scholarly journals Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders

2020 ◽  
Vol 21 (18) ◽  
pp. 6525
Author(s):  
Matas Vitkauskas ◽  
Ajay S. Mathuru
Keyword(s):  
Brain Disorders ◽  
Future Directions ◽  
Lateral Habenula ◽  
New Approach ◽  
Early Results ◽  
New Directions ◽  
The Common ◽  
Induced Changes ◽  
Deep Brain

Depression impacts the lives and daily activities of millions globally. Research into the neurobiology of lateral habenula circuitry and the use of psychedelics for treating depressive states has emerged in the last decade as new directions to devise interventional strategies and therapies. Several clinical trials using deep brain stimulation of the habenula, or using ketamine, and psychedelics that target the serotonergic system such as psilocybin are also underway. The promising early results in these fields require cautious optimism as further evidence from experiments conducted in animal systems in ecologically relevant settings, and a larger number of human studies with improved spatiotemporal neuroimaging, accumulates. Designing optimal methods of intervention will also be aided by an improvement in our understanding of the common genetic and molecular factors underlying disorders comorbid with depression, as well as the characterization of psychedelic-induced changes at a molecular level. Advances in the use of cerebral organoids offers a new approach for rapid progress towards these goals. Here, we review developments in these fast-moving areas of research and discuss potential future directions.

The research on school marketing

2004 ◽  
Vol 42 (3) ◽  
pp. 375-400 ◽  
Author(s):  
Izhar Oplatka ◽  
Jane Hemsley‐Brown
Keyword(s):  
Marketing Strategies ◽  
Future Research ◽  
Educational Marketing ◽  
Marketing Practice ◽  
Future Directions ◽  
Marketing Planning ◽  
School Marketing ◽  
The Common ◽  
Research Questions

This review provides a synthesis of the scholarship that has sought to expand the understanding of educational marketing practice in schools. The following research questions guided this review. What are the common themes and characteristics that emerge from research about marketing in schools? What remains underdeveloped in the characterization of the school marketing and what are the topics for future research? Based on 25 studies identified as pertinent to the current review the topics of: marketing perceptions, marketing planning, marketing strategies and promotion are discussed. The paper concludes by providing an analysis of the limitations of the current research and discussing future directions for research on school marketing.

A Complete Geometric Singular Characterization of the 6/6 Stewart Platform

2018 ◽  
Vol 10 (4) ◽  
Author(s):  
Michael Slavutin ◽  
Avshalom Sheffer ◽  
Offer Shai ◽  
Yoram Reich
Keyword(s):  
Three Dimensional ◽  
Parallel Line ◽  
Stewart Platform ◽  
New Approach ◽  
Singular Configurations ◽  
Geometric Relation ◽  
The Common ◽  
Singular Configuration ◽  
Special Case

This paper introduces the three-dimensional (3D) dual Kennedy theorem in statics, and demonstrates its application to characterize the singular configuration of the 6/6 Stewart Platform (6/6 SP). The proposed characterization is articulated as a simple geometric relation that is easy to apply and check. We find two lines that cross four of the six legs of the platform. Each one of these two lines has a parallel line that crosses the remaining two legs. Each pair of parallel lines defines a plane. The 6/6 SP is in a singular position if the intersection of these two planes is perpendicular to the common normal of the remaining two legs. The method developed for the singular characterization is also used for the analysis of the mobility and forces of the SP. Finally, the proposed method is compared to some known singular configurations, such as Hunt's and Fichter's singular configurations and the 3/6 Stewart Platform (3/6 SP) singularity. The relation between the reported characterizations of the 6/6 SP and other reported works is highlighted. Moreover, it is shown that the known 3/6 SP characterization is a special case of the results reported in the paper. Finally, a characterization of a platform that does not appear in the literature, 5/6 SP, is developed based on the new approach to demonstrate its utility.

Digital x-ray mapping of nanometer-size supported bimetallic catalysts

1988 ◽  
Vol 46 ◽  
pp. 530-531
Author(s):  
L. T. Germinario
Keyword(s):  
Background Radiation ◽  
Metal Cluster ◽  
Single Element ◽  
Beam Diameter ◽  
X Rays ◽  
X Ray ◽  
Major Interest ◽  
Induced Changes

Understanding the role of metal cluster composition in determining catalytic selectivity and activity is of major interest in heterogeneous catalysis. The electron microscope is well established as a powerful tool for ultrastructural and compositional characterization of support and catalyst. Because the spatial resolution of x-ray microanalysis is defined by the smallest beam diameter into which the required number of electrons can be focused, the dedicated STEM with FEG is the instrument of choice. The main sources of errors in energy dispersive x-ray analysis (EDS) are: (1) beam-induced changes in specimen composition, (2) specimen drift, (3) instrumental factors which produce background radiation, and (4) basic statistical limitations which result in the detection of a finite number of x-ray photons. Digital beam techniques have been described for supported single-element metal clusters with spatial resolutions of about 10 nm. However, the detection of spurious characteristic x-rays away from catalyst particles produced images requiring several image processing steps.

Isolation and characterization of oleochemical compounds from watermelon seed

2020 ◽  
Vol 10 (4) ◽  
pp. 79-82
Author(s):  
Madhubhushan M ◽  
Seshaiah S ◽  
Chandrudu J ◽  
Sagar R ◽  
Akila CR
Keyword(s):  
Cutting Tool ◽  
Citrullus Lanatus ◽  
Fatty Esters ◽  
Mineral Oils ◽  
Light Yellow ◽  
Isolation And Characterization ◽  
The Common ◽  
Set Up ◽  
Natural Gradation

The common watermelon item (Citrullus lanatus) seeds were gained from castoffs verdant nourishments for use by decorating, sun ventilation and pulverizing. Light yellow-toned oil was gotten by dissolvable withdrawal using oil atmosphere and the going with traits were gotten using oil ether: pH, refractive rundown, thickness, dissolvable miscibility, coagulating temperature, fire nature, express gravity, streak point and warmth of consuming. With a shallow level of unsaturation, stepped level of smoothness, and proximity of raised degree of the sensible proportion of free unsaturated fats. The low assessment of the solidifying temperature of the oil offered a hint that the oil can be managed in various areas paying little heed to the qualification in temperature. The following level of linoleic destructive of the oil offers a hint of natural gradation of solidarity. Fatty esters are increasing expanding significance as a biodegradable swap for mineral oils. In some request regions, for example, cutting tool oil, gearbox, pressure-driven oils, and greases for raw petroleum creation, the oleochemical items are set up. Nonetheless, certain particular wellsprings of fatty esters are hitherto to be abused for this comparative reason. This exploration subsequently tests into one of the less used wellsprings of fatty esters in watermelon. The oil from the kernels demonstrations a top-notch yield presents significant utilitarian gatherings for change and thus was utilized to set up an assortment of oleochemicals which demonstrated excellence materials in contrast with the routinely utilized oils feed frameworks for oleochemicals after portrayal. The photopolymers acquired indicated piercing vinyl protons for consistent polymerize.

Reason as an Idea

2017 ◽  
Author(s):  
Michael LeBuffe
Keyword(s):  
The Common ◽  
Rational Knowledge ◽  
Human Kind

Spinoza’s characterization of ideas of reason in Ethics 2 makes reason distinctive both psychologically and epistemologically. Psychologically, ideas of reason are frequently present to mind and, as a result, powerful influences on human belief and action; a notable class of ideas of reason, the common notions, are always present to mind. Within such ideas we always regard certain properties to be present in the objects of our experience. Epistemologically, ideas of reason are a distinctively human kind of knowledge, where we cannot immediately know the essences of singular things, as on many views gods or angels might. Instead, in the first instance, rational knowledge is knowledge of properties of things in experience. From such knowledge, Spinoza argues, we can also come to further knowledge by means of processes, and it is these processes that closely resemble what many readers today will recognize as reasoning.

scholarly journals Sustainability Investigation of Vehicles’ CO2 Emission in Hungary

2021 ◽  
Vol 13 (15) ◽  
pp. 8237
Author(s):  
István Árpád ◽  
Judit T. Kiss ◽  
Gábor Bellér ◽  
Dénes Kocsis
Keyword(s):  
Energy Efficiency ◽  
Co2 Emissions ◽  
Energy Supply ◽  
Internal Combustion Engines ◽  
Combustion Engines ◽  
The European Union ◽  
New Approach ◽  
Technology System ◽  
Low Co2

The regulation of vehicular CO2 emissions determines the permissible emissions of vehicles in units of g CO2/km. However, these values only partially provide adequate information because they characterize only the vehicle but not the emission of the associated energy supply technology system. The energy needed for the motion of vehicles is generated in several ways by the energy industry, depending on how the vehicles are driven. These methods of energy generation consist of different series of energy source conversions, where the last technological step is the vehicle itself, and the result is the motion. In addition, sustainability characterization of vehicles cannot be determined by the vehicle’s CO2 emissions alone because it is a more complex notion. The new approach investigates the entire energy technology system associated with the generation of motion, which of course includes the vehicle. The total CO2 emissions and the resulting energy efficiency have been determined. For this, it was necessary to systematize (collect) the energy supply technology lines of the vehicles. The emission results are not given in g CO2/km but in g CO2/J, which is defined in the paper. This new method is complementary to the European Union regulative one, but it allows more complex evaluations of sustainability. The calculations were performed based on Hungarian data. Finally, using the resulting energy efficiency values, the emission results were evaluated by constructing a sustainability matrix similar to the risk matrix. If only the vehicle is investigated, low CO2 emissions can be achieved with vehicles using internal combustion engines. However, taking into consideration present technologies, in terms of sustainability, the spread of electric-only vehicles using renewable energies can result in improvement in the future. This proposal was supported by the combined analysis of the energy-specific CO2 emissions and the energy efficiency of vehicles with different power-driven systems.

scholarly journals An Intrinsic Characterization of Five Points in a CAT(0) Space

2020 ◽  
Vol 8 (1) ◽  
pp. 114-165
Author(s):  
Tetsu Toyoda
Keyword(s):  
Metric Space ◽  
Isometric Embedding ◽  
Metric Spaces ◽  
Necessary Conditions ◽  
New Approach ◽  
Intrinsic Characterization ◽  
New Family

AbstractGromov (2001) and Sturm (2003) proved that any four points in a CAT(0) space satisfy a certain family of inequalities. We call those inequalities the ⊠-inequalities, following the notation used by Gromov. In this paper, we prove that a metric space X containing at most five points admits an isometric embedding into a CAT(0) space if and only if any four points in X satisfy the ⊠-inequalities. To prove this, we introduce a new family of necessary conditions for a metric space to admit an isometric embedding into a CAT(0) space by modifying and generalizing Gromov’s cycle conditions. Furthermore, we prove that if a metric space satisfies all those necessary conditions, then it admits an isometric embedding into a CAT(0) space. This work presents a new approach to characterizing those metric spaces that admit an isometric embedding into a CAT(0) space.

scholarly journals Subtype Characterization and Zoonotic Potential of Cryptosporidium felis in Cats in Guangdong and Shanghai, China

Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 89
Author(s):  
Jiayu Li ◽  
Fuxian Yang ◽  
Ruobing Liang ◽  
Sheng Guo ◽  
Yaqiong Guo ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Phylogenetic Analysis ◽  
Genetic Characterization ◽  
Zoonotic Potential ◽  
Common Occurrence ◽  
High Genetic Diversity ◽  
Gp60 Gene ◽  
The Common ◽  
Subtyping Tool

Cryptosporidiumfelis is an important cause of feline and human cryptosporidiosis. However, the transmission of this pathogen between humans and cats remains controversial, partially due to a lack of genetic characterization of isolates from cats. The present study was conducted to examine the genetic diversity of C. felis in cats in China and to assess their potential zoonotic transmission. A newly developed subtyping tool based on a sequence analysis of the 60-kDa glycoprotein (gp60) gene was employed to identify the subtypes of 30 cat-derived C. felis isolates from Guangdong and Shanghai. Altogether, 20 C. felis isolates were successfully subtyped. The results of the sequence alignment showed a high genetic diversity, with 13 novel subtypes and 2 known subtypes of the XIXa subtype family being identified. The known subtypes were previously detected in humans, while some of the subtypes formed well-supported subclusters with human-derived subtypes from other countries in a phylogenetic analysis of the gp60 sequences. The results of this study confirmed the high genetic diversity of the XIXa subtype family of C. felis. The common occurrence of this subtype family in both humans and cats suggests that there could be cross-species transmission of C. felis.

scholarly journals Genetic characterization at the species and symbiovar level of indigenous rhizobial isolates nodulating Phaseolus vulgaris in Greece

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Evdoxia Efstathiadou ◽  
Georgia Ntatsi ◽  
Dimitrios Savvas ◽  
Anastasia P. Tampakaki
Keyword(s):  
Phaseolus Vulgaris ◽  
Common Bean ◽  
Phylogenetic Affiliation ◽  
Rhizobial Inoculation ◽  
Rhizobial Species ◽  
The Common ◽  
First Time ◽  
Of Greece ◽  
Rhizobial Isolates

AbstractPhaseolus vulgaris (L.), commonly known as bean or common bean, is considered a promiscuous legume host since it forms nodules with diverse rhizobial species and symbiovars. Most of the common bean nodulating rhizobia are mainly affiliated to the genus Rhizobium, though strains belonging to Ensifer, Pararhizobium, Mesorhizobium, Bradyrhizobium, and Burkholderia have also been reported. This is the first report on the characterization of bean-nodulating rhizobia at the species and symbiovar level in Greece. The goals of this research were to isolate and characterize rhizobia nodulating local common bean genotypes grown in five different edaphoclimatic regions of Greece with no rhizobial inoculation history. The genetic diversity of the rhizobial isolates was assessed by BOX-PCR and the phylogenetic affiliation was assessed by multilocus sequence analysis (MLSA) of housekeeping and symbiosis-related genes. A total of fifty fast-growing rhizobial strains were isolated and representative isolates with distinct BOX-PCR fingerpriniting patterns were subjected to phylogenetic analysis. The strains were closely related to R. anhuiense, R. azibense, R. hidalgonense, R. sophoriradicis, and to a putative new genospecies which is provisionally named as Rhizobium sp. I. Most strains belonged to symbiovar phaseoli carrying the α-, γ-a and γ-b alleles of nodC gene, while some of them belonged to symbiovar gallicum. To the best of our knowledge, it is the first time that strains assigned to R. sophoriradicis and harbored the γ-b allele were found in European soils. All strains were able to re-nodulate their original host, indicating that they are true microsymbionts of common bean.

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