scholarly journals Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective and Bipolar Disorder

2021 ◽  
Vol 11 (11) ◽  
pp. 1422
Author(s):  
Atiqul Haq Mazumder ◽  
Jennifer Barnett ◽  
Erkki Tapio Isometsä ◽  
Nina Lindberg ◽  
Minna Torniainen-Holm ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Reaction Time ◽  
Visual Memory ◽  
Age Of Onset ◽  
Neuropsychological Test ◽  
Reaction Time Task ◽  
Hazardous Drinking ◽  
Polygenic Scores ◽  
Males And Females ◽  
Log Linear

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

scholarly journals Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder

2021 ◽  
Vol 11 (9) ◽  
pp. 1154
Author(s):  
Atiqul Haq Mazumder ◽  
Jennifer Barnett ◽  
Erkki Tapio Isometsä ◽  
Nina Lindberg ◽  
Minna Torniainen-Holm ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Reaction Time ◽  
Alcohol Use ◽  
Linear Regression ◽  
Test Performance ◽  
Visual Memory ◽  
Reaction Time Task ◽  
Hazardous Drinking ◽  
Related Disorder ◽  
Housing Status

The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol-related disorder in persons with bipolar disorder (BD). The study population included 1268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol-related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the Alcohol Use Disorders Identification Test for Consumption (AUDIT-C) screening tool. Alcohol-related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on A tablet computer: the 5-choice serial reaction time task, or reaction time (RT) test and the Paired Associative Learning (PAL) test. Depressive symptoms were assessed with the Mental Health Inventory with five items (MHI-5). However, no assessment of current manic symptoms was available. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment of age, education, housing status and depression, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are difficult to explain because of the methodological flaw of not being able to separately assess only participants in euthymic phase.

scholarly journals Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder

2021 ◽  
Author(s):  
Atiqul Haq Mazumder ◽  
Jennifer Barnett ◽  
Erkki Tapio Isometsä ◽  
Nina Lindberg ◽  
Minna Torniainen-Holm ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Reaction Time ◽  
Alcohol Use ◽  
Linear Regression ◽  
Test Performance ◽  
Visual Memory ◽  
Reaction Time Task ◽  
Hazardous Drinking ◽  
Related Disorder ◽  
Housing Status

The purpose of this study was to explore the association of cognition with hazardous drinking and alcohol related disorder in persons with bipolar disorder (BD). The study population included 1,268 persons from Finland with bipolar disorder. Alcohol use was assessed through hazardous drinking and alcohol related disorder including alcohol use disorder (AUD). Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol related disorder diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge automated neuropsychological test battery (CANTAB) on tablet computer: the 5-choice serial reaction time task, or, reaction time (RT) test and the Paired Associative Learning (PAL) test. Association between RT-test and alcohol use was analyzed with log-linear regression, and eβ with 95% confidence intervals (CI) are reported. PAL first trial memory score was analyzed with linear regression, and β with 95% CI are reported. PAL total errors adjusted was analyzed with logistic regression and odds ratios (OR) with 95% CI are reported. After adjustment for age, education and housing status, hazardous drinking was associated with lower median and less variable RT in females while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores in females. Our findings of positive associations between alcohol use and cognition in persons with bipolar disorder are unique.

scholarly journals Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder

2021 ◽  
Vol 11 (6) ◽  
pp. 688
Author(s):  
Atiqul Haq Mazumder ◽  
Jennifer Barnett ◽  
Nina Lindberg ◽  
Minna Torniainen-Holm ◽  
Markku Lähteenvuo ◽  
...  
Keyword(s):  
Reaction Time ◽  
Alcohol Use ◽  
Schizoaffective Disorder ◽  
Test Performance ◽  
Visual Memory ◽  
Alcohol Use Disorder ◽  
Neuropsychological Test ◽  
Reaction Time Task ◽  
Hazardous Drinking ◽  
Housing Status

The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.

scholarly journals Reaction Time and Visual Memory in Connection to Alcohol Use In Schizophrenia and Schizoaffective Disorder

2021 ◽  
Author(s):  
Atiqul Haq Mazumder ◽  
Jennifer Barnett ◽  
Nina Lindberg ◽  
Minna Torniainen-Holm ◽  
Markku Lähteenvuo ◽  
...  
Keyword(s):  
Reaction Time ◽  
Alcohol Use ◽  
Binge Drinking ◽  
Schizoaffective Disorder ◽  
Visual Memory ◽  
Alcohol Use Disorder ◽  
Reaction Time Task ◽  
Hazardous Drinking ◽  
Psychotic Episode ◽  
Male And Female

Purpose of the study was to explore the association of cognition with hazardous drinking, binge drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognitive deficits are common in schizophrenia. Alcohol might be associated with additional cognitive impairment in schizophrenia patients. The study population included 3362 schizophrenia and schizoaffective disorder patients in Finland. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Binge drinking was obtained from the AUDIT-C. Alcohol use disorder (AUD) diagnoses were obtained from the national registrar data. Participants performed two computerized tasks from the Cambridge automated neuropsychological test battery (CANTAB) on tablet computer: the 5-choice serial reaction time task (5-CSRTT), or, reaction time (RT) test and the Paired Associative Learning (PAL) test. Association of alcohol use with RT test and PAL test was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education and age at first psychotic episode, hazardous drinking in females was associated with lower median RT. Compared to never binge drinkers, male and female participants drinking 6 or more doses of alcohol monthly or less had lower median RT. In the PAL test both first trial memory score (FTMS) and total errors adjusted score (TEAS) were associated with better performance in males drinking 6 or more doses of alcohol weekly or more and in females drinking 6 or more doses monthly or less. Higher PAL TEAS was associated with AUD in females Some positive associations between alcohol and cognition were found in male and female schizophrenia and schizoaffective disorder patients with hazardous drinking and binge drinking.

scholarly journals Cognitive impact in bipolar disorder

2019 ◽  
pp. 052-058
Author(s):  
Bourin Michel
Keyword(s):  
Bipolar Disorder ◽  
Verbal Memory ◽  
Visual Memory ◽  
Age Of Onset ◽  
Cognitive Difficulties ◽  
Speed Of Information Processing ◽  
History Of ◽  
Bipolar Patients ◽  
Disability Severity ◽  
Depressive Episodes

It appears that bipolar patients suffer from cognitive difficulties whereas they are in period of thymic stability. These intercritical cognitive difficulties are fairly stable and their severity is correlated with the functional outcome of patients. Nevertheless, the profile of cognitive impairment varies significantly from study to study quantitatively and qualitatively. According to the studies, the authors find difficulties in terms of learning, verbal memory, visual memory, working memory, sustained attention, speed of information processing, functions executive. On the other hand, deficits of general intelligence, motor functions, selective attention, and language are not usually found. One of the reasons for the heterogeneity of results is the difficulty of exploring cognition in bipolar disorder. Many factors must be taken into account, such as the presence of residual mood symptoms, the longitudinal history of the disorder (age of onset, number of episodes due, among others, the neurotoxic impact of depressive episodes and deleterious cognitive effects). (length of hospitalization), level of disability severity, comorbidities (particularly addictive).

scholarly journals An Examination of Adolescent Athletes and Nonathletes on Baseline Neuropsychological Test Scores

2018 ◽  
Vol 53 (4) ◽  
pp. 404-409 ◽  
Author(s):  
Christopher P. Tomczyk ◽  
Megan Mormile ◽  
Megan S. Wittenberg; ◽  
Jody L. Langdon ◽  
Tamerah N. Hunt
Keyword(s):  
High School ◽  
High School Students ◽  
High Schools ◽  
Reaction Time ◽  
Verbal Memory ◽  
Visual Memory ◽  
Neuropsychological Test ◽  
Test Battery ◽  
Cognitive Test ◽  
High School Athletes

Context:  An estimated 15.3 million adolescent students are enrolled in US high schools, with approximately 7.8 million participating in athletics. Researchers have examined various demographics in high school athletes; however, athletic participation may play a larger role in test performance than previously thought. Currently, investigations of concussion assessment may rely on uninjured athletes as controls. However, due to the intense nature of athletics, this may not be an appropriate practice. Objective:  To examine differences between athletes and nonathletes using a common computerized neuropsychological test. Design:  Retrospective cross-sectional study. Setting:  High schools from a school district in Columbus, Ohio. Patients or Other Participants:  A total of 662 adolescent high school students (athletes: n = 383, female n = 18; nonathletes: n = 279, female n = 193). Main Outcome Measure(s):  Participants were administered a computerized neuropsychological test battery (Immediate Post-Concussion Assessment and Cognitive Test [ImPACT]) during baseline concussion assessment. Differences between groups were established for output composite scores. Results:  Differences were found between athletes and nonathletes in composite reaction time (F1,522 = 14.855, P < .001) and total symptom score (F1,427 = 33.770, P < .001). Nonathletes reported more symptoms, whereas athletes had faster reaction times. No differences were present in composite verbal memory, composite visual memory, composite visual motor speed, or composite impulse control (P > .05). Conclusions:  Symptom reporting and reaction time differed between high school athletes and nonathletes. Participation in extracurricular activities may lead to cognitive differences in adolescents that can influence performance on the Immediate Post-Concussion Assessment and Cognitive Test battery. Researchers should account for these differences in baseline performance when making concussion diagnostic and management decisions.

scholarly journals Assessment of the Cambridge Neuropsychological Test Automated Battery test in Saudi children with learning disabilities: A case-control study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 323
Author(s):  
Nouf Al Backer ◽  
Koloud Ateeq Alharbi ◽  
Abdulrahman Alfahadi ◽  
Syed Shahid Habib ◽  
Shahid Bashir
Keyword(s):  
Learning Disabilities ◽  
Reaction Time ◽  
Simple Reaction Time ◽  
Neuropsychological Test ◽  
Motor Planning ◽  
Reaction Time Task ◽  
Control Group ◽  
Simple Reaction Time Task ◽  
Extradimensional Shift ◽  
Planning Task

Background: The neuropsychological tests and its subtests are composed of the motor planning task; simple reaction time task and the intradimensional/extradimensional shift (IED) task from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were developed to examine specific components of cognition. The main objective of this study was to examine the reliability of these CANTAB subtests in pediatric patients with learning disabilities (LD) in Saudi Arabia. Methods: We administered the CANTAB subset test to 92 participants with LD and 68 controls with no LD. The tests performed were motor planning task (MOT), simple reaction time task (SRT) and the intradimensional/extradimensional shift (IED). Results: There was no significant age difference between the case and the control group (case: 9.2 ± 2.4 years versus controls: 9.0 ± 1.6 years, p=0.544). The IED and MOT were significantly longer among patients with LD versus control (p <0.001). LD cases had a longer SRT time than controls (cases: 1050.4 ± 626.5 versus controls: 815.5 ± 133.9, p=0.003). LD patients completed an average of 3.0 stages, than the controls, who were able to complete a mean of 8.4 IED stages (p<0.001). SRT was significantly longer in the case group (965.9 ± 716.4) compared to the controls (747.7 ± 120.7, p=0.014). LD cases made more errors in the motor screening tasks (MOT-Error) compared to the control group (case: 14.6 ± 4.5 versus controls: 12.4 ± 2.7, p<0.001). Conclusion: Patients with LD have poor CANTAB subtest results. If these CANTAB subtests do measure cognitive function, this adds to the accumulating evidence of cognitive impairment association in LD, and such studies should remain an active area of research.

scholarly journals A Dissociation of Attention, Executive Function and Reaction to Difficulty: Development of the MindPulse Test, a Novel Digital Neuropsychological Test for Precise Quantification of Perceptual-Motor Decision-Making Processes

2021 ◽  
Vol 15 ◽  
Author(s):  
Sandra Suarez ◽  
Bertrand Eynard ◽  
Sylvie Granon
Keyword(s):  
Decision Making ◽  
Reaction Time ◽  
Processing Speed ◽  
Neuropsychological Test ◽  
Reaction Time Task ◽  
Decision Time ◽  
Reference Points ◽  
Motor Speed ◽  
Simple Reaction Time Task ◽  
Base Time

Traditionally, neuropsychological testing has assessed processing speed and precision, closely related to the ability to perform high-order cognitive tasks. An individual making a decision under time pressure must constantly rebalance its speed to action in order to account for possible errors. A deficit in processing speed appears to be afrequent disorder caused by cerebral damage — but it can be hard to pinpoint the exact cause of the slowdown. It is therefore important to separate the perceptual-motor component of processing speed from the decision-time component. We present a technique to isolate Reaction Times (RTs): a short digital test to assess the decision-making abilities of individuals by gauging their ability to balance between speed and precision. Our hypothesis is that some subjects willaccelerate, and others slow down in the face of the difficulty. This pilot study, conducted on 83 neurotypical adult volunteers, used images stimuli. The test was designed to measure RTs and correctness. After learning release gesture, the subjects were presented with three tasks: a simple Reaction Time task, a Go/No-Go, and a complex Go/No-Go with 2 simultaneous Choices. All three tasks have in common a perceptual component and a motor response. By measuring the 3 reference points requiring attentional and executive processing, while progressively increasing the conceptual complexity of the task, we were able to compare the processing times for different tasks — thus calculating the deceleration specific to the reaction time linked to difficulty. We defined the difficulty coefficient of a task as being the ratio of the group average time of this task minus the base time/average time of the unit task minus the base time. We found that RTs can be broken down into three elementary, uncorrelated components: Reaction Time, Executive Speed, and Reaction to Difficulty (RD). We hypothesized that RD reflects how the subject reacts to difficulty by accelerating (RD &lt; 0) or decelerating (RD &gt; 0). Thus we provide here a first proof of concept: the ability to measure four axes of the speed-precision trade-off inherent in a subject’s fundamental decision making: perceptual-motor speed, executive speed, subject accuracy, and reaction to difficulty.

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