scholarly journals Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice

2016 ◽  
Vol 17 (12) ◽  
pp. 2056 ◽  
Author(s):  
Wen-Huang Peng ◽  
Yi-Wen Chen ◽  
Meng-Shiou Lee ◽  
Wen-Te Chang ◽  
Jen-Chieh Tsai ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury ◽  
Whole Plant ◽  
Cuscuta Campestris

The Hepatoprotective Effect of Selenium-Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride-Induced Chronic Liver Injury in Rats

2018 ◽  
Vol 83 (2) ◽  
pp. 525-534 ◽  
Author(s):  
Mohammed Hamid ◽  
Yassin Abdulrahim ◽  
Dandan Liu ◽  
Gang Qian ◽  
Alamzeb Khan ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Gum Arabic ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury

scholarly journals Scutellarin Ameliorated Carbon Tetrachloride-Induced Chronic Liver Injury in Mice

2020 ◽  
Author(s):  
Zhimin Miao ◽  
Yingying Zhao ◽  
Chunyan Li ◽  
Lingmin Chen ◽  
Jianeng Zhou ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Function Analysis ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Mrna Levels ◽  
Chronic Liver Injury ◽  
Tnf Α ◽  
Anti Oxidant ◽  
Underlying Mechanisms

Abstract Background: Erigeron breviscapus (Vant.) Hand. -Mazz. is an edible and traditional medical herb and its extract scutellarin (SCU) is a widely used flavonoid showing anti-oxidant and anti-inflammatory activities. The purpose of this study was to evaluate the hepatoprotective effect of SCU on carbon tetrachloride (CCl4)-induced chronic liver injury in mice and reveal the underlying mechanisms. Methods: Chronic liver injury in mice was induced by intraperitoneal injection of 1 ml/kg CCl4 every three days. SCU (15 mg/kg, 30 mg/kg and 60 mg/kg) was administered through gavage every day. Bifendate (120 mg/kg) serves as a positive drug to validate the effectiveness of SCU.Results: The hepatoprotective effect of SCU was confirmed by liver function analysis, histological analysis and TUNEL assay. Administration of SCU recovered the activities of superoxide dismutase (SOD) and reduced the production of malondialdehyde (MDA). Additionally, treatment with SCU significantly decreased the mRNA levels of pro-inflammatory cytokines including IL-6, IL-1β and TNF-α. Moreover, SCU treatment suppressed the activation of NF-κB by decreasing the degradation of IκBα and inhibited the expression of CYP2E1. The 16S rRNA sequencing demonstrated that intake of SCU significantly remodeled gut microbiota, especially enriching the following: Lactobacillus, Coprobacillus, Akkermansia, Bifidobacterium, Parabacteroides. Conclusion: Our findings showed that SCU effectively ameliorated CCl4-induced chronic liver injury. This hepatoprotective effects might be attributed to inhibition of CCl4-induced NF-κB and CYP2E1 activation and enrichment of beneficial microbial community.

scholarly journals Effect of SA3443, a novel cyclic disulfide compound, on chronic liver injury induced by carbon tetrachloride in rats

1990 ◽  
Vol 52 ◽  
pp. 239
Author(s):  
Naruhiro Ishida ◽  
Mihoko Tanaka ◽  
Katsuhiko Nakata ◽  
Kenji Takase ◽  
Shiro Mita
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Chronic Liver ◽  
Chronic Liver Injury

scholarly journals Hepatoprotective effect ofAmomum xanthoidesagainst dimethylnitrosamine-induced sub-chronic liver injury in a rat model

2013 ◽  
Vol 51 (7) ◽  
pp. 930-935 ◽  
Author(s):  
Jing-Hua Wang ◽  
Jian Wang ◽  
Min-Kyung Choi ◽  
Fang Gao ◽  
Dong-Soo Lee ◽  
...  
Keyword(s):  
Liver Injury ◽  
Rat Model ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury

scholarly journals Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury

2008 ◽  
Vol 88 (10) ◽  
pp. 1090-1100 ◽  
Author(s):  
Erawan Borkham-Kamphorst ◽  
Evgenia Kovalenko ◽  
Claudia R C van Roeyen ◽  
Nikolaus Gassler ◽  
Michael Bomble ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Growth Factor ◽  
Liver Injury ◽  
Chronic Liver ◽  
Platelet Derived Growth Factor ◽  
Chronic Liver Injury ◽  
Isoform Expression

CXC Chemokine Receptor 1 Mediates Fibrosis in Carbon Tetrachloride Model of Chronic Liver Injury

2014 ◽  
Vol 219 (3) ◽  
pp. S24
Author(s):  
Christopher M. Freeman ◽  
Gregory C. Wilson ◽  
Rebecca M. Schuster ◽  
Hiroyuki Nojima ◽  
Alex B. Lentsch
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Chemokine Receptor ◽  
Chronic Liver ◽  
Chronic Liver Injury ◽  
Cxc Chemokine ◽  
Chemokine Receptor 1
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