scholarly journals Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2562
Author(s):  
Yan Zhang ◽  
Zhixiang Chen
Keyword(s):  
Stress Responses ◽  
Mammalian Cells ◽  
Plant Stress ◽  
Protein Aggregates ◽  
Degradation Pathway ◽  
Plant Responses ◽  
Stress Memory ◽  
Selective Autophagy ◽  
Cargo Proteins ◽  
Plant Stress Responses

Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates. Cargo selectivity in selective autophagy relies on the action of cargo receptors and adaptors. In mammalian cells, two structurally related proteins p62 and NBR1 act as cargo receptors for selective autophagy of ubiquitinated proteins including aggregation-prone proteins in aggrephagy. Plant NBR1 is the structural and functional homolog of mammalian p62 and NBR1. Since its first reports almost ten years ago, plant NBR1 has been well established to function as a cargo receptor for selective autophagy of stress-induced protein aggregates and play an important role in plant responses to a broad spectrum of stress conditions including heat, salt and drought. Over the past several years, important progress has been made in the discovery of specific cargo proteins of plant NBR1 and their roles in the regulation of plant heat stress memory, plant-viral interaction and special protein secretion. There is also new evidence for a possible role of NBR1 in stress-induced pexophagy, sulfur nutrient responses and abscisic acid signaling. In this review, we summarize these progresses and discuss the potential significance of NBR1-mediated selective autophagy in broad plant responses to both biotic and abiotic stresses.

scholarly journals NBR1-Mediated Selective Autophagy Targets Insoluble Ubiquitinated Protein Aggregates in Plant Stress Responses

PLoS Genetics ◽  
2013 ◽  
Vol 9 (1) ◽  
pp. e1003196 ◽  
Author(s):  
Jie Zhou ◽  
Jian Wang ◽  
Yuan Cheng ◽  
Ying-Jun Chi ◽  
Baofang Fan ◽  
...  
Keyword(s):  
Stress Responses ◽  
Plant Stress ◽  
Protein Aggregates ◽  
Ubiquitinated Protein ◽  
Selective Autophagy ◽  
Plant Stress Responses

scholarly journals E3 Ubiquitin Ligase CHIP and NBR1-Mediated Selective Autophagy Protect Additively against Proteotoxicity in Plant Stress Responses

PLoS Genetics ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. e1004116 ◽  
Author(s):  
Jie Zhou ◽  
Yan Zhang ◽  
Jingxia Qi ◽  
Yingjin Chi ◽  
Baofang Fan ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Stress Responses ◽  
Plant Stress ◽  
E3 Ubiquitin Ligase ◽  
Selective Autophagy ◽  
Plant Stress Responses

scholarly journals Protein Prenylation in Plant Stress Responses

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3906 ◽  
Author(s):  
Michal Hála ◽  
Viktor Žárský
Keyword(s):  
Posttranslational Modifications ◽  
Stress Responses ◽  
Lipid Membrane ◽  
Plant Stress ◽  
Small Gtpases ◽  
Plant Responses ◽  
Protein Prenylation ◽  
Biotic Stresses ◽  
Plant Stress Responses ◽  
As Stress

Protein prenylation is one of the most important posttranslational modifications of proteins. Prenylated proteins play important roles in different developmental processes as well as stress responses in plants as the addition of hydrophobic prenyl chains (mostly farnesyl or geranyl) allow otherwise hydrophilic proteins to operate as peripheral lipid membrane proteins. This review focuses on selected aspects connecting protein prenylation with plant responses to both abiotic and biotic stresses. It summarizes how changes in protein prenylation impact plant growth, deals with several families of proteins involved in stress response and highlights prominent regulatory importance of prenylated small GTPases and chaperons. Potential possibilities of these proteins to be applicable for biotechnologies are discussed.

scholarly journals Coordination and Crosstalk between Autophagosome and Multivesicular Body Pathways in Plant Stress Responses

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 119 ◽  
Author(s):  
Mengxue Wang ◽  
Xifeng Li ◽  
Shuwei Luo ◽  
Baofang Fan ◽  
Cheng Zhu ◽  
...  
Keyword(s):  
Stress Responses ◽  
Plant Stress ◽  
Multivesicular Body ◽  
Endocytic Pathway ◽  
Plant Responses ◽  
Hormone Metabolism ◽  
Plant Stress Responses ◽  
Autophagic Degradation ◽  
Membrane Bound ◽  
Vacuolar Protein

In eukaryotic cells, autophagosomes and multivesicular bodies (MVBs) are two closely related partners in the lysosomal/vacuolar protein degradation system. Autophagosomes are double membrane-bound organelles that transport cytoplasmic components, including proteins and organelles for autophagic degradation in the lysosomes/vacuoles. MVBs are single-membrane organelles in the endocytic pathway that contain intraluminal vesicles whose content is either degraded in the lysosomes/vacuoles or recycled to the cell surface. In plants, both autophagosome and MVB pathways play important roles in plant responses to biotic and abiotic stresses. More recent studies have revealed that autophagosomes and MVBs also act together in plant stress responses in a variety of processes, including deployment of defense-related molecules, regulation of cell death, trafficking and degradation of membrane and soluble constituents, and modulation of plant hormone metabolism and signaling. In this review, we discuss these recent findings on the coordination and crosstalk between autophagosome and MVB pathways that contribute to the complex network of plant stress responses.

scholarly journals Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity

2018 ◽  
Vol 83 (1) ◽  
Author(s):  
Pamlea N. Brady ◽  
Anupam Goel ◽  
Margaret A. Johnson
Keyword(s):  
Stress Responses ◽  
Mammalian Cells ◽  
Inflammatory Responses ◽  
Plant Stress ◽  
Parp Inhibitors ◽  
Host Responses ◽  
Antiviral Protein ◽  
Host Pathogen Interactions ◽  
Host Pathogen ◽  
Plant Stress Responses

SUMMARYThe literature review presented here details recent research involving members of the poly(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of the family, the human enzyme PARP1 is the most extensively studied, resulting in a number of known biological and metabolic roles. This review is focused on the roles played by PARP enzymes in host-pathogen interactions and in diseases with an associated inflammatory response. In mammalian cells, several PARPs have specific roles in the antiviral response; this is perhaps best illustrated by PARP13, also termed the zinc finger antiviral protein (ZAP). Plant stress responses and immunity are also regulated by poly(ADP-ribosyl)ation. PARPs promote inflammatory responses by stimulating proinflammatory signal transduction pathways that lead to the expression of cytokines and cell adhesion molecules. Hence, PARP inhibitors show promise in the treatment of inflammatory disorders and conditions with an inflammatory component, such as diabetes, arthritis, and stroke. These functions are correlated with the biophysical characteristics of PARP family enzymes. This work is important in providing a comprehensive understanding of the molecular basis of pathogenesis and host responses, as well as in the identification of inhibitors. This is important because the identification of inhibitors has been shown to be effective in arresting the progression of disease.

scholarly journals Transgenerational effects of temperature fluctuations in Arabidopsis thaliana

2020 ◽  
Author(s):  
Ying Deng ◽  
Oliver Bossdorf ◽  
Johannes Fredericus Scheepens
Keyword(s):  
Arabidopsis Thaliana ◽  
Heat Stress ◽  
Stress Responses ◽  
Climatic Variability ◽  
Plant Stress ◽  
Plant Responses ◽  
Transgenerational Effects ◽  
Plant Stress Responses ◽  
Effects Of Temperature ◽  
Offspring Generation

Plant stress responses can extend into the following generations, a phenomenon called transgenerational effects. Heat stress, in particular, is known to affect plant offspring, but we do not know to what extent these effects depend on the temporal patterns of the stress, and whether transgenerational responses are adaptive and genetically variable within species. To address these questions, we carried out a two-generation experiment with nine Arabidopsis thaliana genotypes. We subjected the plants to heat stress regimes that varied in timing and frequency, but not in mean temperature, and we then grew the offspring of these plants under controlled conditions as well as under renewed heat stress. The stress treatments significantly carried over to the offspring generation, with timing having stronger effects on plant phenotypes than stress frequency. However there was no evidence that transgenerational effects were adaptive. The magnitudes of transgenerational effects differed substantially among genotypes, and for some traits the strength of plant responses was significantly associated with the climatic variability at the sites of origin. In summary, timing of heat stress not only directly affects plants, but it can also cause transgenerational effects on offspring phenotypes. Genetic variation in transgenerational effects, as well as correlations between transgenerational effects and climatic variability, indicate that transgenerational effects can evolve, and have probably already done so in the past.

scholarly journals Function and Mechanism of Jasmonic Acid in Plant Responses to Abiotic and Biotic Stresses

2021 ◽  
Vol 22 (16) ◽  
pp. 8568
Author(s):  
Yun Wang ◽  
Salma Mostafa ◽  
Wen Zeng ◽  
Biao Jin
Keyword(s):  
Jasmonic Acid ◽  
Plant Hormones ◽  
Stress Responses ◽  
Abiotic Stresses ◽  
Plant Stress ◽  
Plant Responses ◽  
Biotic And Abiotic Stresses ◽  
Research Attention ◽  
Biotic Stresses ◽  
Plant Stress Responses

As sessile organisms, plants must tolerate various environmental stresses. Plant hormones play vital roles in plant responses to biotic and abiotic stresses. Among these hormones, jasmonic acid (JA) and its precursors and derivatives (jasmonates, JAs) play important roles in the mediation of plant responses and defenses to biotic and abiotic stresses and have received extensive research attention. Although some reviews of JAs are available, this review focuses on JAs in the regulation of plant stress responses, as well as JA synthesis, metabolism, and signaling pathways. We summarize recent progress in clarifying the functions and mechanisms of JAs in plant responses to abiotic stresses (drought, cold, salt, heat, and heavy metal toxicity) and biotic stresses (pathogen, insect, and herbivore). Meanwhile, the crosstalk of JA with various other plant hormones regulates the balance between plant growth and defense. Therefore, we review the crosstalk of JAs with other phytohormones, including auxin, gibberellic acid, salicylic acid, brassinosteroid, ethylene, and abscisic acid. Finally, we discuss current issues and future opportunities in research into JAs in plant stress responses.

scholarly journals Transgenerational effects of temperature fluctuations in Arabidopsis thaliana

AoB Plants ◽  
2021 ◽  
Author(s):  
Ying Deng ◽  
Oliver Bossdorf ◽  
J F Scheepens
Keyword(s):  
Arabidopsis Thaliana ◽  
Heat Stress ◽  
Stress Responses ◽  
Climatic Variability ◽  
Plant Stress ◽  
Plant Responses ◽  
Transgenerational Effects ◽  
Plant Stress Responses ◽  
Effects Of Temperature ◽  
Offspring Generation

Abstract Plant stress responses can extend into the following generations, a phenomenon called transgenerational effects. Heat stress, in particular, is known to affect plant offspring, but we do not know to what extent these effects depend on the temporal patterns of the stress, and whether transgenerational responses are adaptive and genetically variable within species. To address these questions, we carried out a two-generation experiment with nine Arabidopsis thaliana genotypes. We subjected the plants to heat stress regimes that varied in timing and frequency, but not in mean temperature, and we then grew the offspring of these plants under controlled conditions as well as under renewed heat stress. The stress treatments significantly carried over to the offspring generation, with timing having stronger effects on plant phenotypes than stress frequency. However, there was no evidence that transgenerational effects were adaptive. The magnitudes of transgenerational effects differed substantially among genotypes, and for some traits the strength of plant responses was significantly associated with the climatic variability at the sites of origin. In summary, timing of heat stress not only directly affects plants, but it can also cause transgenerational effects on offspring phenotypes. Genetic variation in transgenerational effects, as well as correlations between transgenerational effects and climatic variability, indicate that transgenerational effects can evolve, and have probably already done so in the past.

Sign in / Sign up

Export Citation Format

Share Document