scholarly journals Contact Lens Materials: A Materials Science Perspective

Materials ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 261 ◽  
Author(s):  
Christopher Stephen Andrew Musgrave ◽  
Fengzhou Fang

More is demanded from ophthalmic treatments using contact lenses, which are currently used by over 125 million people around the world. Improving the material of contact lenses (CLs) is a now rapidly evolving discipline. These materials are developing alongside the advances made in related biomaterials for applications such as drug delivery. Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. This review provides an advanced perspective on contact lens materials, with an emphasis on materials science employed in developing new CLs. The future trends for CL materials are to graft, incapsulate, or modify the classic CL material structure to provide new or improved functionality. In this paper, we discuss some of the fundamental material properties, present an outlook from related emerging biomaterials, and provide viewpoints of precision manufacturing in CL development.

2013 ◽  
Vol 633 ◽  
pp. 239-252
Author(s):  
Đuro Koruga ◽  
Dragomir Stamenković ◽  
Ivan Djuricic ◽  
Ivana Mileusnic ◽  
Jovana Šakota ◽  
...  

Contact lenses are a common optical aid to provide help with refractive anomalies of the human eye. Construction of contact lenses is a complex engineering task as it requires knowledge of optics, materials science, production and characterization methods for product quality. Besides correcting refractive anomalies, by using contact lenses it is possible to change the characteristics of light through the manipulation of material structure properties. Nanomaterials, such as fullerene C60, are candidates for the medium that interacts with light, thus changing its properties. During material syntheses for contact lenses, fullerenes are added to the base material and optical characteristics of the new nanophotonic material are compared with the base material. The engineering, manufacture and characterization of both a commercial and a new nanophotonic contact lens is presented in this paper. The interaction of water with both base and nanophotonic contact lens materials is described. Using experimental techniques, the phenomena of an exclusion zone (EZ) is also identified.


2013 ◽  
Vol 36 ◽  
pp. e41
Author(s):  
Lakshman Subbaraman ◽  
Hendrik Walther ◽  
Lise Kay ◽  
Lyndon Jones

Cornea ◽  
2012 ◽  
Vol 31 (10) ◽  
pp. 1170-1175 ◽  
Author(s):  
Toshihiko Uno ◽  
Yuichi Ohashi ◽  
Miya Nomachi ◽  
Masaki Imayasu

2019 ◽  
Vol 31 (4) ◽  
pp. 1001-1004
Author(s):  
Nikola Peev

The modern world is very fast and dynamic. Consumer requirements rise to every commodity part of their everyday life - food, clothing, cosmetics, and medical devices. Eye care and eye health are also part of them. Companies producing contact lenses work daily to improve the safety and comfort of wearing, as well as on the technical characteristics of the material (type of material, wear time, module, Dk / t etc.). Silicon hydrogel contact lenses (SiHy) were introduced almost two decades ago. At that time it was estimated that there are about 70 million contact lenses all over the world. Since then, their number has doubled and a significant majority now have silicone-hydrogel contact lenses, resulting in a steady and noticeable reduction in the number of regular hydrogel lenses. When the first one-day silicon-hydrogel contact lenses were introduced in 2008, they were announced as breakthroughs in technology. When they were introduced to the market, they were presented in spherical, toric and multifocal designs, which led to a significant increase in the use / prescription of silicon-hydrogel daily disposable contact lenses. A survey conducted in 2014 by the International Consortium illustrates this point. Although, according to this study, the use of SiHy contact lenses varies widely across the world. In the United States, Canada, Australia and the United Kingdom, four to six times more patients were fitted with silicone-hydrogel CLs compared to hydrogels in 2014 and in each country, daily disposable SiHy contact lenses were prescribed with a larger frequency compared to daily disposable hydrogel lenses. It is important to make a good fit to ensure and increase the comfort of wearing contact lenses. In addition to some of the standard fitting techniques such as: keratometry and choice of base curve of the lens; size and eccentricity; an assessment of the mobility of a lens placed in the eye - look positions, mobility, push up test, can be added and the wetting of the contact lens. Even in perfect fit, if the lens does not interact well with the tear film, it would lead to complaints and discomfort in the patient. The degree of wetting is determined by the balance between adhesive and cohesive forces acting on the surface of the lens. CLs, which can support full wetting, allow a tight coating of the tear film, a smooth recovery of the tear layer after eyelid opening and good visual acuity. The interaction between CL, eye surface and tear film is vital to their successful fit. It has long been known that both the organic and inorganic components of the tear film and anterior surface of the eye can deposit deposits on the contact lenses. There are various non-invasive methods for assessing the tear film and, above all, the lipid layer. Some of these are Non invasive breakup time (NIBUT) and specular biomicroscopy. In the present work we will look at daily disposable silicone-hydrogel contact lenses that have been tested in vivo for good wetting, stability and good regeneration of the tear film.


2015 ◽  
Vol 08 (06) ◽  
pp. 1550044 ◽  
Author(s):  
Beata Kettesy ◽  
Julianna Vardai ◽  
Andras Berta ◽  
Laszlo Modis ◽  
Adam Kemeny-Beke

Purpose: The examination of the effects of second generation lotrafilcon B silicone hydrogel (SiH) lenses on the cornea when worn for three years of daily wear. Material and Methods: 55 healthy patients were divided into two groups: current hydrogel contact lens wearers refitted with lotrafilcon B lenses (Group 1; 28 patients) and neophyte contact lens wearers (Group 2; 27 patients). Each patient's subjective eye comfort was measured with a self-administered questionnaire. The corneas were analyzed using contact specular microscope to measure corneal thickness and the endothelium before the SiH lenses were fitted after four weeks, one month, six months, one year, two years, and three years of lens wear. Results: Subjective complaints of patients in Group 1 were reduced; however patients in Group 2 experienced discomfort during the first two to four weeks of use. In Group 1, objective examinations identified a decrease in endothelial cell density. In Group 2, the endothelial cell density increased slightly in the first two years but decreased after three years. The results indicate that lotrafilcon B slows down the deleterious effects of contact lenses. The coefficient of variation significantly decreased after six months in Group 1 (0.47 vs 0.44; p = 0.049), whereas, in Group 2, the hexagonal cells improved significantly after one month (27.78 vs 28.25; p = 0.025). Conclusion: Based on the subjects involved and the period of time under examination, it can be concluded that high-Dk SiH lenses support the physiological metabolism and functions of the cornea by improving oxygen provision.


2021 ◽  
Vol 23 (1) ◽  
pp. 25-35
Author(s):  
Eghosasere Iyamu ◽  
Frederick Osaro Ekhaise

Purpose: The aim of this study was to investigate the adhesion of bacteria to worn silicone hydrogel and conventional soft contact lenses.Methods: Bacterial adhesion experiments / assays were performed on 24 worn and 6 unworn soft contact lenses each of different materials (high- and low- gas permeable lenses) using the strains such as Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 25923.Results: P. aeruginosa adhered in increased number to worn than unworn Lotrafilcon A and conventional lenses. However, a higher number of P. aeruginosa adhered to unworn than worn Lotrafilcon B, the difference in the mean adhesion was not significant (p = 0.66). S. aureus adhered in significantly decreased number to worn Lotrafilcon A, nelfilcon A, nesofilcon A, etafilcon A and omafilcon A (p<0.05); butsignificantly higher number adhered to worn than unworn polymacon (p<0.05). Lens wear had no effect on the adhesion of S. aureus to Lotrafilcon B (p>0.05). The least adhesion of P. aeruginosa to worn contact lenses was seen with polymacon, while S. aureus adhered in least number to worn Lotrafilcon A compared to the other contact lens materials that demonstrated the same trend in adhesion.Conclusion: The higher adhesion of P. aeruginosa to worn lenses is consistent with the claim that it is the most implicated in all culture-positive contact lens related bacterial keratitis. Lens wear has different effects on bacterial adhesion, which may be due to type of lens materials and bacterial species/genera studied. Keywords: Silicone hydrogel lenses, conventional lenses, Pseudomonas aeruginosa, Staphylococcus aureus, bacterial adhesion.


2021 ◽  
Vol 10 (2) ◽  
pp. 43-49
Author(s):  
Nancy M. Lotfy ◽  
Tariq Alasbali ◽  
Abdulrahman M. Alsharif ◽  
Saeed M Al- Gehedan ◽  
Sabah Jastaneiah ◽  
...  

Background: At completion of transepithelial photorefractive keratectomy (t-PRK) surgery, the eye is usually fitted with a bandage contact lens to reduce discomfort and promote epithelial healing. This study aimed to compare the outcomes of eyes fitted with lotrafilcon B versus comfilcon A, silicone hydrogel bandage contact lenses after t-PRK for the correction of low to moderate myopia, with or without astigmatism. Methods: In this comparative, prospective study, patients with myopia < -6 D with or without astigmatism (< 1.75 D), who underwent t-PRK between January and June 2018, were randomly allocated to the lotrafilcon B and comfilcon A groups. Preoperative characteristics, including age, sex, eye treated, uncorrected visual acuity (UCVA), best-corrected visual acuity, mesopic pupil size, central corneal thickness, and refractive error were recorded. Postoperatively, pain score, UCVA, and corneal epithelial defect size on days 1, 4, and 7 were compared between the two groups. Results: Twenty-nine eyes were included in each group. Demographic characteristics and preoperative measurements were similar between the two groups. UCVA was significantly improved on day 7 as compared to day 1 in the comfilcon A group (P = 0.03), but remained the same in the lotrafilcon B group (P = 0.70) as on day 1 postoperatively. There was no significant difference in UCVA between the two groups at any follow-up visits (all P > 0.05). The pain score on the first postoperative day was significantly higher in the lotrafilcon B-fitted eyes than in the comfilcon A group (P < 0.001), but was significantly reduced in both groups compared to day 1 (both P < 0.001). The epithelial defect in the comfilcon A group was significantly greater than in the lotrafilcon B group (P < 0.001) at day 1 postoperatively, with significant improvement in both groups (both P < 0.001). Conclusions: Healing responses were better with lotrafilcon B than with comfilcon A bandage contact lenses. The patients had a greater mean pain score with lotrafilcon B than with comfilcon A lenses on the first postoperative day, yet the final outcome was comparable between the two groups. We did not encounter any postoperative complications related to contact lens wear. How to cite this article: Lotfy NM, Alasbali T, Alsharif AM, Al-Gehedan SM, Jastaneiah S, Al-Hazaimeh A, Ali H, Khandekar R. Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy. Med Hypothesis Discov Innov Ophthalmol. 2021 Summer; 10(2): 1-7. https://doi.org/10.51329/mehdiophthal1420


Author(s):  
Boris Severinsky

ABSTRACT Purpose To report successful visual rehabilitation of post refractive surgery keratoectasia shortly after corneal collage crosslinking (CXL) procedure achieved with silicone hydrogel mini-scleral (SHmS) contact lens. Materials and methods A 29-year-old woman attended to our clinic with complaints on decreased vision in her left eye. Twelve years earlier she underwent bilateral laser-assisted in situ keratomileusis (LASIK) procedure for myopia correction. Corneal topography revealed bilateral central keratoectasia with maximal keratometry values of 55.4 Diopter (D) for her right eye and 59.7 D for the left, corneal thicknesses were 422 and 443 respectively. The patient underwent an uneventful CXL procedure in her left eye and was fitted with SHmS lens 5 weeks later. The lens was designed to rest over the patients’ sclera and perilimbal cornea and vault the central cornea with minimal support over it. Results SHmS lens fitting resulted in significant subjective improvement in visual acuity (from 20/200, unaided to 20/25, contact lens corrected). The patient was able to wear the lens upto 10 hours a day with stable contact lens corrected vision. No contact lens related complications, such as edema or neovascularization were observed during 3 months follow-up period. As a result of successful restoration of vision in the CXL-treated eye, the patient was scheduled for the procedure in her other eye. Conclusion SHmS contact lens should be considered as an option for the visual rehabilitation of corneas shortly after collagen corneal crosslinking procedure. This novel contact lens modality made from flexible and highly gas permeable material minimizes contact lens influence on corneal recovery after CXL and provides an excellent visual outcome. How to cite this article Severinsky B. Silicone Hydrogel Mini-scleral Contact Lenses after Corneal Collagen Crosslinking for Post-LASIK Keratoectasia. Int J Kerat Ect Cor Dis 2014;3(3):127-129.


2008 ◽  
Vol 28 (4) ◽  
pp. 373-381 ◽  
Author(s):  
Jacinto Santodomingo-Rubido ◽  
Eva Barrado-Navascués ◽  
María-José Rubido-Crespo ◽  
Keiji Sugimoto ◽  
Tadashi Sawano

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