scholarly journals Validation of the Japanese Version of the Center for Epidemiologic Studies Depression Scale—Revised: A Preliminary Analysis

2021 ◽  
Vol 11 (8) ◽  
pp. 107
Author(s):  
Hirohito Tsuboi ◽  
Yui Takakura ◽  
Hiromasa Tsujiguchi ◽  
Sakae Miyagi ◽  
Keita Suzuki ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Depressive Symptoms ◽  
Native Speakers ◽  
Depression Scale ◽  
Japanese Version ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Community Dwelling ◽  
Two Factors ◽  
Study Population

To make the Japanese version of the CESD-R—a revised version of the Center for Epidemiologic Studies depression scale (CES-D)—in the assessment of depressive symptoms in a general population. The English version of CESD-R was translated into Japanese, and back-translated into English by three native speakers of Japanese and English; then, we selected the version most completely consistent with the original items. The CESD-R was applied to 398 community-dwelling people (191 men: 48.0%, and 207 women: 52.0%) who were over 40 years old. The Japanese version of the CES-D was also carried out in the same population. Factor analysis was performed. Additionally, the correlations between the CESD-R and CES-D results were identified. The CESD-R scores showed a significantly positive correlation with CES-D scores (r = 0.74, p < 0.0005). Analysis of the CESD-R yielded a Cronbach’s alpha result of 0.90. Factor analysis revealed one principal factor in the CESD-R, whereas the original CES-D had two factors because of reversed items. The Japanese version of the CESD-R appears to have the reliability to be applicable for assessing depressive symptoms in population-based samples. However, because the Japanese expressions for some items might be unusual, our study population was also limited; further studies on other populations and on incorporating improved Japanese terminology will be needed.

scholarly journals Elevated Levels of Serum IL-17A in Community-Dwelling Women with Higher Depressive Symptoms

2018 ◽  
Vol 8 (11) ◽  
pp. 102 ◽  
Author(s):  
Hirohito Tsuboi ◽  
Hiroyuki Sakakibara ◽  
Yuuki Minamida ◽  
Hiromasa Tsujiguchi ◽  
Masahiro Matsunaga ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depression Scale ◽  
Japanese Version ◽  
Epidemiologic Studies ◽  
Community Dwelling ◽  
Tnf Alpha ◽  
Serum Samples ◽  
Female Community ◽  
Cytokine Levels ◽  
Community Dwellers

Recent studies indicate that patients with depression have increased concentrations of serum pro-inflammatory cytokines. However, studies of IL-17 and studies on community-dwellers are few. The purpose of this study was to investigate serum cytokine levels, especially IL-17A, among subjects with high and low depressive symptoms of a general population. The participants comprised 20 female community-dwellers aged 40 years or older who contributed to a Shika study in Ishikawa, Japan. Ten participants who showed higher and ten who showed lower depressive symptoms among 208 females assessed by the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D) were selected for this study. Serum samples were analyzed for TNF-alpha, IL-6, IL-10, IL-12, and IL-17A using a multiplex Luminex analysis. For the comparison between the high and low depressive groups statistically, linear regression analyses were applied. The serum level of IL-17A was significantly higher among the high depressive participants (p < 0.05) even after controlling possible confounders, whereas there were no differences in TNF-alpha, IL-6, IL-10, or IL-12 between the high and low depressive groups. Our findings supported an association between serum IL-17A levels and depressive symptoms. Peripheral IL-17A immune response may be a preventive and treatment target for depression.

scholarly journals Physical activity and depressive symptoms in community-dwelling elders from southern Brazil

2011 ◽  
Vol 33 (2) ◽  
pp. 165-170 ◽  
Author(s):  
César L. Reichert ◽  
César L. Diogo ◽  
José L. Vieira ◽  
Roberta R. Dalacorte
Keyword(s):  
Physical Activity ◽  
Depressive Symptoms ◽  
Linear Trend ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Population Based ◽  
Community Dwelling ◽  
Active Group ◽  
Lower Prevalence ◽  
Cross Sectional

OBJECTIVE: To determine the existence of a relationship between physical activity and depressive symptoms in community-dwelling elders. METHOD: This is a cross-sectional, population-based study, which included 379 community-dwelling elders from Novo Hamburgo, state of RS, Brazil. The level of physical activity was estimated using the International Physical Activity Questionnaire and depressive symptoms were diagnosed according to the Yesavage Geriatric Depression Scale. The association between the level of physical activity and depressive symptoms was analyzed by logistic regression. RESULTS: A tendency towards a lower prevalence of depressive symptoms was observed in individuals with higher levels of physical activity, both in the sample as a whole as well as among men, but not among women (p for linear trend 0.04, 0.03 and 0.36, respectively). The odds ratio of the presence of depressive symptoms in the very active group, as compared against that of the insufficiently active group was 0.32 (95% CI: 0.12-0.86) for men and 0.76 (95% CI: 0.39-1.46) for women. CONCLUSION: In this population of aged individuals, more intense physical activity is related to a lower prevalence of depressive symptoms. As shown by gender stratification, physical activity is inversely related to depressive symptoms in men, albeit not in women.

scholarly journals Depressive symptoms in community-dwelling persons aged ≥60 years in Inanda, Ntuzuma and KwaMashu in eThekwini, KwaZulu-Natal

2015 ◽  
Vol 21 (1) ◽  
pp. 6 ◽  
Author(s):  
Jayalakshmi Narainsamy ◽  
Jennifer Chipps ◽  
Bilkish Cassim
Keyword(s):  
Logistic Regression ◽  
Depressive Symptoms ◽  
Univariate Analysis ◽  
Secondary Analysis ◽  
Depression Scale ◽  
The Elderly ◽  
Epidemiologic Studies ◽  
Household Size ◽  
Community Dwelling ◽  
Primary Study

<p><strong>Background. </strong>Physical and psychological ailments increase with age; while the physical ailments are well documented, mental health issues have received less attention. </p><p><strong>Objective.</strong> To determine the prevalence of depressive symptoms and associated risk factors in individuals aged <strong>≥</strong>60 years living in a low-resource peri-urban area in South Africa. </p><p><strong>Methods. </strong>Secondary analysis was performed on data obtained from a primary study conducted to determine the influence of socioeconomic and environmental factors on the health status and quality of life in older persons living in the Inanda, Ntuzuma and KwaMashu (INK) area. The Center for Epidemiologic Studies Short Depression Scale (CES-D 10) was used to screen for depressive symptoms in the week preceding the interview, and respondents were categorised as having no (score &lt;10), mild (10 - 14), or severe (&gt;14) depressive symptoms. Risk factor associations were tested using Pearson’s χ<sup>2</sup> tests and logistic regression. </p><p><strong>Results. </strong>There were 1 008 respondents (mean (standard deviation) age 68.9 (7.4) years), of whom 503 (49.1%) did not meet criteria for depressive symptoms. Of the 505 (50.1%) respondents who met the CES-D 10 criteria for depressive symptoms, 422 (41.9%) had mild and 83 (8.2%) had severe depressive symptoms. In the univariate analysis, significant associations were found with age (<em>p=</em>0.011), household size (<em>p=</em>0.007), income (<em>p=</em>0.033), disability (<em>p=</em>0.001), nutritional status (<em>p</em>≤0.001), the inability to count on family (<em>p=</em>0.008) and lack of mastery (<em>p</em>≤0.001). In direct binary logistic regression, there were significant associations with lack of mastery (<em>p≤</em>0.001), inability to count on family (<em>p=</em>0.027), malnutrition (<em>p</em>≤0.001) and household size (<em>p=</em>0.024).</p><p><strong>Conclusion. </strong>This study highlights the high prevalence of depressive symptoms in the elderly in the INK area, and the need to promote successful ageing of the elderly population in this area.</p>

Pathways Between Acculturation and Health

2011 ◽  
Vol 33 (4) ◽  
pp. 524-539 ◽  
Author(s):  
Patricia Y. Miranda ◽  
Hector M. González ◽  
Wassim Tarraf
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Function ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Depression Scale ◽  
The Elderly ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Functional Health ◽  
Cross Sectional

The purpose of this study was to assess the association between acculturation and functional health using multiple proxies of acculturation to examine explanatory pathways to clarify disparate health findings. A population-based cross-sectional, multistage probability sample from the Hispanic Established Populations for the Epidemiologic Studies of the Elderly ( N = 3,050) was used. The dependent variables of neuropsychiatric function were depressive symptoms (Center for Epidemiologic Studies Depression Scale [CES-D]) and cognitive function (mini-mental state examination [MMSE]) examined in separate multivariable regression and structural equation models to examine the pathways between acculturation proxies and neuropsychiatric function. Findings indicated that three acculturation proxies were associated with cognitive function but none were associated with depressive symptoms. English proficiency fully mediated the associations between other acculturation proxies and cognitive function. The findings suggest that language plays a central role in the pathway between acculturation and health among Mexican-origin populations.

Depressive symptoms of informal caregivers are associated with those of community-dwelling dependent care recipients

2010 ◽  
Vol 22 (8) ◽  
pp. 1310-1317 ◽  
Author(s):  
Sachiko Izawa ◽  
Jun Hasegawa ◽  
Hiromi Enoki ◽  
Akihisa Iguch ◽  
Masafumi Kuzuya
Keyword(s):  
Depressive Symptoms ◽  
Geriatric Depression Scale ◽  
Multivariate Logistic Regression Analysis ◽  
Depression Scale ◽  
Japanese Version ◽  
Demographic Characteristics ◽  
Community Dwelling ◽  
Subjective Burden ◽  
Term Care ◽  
Care Recipients

ABSTRACTBackground: The relationship between care recipients’ depressive symptoms and those of caregivers remains unknown. We evaluated the association between the depressive status of caregivers and that of community-dwelling disabled care recipients.Methods: A prospective cohort study of 893 care recipients and paired caregivers was conducted. The care recipients were all eligible for a universal-coverage long-term care insurance program and their ages ranged from 65 to 104 years. They and their paired caregivers (age range 31–90 years) completed the 15-item Geriatric Depression Scale (GDS-15, score range: 0–15) assessment at baseline. The GDS-15 was used to measure the depression of caregivers and recipients with a threshold of <6/6+. The data included each care recipient's demographic characteristics, overall health status, basic activities of daily living, and comorbidities. The data also included the caregiver's demographic characteristics, including the caregiver's relationship to the recipient, and the caregiver's subjective burden as assessed by the Japanese version of the Zarit Burden Interview (ZBI).Results: The mean GDS-15 scores of care recipients and caregivers were 6.7 points and 5.6 points, respectively. There was a positive correlation between the GDS-15 scores of caregivers and care recipients (r = 0.307, p<0.001). Multivariate logistic regression analysis adjusting for potential confounders including ZBI score indicated that the depressive symptoms of caregivers were associated with those whose care recipients were in the groups with moderate and high GDS-15 scores (OR: 1.97, 95% CI: 1.39–2.81, OR: 3.13, 95% CI: 1.87–5.24, respectively).Conclusion: Caregivers’ depressive symptoms are associated with the depressive mood of the care recipients even after adjusting for confounders including caregiver burden.

Subgroups with typical courses of depressive symptoms in an elderly population during 13 years of observation: Results from the Heinz Nixdorf Recall Study

2020 ◽  
Vol 66 (8) ◽  
pp. 799-809
Author(s):  
Miriam Engel ◽  
Karl-Heinz Jöckel ◽  
Nico Dragano ◽  
Miriam Engels ◽  
Susanne Moebus
Keyword(s):  
Depressive Symptoms ◽  
Short Form ◽  
Empirical Studies ◽  
Depression Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Depression Score ◽  
Mean Values ◽  
Heinz Nixdorf Recall Study ◽  
Large Fluctuations

Background: Depressive symptoms are volatile over time but empirical studies of intra-individual variations of depressive symptoms over longer periods are sparse. Aims: We aim to examine fluctuation patterns of depressive symptoms and to investigate the possible influence of age, sex and socioeconomic factors on fluctuation in a population-based sample over a period of 13 years. Methods: We used data of 4,251 participants (45–75 years; 51.0% women at baseline) of the Heinz Nixdorf Recall Study with at least two of nine possible measurements obtained in the period between 2000 and 2017. Depressive symptoms were assessed via the Center for Epidemiologic Studies Depression Scale (CES-D) short form. Based on the individual mean values and standard deviation from all measurements, we categorized participants as G1 ‘stable low’, G2 ‘stable high’, G3 ‘stable around cutoff’ and G4 ‘large fluctuations’. Results: Most participants (82.3%) showed stable low depressive symptoms (G1), whereas 2.3% performed stable high values (G2), 6.9% stable around the cutoff (G3) and 8.6% large fluctuations (G4). Conclusion: Our longitudinal results reveal that almost 18% (G2, G3 and G4) of the participants have an increased depression score or strong fluctuations at times. According to our classification, a higher proportion of the participants show anomalies with regard to depression compared to a simple classification into depressed and nondepressed, especially if this is based on a single measurement. Thus, longitudinal measurements of depression can prevent misclassification and provide valuable information about the course of depressive symptoms for a better understanding of the changes of depression.

scholarly journals Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults

2018 ◽  
Vol 179 (4) ◽  
pp. 239-249 ◽  
Author(s):  
Liset E M Elstgeest ◽  
Elisa J de Koning ◽  
Ingeborg A Brouwer ◽  
Natasja M van Schoor ◽  
Brenda W J H Penninx ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Depression Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Time Points ◽  
Hydroxyvitamin D ◽  
Parallel Change ◽  
Lower Baseline ◽  
25 Hydroxyvitamin D

Objective Previous prospective studies on the association between vitamin D status and depression used a single 25-hydroxyvitamin D (25(OH)D) measurement. We investigated the association between change in serum 25(OH)D and parallel change in depressive symptoms over time in Dutch older adults. Design A population-based, prospective study in two cohorts of older men and women from the Longitudinal Aging Study Amsterdam. Methods Serum 25(OH)D concentrations were determined at two time points: in 1995/1996 and 13 years later in the older cohort (aged 65–88y, n = 173) and in 2002/2003 and 6 years later in the younger cohort (55–65 years, n = 450). At these time points, depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Associations were tested by multiple linear regression analyses. Results During follow-up, serum 25(OH)D concentrations increased in 32.4% of the older cohort and in 69.8% of the younger cohort. In the older cohort, change in 25(OH)D was not associated with change in CES-D score. In the younger cohort, no associations were observed in participants with higher baseline 25(OH)D concentrations (>58.6 nmol/L), but in those with lower baseline 25(OH)D concentrations, an increase in 25(OH)D was associated with a decrease in CES-D score (adjusted B per 10 nmol/L 25(OH)D increase: −0.62 (95% CI: −1.17, −0.07)). Conclusions Our study suggests that over 6 years, an increase in serum 25(OH)D is associated with a small decrease in depressive symptoms in young older adults with lower baseline 25(OH)D. Well-designed intervention trials are required to determine causality.

Low-grade inflammation differentiates between symptoms of apathy and depression in community-dwelling older individuals

2014 ◽  
Vol 27 (4) ◽  
pp. 639-647 ◽  
Author(s):  
Lisa S. M. Eurelings ◽  
Edo Richard ◽  
Piet Eikelenboom ◽  
Willem A. van Gool ◽  
Eric P. Moll van Charante
Keyword(s):  
Depressive Symptoms ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Population Based ◽  
Community Dwelling ◽  
Low Grade ◽  
Older Individuals ◽  
Cross Sectional ◽  
Low Grade Inflammation

ABSTRACTBackground:Systemic low-grade inflammation has repeatedly been associated with depression in old age, but the relationship with apathy is less clear. The present study assessed whether C-reactive protein (CRP) is differentially associated with symptoms of apathy and depression.Methods:A population-based cohort study was carried-out. At baseline and after two and four years of follow-up, CRP levels were assessed and symptoms of apathy and depression were measured using the 15-item Geriatric Depression Scale. Logistic regression analysis was used to investigate the cross-sectional and longitudinal associations of CRP with symptoms of apathy and depression.Results:Two thousand forty-seven community-dwelling participants (70–78 years) without a history of cardiovascular disease or stroke were studied. A cross-sectional association was found between CRP and apathy symptoms at three time points (odds ratio (OR) per natural log unit increase in CRP: baseline visit = 1.40, 95% CI = 1.12–1.75; two-year follow-up visit = 1.62, 95% CI = 1.17–2.25; four-year follow-up visit = 1.51, 95% CI = 1.03–2.21). This did not change after adjustment for demographics and depressive symptoms, and was slightly attenuated after adjustment for cardiovascular risk factors. No cross-sectional association was found with depressive symptoms. Baseline CRP did not predict incident apathy or depressive symptoms during four years of follow-up.Conclusions:Increased CRP levels are associated with apathy symptoms but not with depressive symptoms. This suggests a differential effect of inflammation on apathy and depression. In older persons, symptoms of apathy may be a behavioral manifestation of concurrent low-grade inflammation.

scholarly journals The mediating role of adolescents’ loneliness and social withdrawal in the association between maternal depressive symptoms and suicidality in adolescence: A 20-year population-based study

2021 ◽  
pp. 1-9
Author(s):  
Lamprini Psychogiou ◽  
Marilyn N. Ahun ◽  
Michel Boivin ◽  
Richard E. Tremblay ◽  
Massimiliano Orri ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Indirect Effect ◽  
Social Withdrawal ◽  
Depression Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Maternal Depressive Symptoms ◽  
Mediating Role ◽  
Increased Risk ◽  
Development Data

Abstract We examined whether adolescents’ loneliness and social withdrawal mediated the association between maternal depressive symptoms and adolescent suicidality. Secondary analyses on the Québec Longitudinal Study of Child Development data were conducted (n = 1,623). Each mother completed the Centre for Epidemiologic Studies Depression Scale (at child ages 5 months, 1.5, 3.5, 5, and 7 years). Adolescent's social withdrawal (adolescent, father, and teacher reported at 10, 12, and 13 years) and loneliness (adolescent reported at 10, 12, and 13 years), were assessed using items from the Social Behavior Questionnaire and the Loneliness and Social Satisfaction Questionnaire, respectively. Adolescents completed self-reports to assess suicidal thoughts and attempts at 13, 15, 17, and 20 years. Children of mothers with higher levels of maternal depressive symptoms had an increased risk for suicidality (OR = 1.15, 95% CI: 1.03–1.28). Loneliness explained 16% of the total effect of maternal depressive symptoms on adolescent suicidality (indirect effect OR = 1.02, 95% CI: 1.00–1.04). There was no indirect effect of maternal depressive symptoms on adolescent suicidal outcomes via social withdrawal (indirect effect OR = 1.00, 95% CI: 0.99–1.02). Interventions that target loneliness may be beneficial for decreasing the risk for suicidality among adolescents of mothers with depressive symptoms.

scholarly journals GENETIC MODERATORS OF THE IMPACT OF PHYSICAL ACTIVITY ON DEPRESSIVE SYMPTOMS

2016 ◽  
pp. 1-9
Author(s):  
V.M. DOTSON ◽  
F.C. HSU ◽  
T.Y. LANGAEE ◽  
C.W. MCDONOUGH ◽  
A.C. KING ◽  
...  
Keyword(s):  
Physical Activity ◽  
Depressive Symptoms ◽  
Positive Affect ◽  
Controlled Trial ◽  
Depression Scale ◽  
Somatic Symptoms ◽  
Epidemiologic Studies ◽  
Community Dwelling ◽  
Symptom Dimensions ◽  
The Impact

Background: Converging evidence suggests that physical activity is an effective intervention for both clinical depression and sub-threshold depressive symptoms; however, findings are not always consistent. These mixed results might reflect heterogeneity in response to physical activity, with some subgroups of individuals responding positively, but not others. Objectives: 1) To examine the impact of genetic variation and sex on changes in depressive symptoms in older adults after a physical activity (PA) intervention, and 2) to determine if PA differentially improves particular symptom dimensions of depression. Design: Randomized controlled trial. Setting: Four field centers (Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University). Participants: 396 community-dwelling adults aged 70–89 years who participated in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). Intervention: 12-month PA intervention compared to an education control. Measurements: Polymorphisms in the serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF), and apolipoprotein E (APOE) genes; 12-month change in the Center for Epidemiologic Studies Depression Scale total score, as well as scores on the depressed affect, somatic symptoms, and lack of positive affect subscales. Results: Men randomized to the PA arm showed the greatest decreases in somatic symptoms, with a preferential benefit in male carriers of the BDNF Met allele. Symptoms of lack of positive affect decreased more in men compared to women, particularly in those possessing the 5-HTT L allele, but the effect did not differ by intervention arm. APOE status did not affect change in depressive symptoms. Conclusions: Results of this study suggest that the impact of PA on depressive symptoms varies by genotype and sex, and that PA may mitigate somatic symptoms of depression more than other symptoms. The results suggest that a targeted approach to recommending PA therapy for treatment of depression is viable.

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