scholarly journals Efficacy of Simultaneous Intradermal Vaccination of Swine against Porcine Circovirus 2, Porcine Reproductive and Respiratory Syndrome Virus, Mycoplasma hyopneumoniae and Lawsonia intracellularis

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2225
Author(s):  
Jacquelyn Horsington ◽  
Maarten Witvliet ◽  
Antonius A. C. Jacobs ◽  
Ruud P. A. M. Segers
Keyword(s):  
Clinical Signs ◽  
Mycoplasma Hyopneumoniae ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Lawsonia Intracellularis ◽  
Intradermal Vaccination ◽  
Combined Application ◽  
Labour Costs ◽  
Porcine Circovirus 2 ◽  
Reduced Time

The combined application of vaccines in swine offers many benefits, including reduced time and labour costs, and improved animal welfare, due to fewer injections and manipulations. This study investigated if simultaneous intradermal vaccinations against porcine circovirus 2, porcine reproductive and respiratory syndrome virus, Mycoplasma hyopneumoniae, and Lawsonia intracellularis, using a specialised needle-free applicator would confer comparable protection against experimental infection compared to the single vaccines. In all cases, the administration of the vaccines together was as efficacious as the administration of the vaccines alone, significantly reducing clinical signs associated with each of the four pathogens.

scholarly journals Swine torque teno virus detection in pig commercial vaccines, enzymes for laboratory use and human drugs containing components of porcine origin

2009 ◽  
Vol 90 (3) ◽  
pp. 648-653 ◽  
Author(s):  
Tuija Kekarainen ◽  
Laura Martínez-Guinó ◽  
Joaquim Segalés
Keyword(s):  
Virus Detection ◽  
Mycoplasma Hyopneumoniae ◽  
The Other ◽  
Porcine Circovirus ◽  
Respiratory Syndrome Virus ◽  
Dna Viruses ◽  
Circular Dna ◽  
Wasting Syndrome ◽  
High Prevalence ◽  
Porcine Origin

Torque teno viruses (TTVs) are vertebrate infecting, single-stranded circular DNA viruses. Two genetically distinct TTV genogroups (TTV1 and TTV2) infect swine worldwide with high prevalence. Currently, swine TTVs are considered non-pathogenic, although TTV2 has been linked to post-weaning multisystemic wasting syndrome, a porcine circovirus disease. On the other hand, pig materials are an important source of components used in porcine vaccine manufacturing, human drugs and commercial enzyme products. However, there is little information about the possible existence of extraneous viruses in products containing porcine-derived components. In the present study, 26 commercial swine vaccines, seven human drugs and three enzyme products from porcine origin were tested for the presence of TTV1 and TTV2 genomes by PCR. Four vaccines against Mycoplasma hyopneumoniae were positive for TTV2 by PCR. Three M. hyopneumoniae, one porcine parvovirus and one porcine reproductive and respiratory syndrome virus vaccines were PCR positive for TTV1. One human drug contained TTV1 DNA as well as a trypsin enzyme; a porcine-derived elastase product was positive for both TTV genogroups. These results show that swine TTVs are contaminants not only of swine vaccines but also of human drugs containing porcine components and enzymes for laboratory use.

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