scholarly journals Evaluation of the Anti-Inflammatory Activity of Raisins (Vitis vinifera L.) in Human Gastric Epithelial Cells: A Comparative Study

2016 ◽  
Vol 17 (7) ◽  
pp. 1156 ◽  
Author(s):  
Chiara Di Lorenzo ◽  
Enrico Sangiovanni ◽  
Marco Fumagalli ◽  
Elisa Colombo ◽  
Gianfranco Frigerio ◽  
...  
2019 ◽  
Vol 57 ◽  
pp. 95-102 ◽  
Author(s):  
Enrico Sangiovanni ◽  
Marco Fumagalli ◽  
Laura Santagostini ◽  
Martino Forino ◽  
Stefano Piazza ◽  
...  

2016 ◽  
Vol 20 ◽  
pp. 291-302 ◽  
Author(s):  
Daniele Fraternale ◽  
Alexander Rudov ◽  
Francesco Prattichizzo ◽  
Fabiola Olivieri ◽  
Donata Ricci ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3787
Author(s):  
Achille Parfait Atchan Nwakiban ◽  
Marco Fumagalli ◽  
Stefano Piazza ◽  
Andrea Magnavacca ◽  
Giulia Martinelli ◽  
...  

In Cameroon, local plants are traditionally used as remedies for a variety of ailments. In this regard, several papers report health benefits of Cameroonian spices, which include antioxidant and anti-microbial properties, whereas gastric anti-inflammatory activities have never been previously considered. The present study investigates the antioxidant and anti-inflammatory activities of hydro-alcoholic extracts of eleven Cameroonian spices in gastric epithelial cells (AGS and GES-1 cells). The extracts showed antioxidant properties in a cell-free system and reduced H2O2-induced ROS generation in gastric epithelial cells. After preliminary screening on TNFα-induced NF-κB driven transcription, six extracts from Xylopia parviflora, Xylopia aethiopica, Tetrapleura tetraptera, Dichrostachys glomerata, Aframomum melegueta, and Aframomum citratum were selected for further studies focusing on the anti-inflammatory activity. The extracts reduced the expression of some NF-κB-dependent pro-inflammatory mediators strictly involved in the gastric inflammatory process, such as IL-8, IL-6, and enzymes such as PTGS2 (COX-2), without affecting PTGS1 (COX-1). In conclusion, the selected extracts decreased pro-inflammatory markers by inhibiting the NF-κB signaling in gastric cells, justifying, in part, the traditional use of these spices. Other molecular mechanisms cannot be excluded, and further studies are needed to better clarify their biological activities at the gastric level.


2015 ◽  
Vol 6 (8) ◽  
pp. 2453-2463 ◽  
Author(s):  
E. Sangiovanni ◽  
C. Di Lorenzo ◽  
E. Colombo ◽  
F. Colombo ◽  
M. Fumagalli ◽  
...  

Vitis viniferaL. water extract from dried leaves maintains its anti-inflammatory activity afterin vitrogastric digestion.


2019 ◽  
Author(s):  
APA Nwakiban ◽  
E Sangiovanni ◽  
S Piazza ◽  
M Fumagalli ◽  
S Khalilpour ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Ştefania Silvia Balea ◽  
Alina Elena Pârvu ◽  
Marcel Pârvu ◽  
Laurian Vlase ◽  
Cristina Adriana Dehelean ◽  
...  

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