scholarly journals Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 517
Author(s):  
Aniceta Ada Mikulska ◽  
Teresa Grzelak ◽  
Marta Pelczyńska ◽  
Paweł Bogdański ◽  
Krystyna Czyżewska
Keyword(s):  
Physical Activity ◽  
Total Antioxidant Status ◽  
Anthropometric Parameters ◽  
Anthropometric Indices ◽  
Hypertensive Patients ◽  
Clock Proteins ◽  
Total Antioxidant ◽  
Lipids Profile ◽  
Cryptochrome 1

Background: Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins—cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, and quality of sleep) in hypertensive patients. Methods: In 31 females with hypertension (HT) and 55 non-hypertensive women (NHT) the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile, and glycemia were analyzed. Blood pressure and anthropometric measurements, nutritional, exercise, and sleep analyses were performed. Results: In the HT group, the CRY1 level was 37.38% lower than in the NHT group. No differences were noted in CLOCK concentration between groups. BMI, FBG, and TG were higher in the HT group compared to the NHT group, while TC, LDL, and HDL levels were similar. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity, or sleep quality, although CRY1 was associated with some anthropometric indicators. In the HT group, increased CLOCK and CRY1 values were associated with a high TAS level. Conclusions: The serum level of CRY1 could be considered in a detailed diagnostic of hypertension risk in populations with abnormal anthropometric indices.

scholarly journals Assessment of Selected Clock Proteins (CLOCK, CRY1) and their Relationship with Biochemical, Anthropometric and Lifestyle Parameters in Hypertensive Patients

2020 ◽  
Author(s):  
Aniceta Ada Mikulska ◽  
Teresa Grzelak ◽  
Marta Pelczyńska ◽  
Paweł Bogdański ◽  
Krystyna Czyżewska
Keyword(s):  
Physical Activity ◽  
Saturated Fatty Acids ◽  
Total Antioxidant Status ◽  
Anthropometric Parameters ◽  
Hypertensive Patients ◽  
Clock Proteins ◽  
Total Antioxidant ◽  
Lipids Profile ◽  
Cryptochrome 1

Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins- cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) and to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, quality of sleep) in hypertensive patients. In 25 female with hypertension (HT) and 49 non-hypertensive women (NHT), the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile and glycemia were conducted. Blood pressure and anthropometric measurements, nutritional, exercise and sleep analyses were performed. In HT the CRY1 level was 40.2% lower than in the NHT. No differences were noted in CLOCK concentration between groups. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity and sleep quality, although CRY1 was associated with some anthropometric parameters. There was a negative correlation between the CLOCK concentration and the amount of saturated fatty acids consumed (24h) in HT. That indicates the possible influence of the diet on the CLOCK level. In a detailed prognosis of the risk of hypertension, it is worth considering the measurement of the level of CRY1 in populations with abnormal anthropometric indices.

scholarly journals Quality of Dabai Pulp Oil Extracted by Supercritical Carbon Dioxide and Supplementation in Hypercholesterolemic Rat—A New Alternative Fat

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 262
Author(s):  
Noor Atiqah Aizan Abdul Kadir ◽  
Azrina Azlan ◽  
Faridah Abas ◽  
Intan Safinar Ismail
Keyword(s):  
Fatty Acid Content ◽  
Total Antioxidant Status ◽  
High Cholesterol Diet ◽  
Reactive Protein ◽  
Total Antioxidant ◽  
Canarium Odontophyllum ◽  
Coa Reductase ◽  
Factor Α ◽  
Necrosis Factor

Dabai pulp oil (DPO) is new oil extracted from the pulp of Canarium odontophyllum. The quality and efficacy of DPO are needed to promote its potential as a new alternative fat. Therefore, we investigate the quality of DPO, which includes moisture and volatile content (MVC), free fatty acid content (FFA), iodine value (IV), and peroxide value (PV). Furthermore, we evaluate the efficacy of DPO against hypercholesterolemia elicited by a high-cholesterol diet in rats. The MVC of DPO was <0.001 ± 0.00%. Next, the FFA in DPO was 2.57 ± 0.03%, and the IV of DPO was 53.74 ± 0.08 g iodine/100 g oil. Meanwhile, the PV of DPO was 4.97 ± 0.00 mEq/kg. Supplementation of DPO in hypercholesterolemic rats for 30 days revealed the hypocholesterolemic effect (significant reduction of total cholesterol, triglyceride, and 3-hydroxy-3-methylglutaryl-CoA reductase) accompanied by a significant reduction of inflammatory markers (C-reactive protein, interleukin-6 and tumour necrosis factor-α), and lipid peroxidation (MDA). We also observed a significant improvement of lipoprotein lipase (LPL) and antioxidant capacities (total antioxidant status, superoxide dismutase, glutathione peroxidase, and catalase) of the rats. The results on the quality and efficacy of locally made DPO suggest its potential use as a healthy alternative fat in the future.

scholarly journals Bariatric Surgery: Consequences on Functional Capacities in Patients With Obesity

2021 ◽  
Vol 12 ◽  
Author(s):  
Aline Reinmann ◽  
Simone Chantal Gafner ◽  
Roger Hilfiker ◽  
Anne-Violette Bruyneel ◽  
Zoltan Pataky ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Bariatric Surgery ◽  
Weight Loss ◽  
Lower Limb ◽  
Dynamic Balance ◽  
Anthropometric Parameters ◽  
Walking Capacity ◽  
Functional Capacities

IntroductionBariatric surgery leads to loss of fat and fat-free mass (FFM). To preserve FFM it is recommended that weight loss interventions are accompanied by physical activity. However, it remains unknown if functional capacities spontaneously improve after a substantial weight loss. Study’s aim was to assess the effect of bariatric surgery on strength, functional capacities and quality of life of participants with a body mass index (BMI) ≥ 35 kg/m2.MethodAnthropometric parameters (weight, BMI, waist circumference), physical functions (quadriceps strength, walking capacity, spatio-temporal gait parameters, dynamic balance, lower limb power) and quality of life were assessed before and at three months after the bariatric surgery in 33 individuals who did not follow any physical activity program.ResultsThe anthropometric parameters, quality of life and three functional abilities (walking capacity, normal gait speed and lower limb power) improved significantly three months post-surgery. In contrast, fast gait speed, absolute strength, normalized strength, and dynamic balance did not improve.DiscussionA massive weight loss should be accompanied by an exercise program aiming to maintain FFM and to enhance muscle strength and balance. Such a program might also enhance functional capacities and help to sustain the weight loss over time.

scholarly journals Rutin Content in Buckwheat Enriched Bread and Influence of its Consumption on Plasma Total Antioxidant Status

2009 ◽  
Vol 27 (Special Issue 1) ◽  
pp. S236-S240 ◽  
Author(s):  
T. Bojňanská ◽  
H. Frančáková ◽  
P. Chlebo ◽  
A. Vollmannová
Keyword(s):  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Biologically Active ◽  
Active Components ◽  
Overall Acceptability ◽  
Total Antioxidant ◽  
Acceptability Rating ◽  
Baked Products ◽  
Plasma Total Antioxidant Status

The goal of this study is the evaluation of enriched bread prepared with an addition of buckwheat as a source of biologically active components in nutrition. Experimental pastry was baked using buckwheat wholegrain flour blended with wheat flour in different portions (10%, 20%, 30%, 40% and 50%) in order to observe the influence of buckwheat addition on dough processing and the quality of the final baked products. Taking into account the overall acceptability rating, it was concluded that bread with an addition of up to 30% of buckwheat could be baked with satisfactory evaluation results. The content of rutin in loaves in a consumable form prepared with a buckwheat addition varied between 7.76 mg/kg and 26.90 mg/kg. The clinical study which followed the baking experiment was based on the consumption of enriched bread (30% buckwheat, between 34.7 mg/kg and 38.2 mg/kg rutin content in dry matter) by a group of volunteers during a period of four weeks. The results approved the increase of the total antioxidant status thanks to the buckwheat enriched bread consumption from the value of 1.135 ± 0.066 mmol/dm<sup>3</sup> at the beginning of the study to 1.46 ± 0.083 mmol/dm<sup>3</sup> at the end of the study, i.e. significant differences.

scholarly journals Assessment of Changes in Concentration of Total Antioxidant Status, Acute-Phase Protein, and Prolactin in Patients with Osteoarthritis Subjected to a Complex Spa Treatment with Radon Water: Preliminary Results

PPAR Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jadwiga Kuciel-Lewandowska ◽  
Michał Kasperczak ◽  
Lilla Pawlik-Sobecka ◽  
Małgorzata Paprocka-Borowicz ◽  
Jan Gnus
Keyword(s):  
Acute Phase Protein ◽  
Total Antioxidant Status ◽  
Control Group ◽  
Study Group ◽  
Total Antioxidant ◽  
Clinical Benefits ◽  
Spa Treatment ◽  
Radon Water ◽  
Spinal Osteoarthritis

Spa treatment brings many clinical benefits such as improved physical activity, pain relief, and improved quality of life. In the literature, there are only few objective studies evaluating changes in metabolism possibly influencing clinical outcomes. The main purpose of our study was the assessment of the effect of spa treatment on changes in concentration of TAS, CRP, and PRL in patients with osteoarthritis. Patients receiving spa treatment were enrolled. TAS, CRP, and PRL levels were obtained using standard tests before the beginning of treatment as well as on days 5 and 18. The study group consisted of n=35 patients with peripheral joint and spinal osteoarthritis. The control group consisted of 15 people selected from the resort staff, who also suffered from osteoarthritis and had no contact with radon. An increase in TAS concentration was found in the study group following therapy while the control group was characterized by a significant decrease in TAS. On day 5, an increase in TAS concentration was found in both groups, however, with much worse result in the control group. No changes in CRP concentration were statistically significant. PRL concentration was proven to decrease in a statistically significant way after treatment in the study group. This trial is registered with NCT03274128.

scholarly journals Physical Activity, Anthropometric Characteristics, and Quality of Life of Middle-Aged Women Living in Rural and Nomadic Areas of Kermanshah Province

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Rastegar Hoseini ◽  
Nariman Rahmani ◽  
Zahra Hoseini ◽  
Elahe Bahmani ◽  
Mahsa Ahmadi Darmian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Rural Women ◽  
Short Form ◽  
Activity Level ◽  
Middle Aged ◽  
Anthropometric Parameters ◽  
Geographical Differences ◽  
Anthropometric Characteristics

Background: High physical activity level (PAL) and anthropometric characteristics (AC) are positively associated with quality of life (QoL). Several studies have investigated rural-urban differences in PAL, AC, and QoL. However, cultural and geographical differences have not been studied yet. Objectives: This study aimed to examine PAL, AC, and QoL of middle-aged women living in rural and nomadic Areas of Kermanshah province (Sarpol-e-Zahab, Paveh, and Kangavar cities). Methods: In this descriptive-analytical study, using the multi-stage (Cluster) sampling techniques, 1635 nomadic rural women from three cities of Kermanshah province (Sarpol-e Zahab (n = 609); Paveh (n = 480) and Kangavar (n = 546)) were volunteered. After filling out the consent form, the PAL and QOL questionnaires were completed and anthropometric parameters were measured. The PAL was assessed using the Baecke physical activity questionnaire, and the QOL was measured by the QoL Questionnaire (short-form-SF-12). Results: The findings showed that BW, BMI, BFP, and WHR were 68.01 ± 14.90, 27.46 ± 5.33, 29.41 ± 9.28, and 0.91 in Sarpol-e Zahab; 67.90 ± 15.56, 27.88 ± 17.85, 33.03 ± 11.97, and 0.93 in Paveh; and 69.24 ± 14.74, 28.31 ± 5.59, 30.91 ± 11.67, and 0.92 in Kangavar, respectively. In Paveh city, the PAL and QOL (14.37 ± 5.10; 23.08 ± 2.32; P = 0.001, respectively) were significantly higher than Kangavar (12.23 ± 3.18; 20.28 ± 3.32) and Sarpol-e-Zahab (10.57 ± 6.11; 16.24 ± 7.22) cities. A significant association was found between PAL and QOL (P = 0.001). Calculations: Based on the findings, increasing the PAL of middle-aged women might improve QoL and AC.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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