scholarly journals Analyzing the Effects of Parameters for Tremor Modulation via Phase-Locked Electrical Stimulation on a Peripheral Nerve

2022 ◽  
Vol 12 (1) ◽  
pp. 76
Author(s):  
Jeonghee Kim ◽  
Thomas Wichmann ◽  
Omer T. Inan ◽  
Stephen P. DeWeerth
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Essential Tremor ◽  
Large Scale ◽  
Transfer Task ◽  
Stimulation Parameter ◽  
Promising Alternative ◽  
Non Invasive ◽  
Stimulation Parameters ◽  
Stimulation System

(1) Background: Non-invasive neuromodulation is a promising alternative to medication or deep-brain stimulation treatment for Parkinson’s Disease or essential tremor. In previous work, we developed and tested a wearable system that modulates tremor via the non-invasive, electrical stimulation of peripheral nerves. In this article, we examine the proper range and the effects of various stimulation parameters for phase-locked stimulation. (2) Methods: We recruited nine participants with essential tremor. The subjects performed a bean-transfer task that mimics an eating activity to elicit kinetic tremor while using the wearable stimulation system. We examined the effects of stimulation with a fixed duty cycle, at different stimulation amplitudes and frequencies. The epochs of stimulation were locked to one of four phase positions of ongoing tremor, as measured with an accelerometer. We analyzed stimulation-evoked changes of the frequency and amplitude of tremor. (3) Results: We found that the higher tremor amplitude group experienced a higher rate of tremor power reduction (up to 65%) with a higher amplitude of stimulation when the stimulation was applied at the ±peak of tremor phase. (4) Conclusions: The stimulation parameter can be adjusted to optimize tremor reduction, and this study lays the foundation for future large-scale parameter optimization experiments for personalized peripheral nerve stimulation.

scholarly journals Essential tremor amplitude modulation by median nerve stimulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carolina Reis ◽  
Beatriz S. Arruda ◽  
Alek Pogosyan ◽  
Peter Brown ◽  
Hayriye Cagnan
Keyword(s):  
Electrical Stimulation ◽  
Essential Tremor ◽  
Median Nerve ◽  
Closed Loop ◽  
Control Policy ◽  
Non Invasive ◽  
Peripheral Stimulation ◽  
Median Nerve Stimulation ◽  
Number Of Patients ◽  
Stimulation Paradigm

AbstractEssential tremor is a common neurological disorder, characterised by involuntary shaking of a limb. Patients are usually treated using medications which have limited effects on tremor and may cause side-effects. Surgical therapies are effective in reducing essential tremor, however, the invasive nature of these therapies together with the high cost, greatly limit the number of patients benefiting from them. Non-invasive therapies have gained increasing traction to meet this clinical need. Here, we test a non-invasive and closed-loop electrical stimulation paradigm which tracks peripheral tremor and targets thalamic afferents to modulate the central oscillators underlying tremor. To this end, 9 patients had electrical stimulation delivered to the median nerve locked to different phases of tremor. Peripheral stimulation induced a subtle but significant modulation in five out of nine patients—this modulation consisted mainly of amplification rather than suppression of tremor amplitude. Modulatory effects of stimulation were more pronounced when patient’s tremor was spontaneously weaker at stimulation onset, when significant modulation became more frequent amongst subjects. This data suggests that for selected individuals, a more sophisticated control policy entailing an online estimate of both tremor phase and amplitude, should be considered in further explorations of the treatment potential of tremor phase-locked peripheral stimulation.

Patient-driven loop control for hand function restoration in a non-invasive functional electrical stimulation system

2008 ◽  
Vol 30 (19) ◽  
pp. 1499-1505 ◽  
Author(s):  
Ying-Han Chiou ◽  
Jer-Junn Luh ◽  
Shih-Ching Chen ◽  
Yu-Luen Chen ◽  
Jin-Shin Lai ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Functional Electrical Stimulation ◽  
Hand Function ◽  
Loop Control ◽  
Non Invasive ◽  
Stimulation System

scholarly journals Enhancing osteoblast survival through pulsed electrical stimulation and implications for osseointegration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Emily Pettersen ◽  
Furqan A. Shah ◽  
Max Ortiz-Catalan
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Cell Survival ◽  
Nerve Stimulation ◽  
Peripheral Nerve Stimulation ◽  
Dependent Manner ◽  
Stimulation Parameters ◽  
Wide Range ◽  
The Impact

AbstractElectrical stimulation has been suggested as a means for promoting the direct structural and functional bonding of bone tissue to an artificial implant, known as osseointegration. Previous work has investigated the impact of electrical stimulation in different models, both in vitro and in vivo, using various electrode configurations for inducing an electric field with a wide range of stimulation parameters. However, there is no consensus on optimal electrode configuration nor stimulation parameters. Here, we investigated a novel approach of delivering electrical stimulation to a titanium implant using parameters clinically tested in a different application, namely peripheral nerve stimulation. We propose an in vitro model comprising of Ti6Al4V implants precultured with MC3T3-E1 preosteoblasts, stimulated for 72 h at two different pulse amplitudes (10 µA and 20 µA) and at two different frequencies (50 Hz and 100 Hz). We found that asymmetric charge-balanced pulsed electrical stimulation improved cell survival and collagen production in a dose-dependent manner. Our findings suggest that pulsed electrical stimulation with characteristics similar to peripheral nerve stimulation has the potential to improve cell survival and may provide a promising approach to improve peri-implant bone healing, particularly to neuromusculoskeletal interfaces in which implanted electrodes are readily available.

EFFECT OF STIMULUS PARAMETERS IN THE TREATMENT OF SEIZURES BY ELECTRICAL STIMULATION IN THE KAINATE ANIMAL MODEL

2011 ◽  
Vol 21 (02) ◽  
pp. 151-162 ◽  
Author(s):  
POOJA RAJDEV ◽  
MATTHEW WARD ◽  
PEDRO IRAZOQUI
Keyword(s):  
Electrical Stimulation ◽  
Pulse Width ◽  
Closed Loop ◽  
Seizure Activity ◽  
Open Loop ◽  
Stimulation Frequency ◽  
Total Charge ◽  
Stimulation Parameter ◽  
Loop Control ◽  
Stimulation Parameters

Preliminary results from animal and clinical studies demonstrate that electrical stimulation of brain structures can reduce seizure frequency in patients with refractory epilepsy. Since most researchers derive stimulation parameters by trial and error, it is unclear what stimulation frequency, amplitude and duration constitutes a set of optimal stimulation parameters for aborting seizure activity in a given patient. In this investigation, we begin to quantify the independent effects of stimulation parameters on electrographic seizures, such that they could be used to develop an efficient closed-loop prosthesis that intervenes before the clinical onset of a seizure and seizure generalization. Biphasic stimulation is manually delivered to the hippocampus in response to a visually detected electrographic seizure. Such focal, responsive stimulation allows for anti-seizure treatment delivery with improved temporal and spatial specificity over conventional open-loop stimulation paradigms, with the possibility of avoiding tissue damage stemming from excessive exposure to electrical stimulation. We retrospectively examine the effects of stimulation frequency (low, medium and high), pulse-width (low and high) and amplitude (low and high) in seizures recorded from 23 kainic acid treated rats. We also consider the effects of total charge delivered and the rate of charge delivery, and identify stimulation parameter sets that induce after-discharges or more seizures. Among the stimulation parameters evaluated, we note 2 major findings. First, stimulation frequency is a key parameter for inhibiting seizure activity; the anti-seizure effect cannot be attributed to only the charge delivered per phase. Second, an after-discharge curve shows that as the frequency and pulse-width of stimulation increases, smaller pulse amplitudes are capable of eliciting an after-discharge. It is expected that stimulation parameter optimization will lead to devices with enhanced treatment efficacies and reduced side-effect profiles, especially when used in conjunction with seizure prediction or detection algorithms in a closed-loop control application.

scholarly journals A Gastrointestinal Electrical Stimulation System Based on Transcutaneous Power Transmission Technology

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Bingquan Zhu ◽  
Yongbing Wang ◽  
Guozheng Yan ◽  
Pingping Jiang ◽  
Zhiqiang Liu
Keyword(s):  
Electrical Stimulation ◽  
Power Transmission ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Stimulation Protocol ◽  
Stimulation Parameters ◽  
Parametric Studies ◽  
Stimulation System ◽  
Electrical Stimulator ◽  
Extended Power

Electrical stimulation has been suggested as a possible treatment for various functional gastrointestinal disorders (FGID). This paper presents a transcutaneous power supplied implantable electrical stimulation system. This technology solves the problem of supplying extended power to an implanted electrical stimulator. After implantation, the stimulation parameters can be reprogrammed by the external controller and then transmitted to the implanted stimulator. This would enable parametric studies to investigate the efficacy of various stimulation parameters in promoting gastrointestinal contractions. A pressure detector in the internal stimulator can provide real-time feedback about variations in the gastrointestinal tract. An optimal stimulation protocol leading to cecal contractions has been proposed: stimulation bursts of 3 ms pulse width, 10 V amplitude, 40 Hz frequency, and 20 s duration. The animal experiment demonstrated the functionality of the system and validated the effects of different stimulation parameters on cecal contractions.

Efficient Schedule of Energy-Constrained UAV Using Crowdsourced Buses in Last-Mile Parcel Delivery

2021 ◽  
Vol 5 (1) ◽  
pp. 1-23
Author(s):  
Yan Pan ◽  
Shining Li ◽  
Qianwu Chen ◽  
Nan Zhang ◽  
Tao Cheng ◽  
...  
Keyword(s):  
Traffic Congestion ◽  
Large Scale ◽  
Load Capacity ◽  
Scheduling Algorithm ◽  
Cost Effective ◽  
Promising Alternative ◽  
Logistics Industry ◽  
Last Mile ◽  
Delivery Scheduling ◽  
Schedule Approach

Stimulated by the dramatical service demand in the logistics industry, logistics trucks employed in last-mile parcel delivery bring critical public concerns, such as heavy cost burden, traffic congestion and air pollution. Unmanned Aerial Vehicles (UAVs) are a promising alternative tool in last-mile delivery, which is however limited by insufficient flight range and load capacity. This paper presents an innovative energy-limited logistics UAV schedule approach using crowdsourced buses. Specifically, when one UAV delivers a parcel, it first lands on a crowdsourced social bus to parcel destination, gets recharged by the wireless recharger deployed on the bus, and then flies from the bus to the parcel destination. This novel approach not only increases the delivery range and load capacity of battery-limited UAVs, but is also much more cost-effective and environment-friendly than traditional methods. New challenges therefore emerge as the buses with spatiotemporal mobility become the bottleneck during delivery. By landing on buses, an Energy-Neutral Flight Principle and a delivery scheduling algorithm are proposed for the UAVs. Using the Energy-Neutral Flight Principle, each UAV can plan a flying path without depleting energy given buses with uncertain velocities. Besides, the delivery scheduling algorithm optimizes the delivery time and number of delivered parcels given warehouse location, logistics UAVs, parcel locations and buses. Comprehensive evaluations using a large-scale bus dataset demonstrate the superiority of the innovative logistics UAV schedule approach.

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