scholarly journals Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis

2018 ◽  
Vol 19 (8) ◽  
pp. 2281 ◽  
Author(s):  
Leonardo Sandrini ◽  
Alessandro Di Minno ◽  
Patrizia Amadio ◽  
Alessandro Ieraci ◽  
Elena Tremoli ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Obese Patients ◽  
Review Of Literature ◽  
Bdnf Expression ◽  
Subject Recruitment ◽  
And Storage ◽  
The Brain ◽  
Circulating Levels

Reduction in brain-derived neurotrophic factor (BDNF) expression in the brain as well as mutations in BDNF gene and/or of its receptor are associated to obesity in both human and animal models. However, the association between circulating levels of BDNF and obesity is still not defined. To answer this question, we performed a meta-analysis carrying out a systematic search in electronic databases. Ten studies (307 obese patients and 236 controls) were included in the analysis. Our data show that obese patients have levels of BDNF similar to those of controls (SMD: 0.01, 95% CI: −0.28, 0.30, p = 0.94). The lack of difference was further confirmed both in studies in which BDNF levels were assessed in serum (MD: −0.93 ng/mL, 95% CI: −3.34, 1.48, p = 0.45) and in plasma (MD: 0.15 ng/mL, 95% CI: −0.09, 0.39, p = 0.23). Data evaluation has shown that some bias might affect BDNF measurements (e.g., subject recruitment, procedures of sampling, handling, and storage), leading to a difficult interpretation of the results. Standardization of the procedures is still needed to reach strong, affordable, and reliable conclusions.

Is the Val66Met polymorphism of the brain-derived neurotrophic factor gene associated with panic disorder? A meta-analysis

2015 ◽  
Vol 9 (2) ◽  
pp. e12228 ◽  
Author(s):  
Kaiyuan Chen ◽  
Na Wang ◽  
Jie Zhang ◽  
Xiaohong Hong ◽  
Haiyun Xu ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Factor Gene ◽  
The Brain

The brain-derived neurotrophic factor (BDNF) system as a therapeutical target for development of drugs restoring innervation

2017 ◽  
pp. 142-152
Author(s):  
Д.В. Стамбольский ◽  
О.С. Плеханова ◽  
И.Ю. Юдина ◽  
Н.И. Калинина ◽  
М.Н. Карагяур ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Current Data ◽  
Bdnf Expression ◽  
Promising Therapeutic Target ◽  
Nervous System Function ◽  
The Brain ◽  
Stimulation Of

Мозговой нейротрофический фактор (BDNF) является одним из основных нейротрофических факторов, участвующих в поддержании функционирования и регенерации нервной системы. В последние годы BDNF рассматривают как многообещающую терапевтическую мишень, на основании полученных данных о том, что BDNF улучшает регенерацию нейронов. Цель обзора - суммировать данные об экспрессии BDNF, его сигнализации, эффектах и механизмах стимуляции реиннервации. Анализ исследований последних десятилетий позволяет сделать заключение о целесообразности и перспективности разработок, направленных на создание лекарственных препаратов на основе BDNF для регенерации компонентов нервной системы. Brain-derived neurotrophic factor (BDNF) is a major neurotrophic factor maintaining the nervous system function and regeneration. Based on reports indicating that BDNF enhances neuronal regeneration, in recent years, BDNF has been considered a promising therapeutic target. The aim of this review was to summarize current data on BDNF expression, signaling, and mechanisms for stimulation of reinnervation. Conclusion. Recent studies of the role of BDNF showed that continuation of research and development of BDNF-based drugs stimulating regeneration of nervous system components is advisable and promising.

BDNF 196 G/A and COMT Val158Met Polymorphisms and Susceptibility to ADHD: A Meta-Analysis

2015 ◽  
Vol 22 (9) ◽  
pp. 872-877 ◽  
Author(s):  
Young Ho Lee ◽  
Gwan Gyu Song
Keyword(s):  
Confidence Interval ◽  
Neurotrophic Factor ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Brain Derived Neurotrophic Factor ◽  
Comt Val158met ◽  
Study Participants ◽  
The Brain

Objective: The aim of this study was to determine whether the brain-derived neurotrophic factor ( BDNF) 196 G/A or catechol- O-methyltransferase ( COMT) Val158Met polymorphisms is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of the associations between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD. Results: Sixteen studies consisting of 3,594 patients with ADHD and 4,040 controls were included in this meta-analysis. Our results showed no association between ADHD and the BDNF 196A allele in all participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 1.146], p = .638), European or Asian population. Meta-analysis indicated no association between ADHD and the COMT G allele in all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p = .196), European or Asian population. Conclusion: This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.

scholarly journals The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis

2011 ◽  
Vol 15 (08) ◽  
pp. 1037-1042 ◽  
Author(s):  
Clement C. Zai ◽  
Mirko Manchia ◽  
Vincenzo De Luca ◽  
Arun K. Tiwari ◽  
Nabilah I. Chowdhury ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Suicidal Behaviour ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene ◽  
The Brain

scholarly journals Environmental Enrichment Effects on the Brain-Derived Neurotrophic Factor Expression in Healthy Condition, Alzheimer’s Disease, and Other Neurodegenerative Disorders

2021 ◽  
pp. 1-18
Author(s):  
Debora Cutuli ◽  
Eugenia Landolfo ◽  
Laura Petrosini ◽  
Francesca Gelfo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurotrophic Factor ◽  
Environmental Enrichment ◽  
Brain Plasticity ◽  
Regulation Of Gene Expression ◽  
Experimental Studies ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Expression ◽  
The Brain

Brain-derived neurotrophic factor (BDNF), a protein belonging to the neurotrophin family, is known to be heavily involved in synaptic plasticity processes that support brain development, post-lesion regeneration, and cognitive performances, such as learning and memory. Evidence indicates that BDNF expression can be epigenetically regulated by environmental stimuli and thus can mediate the experience-dependent brain plasticity. Environmental enrichment (EE), an experimental paradigm based on the exposure to complex stimulations, constitutes an efficient means to investigate the effects of high-level experience on behavior, cognitive processes, and neurobiological correlates, as the BDNF expression. In fact, BDNF exerts a key role in mediating and promoting EE-induced plastic changes and functional improvements in healthy and pathological conditions. This review is specifically aimed at providing an updated framework of the available evidence on the EE effects on brain and serum BDNF levels, by taking into account both changes in protein expression and regulation of gene expression. A further purpose of the present review is analyzing the potential of BDNF regulation in coping with neurodegenerative processes characterizing Alzheimer’s disease (AD), given BDNF expression alterations are described in AD patients. Moreover, attention is also paid to EE effects on BDNF expression in other neurodegenerative disease. To investigate such a topic, evidence provided by experimental studies is considered. A deeper understanding of environmental ability in modulating BDNF expression in the brain may be fundamental in designing more tuned and effective applications of complex environmental stimulations as managing approaches to AD.

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