scholarly journals Cognitive Fatigue Is Associated with Altered Functional Connectivity in Interoceptive and Reward Pathways in Multiple Sclerosis

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 930
Author(s):  
Michelle H. Chen ◽  
John DeLuca ◽  
Helen M. Genova ◽  
Bing Yao ◽  
Glenn R. Wylie
Keyword(s):  
Multiple Sclerosis ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Cognitive Load ◽  
Memory Task ◽  
Reward Processing ◽  
Anterior Cingulate ◽  
Cognitive Fatigue ◽  
Adequate Treatment ◽  
Residual Functional

Cognitive fatigue is common and debilitating among persons with multiple sclerosis (pwMS). Neural mechanisms underlying fatigue are not well understood, which results in lack of adequate treatment. The current study examined cognitive fatigue-related functional connectivity among 26 pwMS and 14 demographically matched healthy controls (HCs). Participants underwent functional magnetic resonance imaging (fMRI) scanning while performing a working memory task (n-back), with two conditions: one with higher cognitive load (2-back) to induce fatigue and one with lower cognitive load (0-back) as a control condition. Task-independent residual functional connectivity was assessed, with seeds in brain regions previously implicated in cognitive fatigue (dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex (vmPFC), dorsal anterior cingulate cortex (dACC), insula, and striatum). Cognitive fatigue was measured using the Visual Analogue Scale of Fatigue (VAS-F). Results indicated that as VAS-F scores increased, HCs showed increased residual functional connectivity between the striatum and the vmPFC (crucial in reward processing) during the 2-back condition compared to the 0-back condition. In contrast, pwMS displayed increased residual functional connectivity from interoceptive hubs—the insula and the dACC—to the striatum. In conclusion, pwMS showed a hyperconnectivity within the interoceptive network and disconnection within the reward circuitry when experiencing cognitive fatigue.

scholarly journals The Lateral and Ventromedial Prefrontal Cortex Work as a Dynamic Integrated System: Evidence from fMRI Connectivity Analysis

2009 ◽  
Vol 21 (1) ◽  
pp. 141-154 ◽  
Author(s):  
Olivia Longe ◽  
Carl Senior ◽  
Gina Rippon
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Cognitive Processing ◽  
Emotional Processing ◽  
Memory Load ◽  
Memory Task ◽  
Reward Processing ◽  
Integrated System ◽  
Reciprocal Relationship ◽  
Anterior Cingulate

Recent functional magnetic resonance imaging (fMRI) investigations of the interaction between cognition and reward processing have found that the lateral prefrontal cortex (PFC) areas are preferentially activated to both increasing cognitive demand and reward level. Conversely, ventromedial PFC (VMPFC) areas show decreased activation to the same conditions, indicating a possible reciprocal relationship between cognitive and emotional processing regions. We report an fMRI study of a rewarded working memory task, in which we further explore how the relationship between reward and cognitive processing is mediated. We not only assess the integrity of reciprocal neural connections between the lateral PFC and VMPFC brain regions in different experimental contexts but also test whether additional cortical and subcortical regions influence this relationship. Psychophysiological interaction analyses were used as a measure of functional connectivity in order to characterize the influence of both cognitive and motivational variables on connectivity between the lateral PFC and the VMPFC. Psychophysiological interactions revealed negative functional connectivity between the lateral PFC and the VMPFC in the context of high memory load, and high memory load in tandem with a highly motivating context, but not in the context of reward alone. Physiophysiological interactions further indicated that the dorsal anterior cingulate and the caudate nucleus modulate this pathway. These findings provide evidence for a dynamic interplay between lateral PFC and VMPFC regions and are consistent with an emotional gating role for the VMPFC during cognitively demanding tasks. Our findings also support neuropsychological theories of mood disorders, which have long emphasized a dysfunctional relationship between emotion/motivational and cognitive processes in depression.

scholarly journals Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
G. R. Wylie ◽  
B. Yao ◽  
H. M. Genova ◽  
M. H. Chen ◽  
J. DeLuca
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Dorsolateral Prefrontal Cortex ◽  
Functional Neuroimaging ◽  
Anterior Cingulate ◽  
Healthy Individuals ◽  
Dorsal Anterior Cingulate Cortex ◽  
Mental Work ◽  
Cognitive Fatigue ◽  
Dorsolateral Prefrontal

AbstractCognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a “fatigue network”. These include the striatum of the basal ganglia, the dorsolateral prefrontal cortex (DLPFC), the dorsal anterior cingulate cortex (dACC), the ventro-medial prefrontal cortex (vmPFC) and the anterior insula. However, no work has been conducted to assess whether the connectivity between these regions changes as a function of cognitive fatigue. We used a task-based functional neuroimaging paradigm to induce fatigue in 39 healthy individuals, regressed the signal associated with the task out of the data, and investigated how the functional connectivity between these regions changed as cognitive fatigue increased. We observed functional connectivity between these regions and other frontal regions largely decreased as cognitive fatigue increased while connectivity between these seeds and more posterior regions increased. Furthermore the striatum, the DLPFC, the insula and the vmPFC appeared to be central ‘nodes’ or hubs of the fatigue network. These findings represent the first demonstration that the functional connectivity between these areas changes as a function of cognitive fatigue.

Age differences in ventromedial prefrontal cortex functional connectivity during socioemotional content processing

2020 ◽  
Vol 48 (7) ◽  
pp. 1-19
Author(s):  
Ryan T. Daley ◽  
Holly J. Bowen ◽  
Eric C. Fields ◽  
Angela Gutchess ◽  
Elizabeth A. Kensinger
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Inferior Frontal Gyrus ◽  
Age Groups ◽  
Emotional Content ◽  
Ventromedial Prefrontal Cortex ◽  
Anterior Cingulate ◽  
Supramarginal Gyrus ◽  
Age Related ◽  
Content Processing

Self-relevance effects are often confounded by the presence of emotional content, rendering it difficult to determine how brain networks functionally connected to the ventromedial prefrontal cortex (vmPFC) are affected by the independent contributions of self-relevance and emotion. This difficulty is complicated by age-related changes in functional connectivity between the vmPFC and other default mode network regions, and regions typically associated with externally oriented networks. We asked groups of younger and older adults to imagine placing emotional and neutral objects in their home or a stranger's home. An age-invariant vmPFC cluster showed increased activation for self-relevant and emotional content processing. Functional connectivity analyses revealed age × self-relevance interactions in vmPFC connectivity with the anterior cingulate cortex. There were also age × emotion interactions in vmPFC functional connectivity with the anterior insula, orbitofrontal gyrus, inferior frontal gyrus, and supramarginal gyrus. Interactions occurred in regions with the greatest differences between the age groups, as revealed by conjunction analyses. Implications of the findings are discussed.

Effects of unilateral deactivations of dorsolateral prefrontal cortex and anterior cingulate cortex on saccadic eye movements

2014 ◽  
Vol 111 (4) ◽  
pp. 787-803 ◽  
Author(s):  
Michael J. Koval ◽  
R. Matthew Hutchison ◽  
Stephen G. Lomber ◽  
Stefan Everling
Keyword(s):  
Prefrontal Cortex ◽  
Eye Movements ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Saccadic Eye Movements ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsolateral Prefrontal ◽  
Single Neuron Recording

The dorsolateral prefrontal cortex (dlPFC) and anterior cingulate cortex (ACC) have both been implicated in the cognitive control of saccadic eye movements by single neuron recording studies in nonhuman primates and functional imaging studies in humans, but their relative roles remain unclear. Here, we reversibly deactivated either dlPFC or ACC subregions in macaque monkeys while the animals performed randomly interleaved pro- and antisaccades. In addition, we explored the whole-brain functional connectivity of these two regions by applying a seed-based resting-state functional MRI analysis in a separate cohort of monkeys. We found that unilateral dlPFC deactivation had stronger behavioral effects on saccades than unilateral ACC deactivation, and that the dlPFC displayed stronger functional connectivity with frontoparietal areas than the ACC. We suggest that the dlPFC plays a more prominent role in the preparation of pro- and antisaccades than the ACC.

The Effect of Divided Attention on Encoding and Retrieval in Episodic Memory Revealed by Positron Emission Tomography

2000 ◽  
Vol 12 (2) ◽  
pp. 267-280 ◽  
Author(s):  
Tetsuya Iidaka ◽  
Nicole D. Anderson ◽  
Shitij Kapur ◽  
Roberto Cabez ◽  
Fergus I. M. Craik
Keyword(s):  
Positron Emission Tomography ◽  
Prefrontal Cortex ◽  
Episodic Memory ◽  
Divided Attention ◽  
Memory Performance ◽  
Memory Task ◽  
Anterior Cingulate ◽  
Emission Tomography ◽  
Positron Emission ◽  
Encoding And Retrieval

The effects of divided attention (DA) on episodic memory encoding and retrieval were investigated in 12 normal young subjects by positron emission tomography (PET). Cerebral blood flow was measured while subjects were concurrently performing a memory task (encoding and retrieval of visually presented word pairs) and an auditory tone-discrimination task. The PET data were analyzed using multivariate Partial Least Squares (PLS), and the results revealed three sets of neural correlates related to specific task contrasts. Brain activity, relatively greater under conditions of full attention (FA) than DA, was identified in the occipital-temporal, medial, and ventral-frontal areas, whereas areas showing relatively more activity under DA than FA were found in the cerebellum, temporo-parietal, left anterior-cingulate gyrus, and bilateral dorsolateral-prefrontal areas. Regions more active during encoding than during retrieval were located in the hippocampus, temporal and the prefrontal cortex of the left hemisphere, and regions more active during retrieval than during encoding included areas in the medial and right-prefrontal cortex, basal ganglia, thalamus, and cuneus. DA at encoding was associated with specific decreases in rCBF in the left-prefrontal areas, whereas DA at retrieval was associated with decreased rCBF in a relatively small region in the right-prefrontal cortex. These different patterns of activity are related to the behavioral results, which showed a substantial decrease in memory performance when the DA task was performed at encoding, but no change in memory levels when the DA task was performed at retrieval.

scholarly journals Modulation of Resting Connectivity Between the Mesial Frontal Cortex and Basal Ganglia

2018 ◽  
Author(s):  
Traian Popa ◽  
Laurel S. Morris ◽  
Rachel Hunt ◽  
Zhi-De Deng ◽  
Silvina Horovitz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Ventral Striatum ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Unexpected Finding ◽  
Independent Components Analysis ◽  
Independent Components ◽  
Components Analysis

AbstractThe mesial prefrontal cortex, cingulate cortex and the ventral striatum are key nodes of the human mesial fronto-striatal circuit involved in decision-making and executive function and pathological disorders. Here we ask whether deep wide-field repetitive transcranial magnetic stimulation (rTMS) targeting the mesial prefrontal cortex (MPFC) influences resting state functional connectivity. In Study 1, we examined functional connectivity using resting state multi-echo and independent components analysis in 154 healthy subjects to characterize default connectivity in the MPFC and mid-cingulate cortex (MCC). In Study 2, we used inhibitory, 1 Hz deep rTMS with the H7-coil targeting MPFC and dorsal anterior cingulate (dACC) in a separate group of 20 healthy volunteers and examined pre-and post-TMS functional connectivity using seed-based and independent components analysis. In Study 1, we show that MPFC and MCC have distinct patterns of functional connectivity with MPFC–ventral striatum showing negative, whereas MCC–ventral striatum showing positive functional connectivity. Low-frequency rTMS decreased functional connectivity of MPFC and dACC with the ventral striatum. We further showed enhanced connectivity between MCC and ventral striatum. These findings emphasize how deep inhibitory rTMS using the H7-coil can influence underlying network functional connectivity by decreasing connectivity of the targeted MPFC regions, thus potentially enhancing response inhibition and decreasing drug cue reactivity processes relevant to addictions. The unexpected finding of enhanced default connectivity between MCC and ventral striatum may be related to the decreased influence and connectivity between the MPFC and MCC. These findings are highly relevant to the treatment of disorders relying on the mesioprefrontal–cingulo–striatal circuit.

Neurocircuitry Underlying OCD

2017 ◽  
Author(s):  
Suzanne N. Haber
Keyword(s):  
Prefrontal Cortex ◽  
Orbitofrontal Cortex ◽  
Treatment Strategies ◽  
Reward Processing ◽  
Ventromedial Prefrontal Cortex ◽  
Anterior Cingulate ◽  
Reward Learning ◽  
Imaging Studies ◽  
Dorsal Anterior Cingulate Cortex ◽  
Individual Level

Structural and functional imaging studies have identified abnormalities in the brains of individuals with OCD. The most consistent findings point to pathology in the circuitry connecting the prefrontal cortex with the basal ganglia, and especially to abnormalities in the orbitofrontal cortex (OFC), ventromedial prefrontal cortex (vmPFC), dorsal anterior cingulate cortex (dACC), and striatum. This chapter describes the detailed anatomy and interconnectivity of these structures, together with its functional correlates, to provide context for the more detailed treatment of abnormalities seen in OCD provided in the chapters that follow. These corticostriatal circuits are critical for reward processing, reward learning, and action selection, and so disruption in these circuitries in OCD may underlie abnormalities in these domains. Precisely defining the anatomy of these circuits and how it is disrupted in OCD, at both the group and individual level, is increasingly important, as it may help us to optimize anatomically targeted treatment strategies.

Cognitive Rehabilitation Modifies Functional Connectivity of the Anterior Cingulate Cortex in Multiple Sclerosis (S51.003)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S51.003-S51.003 ◽  
Author(s):  
L. Panicari ◽  
M. Rocca ◽  
P. Valsasina ◽  
G. C. Riccitelli ◽  
F. Mattioli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Cognitive Rehabilitation ◽  
Cingulate Cortex ◽  
Anterior Cingulate
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