scholarly journals Comparative Effect of Collaborative Care, Pain Medication, and Duloxetine in the Treatment of Major Depressive Disorder and Comorbid (Sub)Chronic Pain: Results of an Exploratory Randomized, Placebo-Controlled, Multicenter Trial (CC:PAINDIP)

2018 ◽  
Vol 9 ◽  
Author(s):  
Eric W. de Heer ◽  
Jack Dekker ◽  
Aartjan T. F. Beekman ◽  
Harm W. J. van Marwijk ◽  
Tjalling J. Holwerda ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Collaborative Care ◽  
Multicenter Trial ◽  
Pain Medication ◽  
Comparative Effect ◽  
Major Depressive

scholarly journals A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder

2004 ◽  
Vol 50 (9) ◽  
pp. 2974-2984 ◽  
Author(s):  
Lesley M. Arnold ◽  
Yili Lu ◽  
Leslie J. Crofford ◽  
Madelaine Wohlreich ◽  
Michael J. Detke ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Multicenter Trial ◽  
Major Depressive ◽  
Double Blind

Alternative diagnostic criteria for major depressive disorder in patients with chronic pain

Pain ◽  
2001 ◽  
Vol 91 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Keith G. Wilson ◽  
Samuel F. Mikail ◽  
Joyce L. DʼEon ◽  
Joanne E. Minns
Keyword(s):  
Chronic Pain ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Diagnostic Criteria ◽  
Major Depressive

scholarly journals Cost-effectiveness of collaborative care for the treatment of major depressive disorder in primary care. A systematic review

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Kirsten M van Steenbergen-Weijenburg ◽  
Christina M van der Feltz-Cornelis ◽  
Eva K Horn ◽  
Harm WJ van Marwijk ◽  
Aartjan TF Beekman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Primary Care ◽  
Major Depressive Disorder ◽  
Cost Effectiveness ◽  
Depressive Disorder ◽  
Collaborative Care ◽  
Major Depressive

scholarly journals Major Depressive Disorder and Sleep Disturbance in Patients with Chronic Pain

2014 ◽  
Vol 19 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Patricia C Emery ◽  
Keith G Wilson ◽  
John Kowal
Keyword(s):  
Chronic Pain ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sleep Hygiene ◽  
Dysfunctional Beliefs ◽  
Major Depressive ◽  
Hygiene Practices ◽  
Chronic Pain Patients ◽  
Pain Patients ◽  
Presleep Arousal

BACKGROUND: Disturbed sleep is a common problem in both chronic pain and major depressive disorder (MDD). Moreover, many patients with chronic pain are depressed.OBJECTIVES: To examine the effects of depression on the sleep behaviour of chronic pain patients by comparing patients who did or did not meet diagnostic criteria for MDD.METHODS: A total of 60 patients with chronic musculoskeletal pain underwent structured diagnostic interviews for MDD and insomnia, and completed questionnaires assessing pain severity, disability, sleep quality, beliefs and attitudes about sleep, and sleep hygiene. For four consecutive days, they also completed a sleep diary, and reported on sleep hygiene practices and presleep arousal.RESULTS: Thirty-three patients (55%) met diagnostic criteria for MDD, most of whom (n=32 [97%]) also fulfilled criteria for insomnia disorder. Insomnia was also common among patients without MDD (21 of 27 [78%]). Participants with MDD had higher self-reports of pain, disability, dysfunctional beliefs about sleep, and, on a prospective basis, greater presleep arousal and poorer sleep hygiene. However, diary assessments of specific sleep parameters (eg, sleep onset latency, total sleep time, sleep efficiency) did not differ between the groups.DISCUSSION: Chronic pain patients with comorbid MDD exhibited more dysfunctional beliefs about sleep, poorer sleep hygiene practices and greater presleep arousal; however, diary-recorded sleep characteristics may not differ from those of patients without MDD. Chronic pain itself may disturb sleep so extensively that MDD introduces little additive effect.CONCLUSION: MDD in chronic pain may be related to the cognitive and behavioural aspects of insomnia, rather than to an incremental disturbance in the initiation or maintenance of sleep.

scholarly journals Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5

2018 ◽  
Author(s):  
Keira J.A. Johnston ◽  
Mark J. Adams ◽  
Barbara I. Nicholl ◽  
Joey Ward ◽  
Rona J Strawbridge ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
False Discovery Rate ◽  
Complex Traits ◽  
Pleiotropic Effects ◽  
Chromosome 1 ◽  
Chromosome 14 ◽  
Major Depressive ◽  
False Discovery

AbstractChronic pain is highly prevalent worldwide, with a significant socioeconomic burden, and also contributes to excess mortality. Chronic pain is a complex trait that is moderately heritable and genetically, as well as phenotypically, correlated with major depressive disorder (MDD). Use of the Conditional False Discovery Rate (cFDR) approach, which leverages pleiotropy identified from existing GWAS outputs, has been successful in discovering novel associated variants in related phenotypes. Here, genome-wide association study outputs for both von Korff chronic pain grade as a quasi-quantitative trait and for MDD were used to identify variants meeting a cFDR threshold for each outcome phenotype separately, as well as a conjunctional cFDR (ccFDR) threshold for both phenotypes together. Using a moderately conservative threshold, we identified a total of 11 novel single nucleotide polymorphisms (SNPs), six of which were associated with chronic pain grade and nine of which were associated with MDD. Four SNPs on chromosome 14 were associated with both chronic pain grade and MDD. SNPs associated only with chronic pain grade were located within SLC16A7 on chromosome 12. SNPs associated only with MDD were located either in a gene-dense region on chromosome 1 harbouring LINC01360, LRRIQ3, FPGT and FPGT-TNNI3K, or within/close to LRFN5 on chromosome 14. The SNPs associated with both outcomes were also located within LRFN5. Several of the SNPs on chromosomes 1 and 14 were identified as being associated with expression levels of nearby genes in the brain and central nervous system. Overall, using the cFDR approach, we identified several novel genetic loci associated with chronic pain and we describe likely pleiotropic effects of a recently identified MDD locus on chronic pain.Author SummaryGenetic variants explaining variation in complex traits can often be associated with more than one trait at once (‘pleiotropy’). Taking account of this pleiotropy in genetic studies can increase power to find sites in the genome harbouring trait-associated variants. In this study we used the suspected underlying pleiotropy between chronic pain and major depressive disorder to discover novel variants associated with chronic pain, and to investigate genetic variation that may be shared between the two disorders.

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