scholarly journals A Comprehensive Review on the Synthesis and Versatile Applications of Biologically Active Pyridone-Based Disperse Dyes

2020 ◽  
Vol 17 (13) ◽  
pp. 4714 ◽  
Author(s):  
Alya M. Al-Etaibi ◽  
Morsy Ahmed El-Apasery
Keyword(s):  
High Temperature ◽  
Anticancer Agents ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Disperse Dyes ◽  
Comprehensive Review ◽  
Dyeing Method

This review summarizes our contributions during last decade on the synthesis of arylazopyridones that may be used as disperse dyes for hydrophobic fabrics utilizing an environmentally benign high temperature dyeing method. The review also discusses the advantages of select disperse dyes based on pyridone moieties as antioxidant, antimicrobial and anticancer agents.

scholarly journals Nano TiO2 Imparting Multifunctional Performance on Dyed Polyester Fabrics with some Disperse Dyes Using High Temperature Dyeing as an Environmentally Benign Method

2020 ◽  
Vol 17 (4) ◽  
pp. 1377 ◽  
Author(s):  
Alya M. Al-Etaibi ◽  
Morsy Ahmed El-Apasery
Keyword(s):  
High Temperature ◽  
Low Temperature ◽  
Value Added ◽  
Polyester Fabric ◽  
Disperse Dyes ◽  
Blue Dye ◽  
Color Strength ◽  
Polyester Fabrics ◽  
Self Cleaning ◽  
Dyeing Method

Polyester fabrics were dyed with prepared disperse dyes using the high temperature dyeing method. The dye exhaustion of the dye baths were compared to the low-temperature dyeing method in an attempt to study the proportion of the dye effluent solution that affects the environment. The dye uptake of the high temperature dyeing method (HT) of polyester fabric was compared with low temperature dyeing, hence (HT) increased the color strength of the investigated dyes by 309 and 265%. This means that the amount of dye present in the dye effluents by using the high-temperature dyeing method is almost non-existent, and this is reflected positively on the environment as these wastes pollute the environment. Post-treated polyester fabric was prepared through a two-step hot process after being immersed in a solution of Titanium (IV) oxide nanoparticle sizeTiO2 NPs (21 nm primary particle size) at 80 °C followed by curing at 140 °C. The treated fabric realized an optimum UV protection factor of 34.9 and 283.6 degrees. These fabrics also demonstrated a strong ability to improve the light fastness properties. Finally, the potential applications of such value-added fabrics as self-cleaning and antifungal activities were investigated. The results indicated that the treated dyed fabrics with TiO2 NPs endowed fabrics with the excellent self-cleaning of methylene blue dye. From the above, the treated fabrics with nano-titanium dioxide can be used in some promising fields, for example, medical ones.

Oxazole-Based Compounds As Anticancer Agents

2020 ◽  
Vol 26 (41) ◽  
pp. 7337-7371 ◽  
Author(s):  
Maria A. Chiacchio ◽  
Giuseppe Lanza ◽  
Ugo Chiacchio ◽  
Salvatore V. Giofrè ◽  
Roberto Romeo ◽  
...  
Keyword(s):  
Cancer Research ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Chemical Diversity ◽  
Biologically Active ◽  
New Drugs ◽  
The Core ◽  
Anti Cancer ◽  
Biologically Active Derivatives

: Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Diverse thiophenes as scaffolds in anti-cancer drug development: A concise review

2020 ◽  
Vol 20 ◽  
Author(s):  
Neha V. Bhilare ◽  
Pratibha B. Auti ◽  
Vinayak S. Marulkar ◽  
Vilas J. Pise
Keyword(s):  
Drug Development ◽  
Anticancer Agents ◽  
Heterocyclic Ring ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Cancer Drug ◽  
Active Compounds ◽  
Natural Origin ◽  
Concise Review ◽  
Anti Cancer

: Thiophenes are one among the abundantly found heterocyclic ring systems in many biologically active compounds. Moreover various substituted thiophenes exert numerous pharmacological actions on account of their isosteric resemblance with compounds of natural origin thus rendering them with diverse actions like antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, antiallergic, hypotensives etc.. In this review we specifically explore the chemotherapeutic potential of variety of structures consisting of thiophene scaffolds as prospective anticancer agents.

scholarly journals Metabolic Engineering of Yeast and Plants for the Production of the Biologically Active Hydroxystilbene, Resveratrol

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Philippe Jeandet ◽  
Bertrand Delaunois ◽  
Aziz Aziz ◽  
David Donnez ◽  
Yann Vasserot ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Stilbene Synthase ◽  
Molecular Engineering ◽  
Biologically Active ◽  
The Other ◽  
Alternative Mechanism ◽  
Comprehensive Review ◽  
Transgenic Lines ◽  
Key Enzyme ◽  
Recombinant Microorganisms

Resveratrol, a stilbenic compound deriving from the phenyalanine/polymalonate route, being stilbene synthase the last and key enzyme of this pathway, recently has become the focus of a number of studies in medicine and plant physiology. Increased demand for this molecule for nutraceutical, cosmetic and possibly pharmaceutic uses, makes its production a necessity. In this context, the use of biotechnology through recombinant microorganisms and plants is particularly promising. Interesting results can indeed arise from the potential of genetically modified microorganisms as an alternative mechanism for producing resveratrol. Strategies used to tailoring yeast as they do not possess the genes that encode for the resveratrol pathway, will be described. On the other hand, most interest has centered in recent years, onSTSgene transfer experiments from various origins to the genome of numerous plants. This work also presents a comprehensive review on plant molecular engineering with theSTSgene, resulting in disease resistance against microorganisms and the enhancement of the antioxidant activities of several fruits in transgenic lines.

scholarly journals A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1479 ◽  
Author(s):  
Katarzyna Gach-Janczak ◽  
Joanna Drogosz-Stachowicz ◽  
Angelika Długosz-Pokorska ◽  
Rafał Jakubowski ◽  
Tomasz Janecki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Anticancer Agents ◽  
Biologically Active ◽  
Human Leukemia ◽  
Apoptosis Induction ◽  
Hybrid Compound ◽  
Drug Candidates ◽  
Natural Substances ◽  
High Cytotoxic Activity ◽  
Induced Apoptosis

In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents is based on the conjugation of two or more biologically active structural motifs into one hybrid compound. In this study, we investigated the anticancer potential of 4-benzyl-5,7-dimethoxy-4-methyl-3-methylidene-3,4-dihydro-2H-chroman-2-one (DL-247), a new hybrid molecule combining a chroman-2-one skeleton with an exo-methylidene bond conjugated with a carbonyl group, in human myeloid leukemia HL-60 cell line. The cytotoxicity of the new compound was tested using MTT assay. The effect of DL-247 on cell proliferation and apoptosis induction were studied by flow cytometry, fluorometric assay and ELISA analysis. DL-247 displayed high cytotoxic activity (IC50 = 1.15 µM, after 24 h incubation), significantly inhibited cell proliferation and induced apoptosis by both, the intrinsic and extrinsic pathways. A combination of DL-247 with taxol exhibited a strong synergistic effect on DNA damage generation, apoptosis induction and inhibition of cell growth.

scholarly journals Dyeing of Polyester Fabric with Natural Colorants Extracted from Mahogany (Swieteniamahagoni) Seed Pods

2020 ◽  
Vol 11 (1) ◽  
pp. 37-42
Author(s):  
Md Abdullah Al Mamun ◽  
Mohammad Mamun Hossain ◽  
Mubarak Ahmad Khan
Keyword(s):  
Crude Extract ◽  
Polyester Fabric ◽  
Disperse Dyes ◽  
Color Fastness ◽  
Color Strength ◽  
Uv And Ir Spectra ◽  
Natural Colorants ◽  
Dyeing Method ◽  
Exhaust Dyeing ◽  
Dyed Fabric

Polyester fabric is usually dyed with disperse dyes which has severe limitations specially toxicity and environmental issues. The aim of the present research is to introduce an ecofriendly dyeing process for polyester fabric with natural dyes. The natural colorants were extracted from mahogany seed pods using the simple acid boiling method. The spectroscopic analysis of the crude extract was carried out by UV and IR spectra of the extracted dyes and illuminated the presence of natural tannins as coloring materials in the crude extract. 10g fabric was dyed in 200cc extracted solution at 130⁰C for 60 minutes in exhaust dyeing method followed by neutralization and soaping. Finally, a light brown dyed fabric was obtained. The dyed fabric exhibited color strength in terms of k/s value of 0.63 (λmax 360nm), lightness of 80.565 and chromaticity value of 12.002 CIE units. Different samples were dyed by fluctuating the dyeing period. The dyeing traits of the dyed materials were judged in terms of their color strength and fatness properties. All testes were carried out following the ISO standards. From the results, it is lucid that the dyed fabric showed acceptable color fastness properties in case of all fastness except color fastness to light. It is observed that dyeing time had profound influence on the color strength (k/s value) of the dyed material. The k/s value increases with the increase of dyeing period up to 120 minutes. The maximum color strength (0.76) was noted for the fabric. The shorter dyeing time produces lighter samples and the longer dyeing time produced colorful samples. Journal of Engineering Science 11(1), 2020, 37-42

A comprehensive review on high-temperature fuel cells with carbon capture

2020 ◽  
Vol 275 ◽  
pp. 115342 ◽  
Author(s):  
Fu Wang ◽  
Shuai Deng ◽  
Houcheng Zhang ◽  
Jiatang Wang ◽  
Jiapei Zhao ◽  
...  
Keyword(s):  
Fuel Cells ◽  
High Temperature ◽  
Carbon Capture ◽  
Comprehensive Review

Chinese Herbal Medicine-Based Cancer Therapy: Novel Anticancer Agents Targeting MicroRNAs to Regulate Tumor Growth and Metastasis

2019 ◽  
Vol 47 (08) ◽  
pp. 1711-1735 ◽  
Author(s):  
Fu Peng ◽  
Xiaofang Xie ◽  
Cheng Peng
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Anticancer Agents ◽  
Biologically Active ◽  
Active Components ◽  
Rna Molecules ◽  
Chinese Herbal ◽  
Non Coding Rna ◽  
Wide Range ◽  
Tumor Growth And Metastasis

MicroRNAs, small non-coding RNA molecules, have gained a reputation of the most substantial regulators in gene network with the ability to down-regulate their targets. Accumulating evidence shifted insight toward microRNAs regulation as the key element of cancer initiation, development, and aggression. Recent studies have attached the importance of traditional Chinese medicine (TCM) to the treatment of various cancers, and the functional natural compounds have been considered as novel anticancer agents to directly inhibit tumor progression. In more recent decades, a wide range of biologically active components of TCM has gained increasing attention to their applications in the modulation of microRNAs. This review is on the purpose of demonstrating the significance of TCM bioactive ingredients in microRNAs regulation for cancer treatment according to the reports mainly in the recent six years, providing the evidence of efficient Chinese herbal medicine-based therapy and effective pro-diagnosis focusing on microRNAs expression of cancer patients.

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