela Lo Bianco ◽  
Stefano Catanzaro ◽  
Silvia Marino ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Magnetic Resonance ◽  
Clinical Symptoms ◽  
Single Case ◽  
International Headache Society ◽  
Specific Treatment ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Recurrent Painful Ophthalmoplegic Neuropathy

Abstract Background: Ophthalmoplegic migraine, renamed “Recurrent Painful Ophthalmoplegic Neuropathy (RPON) in 2013 by the International Headache Society is a rare neurologic disorder characterized by recurrent attacks of ophthalmoplegia associated to ipsilateral headache. The etiology is still unknown. Typical magnetic resonance imaging findings show a focal nerve thickening and contrast enhancement. In the majority of cases, there is a full recovery within days or weeks. There is no evidence supporting a specific treatment. The review defines the characteristics of the recurrent painful ophthalmoplegic neuropathy in patients within 2 years of age underlying the importance of the role of magnetic resonance imaging even in presence of the first attack. Thus, an emblematic case report is presented.Case presentation: The authors present a case of third cranial nerve paresis in a 17-month-old male child, presenting a neuroradiological pattern highly suggestive of schwannoma, aneurism or recurrent painful ophthalmoplegic neuropathy. Thus, a review of the literature with the pediatric casuistry of recurrent painful ophthalmoplegic neuropathy occurred within 2 years of age focusing on diagnostic considerations is presented. The authors highlight the importance to consider recurrent painful ophthalmoplegic neuropathy in presence of magnetic resonance imaging findings and clinical symptoms referable to aneurysm or schwannoma. Thus, the review defines the characteristics and the neuroradiological findings at the first RPON attack occurred under 2 years of age.Conclusion: Although two attacks are necessary, the review strongly suggests to consider recurrent painful ophthalmoplegic neuropathy even at the first attack, in presence of described characteristics and the aforementioned magnetic resonance imaging findings.

Erythema multiforme major secondary to a cosmetic facial cream: first case report

2016 ◽  
Vol 121 (1) ◽  
pp. e10-e15 ◽  
Author(s):  
Andre A. Farquharson ◽  
Eric T. Stoopler ◽  
Alicia M. Houston ◽  
Ronald S. Brown
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
First Case ◽  
Erythema Multiforme Major

scholarly journals Erythema multiforme major after treatment with bosutinib: a case report

2016 ◽  
Vol 27 ◽  
pp. vii105
Author(s):  
Junya Makiyama ◽  
Hideki Kitanosono ◽  
Yuji Moriwaki ◽  
Tetsuo Shukuwa ◽  
Shinichiro Yoshida
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
Erythema Multiforme Major

scholarly journals Dermatologic and Ophthalmologic Treatment of Erythema Multiforme Major: A Case Report

Cureus ◽  
2021 ◽  
Author(s):  
Barbara Senger ◽  
Shayan A Memar ◽  
Alex Ahmann ◽  
Jeremy J Houser ◽  
Lauren Doughty-McDonald
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
Erythema Multiforme Major

scholarly journals A Systematic Review of Clinical Studies on Mucocutaneous Manifestations of COVID-19: Virus-Related and Drug-Related

2021 ◽  
Author(s):  
Elham Behrangi ◽  
Mohammadreza Ghassemi ◽  
Afsaneh Sadeghzadeh-Bazargan ◽  
Masoumeh Roohaninasab ◽  
Niloufar Najar Nobari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Symptoms ◽  
Skin Lesions ◽  
The Body ◽  
Inclusion Criteria ◽  
Cutaneous Lesions ◽  
Drug Induced ◽  
Skin Biopsies ◽  
Dermatologic Manifestations ◽  
Primary Skin Lesions

Coronavirus could affect almost any part of the body including the skin. In this systematic review, the primary skin lesions resulting from the direct activity of the virus or the medications used for treatment and the changes in the behavior of the virus regarding the occurrence of these symptoms over time were assessed. PubMed/MEDLINE, Embase, PsycINFO, TRIP Cochrane, Cochrane Skin were searched for all published articles from February 19 to July 1, 2020, which met the inclusion criteria. Thirty-six related articles were extracted. Twenty-eight studies reported virus-related mucocutaneous eruptions and 8 articles, the drug-reactions. Data of 583 patients were included. Skin lesions of COVID-19 could be caused by both the virus itself or the influence of drugs used for the treatment. Morbilliform rashes, urticaria, and acral-vasculopathic cutaneous lesions were at the forefront of primary COVID-dependent skin lesions with no significant change during time, Also, Hydroxychloroquine, lopinavir/ritonavir, paracetamol, and antibiotics were reported as the main causes of drug-induced rashes. Since dermatologic manifestations may occur prior or simultaneously/after other COVID clinical symptoms, so they may helpful in patients’ early diagnosis or prediction of internal organ involvements via histopathologic evaluations of skin biopsies especially about vasculopathic and vasculitic, respectively.

scholarly journals Rheumatoid Arthritis with Avascular Necrosis of Femur Head (AVN): A Case Report

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
Rani Khushboo ◽  
Umesh Kumar Sapra ◽  
Vidula Gujjarwar
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Inflammatory Disease ◽  
Clinical Symptoms ◽  
Visual Analogue Score ◽  
The Body ◽  
Femur Head ◽  
Remarkable Improvement ◽  
Systemic Inflammatory Disease ◽  
The Status

 Rheumatoid arthritis is a chronic systemic inflammatory disease whichinvolve multiple joints  of the body.The clinical symptoms of the Rheumatoid Arthritisresemble with Amavata described in Ayurvedic literature. In thisdisease, the vitiated Vatadosha and Ama spread all along the body and  localisein kaphasthana likejoints and producing symptoms like pain, stiffness, swelling, tendernessetc.Treatment principle recommended are to correct the status of the digestive fireof the bodyand balance of Vata in the body. In this case, a male patient of 28 years old presented with the symptoms of inabilityto walk and stand without support associated with pain, swelling and  stiffnessover multiple jointsalong with deformity of hands. Pain was assessed by Visual analogue score(VAS).The patient was admitted in IPD of the hospital andtreatedwith Ayurvedic  medicines and Panchakarma therapy for 28 days. Remarkable improvement was seen in pain, swelling and stiffness after the treatment.

scholarly journals Weil’s syndrome (Leptospiral infection): A case report

2007 ◽  
Vol 60 (9-10) ◽  
pp. 493-496
Author(s):  
Zeljko Mijailovic ◽  
Predrag Canovic ◽  
Olgica Gajovic
Keyword(s):  
Renal Failure ◽  
Case Report ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Severe Form ◽  
The Body ◽  
Symptomatic Therapy ◽  
Clinical Syndromes ◽  
Febrile Condition ◽  
Therapeutic Measures

Introduction. Leptospirosis is an acute zoonotic infection, caused by spirochetes of the genus Leptospira. It is characterized by extensive vasculitis. It is usually transmitted indirectly, per contaminated water, rarely directly, through contact with infected animals. Leptospira bacteria commonly enter the body through damaged skin or mucous membranes. The clinical syndromes may vary from a subclinical infection and mild febrile condition to severe clinical symptoms with jaundice and renal failure. Case report. This is a case report of a patient with leptospirosis (Weil's disease) whose clinical manifestations included: icterus, renal failure, hemorrhagic syndrome and disturbances of consciousness. After the use of antibiotics, symptomatic and substitution therapy, all symptoms resolved completely. However, in our patient, hemodialysis was necessary due to renal failure, as a palliative measure. Discussion. Weil?s syndrome is a severe form of leptospirosis, which can be fatal. Early clinical diagnosis of the disease, as well as serologic verification of infection, are very important prerequisites, followed by antibiotic and other symptomatic therapy, as soon as possible. Conclusion. This is a case report of a patient with rare clinical manifestations of leptosirosis. Although presenting with severe symptoms, thanks to palliative therapeutic measures, complete and fast recovery was achieved. We especially point out the role of hemodialysis in the treatment of this patient. .

scholarly journals Treatment of Drug-Induced Erythema Multiforme: Case Report

2019 ◽  
Vol 44 (4) ◽  
pp. 183-188
Author(s):  
Hae-Ohk Lee ◽  
Hye-Min Ju ◽  
Ji-Yeon Lee ◽  
Hye-Mi Jeon ◽  
Kyung-Hee Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
Drug Induced

scholarly journals A Rare and Unusual Cause of Epistaxis

2016 ◽  
Vol 24 (1) ◽  
pp. 36-38
Author(s):  
Ajay Mallick ◽  
Vijay Bhalla ◽  
Ravi Roy
Keyword(s):  
Case Report ◽  
General Anaesthesia ◽  
Nasal Obstruction ◽  
Local Anaesthesia ◽  
Clinical Symptoms ◽  
Tracheobronchial Tree ◽  
Aerodigestive Tract ◽  
The Body ◽  
Nasal Endoscope ◽  
Blood Sucking

INTRODUCTION:  Leeches are blood sucking parasites of the phylum Amelida subgroup Hirudinea. Leech infestation is known as hirudiniasis. Endoparasitic infestation by leech is rarely reported in literature. The parasites enter the body by bathing or drinking infected water. They attach to the mucosa of the aerodigestive tract and suck blood whereby greatly increasing in size, with resultant clinical symptoms. CASE REPORT: A 52 year male presented with unilateral epistaxis and nasal obstruction. Nasal examination revealed a live leech. The leech was found lodged in the nasopharynx. The patient was unaware of the leech in his body. The leech was removed alive with the use of a nasal endoscope under local anaesthesia.  DISCUSSION : Leech infestation is a rare cause  of epistaxis. Absence of pain and difficult visualisation make the diagnosis difficult and delayed. There are various methods described in literature to remove leeches from the body. General anaesthesia may be required for its removal especially in children and when the leech is lodged in the tracheobronchial tree. CONCLUSION : The aim of presentation is to report a rare unusual cause of epistaxis, leech infestation of the nasopharynx and method of removal of the leech safely under local anaesthesia.

scholarly journals Erythema Multiforme- Case Report with Review

2014 ◽  
Vol 02 (03) ◽  
pp. 166-168
Author(s):  
Neha Gupta ◽  
Amol Bansal ◽  
Aarti Bansal
Keyword(s):  
Case Report ◽  
Hypersensitivity Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Cytotoxic T Lymphocytes ◽  
Erythema Multiforme ◽  
Wide Spectrum ◽  
Cell Necrosis ◽  
Erythema Multiforme Major ◽  
Life Threatening ◽  
Inflammatory Drugs

AbstractErythema Multiforme is a rare, acute, inflammatory mucocutaneous condition caused by a hypersensitivity reaction with the appearance of cytotoxic T lymphocytes in the epithelium that induce apoptosis in keratinocytes, which leads to satellite cell necrosis. Reactions to drugs are quite common and are generally mild, hence not reported. However, occasionally life threatening reactions including Erythema multiforme major (Steven Johnson’s syndrome) and Toxic Epidermal Necrolysis may occur. A wide spectrum of drugs can sometimes give rise to Erythema Multiforme. We report a case of Erythema Multiforme following administration of Non Steroidal Anti-Inflammatory Drugs.

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