scholarly journals Standardized Incidence Ratio and Standardized Mortality Ratio of Malignant Mesothelioma in a Worker Cohort Using Employment Insurance Database in Korea

2021 ◽  
Vol 18 (20) ◽  
pp. 10682
Author(s):  
Eun-A Kim
Keyword(s):  
Malignant Mesothelioma ◽  
Food Service ◽  
Standardized Mortality Ratio ◽  
Standardized Incidence Ratio ◽  
Employment Insurance ◽  
Long Latency ◽  
Long Term Follow Up ◽  
Mortality Ratio ◽  
Carcinogenic Effects ◽  
Indirect Standardization

Malignant mesothelioma is one of the appropriate indicators for assessing the carcinogenic effects of asbestos. This study compared the risk ratio of mesothelioma according to the industry in the worker cohort. A cohort was constructed using the Korean employment insurance system during 1995–2017, enrolling 13,285,895 men and 10,452,705 women. The standardized mortality ratio (SMR) and standardized incidence ratio (SIR) were calculated using the indirect standardization method. There were 641 malignant mesotheliomas that occurred; the SIR was significantly higher than the general population (men 1.36, 95% confidence interval(CI) 1.24–1.48, women 1.44, 95% CI: 1.23–1.7). More than half (52.8%) of malignant mesothelioma cases occurred in the manufacturing (n = 240, 38.6%, SIR: men, 1.72, 95% CI: 1.37–2.15, women, 3.31, 95% CI: 1.71–5.79) and construction industries (n = 88, 14.2%, SIR: men, 1.54 95% CI: 1.33–1.78, women, 1.62 95% CI: 1.25–2.11). The accommodation and food service (men, 2.56 95% CI: 1.28–4.58, women 1.35, 95% CI: 0.65–2.48) and real estate (men 1.34, 95% CI: 0.98–1.83, women 1.95, 95% CI: 0.78–4.02) also showed a high SIR, indicating the risk of asbestos-containing materials in old buildings. The incidence of malignant mesothelioma is likely to increase in the future, given the long latency of this disease. Moreover, long-term follow-up studies will be needed.

scholarly journals Hospital Standardized Mortality Ratio: Consequences of Adjusting Hospital Mortality with Indirect Standardization

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e59160 ◽  
Author(s):  
Maurice E. Pouw ◽  
Linda M. Peelen ◽  
Hester F. Lingsma ◽  
Daniel Pieter ◽  
Ewout Steyerberg ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Standardized Mortality Ratio ◽  
Mortality Ratio ◽  
Indirect Standardization

scholarly journals Application of Standardized Proportional Mortality Ratio to the Assessment of Health Risk in Relatively Healthy Populations: Using a Study of Cancer Risk in Telecommunication Workers with Excess Exposure to Acid Mists as an Example

2021 ◽  
Vol 18 (18) ◽  
pp. 9870
Author(s):  
Ying-Fong Ker ◽  
Perng-Jy Tsai ◽  
How-Ran Guo
Keyword(s):  
Cancer Risk ◽  
Geometric Mean ◽  
Epidemiological Studies ◽  
Standardized Mortality Ratio ◽  
Acid Mist ◽  
Proportional Mortality ◽  
Mortality Ratio ◽  
Carcinogenic Effects ◽  
Study Population

When a study population is relatively healthy, such as an occupational population, epidemiological studies are likely to underestimate risk. We used a case study on the cancer risk of workers with exposure to acid mists, a well-documented carcinogen, to demonstrate that using proportional mortality ratios (PMRs) is more appropriate than mortality ratios in assessing risk in terms of mortality. The study included 10,229 employees of a telecommunication company who worked in buildings with battery rooms. In these buildings, the battery rooms had the highest levels of sulfuric acid in the air (geometric mean = 10.7 μg/m3). With the general population in Taiwan as a reference, a decreased standardized mortality ratio (0.42, p < 0.01) from all causes combined, between 1 January 1985 and 31 December 1996, was observed, indicating a healthy worker effect. When we reanalyzed the data using standardized PMR, elevated risks were observed for all cancers combined (1.46, p = 0.01) and cancers of the digestive organs and peritoneum (1.61, p = 0.02), especially stomach cancer (2.94, p = 0.01). The results showed that PMR can detect increases in mortality when a study population is generally healthier than the comparison population and call for further studies on the possible carcinogenic effects of low-level acid mist exposures on the stomach.

scholarly journals Sine scleroderma, limited cutaneous, and diffused cutaneous systemic sclerosis survival and predictors of mortality

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Sébastien De Almeida Chaves ◽  
Tiphaine Porel ◽  
Mickael Mounié ◽  
Laurent Alric ◽  
Léonardo Astudillo ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cardiac Involvement ◽  
Cox Regression ◽  
Survival Rates ◽  
University Hospital ◽  
Standardized Mortality Ratio ◽  
Predictors Of Mortality ◽  
Long Term Follow Up ◽  
Mortality Ratio

Abstract Background Systemic sclerosis (SSc) is associated with a variability of mortality rates in the literature. Objective To determine the mortality and its predictors in a long-term follow-up of a bi-centric cohort of SSc patients. Methods A retrospective observational study by systematically analyzing the medical records of patients diagnosed with SSc in Toulouse University Hospital and Ducuing Hospital. Standardized Mortality Ratio (SMR), mortality at 1, 3, 5, 10, and 15 years of disease and causes of death were described. Predictors of mortality using Cox regression were assessed. Results Three hundred seventy-five patients were included: 63 with diffuse cutaneous SSc, 279 with limited cutaneous SSc, and 33 with sine scleroderma. The SMR ratio was 1.88 (95% CI 1.46–1.97). The overall survival rates were 97.6% at 1 year, 93.4% at 3 years, 87.1% at 5 years, 77.9% at 10 years, and 61.3% at 15 years. Sixty-nine deaths were recorded. 46.4% were SSc related deaths secondary to interstitial lung disease (ILD) (34.4%), pulmonary hypertension (31.2%), and digestive tract involvement (18.8%). 53.6% were non-related to SSc: cardiovascular disorders (37.8%) and various infections (35.1%) largely distanced those from cancer (13.5%). Four significant independent predictive factors were identified: carbon monoxide diffusing capacity (DLCO) < 70% (HR=3.01; p=0.0053), C-reactive protein (CRP) >5 mg/l (HR=2.13; p=0.0174), cardiac involvement (HR=2.86; p=0.0012), and the fact of being male (HR=3.25; p=0.0004). Conclusion Long-term data confirmed high mortality of SSc. Male sex, DLCO <70%, cardiac involvement, and CRP> 5mg/l were identified as independent predictors of mortality.

scholarly journals Sine Scleroderma, Limited Cutaneous and Diffused Cutaneous Systemic Sclerosis Survival and Predictors of Mortality

2021 ◽  
Author(s):  
Sebastien De Almeida Chaves ◽  
Tiphaine Porel ◽  
Mickael Mounié ◽  
Laurent Alric ◽  
Léonardo Astudillo ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cardiac Involvement ◽  
Cox Regression ◽  
Survival Rates ◽  
University Hospital ◽  
Standardized Mortality Ratio ◽  
Predictors Of Mortality ◽  
Long Term Follow Up ◽  
Mortality Ratio

Abstract Background: Systemic sclerosis (SSc) is associated with a variability of mortality rate in the literature.Objective: To determine the mortality and its predictors in a long-term follow- up of a bi-centric cohort of SSc patients.Methods: A retrospective observational study by systematically analyzing the medical records of patients diagnosed with SSc in Toulouse University Hospital and Ducuing Hospital. Standardized Mortality Ratio (SMR), mortality at 1, 3, 5, 10 and 15 years of disease and causes of death were described. Predictors of mortality using Cox regression were assessed.Results: 375 patients were included: 63 with diffuse cutaneous SSc, 279 with limited cutaneous SSc and 33 with sine scleroderma. The SMR ratio was 1.88 (95% CI 1.46-1.97). The overall survival rates were 97.6% at 1 year, 93.4% at 3 years, 87.1% at 5 years, 77.9% at 10 years and 61.3% at 15 years. 69 deaths were recorded. 46.4% were SSc related deaths secondary to interstitial lung disease (ILD) (34.4%), pulmonary hypertension (31.2%) and digestive tract involvement (18.8%). 53.6% were non-related to SSc: cardiovascular disorders (37.8%) and various infections (35.1%) largely distanced those from cancer (13.5%). Four significant independent predictive factors were identified: carbon monoxide diffusing capacity (DLCO) < 70% (HR=3.01; p=0.0053), C-reactive protein (CRP) >5 mg/l (HR=2.13; p=0.0174), cardiac involvement (HR=2.86; p=0.0012) and the fact of being male (HR=3.25; p=0.0004).Conclusion: Long term data confirmed high mortality of SSc. Male sex, DLCO <70%, cardiac involvement and CRP> 5mg/l were identified as independent predictors of mortality.

scholarly journals Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry

2017 ◽  
Vol 176 (5) ◽  
pp. 645-655 ◽  
Author(s):  
Luigi Maione ◽  
Thierry Brue ◽  
Albert Beckers ◽  
Brigitte Delemer ◽  
Patrick Petrossians ◽  
...  
Keyword(s):  
Disease Control ◽  
Standardized Mortality Ratio ◽  
Standardized Incidence Ratio ◽  
Upper Limit ◽  
Igf I ◽  
Mortality Ratio ◽  
French Registry ◽  
Over Time ◽  
Age And Sex

Context Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. Design The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and prospectively from 1999 to 2012. Results Data could be analyzed for 999 of the 1034 patients included in the registry (46% males). Disease control, defined as IGF-I normalization (adjusted for age and sex), was achieved in 75% of patients at the last follow-up visit. Half the patients with uncontrolled disease had IGF-I levels below 1.5 times the upper limit of normal (ULN). The proportion of patients with surgically cured disease did not change markedly over time, whereas the proportion of patients with uncontrolled disease fell and the proportion of patients with medically controlled disease rose. Cardiovascular, metabolic, respiratory and rheumatologic comorbidities and their outcomes were recorded for most patients, and no noteworthy overall deterioration was noted over time. Cancer occurred in 10% of patients, for a standardized incidence ratio of 1.34 (95% CI: 0.94–1.87) in men and 1.24 (0.77–1.73) in women. Forty-one patients died during follow-up, for a standardized mortality ratio of 1.05 (0.70–1.42). Most deaths were due to cancer. Conclusions The majority of patients with acromegaly now have successful disease control thanks to the multistep management. The incidence of comorbidities following diagnosis of acromegaly is very low. Life expectancy is now close to that of the general population, probably owing to better management of the GH/IGF-I excess and comorbidities.

Cancer mortality in workers exposed to dieldrin and aldrin: an update

2002 ◽  
Vol 18 (2) ◽  
pp. 63-70 ◽  
Author(s):  
Gerard MH Swaen ◽  
Geert de Jong ◽  
Jos JM Slangen ◽  
Ludovic GPM van Amelsvoort
Keyword(s):  
Occupational Exposure ◽  
Cancer Mortality ◽  
Total Mortality ◽  
Exposure Period ◽  
Standardized Mortality Ratio ◽  
Total Intake ◽  
Disease Mortality ◽  
Cohort Mortality Study ◽  
Mortality Ratio ◽  
Carcinogenic Effects

This study was conducted to investigate the possible long-term health effects, in particular carcinogenic effects, of occupational exposure to the organochlorine insecticides dieldrin and aldrin. We updated an earlier cohort mortality study of 570 employees involved in the production of these insecticides. All of the employees had worked in the production plants between 1 January 1954 and 1 January 1970 and were followed for cause-specific mortality until 1 January 2001. Based on dieldrin levels in blood samples taken during the exposure period, available for 343 workers, individual estimates of the total intake of dieldrin were estimated for all individual subjects in the cohort. The estimated total intake ranged from 11 to 7755 mg of dieldrin, with an average of 737 mg. One hundred and seventy-one workers had died before 1 January 2001, compared with an expected number of 226.6, giving a standardized mortality ratio (SM R) of 75.6 [95% confidence interval (CI): 64.6-87.7]. This deficit in total mortality was mainly attributable to a deficit in cardiovascular disease mortality, but cancer mortality was also lower than expected. The observed number of deaths from rectal cancer was significantly higher than expected (SM R 3/4-300.0; 95% CI: 109.5-649.3), but was most pronounced in the low-intake subgroup and appears to be unrelated to exposure to dieldrin and aldrin. This study reinforces the earlier findings that occupational exposure of workers to significant amounts of dieldrin and aldrin has not led to a higher cancer mortality than would be found in an unexposed population.

The Standardized Mortality Ratio and Life Expectancy

1992 ◽  
Vol 135 (7) ◽  
pp. 824-831 ◽  
Author(s):  
Shan P. Tsai ◽  
Robert J. Hardy ◽  
C. P. Wen
Keyword(s):  
Life Expectancy ◽  
Standardized Mortality Ratio ◽  
Mortality Ratio

Identifying Emergency-Sensitive Conditions for the Calculation of an Emergency Care Inhospital Standardized Mortality Ratio

2014 ◽  
Vol 63 (4) ◽  
pp. 418-424.e2 ◽  
Author(s):  
Simon Berthelot ◽  
Eddy S. Lang ◽  
Hude Quan ◽  
Henry T. Stelfox ◽  
Patrick Archambault ◽  
...  
Keyword(s):  
Emergency Care ◽  
Standardized Mortality Ratio ◽  
Mortality Ratio ◽  
Sensitive Conditions
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