scholarly journals Impact of Artificial Infiltration on the Removal of Nonsteroidal Anti-Inflammatory Drugs during Treatment of Surface Water

Energies ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 8406
Author(s):  
Aleksandra Makała ◽  
Zbysław Dymaczewski ◽  
Joanna Jeż-Walkowiak ◽  
Agnieszka Strykowska ◽  
Joanna Zembrzuska
Keyword(s):  
Surface Water ◽  
High Performance ◽  
Natural Waters ◽  
Solid Phase ◽  
Biologically Active ◽  
Forced Flow ◽  
Infiltration Process ◽  
Experimental Installation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The content of pharmaceuticals in natural waters is steadily increasing. Especially nonsteroidal anti-inflammatory drugs (NSAIDs) are often detected in natural waters due to their widespread use. This group of compounds includes commonly used representatives, such as paracetamol and ketoprofen. The quality of natural waters determines the processes applied for the treatment of drinking water. The methods used in order to remove pharmaceuticals from treated water include adsorption and biologically active filtration. Both processes also occur during artificial infiltration (forced flow of intake surface water through the ground to the collecting wells) at surface water intakes. The processes, which occur in the soil, change the water quality characteristics to a great extent. The goal of the study was to evaluate the removal efficiency of paracetamol and ketoprofen in the process of artificial infiltration used as a pre-treatment of surface water. The studies were conducted at a field experimental installation located at the technical artificial infiltration intake. The experimental installation consisted of three metering wells (piezometers) which were located on the way between the bank of the infiltration pond and the collecting well. The collected water samples allowed to evaluate the change of selected NSAIDs concentrations during the passage of water through the ground. The analysis procedure included solid phase extraction (SPE) and high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Removal of the studied NSAIDs in the infiltration process occurred with variable effectiveness throughout the year. Paracetamol was removed with annual efficiency equal to 42%, although no significant removal of ketoprofen was observed.

scholarly journals Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using Micro-Solid Phase Extraction

2019 ◽  
Vol 19 (3) ◽  
pp. 684 ◽  
Author(s):  
Mohammad Salim Tabish ◽  
Nor Suhaila Mohamad Hanapi ◽  
Wan Nazihah Wan Ibrahim ◽  
Nor’ashikin Saim ◽  
Noorfatimah Yahaya
Keyword(s):  
Graphene Oxide ◽  
Solid Phase Extraction ◽  
Electrostatic Interactions ◽  
High Performance ◽  
Solid Phase ◽  
Tap Water ◽  
Phase Extraction ◽  
Composite Sorbent ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

In this work, a bio-composite sorbent, alginate incorporated graphene oxide (Alg/GO) is prepared for the micro solid phase extraction of non-steroidal anti-inflammatory drugs (NSAIDs) from water samples. The sorbent was prepared in a suspended solution form at a ratio of 0.3:1 (w/v %) of graphene oxide (GO) and alginate (Alg). The chemical structure, morphology and surface area of the composite beads were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and Brunauer–Emmett–Teller (BET). GO showed good miscibility and well dispersion through intermolecular hydrogen bonds and electrostatic interactions within the Alg matrix. The synthesized sorbent was applied for the determination of the selected drugs in a tap water sample using micro-solid phase extraction technique and was analyzed by high-performance liquid chromatography-ultraviolet detector (HPLC-UV). The results showed good linearity in the range of 10–1000 µg L–1 with correlation coefficients (r ≥ 0.9979), low detection limits (LOD) between 3.1–4.6 µg L–1, excellent relative recoveries in the range of 99.6–102.1% and good reproducibility (RSD ≤ 3.9%). Thus, these validated results showed that Alg/GO could be potential and useful as a bio-composite sorbent for micro-solid phase extraction for the analysis of targeted drugs from aqueous matrices.

scholarly journals Lab-In-Syringe with Bead Injection Coupled Online to High-Performance Liquid Chromatography as Versatile Tool for Determination of Nonsteroidal Anti-Inflammatory Drugs in Surface Waters

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5358
Author(s):  
Celestine Vubangsi Gemuh ◽  
Burkhard Horstkotte ◽  
Petr Solich
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Solid Phase ◽  
Versatile Tool ◽  
Oasis Hlb ◽  
Automated Sample Preparation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Bead Injection

We report on the hyphenation of the modern flow techniques Lab-In-Syringe and Lab-On-Valve for automated sample preparation coupled online with high-performance liquid chromatography. Adopting the bead injection concept on the Lab-On-Valve platform, the on-demand, renewable, solid-phase extraction of five nonsteroidal anti-inflammatory drugs, namely ketoprofen, naproxen, flurbiprofen, diclofenac, and ibuprofen, was carried out as a proof-of-concept. In-syringe mixing of the sample with buffer and standards allowed straightforward pre-load sample modification for the preconcentration of large sample volumes. Packing of ca. 4.4 mg microSPE columns from Oasis HLB® sorbent slurry was performed for each sample analysis using a simple microcolumn adapted to the Lab-On-Valve manifold to achieve low backpressure during loading. Eluted analytes were injected into online coupled HPLC with subsequent separation on a Symmetry C18 column in isocratic mode. The optimized method was highly reproducible, with RSD values of 3.2% to 7.6% on 20 µg L−1 level. Linearity was confirmed up to 200 µg L−1 and LOD values were between 0.06 and 1.98 µg L−1. Recovery factors between 91 and 109% were obtained in the analysis of spiked surface water samples.

scholarly journals Supramolecular Solvent-Based Microextraction of Selected Anticonvulsant and Nonsteroidal Anti-Inflammatory Drugs from Sediment Samples

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5671
Author(s):  
Sylwia Bajkacz ◽  
Paulina Adamczewska ◽  
Klaudia Kokoszka ◽  
Elżbieta Kycia-Słocka ◽  
Adam Sochacki ◽  
...  
Keyword(s):  
Water Samples ◽  
High Performance ◽  
Solid Phase ◽  
Extraction Procedure ◽  
Single Step ◽  
Sample Treatment ◽  
Sediment Samples ◽  
Supramolecular Solvent ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The increase in the production and consumption of pharmaceuticals increases their presence in the global environment, which may result in direct threats to living organisms. For this reason, there is a need for new methods to analyze drugs in environmental samples. Here, a new procedure for separating and determining selected drugs (diclofenac, ibuprofen, and carbamazepine) from bottom sediment and water samples was developed. Drugs were determined by ultra-high performance liquid chromatography coupled with an ultraviolet detector (UHPLC-UV). In this work, a universal and single-step sample treatment, based on supramolecular solvents (SUPRAS), was proposed to isolate selected anticonvulsants and nonsteroidal anti-inflammatory drugs (NSAIDs) from sediment samples. The following parameters were experimentally selected: composition of the supramolecular solvent (composition THF:H2O (v/v), amount of decanoic acid), volume of extractant, sample mass, extraction time, centrifugation time, and centrifugation speed. Finally, the developed procedure was validated. A Speedisk procedure was also developed to extract selected drugs from water samples. The recovery of analytes using the SUPRAS procedure was in the range of 88.8–115%, while the recoveries of the Speedisk solid-phase extraction procedure ranged from 81.0–106%. The effectiveness of the sorption of the tested drugs by sediment was also examined.

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