scholarly journals Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1827
Author(s):  
Amandine Robac ◽  
Pauline Neveu ◽  
Alizée Hugede ◽  
Elisabeth Garrido ◽  
Lionel Nicol ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Stimulation ◽  
Locomotor Recovery ◽  
Positive Effects ◽  
Cellular Events ◽  
Cord Injury ◽  
Permanent Loss ◽  
Incurable Condition ◽  
Injury Models

Spinal cord injury (SCI) is an incurable condition in which the brain is disconnected partially or completely from the periphery. Mainly, SCIs are traumatic and are due to traffic, domestic or sport accidents. To date, SCIs are incurable and, most of the time, leave the patients with a permanent loss of sensitive and motor functions. Therefore, for several decades, researchers have tried to develop treatments to cure SCI. Among them, recently, our lab has demonstrated that, in mice, repetitive trans-spinal magnetic stimulation (rTSMS) can, after SCI, modulate the lesion scar and can induce functional locomotor recovery non-invasively. These results are promising; however, before we can translate them to humans, it is important to reproduce them in a more clinically relevant model. Indeed, SCIs do not lead to the same cellular events in mice and humans. In particular, SCIs in humans induce the formation of cystic cavities. That is why we propose here to validate the effects of rTSMS in a rat animal model in which SCI leads to the formation of cystic cavities after penetrating and contusive SCI. To do so, several techniques, including immunohistochemical, behavioral and MRI, were performed. Our results demonstrate that rTSMS, in both SCI models, modulates the lesion scar by decreasing the formation of cystic cavities and by improving axonal survival. Moreover, rTSMS, in both models, enhances functional locomotor recovery. Altogether, our study describes that rTSMS exerts positive effects after SCI in rats. This study is a further step towards the use of this treatment in humans.

scholarly journals Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats

2021 ◽  
Author(s):  
Amandine Robac ◽  
Pauline Neveu ◽  
Alizée Hugede ◽  
Elisabeth Garrido ◽  
Lionel Nicol ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Magnetic Stimulation ◽  
Locomotor Recovery ◽  
Positive Effects ◽  
Cellular Events ◽  
Cord Injury ◽  
Permanent Loss ◽  
Incurable Condition ◽  
Injury Models

Abstract Spinal cord injury (SCI) is an incurable condition in which the brain is disconnected partially or completely from the periphery. Mainly SCI are traumatic and are due to traffic, domestic or sport accidents. To date SCI are incurable and let, most of the time, the patients with a permanent loss of sensitive and motor functions. Therefore, since several decades researchers tried to develop treatments to cure SCI. Among them, recently, our lab have demonstrated that in mice, repetitive trans-spinal magnetic stimulation (rTSMS) can, after SCI, modulate the lesion scar and can induce functional locomotor recovery non-invasively. These results are promising, however before to translate them to Humans it is important to reproduce them in a more clinically relevant model. Indeed, SCI do not lead to the same cellular events in mice and Humans. In particular, SCI in Humans induce the formation of cystic cavities. That is why we propose here to validate the effects of rTSMS in rat, animal model in which SCI lead to the formation of cystic cavities, after penetrating and contusive SCI. To do so, several techniques including immunohistochemical, behavioral and MRI have been performed. Our results demonstrate that rTSMS, in both SCI models, modulates the lesion scar by decreasing the formation of cystic cavities and by improving axonal survival. Moreover, rTSMS, in both models, enhances functional locomotor recovery. Altogether, our study describes that rTSMS exerts positive effects after SCI in rats. This study is a further step towards the use of this treatment in Humans.

Abstract #29: Scaling Spinal Cord injury Models for Non-invasive Stimulation

2019 ◽  
Vol 12 (2) ◽  
pp. e10-e11
Author(s):  
Dennis Q. Truong ◽  
Catherine Maglione ◽  
Yishai Valter ◽  
Louis Zannou ◽  
A. Duke Shereen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Non Invasive ◽  
Cord Injury ◽  
Injury Models

scholarly journals 1-kHz high-frequency spinal cord stimulation alleviates chronic refractory pain after spinal cord injury: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chiaki Yamada ◽  
Aiko Maeda ◽  
Katsuyuki Matsushita ◽  
Shoko Nakayama ◽  
Kazuhiro Shirozu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
High Frequency ◽  
Cervical Vertebrae ◽  
Intractable Pain ◽  
Target Area ◽  
Positive Effects ◽  
Cord Injury

Abstract Background Patients with spinal cord injury (SCI) frequently complain of intractable pain that is resistant to conservative treatments. Here, we report the successful application of 1-kHz high-frequency spinal cord stimulation (SCS) in a patient with refractory neuropathic pain secondary to SCI. Case presentation A 69-year-old male diagnosed with SCI (C4 American Spinal Injury Association Impairment Scale A) presented with severe at-level bilateral upper extremity neuropathic pain. Temporary improvement in his symptoms with a nerve block implied peripheral component involvement. The patient received SCS, and though the tip of the leads could not reach the cervical vertebrae, a 1-kHz frequency stimulus relieved the intractable pain. Conclusions SCI-related symptoms may include peripheral components; SCS may have a considerable effect on intractable pain. Even when the SCS electrode lead cannot be positioned in the target area, 1-kHz high-frequency SCS may still produce positive effects.

Augmented Locomotor Recovery after Spinal Cord Injury in the Athymic Nude Rat

2006 ◽  
Vol 23 (5) ◽  
pp. 660-673 ◽  
Author(s):  
Jason R. Potas ◽  
Yu Zheng ◽  
Charbel Moussa ◽  
Melinda Venn ◽  
Catherine A. Gorrie ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Locomotor Recovery ◽  
Nude Rat ◽  
Cord Injury

Epidural electrical stimulation to facilitate locomotor recovery after spinal cord injury

2021 ◽  
Author(s):  
Johannie Audet ◽  
Charly G. Lecomte
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Clinical Implementation ◽  
Preclinical Models ◽  
Lumbosacral Region ◽  
Locomotor Recovery ◽  
Promising Therapeutic Approach ◽  
Cord Injury ◽  
Stimulation Of

Tonic or phasic electrical epidural stimulation of the lumbosacral region of the spinal cord facilitates locomotion and standing in a variety of preclinical models with severe spinal cord injury. However, the mechanisms of epidural electrical stimulation that facilitate sensorimotor functions remain largely unknown. This review aims to address how epidural electrical stimulation interacts with spinal sensorimotor circuits and discusses the limitations that currently restrict the clinical implementation of this promising therapeutic approach.

Lack of adenylate cyclase 1 (AC1): Consequences on corticospinal tract development and on locomotor recovery after spinal cord injury

2014 ◽  
Vol 1549 ◽  
pp. 1-10 ◽  
Author(s):  
H. Nait Taleb Ali ◽  
M.P. Morel ◽  
M. Doulazmi ◽  
S. Scotto-Lomassese ◽  
P. Gaspar ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adenylate Cyclase ◽  
Corticospinal Tract ◽  
Locomotor Recovery ◽  
Cord Injury
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