scholarly journals Application of Image Fusion in Diagnosis and Treatment of Liver Cancer

2020 ◽  
Vol 10 (3) ◽  
pp. 1171 ◽  
Author(s):  
Chengxi Li ◽  
Andrew Zhu
Keyword(s):  
Liver Disease ◽  
Radiofrequency Ablation ◽  
Medical Imaging ◽  
Image Fusion ◽  
Liver Tumors ◽  
Imaging Modality ◽  
Fusion Technology ◽  
Tumor Treatment ◽  
Anatomical Imaging ◽  
Functional Images

With the accelerated development of medical imaging equipment and techniques, image fusion technology has been effectively applied for diagnosis, biopsy and radiofrequency ablation, especially for liver tumor. Tumor treatment relying on a single medical imaging modality might face challenges, due to the deep positioning of the lesions, operation history and the specific background conditions of the liver disease. Image fusion technology has been employed to address these challenges. Using the image fusion technology, one could obtain real-time anatomical imaging superimposed by functional images showing the same plane to facilitate the diagnosis and treatments of liver tumors. This paper presents a review of the key principles of image fusion technology, its application in tumor treatments, particularly in liver tumors, and concludes with a discussion of the limitations and prospects of the image fusion technology.

Utility of real-time image fusion technology in ultrasonography-guided fiducial marker implantation for stereotactic body radiation therapy for liver tumors

2020 ◽  
pp. 028418512093447
Author(s):  
Koji Tokunaga ◽  
Akihiro Furuta ◽  
Yusuke Iizuka ◽  
Hiroyoshi Isoda ◽  
Kaori Togashi
Keyword(s):  
Radiation Therapy ◽  
Image Fusion ◽  
Stereotactic Body Radiation Therapy ◽  
Liver Tumors ◽  
Fiducial Marker ◽  
Target Point ◽  
Fusion Technology ◽  
Technical Success ◽  
Real Time Image ◽  
Time Image

Background Ultrasonography (US) is useful when implanting fiducial markers in the liver. However, the implant position is sometimes lost. Recently, real-time image fusion technology (Volume Navigation [V-navi]; GE Healthcare, Milwaukee, WI, USA) has been introduced as a technique for using images from different modalities, and its utility for fiducial marker implantation has been hypothesized. Purpose To evaluate the utility of US-guided fiducial marker implantation in the liver using V-navi compared to conventional US. Material and Methods We retrospectively reviewed 35 patients who underwent fiducial marker implantation for stereotactic body radiation therapy of liver tumors in 2013–2018. To avoid artifacts obscuring the tumor, the target point of implantation was set 10 mm cranial or caudal to the tumor. Marker implantation was then performed using US alone (US group, n = 24) or V-navi with computed tomography (CT) or magnetic resonance imaging (V-navi group, n = 11). Postprocedural CT was evaluated to determine technical success, distances between marker and either tumor surface or target point, and whether marker-induced artifacts obscured the tumor. Complications were also evaluated. Results were compared between groups. Results Technical success was obtained in 33 patients. Distance between the tumor and marker showed no significant difference between groups. Distance between target point and marker was shorter in the V-navi group ( P = 0.0093). Tumor-obscuring artifacts were seen in 12 patients (V-navi group, n = 1; US group, n = 11; P = 0.055). The only complication was minor bleeding in the US group (n = 1). Conclusion V-navi appears useful for US-guided fiducial marker implantation in the liver compared with conventional US.

Transthoracic Percutaneous Radiofrequency Ablation for Liver Tumors in the Hepatic Dome

2004 ◽  
Vol 15 (11) ◽  
pp. 1323-1327 ◽  
Author(s):  
Toyomichi Shibata ◽  
Toshiya Shibata ◽  
Yoji Maetani ◽  
Takeshi Kubo ◽  
Kyo Itoh ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Tumors ◽  
Percutaneous Radiofrequency Ablation ◽  
Hepatic Dome

scholarly journals Role of autophagy in the pathogenesis of liver diseases

2011 ◽  
Vol 152 (49) ◽  
pp. 1955-1961 ◽  
Author(s):  
Klára Werling
Keyword(s):  
Endoplasmic Reticulum ◽  
Liver Disease ◽  
Liver Diseases ◽  
Liver Tumors ◽  
Liver Steatosis ◽  
Prognostic Significance ◽  
Adenosine Monophosphate ◽  
Mutant Proteins ◽  
Alpha 1 Antitrypsin Deficiency

Autophagy is a self-digestion process that plays an important role in the development, differentiation and homeostasis of cells, helping their survival during starvation and hypoxia. Accumulated mutant proteins in the endoplasmic reticulum can be degraded by autophagy in alpha-1 antitrypsin deficiency. Hepatitis C and B virus may exploit the autophagy pathway to escape the innate immune response and to promote their own replication. Autophagy is decreased in response to chronic alcohol consumption, likely due to a decrease in 5’-adenosine monophosphate-activated protein kinase, increase in mTOR activity and due to an alteration in vesicle transport in hepatocytes. In obesity and alcoholic liver disease the decreased function of autophagy causes formation of Mallory-Denk bodies and cell death. The deficient autophagy can contribute to liver steatosis, to endoplasmic reticulum stress, and to progression of liver disease. Autophagy defect in hepatocellular carcinoma suggests that it can serve a tumor-suppressor function. The autophagy protein Beclin-1 levels have prognostic significance in liver tumors. Understanding of the molecular mechanism and the role of autophagy may lead to more effective therapeutic strategies in liver diseases in the future. Orv. Hetil., 2011, 152, 1955–1961.

Radiofrequency ablation in the treatment of liver tumors in children

2012 ◽  
Vol 47 (3) ◽  
pp. e7-e12 ◽  
Author(s):  
Stijn van Laarhoven ◽  
Robertine van Baren ◽  
Rienk Yde Johan Tamminga ◽  
Koert Pieter de Jong
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Tumors

Automatic radiofrequency ablation planning for liver tumors

2021 ◽  
Author(s):  
Peizhao Yu ◽  
Tianyu Fu ◽  
Chan Wu ◽  
Yurong Jiang ◽  
Jian Yang
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Tumors
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