scholarly journals Acute Pulmonary Embolism Severity Assessment Evaluated with Dual Energy CT Perfusion Compared to Conventional CT Angiographic Measurements

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 495
Author(s):  
Samir Jawad ◽  
Peter Sommer Ulriksen ◽  
Anna Kalhauge ◽  
Kristoffer Lindskov Hansen

The purpose of the study was to investigate whether Dual Energy CT (DECT) can be used as a diagnostic tool to assess the severity of acute pulmonary embolism (PE) by correlating parenchymal perfusion defect volume, obstruction score and right ventricular-to-left ventricular (RV/LV) diameter ratio using CT angiography (CTA) and DECT perfusion imaging. A total of 43 patients who underwent CTA and DECT perfusion imaging with clinical suspicion of acute PE were retrospectively included in the study. In total, 25 of these patients had acute PE findings on CTA. DECT assessed perfusion defect volume (PDvol) were automatically and semiautomatically quantified. Overall, two CTA methods for risk assessment in patients with acute PE were assessed: the RV/LV diameter ratio and the Modified Miller obstruction score. Automatic PDvol had a weak correlation (r = 0.47, p = 0.02) and semiautomatic PDvol (r = 0.68, p < 0.001) had a moderate correlation to obstruction score in patients with confirmed acute PE, while only semiautomatic PDvol (r = 0.43, p = 0.03) had a weak correlation with the RV/LV diameter ratio. Our data indicate that PDvol assessed by DECT software technique may be a helpful tool to assess the severity of acute PE when compared to obstruction score and RV/LV diameter ratio.

Author(s):  
Thomas M Berghaus ◽  
Fabian Geissenberger ◽  
Dinah Konnerth ◽  
Michael Probst ◽  
Thomas Kröncke ◽  
...  

Purpose: Right ventricular (RV) dysfunction in acute pulmonary embolism (PE) is a critical determinant of outcome. Obstructive sleep apnea (OSA) is a common comorbidity of PE and might also affect RV function. Therefore, we sought to investigate RV dysfunction in PE patients in proportion to the severity of OSA by evaluating the right-to-left ventricular (RV/LV) diameter ratio on computed tomographic pulmonary angiography (CTPA). Materials and Methods: 197 PE patients were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. RV dilatation was defined as an RV/LV diameter ratio of ⩾ 1.0. Results: RV dilatation was significantly more frequent in OSA patients compared to study participants without OSA (66.4% vs 49.1%, P = .036). Elevated troponin I values, indicating myocardial injury due to acute, PE-related RV strain, were significantly more frequent in OSA patients with an apnea-hypopnea index (AHI) ⩾ 15/h compared to those with an AHI < 15/h (62.1% vs 45.8%, P = .035). However, RV dysfunction documented by the RV/LV diameter ratio on CTPA was not significantly associated with the severity of OSA in multivariable regression analysis. Conclusion: Patients with moderate or severe OSA might compensate acute, PE-related RV strain better, as they are adapted to repetitive right heart pressure overloads during sleep.


2021 ◽  
Vol 77 (18) ◽  
pp. 1797
Author(s):  
Mary E. Acosta ◽  
Rajeev Anchan ◽  
Stephanie Besser ◽  
Luis Landeras ◽  
Jonathan Paul

2013 ◽  
Vol 23 (10) ◽  
pp. 2666-2675 ◽  
Author(s):  
Long Jiang Zhang ◽  
Chang Sheng Zhou ◽  
U. Joseph Schoepf ◽  
Hui Xue Sheng ◽  
Sheng Yong Wu ◽  
...  

2021 ◽  
Vol 11 (5) ◽  
pp. 1817-1827
Author(s):  
Bernhard Petritsch ◽  
Pauline Pannenbecker ◽  
Andreas M. Weng ◽  
Jan-Peter Grunz ◽  
Simon Veldhoen ◽  
...  

2012 ◽  
Vol 81 (12) ◽  
pp. 3711-3718 ◽  
Author(s):  
Lucas L. Geyer ◽  
Michael Scherr ◽  
Markus Körner ◽  
Stefan Wirth ◽  
Paul Deak ◽  
...  

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