scholarly journals Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause

2018 ◽  
Vol 7 (10) ◽  
pp. 297 ◽  
Author(s):  
Delia Tit ◽  
Simona Bungau ◽  
Ciprian Iovan ◽  
Delia Nistor Cseppento ◽  
Laura Endres ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Bone Resorption ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Postmenopausal Osteoporosis ◽  
Hormone Replacement ◽  
Developed Countries ◽  
Soy Isoflavones ◽  
Control Group ◽  
Mineral Density

Postmenopausal osteoporosis is the most common form of osteoporosis and one of the major public health problems in developed countries. The prevalence of this condition, associated with the physiological stage of menopause, is continuously increasing. This study evaluated the effectiveness of soy isoflavones as compared to hormone replacement therapy (HRT) in low doses, on the prevention of postmenopausal osteoporosis, by determining bone mineral density (BMD) and urinary deoxypyridinoline (D-pyr) in physiological postmenopausal women. The study was conducted over a period of 12 months, on three parallel groups, which included a total of 325 postmenopausal women (HRT group: n = 95; phytoestrogens group: n = 124; control group: n = 106). At the one-year evaluation, we observed T-score normalization in a small number of cases (5.26%, 2.42% and 0.00%, respectively). The average values of D-Pyr decreased by 11.38% in the group treated with phytoestrogens (p < 0.05) and by 15.32% in the group that followed HRT (p < 0.05); it increased by 4.38% in the control group (p > 0.05). Both therapies have beneficial effects on bone metabolism, leading to a significant decrease in the evolution of bone resorption and there are no major differences between the efficacy of HRT and phytoestrogens in terms of the effects on BMD and bone resorption.

scholarly journals Nonassociation of Estrogen Receptor Genotypes with Bone Mineral Density and Estrogen Responsiveness to Hormone Replacement Therapy in Korean Postmenopausal Women

1997 ◽  
Vol 82 (4) ◽  
pp. 991-995 ◽  
Author(s):  
Ki Ok Han ◽  
In Gul Moon ◽  
Young Soon Kang ◽  
Ho Yeon Chung ◽  
Hun Ki Min ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Hormone Replacement Therapy ◽  
Lumbar Spine ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Gene Locus ◽  
Restriction Site ◽  
Hormone Replacement ◽  
Mineral Density

Abstract Hormone replacement therapy (HRT) prevents bone loss in postmenopausal women, but some women are resistant to therapy. A recently reported case of severe estrogen resistance caused by a germ-line mutation at the estrogen receptor (ER) gene locus suggests the possibility that other variants of the ER gene could be responsible for resistance to HRT and could also be an answer to the heritable components of bone density. Three restriction fragment length polymorphisms (RFLPs) at the ER gene locus, represented as BstUI (or B variant), PvuII, and XbaI, and their relationship to bone mineral density (BMD) and estrogen responsiveness to HRT were examined in 248 healthy postmenopausal women, aged 41–68 yr (mean± sd, 52.0 ± 4.6 yr) in Korea. The BstUI restriction site was not found in Korean women. The distribution of the PvuII and XbaI RFLPs was as follows: PP, 35 (14.1%); Pp, 136 (54.8%); pp, 77 (31.1%); and XX, 18 (7.3%); Xx, 72 (29.0%); and xx, 158 (63.7%), respectively (capital letters signify the absence of and lower case letters signify the presence of the restriction site of each RFLP). There was no significant relation between ER genotypes and z score values of lumbar spine BMD. Also, no significant genotypic differences were found in the change in lumbar spine BMD and those in biochemical markers before and after 1 yr of HRT. These data indicate no significant effects of ER genotypes on BMD and estrogen responsiveness after HRT.

scholarly journals Effect of hormone replacement therapy on the bone mass and urinary excretion of pyridinium cross-links

2000 ◽  
Vol 118 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Dolores Perovano Pardini ◽  
Anibal Tagliaferri Sabino ◽  
Ana Maria Meneses ◽  
Teresa Kasamatsu ◽  
José Gilberto Henriques Vieira
Keyword(s):  
Hormone Replacement Therapy ◽  
Bone Resorption ◽  
Bone Mass ◽  
Urinary Excretion ◽  
Replacement Therapy ◽  
High Performance ◽  
Hormone Replacement ◽  
Mineral Density ◽  
Cross Links ◽  
Post Menopausal

CONTEXT: The menopause accelerates bone loss and is associated with an increased bone turnover. Bone formation may be evaluated by several biochemical markers. However, the establishment of an accurate marker for bone resorption has been more difficult to achieve. OBJECTIVE: To study the effect of hormone replacement therapy (HRT) on bone mass and on the markers of bone resorption: urinary excretion of pyridinoline and deoxypyridinoline. DESIGN: Cohort correlational study. SETTING: Academic referral center. SAMPLE: 53 post-menopausal women, aged 48-58 years. MAIN MEASUREMENTS: Urinary pyr and d-pyr were measured in fasting urine samples by spectrofluorometry after high performance liquid chromatography and corrected for creatinine excretion measured before treatment and after 1, 2, 4 and 12 months. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (DEXA) before treatment and after 12 months of HRT. RESULTS: The BMD after HRT was about 4.7% (P < 0.0004); 2% (P < 0.002); and 3% (P < 0.01) higher than the basal values in lumbar spine, neck and trochanter respectively. There were no significant correlations between pyridinium cross-links and age, weight, menopause duration and BMD. The decrease in pyr and d-pyr was progressive after HRT, reaching 28.9% (P < 0.0002), and 42% (P < 0.0002) respectively after 1 year. CONCLUSIONS: Urinary pyridinoline and deoxypyridinoline excretion decreases early in hormone replacement therapy, reflecting a decrease in the bone resorption rate, and no correlation was observed with the bone mass evaluated by densitometry.

Strength Training Preserves the Bone Mineral Density of Postmenopausal Women Without Hormone Replacement Therapy

2009 ◽  
Vol 21 (3) ◽  
pp. 519-527 ◽  
Author(s):  
Danilo Sales Bocalini ◽  
Andrey Jorge Serra ◽  
Leonardo dos Santos ◽  
Neif Murad ◽  
Rozeli Ferreira Levy
Keyword(s):  
Bone Mineral Density ◽  
Hormone Replacement Therapy ◽  
Strength Training ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Mineral Density

Effect of Hormone Replacement Therapy on Ocular Hemodynamics in Postmenopausal Women

2001 ◽  
Vol 11 (3) ◽  
pp. 277-280 ◽  
Author(s):  
H. Atílla ◽  
A. Arslanpençe ◽  
F. Batioğlu ◽  
T. Eryilmaz ◽  
S. Aytaç ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Doppler Ultrasonography ◽  
Hormone Replacement ◽  
Control Group ◽  
Medication History ◽  
The Mean ◽  
Ocular Hemodynamics ◽  
Flow Velocities

Purpose To evaluate the effect of hormone replacement therapy on ocular hemodynamics in postmenopausal women. Methods Ocular Doppler ultrasonography was performed in 20 postmenopausal women on hormone replacement therapy (HRT) and in 20 women without treatment, as the control group. Central retinal artery (CRA), posterior ciliary artery (PCA) and ophthalmic artery (OA) flow velocities and vascular resistances were measured prospectively by a radiologist blinded to the therapy. There were no associated systemic or ocular diseases or any medication history. Results The mean age of the patients on HRT was 50.05 ± 4.5 yrs (range 44 - 62). The mean age of the control group was 52.8 ± 4.09 yrs (range 46 - 65). The mean duration of HRT was 1.6 ± 1.4 yrs (range 3 months - 5 years). There were no differences between the groups in terms of flow velocities, vascular resistivities or pulsatility indices of OA, CRA and PCA (p>0.05). Conclusions HRT is essential in postmenopausal women for relief of vasomotor symptoms, cardioprotection and prevention of osteoporosis. Even though vaso-occlusive complications of hormone preparations have been reported, we did not observe any changes in ocular hemodynamics detectable with Doppler ultrasonography.

scholarly journals Effects of Hormone Replacement Therapy on Bone Mineral Density in Postmenopausal Women With Primary Hyperparathyroidism

2000 ◽  
Vol 160 (14) ◽  
pp. 2161 ◽  
Author(s):  
Brandon J. Orr-Walker ◽  
Margaret C. Evans ◽  
Judy M. Clearwater ◽  
Anne Horne ◽  
Andrew B. Grey ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Hormone Replacement Therapy ◽  
Primary Hyperparathyroidism ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Mineral Density
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