scholarly journals Restless Legs Syndrome: Known Knowns and Known Unknowns

2022 ◽  
Vol 12 (1) ◽  
pp. 118
Author(s):  
Elena Antelmi ◽  
Lorenzo Rocchi ◽  
Anna Latorre ◽  
Daniele Belvisi ◽  
Francesca Magrinelli ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Movement Disorders ◽  
Neurological Disorder ◽  
Brain Structures ◽  
Circadian Pattern ◽  
Restless Legs ◽  
Open Questions ◽  
Sensorimotor Interaction ◽  
Known Unknowns ◽  
Lines Of Evidence

Although restless legs syndrome (RLS) is a common neurological disorder, it remains poorly understood from both clinical and pathophysiological perspectives. RLS is classified among sleep-related movement disorders, namely, conditions characterized by simple, often stereotyped movements occurring during sleep. However, several clinical, neurophysiological and neuroimaging observations question this view. The aim of the present review is to summarize and query some of the current concepts (known knowns) and to identify open questions (known unknowns) on RLS pathophysiology. Based on several lines of evidence, we propose that RLS should be viewed as a disorder of sensorimotor interaction with a typical circadian pattern of occurrence, possibly arising from neurochemical dysfunction and abnormal excitability in different brain structures.

Restless arm syndrome: a rare disease?

2021 ◽  
Vol 14 (9) ◽  
pp. e244890
Author(s):  
Ulrich Moser ◽  
Jasmin Schwab
Keyword(s):  
Rare Disease ◽  
Restless Legs Syndrome ◽  
Neurological Disorder ◽  
Lower Limbs ◽  
Restless Legs ◽  
Patient Reported

Restless legs syndrome (RLS) is a common neurological disorder characterised by an irresistible urge to move the lower limbs, often accompanied by unpleasant sensations in the legs, typically occurring in the evening and at night and improving with movement. Restless arms syndrome (RAS) predominantly affects the arms, while the legs are rarely affected. RAS appears to be very rare, with very few cases described to date, but the diagnosis of RAS is probably made too infrequently, especially for milder and transient forms. The patient reported here even had severe symptoms for years that could have indicated RAS. He observed an immediate improvement in all RAS-related symptoms after administration of 100 mg L-dopa +25 mg benserazide, which continues to this day. Clinicians should always be alert for RLS-like symptoms in one or both arms that worsen at rest and improve with movement, thinking of possible RAS.

scholarly journals Lack of Association Between Shape and Volume of Subcortical Brain Structures and Restless Legs Syndrome

2018 ◽  
Vol 9 ◽  
Author(s):  
Marco Hermesdorf ◽  
Benedikt Sundermann ◽  
Rajesh Rawal ◽  
András Szentkirályi ◽  
Udo Dannlowski ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Brain Structures ◽  
Restless Legs ◽  
Subcortical Brain ◽  
Subcortical Brain Structures

Hyperkinetic movement disorders

2016 ◽  
Author(s):  
Sathiji Nageshwaran ◽  
Heather C Wilson ◽  
Anthony Dickenson ◽  
David Ledingham
Keyword(s):  
Huntington's Disease ◽  
Clinical Features ◽  
Restless Legs Syndrome ◽  
Movement Disorders ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Evidence Based ◽  
Pharmacological Management ◽  
Restless Legs ◽  
Sydenham's Chorea

This chapter discusses the clinical features and evidence-based pharmacological management of tremor, dystonia (focal, generalized, and dopa-responsive dystonia), tics and Tourette’s syndrome, chorea (Huntington’s disease (HD) and Sydenham’s chorea), ballism and athetosis, myoclonus, and restless legs syndrome (RLS).

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