scholarly journals Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder

2021 ◽  
Vol 10 (22) ◽  
pp. 5414
Author(s):  
Sooyeoun You ◽  
Kyoung-Sook Won ◽  
Keun-Tae Kim ◽  
Hyang-Woon Lee ◽  
Yong-Won Cho
Keyword(s):  
Autonomic Dysfunction ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Receiver Operating Curve ◽  
Mibg Uptake ◽  
Sleep Behavior ◽  
Cardiac Autonomic Dysfunction ◽  
Rem Sleep Without Atonia ◽  
Heart To Mediastinum Ratio

123I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to assess cardiac autonomic dysfunction and demonstrate its correlation with clinical and polysomnographic characteristics in patients with isolated rapid eye movement (REM) sleep behavior disorder. All subjects including 39 patients with isolated REM sleep behavior disorder and 17 healthy controls underwent MIBG cardiac scintigraphy for cardiac autonomic dysfunction assessment. The isolated REM sleep behavior disorder was confirmed by in-lab overnight polysomnography. A receiver operating curve was constructed to determine the cut-off value of the early and delayed heart-to-mediastinum ratio in patients with isolated REM sleep behavior disorder. Based on each cut-off value, a comparison analysis of REM sleep without atonia was performed by dividing isolated REM sleep behavior disorder patients into two groups. MIBG uptake below the cut-off value was associated with higher REM sleep without atonia. The lower heart-to-mediastinum ratio had significantly higher REM sleep without atonia (%), both with cut-off values of early (11.0 ± 5.6 vs. 29.3 ± 23.2%, p = 0.018) and delayed heart-to-mediastinum ratio (9.1 ± 4.3 vs. 30.0 ± 22.9%, p = 0.011). These findings indicate that reduced MIBG uptake is associated with higher REM sleep without atonia in isolated REM sleep behavior disorder.

scholarly journals MIBG Cardiac Scintigraphy as a Potential Biomarker That Reflects Severity in Idiopathic REM Sleep Behavior Disorder

2021 ◽  
Author(s):  
Sooyeoun You ◽  
Kyoung Sook Won ◽  
Keun Tae Kim ◽  
Hyang Woon Lee ◽  
Yong Won Cho
Keyword(s):  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Receiver Operating Curve ◽  
Mibg Uptake ◽  
Sleep Behavior ◽  
Cardiac Autonomic Dysfunction ◽  
Potential Biomarker ◽  
Rem Sleep Without Atonia ◽  
Heart To Mediastinum Ratio

Abstract Study Objectives: 123I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was performed to demonstrate the correlation with clinical characteristics of patients with idiopathic REM sleep behavior disorder (iRBD) and we found the factors that are associated with neurodegenerative diseases. Methods: All subjects including 39 patients with iRBD and 17 healthy controls underwent MIBG cardiac scintigraphy to assess cardiac autonomic dysfunction. The iRBDs were confirmed by in-lab overnight polysomnography. Receiver operating curve was performed to determine cut-off value of early and delayed heart to mediastinum ratio (HMR) in patients with iRBD. Based on each cut-off value, comparison analysis about RWA was performed by dividing into two groups within iRBD patients.Results: MIBG uptake below the cut-off value is associated with higher REM sleep without atonia (RWA). The lower HMR had significantly higher RWA (%) both with the cut-off value of early (11.0±5.6 VS 29.3±23.2, p=0.018) and delayed HMR (9.1±4.3 VS 30.0±22.9, p=0.011).Conclusion: This study suggests that MIBG uptake is a potential biomarker of the severity of RWA in iRBD.

Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder

2010 ◽  
Vol 25 (14) ◽  
pp. 2304-2310 ◽  
Author(s):  
Ronald B. Postuma ◽  
Paola A. Lanfranchi ◽  
Helene Blais ◽  
Jean-Francois Gagnon ◽  
Jacques Y. Montplaisir
Keyword(s):  
Autonomic Dysfunction ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Cardiac Autonomic Dysfunction

scholarly journals P077 Reliability of the Clinical Characterization of Isolated REM Sleep Behavior Disorder

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A46-A46
Author(s):  
D Levendowski ◽  
J Lee-Iannotti ◽  
D Shprecher ◽  
C Guevarra ◽  
P Timm ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Rem Sleep ◽  
False Positive ◽  
False Negative ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Negative Case ◽  
Rem Sleep Without Atonia

Abstract Purpose Compare agreements between polysomnography-based (PSG) diagnosis of isolated REM-sleep-behavior-disorder (iRBD) and Non-REM-Hypertonia (NRH), a novel biomarker independently associated with synucleinopathy-related neurodegenerative diseases. Methods Sixteen patients with histories of dream-enactment-behavior (DEB)(women=38%; age:64.6±13.0) underwent PSG with simultaneously-recorded Sleep Profiler (SP). Two boarded sleep neurologists independently characterized iRBD. Physician1 combined abnormal qualitative REM-sleep-without-atonia (RSWA) by submental electromyography, with video-confirmation of probably DEB. Physician2 relied solely on qualitative RSWA. SP was auto-staged, technically reviewed, and reprocessed for automated abnormal NRH detection. Kappa scores measured physician and NRH agreements. Results In the 14 records with REM sleep, iRBD was characterized in: Physician1=64%, Physician2=79%, NRH=71% of the records. Across the three methods, unanimous iRBD agreement occurred in 57% of the records (positive=7, negative=1). The between-physician agreement in iRBD classifications was fair (kappa=0.32). The agreement between NRH and Physician1 was moderate (kappa=0.52) versus slight with Physician2 (kappa=0.05). NRH comparisons to consensus physician agreement yielded one false-positive and one false-negative iRBD finding. Physician2 classified: a) iRBD in two cases that were negative by Physician1 and NRH, and b) one negative case that Physician1 and NRH characterized as iRBD. Physician1 identified one negative case that was classified iRBD by Physician2 and NRH. Additionally, NRH was abnormal in one of the two records with no REM sleep. Discussion NRH may assist in iRBD risk assessment, given it agreed with at least one physician in 86% of the cases and the between-physician iRBD agreement was only fair. NRH also characterized iRBD-risk in patients with insufficient REM sleep for RSWA assessment.

scholarly journals REM sleep behavior disorder in children with type 1 Narcolepsy treated with Sodium Oxybate

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011157
Author(s):  
Elena Antelmi ◽  
Marco Filardi ◽  
Fabio Pizza ◽  
Stefano Vandi ◽  
Monica Moresco ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Sleep Stage ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sodium Oxybate ◽  
Direct Role ◽  
Sleep Behavior ◽  
Rem Sleep Without Atonia ◽  
Nighttime Sleep

Objective:The aim was to study the effect of stable treatment with Sodium Oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1.Methods:Nineteen NT1 children and adolescents (nine females; mean age 12.5±2.7, mean disease duration: 3.4±1.6 years) underwent neurological investigations and video-polysomnography (v-PSG) at baseline and after three months of stable treatment with SO.v-PSG was independently analysed by two sleep experts, in order to rate RBD episodes. RSWA was automatically computed by means of the validated REM sleep atonia index (RAI).Results:Compared to baseline, RAI significantly improved (p< 0.05) and complex movements during REM sleep were remarkably reduced after stable treatment with SO. Compared to baseline, children also reported improvement in clinical complaints and showed a different nighttime sleep stage architecture.Conclusions:RBD and RSWA improved after treatment with SO, pointing to a direct role of the drug in modulating motor control during REM sleep.

REM sleep without atonia predicts cognitive impairment in REM sleep behavior disorder

2015 ◽  
Vol 16 ◽  
pp. S349
Author(s):  
D. Sandness ◽  
E. St. Louis ◽  
B. Boeve ◽  
M. Silber
Keyword(s):  
Cognitive Impairment ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Rem Sleep Without Atonia
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