scholarly journals Discrimination of Acne Vulgaris with Human Scalp Hair tissues using - FTIR-ATR Spectroscopy

2020 ◽  
Author(s):  
Padmavathi R, M.Sc.,M.Phil ◽  
Rajamannan B, M.Sc.,Ph.D ◽  
Gunasekaran S, M.Sc.,Ph.D.,D.Sc ◽  
Ramkumar GR, M.SC., Ph.D ◽  
Sankari G, M.Sc.,Ph.D ◽  
...  
Keyword(s):  
Scalp Hair ◽  
Acne Vulgaris ◽  
Human Scalp Hair ◽  
Atr Spectroscopy

scholarly journals Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using - FTIR-ATR Spectroscopy

2019 ◽  
Author(s):  
Padmavathi R ◽  
Gunasekaran S ◽  
Rajamannan B ◽  
Ramkumar GR ◽  
Sankari G ◽  
...  
Keyword(s):  
Scalp Hair ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Pilosebaceous Unit ◽  
Tissue Samples ◽  
Spectral Signatures ◽  
Human Scalp Hair ◽  
Chronic Skin ◽  
Noninvasive Sample ◽  
Atr Spectroscopy

Acne vulgaris is a chronic skin disease which occurs due to inflammation of the hair follicles and sebum-producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P.acne. Human sebum is dominantly made up of 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P.acne overgrowth which induces monocytes and pro-inflammatory cytokines attract neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyperproliferation i.e., Acne vulgaris. The actual biomolecular changes due to acne vulgaris disease are present in the blood and in the sebum and also in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair tissue samples through acne bio-markers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters.

scholarly journals Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using FTIR-ATR Spectroscopy

2020 ◽  
Author(s):  
Padmavathi Ramanujam ◽  
Rajamannan B ◽  
Gunasekaran S ◽  
Ramkumar GR ◽  
Sankari G ◽  
...  
Keyword(s):  
Scalp Hair ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Pilosebaceous Unit ◽  
Spectral Signatures ◽  
Human Scalp Hair ◽  
Hair Samples ◽  
Chronic Skin ◽  
Noninvasive Sample ◽  
Atr Spectroscopy

Acne vulgaris is a chronic skin disease, which occurs due to inflammation of the hair follicles and sebum-producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P. Acne. Human sebum is dominantly made up of about 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene, and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P. Acne overgrowth which induces monocytes and pro-inflammatory cytokines attract neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyperproliferation i.e., Acne vulgaris. The actual Biomolecular changes due to acne vulgaris disease are present in the blood, in the sebum, and in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair samples through acne biomarkers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters.

scholarly journals Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using FTIR-ATR Spectroscopy

2020 ◽  
Author(s):  
Padmavathi Ramanujam ◽  
Rajamannan B ◽  
Guasekaran S ◽  
Ramkumar GR ◽  
Sankari G ◽  
...  
Keyword(s):  
Scalp Hair ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Pilosebaceous Unit ◽  
Tissue Samples ◽  
Human Scalp Hair ◽  
Future Drug ◽  
Chronic Skin ◽  
Noninvasive Sample ◽  
Atr Spectroscopy

Acne vulgaris is a chronic skin disease, which occurs due to inflammation of the hair follicles and sebum producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P.acne. Human sebum is dominantly made up of 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P.acne over growth which induces monocytes and pro inflammatory cytokines attracts neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyper proliferation i.e., Acne vulgaris. The actual biomolecular changes due to acne vulgaris disease are present in the blood, in the sebum, and in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair tissue samples through acne biomarkers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters. This work represents a first step in the development of the analytical tool for future drug development.

scholarly journals Lead in Human Scalp Hair: Some Factors Affecting its Variability

1975 ◽  
Vol 64 (5) ◽  
pp. 342-348 ◽  
Author(s):  
L.E. Kopito ◽  
H. Shwachman
Keyword(s):  
Scalp Hair ◽  
Factors Affecting ◽  
Human Scalp Hair

Analysis of a new fluoroquinolone derivative (Q-35) in human scalp hair as an index of drug exposure and as a time marker in hair

1994 ◽  
Vol 106 (5) ◽  
pp. 237-243 ◽  
Author(s):  
Toshihiko Uematsu ◽  
Yasutsugu Ohsawa ◽  
Atsuhiro Mizuno ◽  
Mitsuyoshi Nakashima
Keyword(s):  
Drug Exposure ◽  
Scalp Hair ◽  
Time Marker ◽  
Human Scalp Hair

scholarly journals Preliminary study on morphometric analysis of the human scalp hair for discrimination of ethnic Malay and ethnic Chinese in Malaysia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Loong Chuen Lee ◽  
Wan Nur Syazwani Wan Mohamad Fuad ◽  
Sharifah Shakilah Abdullah ◽  
Kay Loke Ong
Keyword(s):  
Morphometric Analysis ◽  
Scalp Hair ◽  
Human Scalp Hair ◽  
Ethnic Chinese ◽  
Preliminary Study

scholarly journals Human scalp hair as a monitor of individual dosage history : Measurement of chlorpromazine in hair.

1991 ◽  
Vol 55 ◽  
pp. 241
Author(s):  
Hiroshi Sato ◽  
Toshihiko Uematsu ◽  
Atsuhiro Mizuno ◽  
Mitsuyoshi Nakashima
Keyword(s):  
Scalp Hair ◽  
Human Scalp Hair
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