scholarly journals LES of Particle-Laden Flow in Sharp Pipe Bends with Data-Driven Predictions of Agglomerate Breakage by Wall Impacts

Fluids ◽  
2021 ◽  
Vol 6 (12) ◽  
pp. 424
Author(s):  
Ali Khalifa ◽  
Jasper Gollwitzer ◽  
Michael Breuer

The breakage of agglomerates due to wall impact within a turbulent two-phase flow is studied based on a recently developed model which relies on two artificial neural networks (ANNs). The breakup model is intended for the application within an Euler-Lagrange approach using the point-particle assumption. The ANNs were trained based on comprehensive DEM simulations. In the present study the entire simulation methodology is applied to the flow through two sharp pipe bends considering two different Reynolds numbers. In a first step, the flow structures of the continuous flow arising in both bend configurations are analyzed in detail. In a second step, the breakage behavior of agglomerates consisting of spherical, dry and cohesive silica particles is predicted based on the newly established simulation methodology taking agglomeration, fluid-induced breakage and breakage due to wall impact into account. The latter is found to be the dominant mechanism determining the resulting size distribution at the bend outlet. Since the setups are generic geometries found in dry powder inhalers, important knowledge concerning the effect of the Reynolds number as well as the design type (one-step vs. two-step deflection) can be gained.

2007 ◽  
Author(s):  
Wenhong Liu ◽  
Liejin Guo ◽  
Ximin Zhang ◽  
Kai Lin ◽  
Long Yang ◽  
...  

2021 ◽  
Vol 655 (1) ◽  
pp. 012024
Author(s):  
O.H. Ajesi ◽  
M.B. Latif ◽  
S.T. Gbenu ◽  
C. A. Onumejor ◽  
M. K. Fasasi ◽  
...  

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ye Wang ◽  
Jiongdong Zhao ◽  
Yu Zhu ◽  
Shurong Dong ◽  
Yang Liu ◽  
...  

AbstractHere, we present integrated nanorod arrays on microfluidic chips for fast and sensitive flow-through immunoassays of physiologically relevant macromolecules. Dense arrays of Au nanorods are easily fabricated through one-step oblique angle deposition, which eliminates the requirement of advanced lithography methods. We report the utility of this plasmonic structure to improve the detection limit of the cardiac troponin I (cTnI) assay by over 6 × 105-fold, reaching down to 33.9 fg mL−1 (~1.4 fM), compared with an identical assay on glass substrates. Through monolithic integration with microfluidic elements, the device enables a flow-through assay for quantitative detection of cTnI in the serum with a detection sensitivity of 6.9 pg mL−1 (~0.3 pM) in <6 min, which was 4000 times lower than conventional glass devices. This ultrasensitive detection arises from the large surface area for antibody conjugation and metal-enhanced fluorescent signals through plasmonic nanostructures. Moreover, due to the parallel arrangement of flow paths, simultaneous detection of multiple cancer biomarkers, including prostate-specific antigen and carcinoembryonic antigen, has been fulfilled with increased signal-to-background ratios. Given the high performance of this assay, together with its simple fabrication process that is compatible with standard mass manufacturing techniques, we expect that the prepared integrated nanorod device can bring on-site point-of-care diagnosis closer to reality.


1992 ◽  
Vol 114 (1) ◽  
pp. 14-30 ◽  
Author(s):  
E. F. Caetano ◽  
O. Shoham ◽  
J. P. Brill

Mechanistic models have been developed for each of the existing two-phase flow patterns in an annulus, namely bubble flow, dispersed bubble flow, slug flow, and annular flow. These models are based on two-phase flow physical phenomena and incorporate annulus characteristics such as casing and tubing diameters and degree of eccentricity. The models also apply the new predictive means for friction factor and Taylor bubble rise velocity presented in Part I. Given a set of flow conditions, the existing flow pattern in the system can be predicted. The developed models are applied next for predicting the flow behavior, including the average volumetric liquid holdup and the average total pressure gradient for the existing flow pattern. In general, good agreement was observed between the experimental data and model predictions.


2021 ◽  
Vol 1877 (1) ◽  
pp. 012035
Author(s):  
Shengxiang Lin ◽  
Huanxiong Xia ◽  
Zhenyu Zhang ◽  
Jianhua Liu ◽  
Honglei Wang

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