scholarly journals Artificial Intelligence Aided Design of Tissue Engineering Scaffolds Employing Virtual Tomography and 3D Convolutional Neural Networks

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5278
Author(s):  
María Dolores Bermejillo Barrera ◽  
Francisco Franco-Martínez ◽  
Andrés Díaz Lantada

Design requirements for different mechanical metamaterials, porous constructions and lattice structures, employed as tissue engineering scaffolds, lead to multi-objective optimizations, due to the complex mechanical features of the biological tissues and structures they should mimic. In some cases, the use of conventional design and simulation methods for designing such tissue engineering scaffolds cannot be applied because of geometrical complexity, manufacturing defects or large aspect ratios leading to numerical mismatches. Artificial intelligence (AI) in general, and machine learning (ML) methods in particular, are already finding applications in tissue engineering and they can prove transformative resources for supporting designers in the field of regenerative medicine. In this study, the use of 3D convolutional neural networks (3D CNNs), trained using digital tomographies obtained from the CAD models, is validated as a powerful resource for predicting the mechanical properties of innovative scaffolds. The presented AI-aided or ML-aided design strategy is believed as an innovative approach in area of tissue engineering scaffolds, and of mechanical metamaterials in general. This strategy may lead to several applications beyond the tissue engineering field, as we analyze in the discussion and future proposals sections of the research study.

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lara Lloret Iglesias ◽  
Pablo Sanz Bellón ◽  
Amaia Pérez del Barrio ◽  
Pablo Menéndez Fernández-Miranda ◽  
David Rodríguez González ◽  
...  

AbstractDeep learning is nowadays at the forefront of artificial intelligence. More precisely, the use of convolutional neural networks has drastically improved the learning capabilities of computer vision applications, being able to directly consider raw data without any prior feature extraction. Advanced methods in the machine learning field, such as adaptive momentum algorithms or dropout regularization, have dramatically improved the convolutional neural networks predicting ability, outperforming that of conventional fully connected neural networks. This work summarizes, in an intended didactic way, the main aspects of these cutting-edge techniques from a medical imaging perspective.


2021 ◽  
Author(s):  
Ramy Abdallah ◽  
Clare E. Bond ◽  
Robert W.H. Butler

<p>Machine learning is being presented as a new solution for a wide range of geoscience problems. Primarily machine learning has been used for 3D seismic data processing, seismic facies analysis and well log data correlation. The rapid development in technology with open-source artificial intelligence libraries and the accessibility of affordable computer graphics processing units (GPU) makes the application of machine learning in geosciences increasingly tractable. However, the application of artificial intelligence in structural interpretation workflows of subsurface datasets is still ambiguous. This study aims to use machine learning techniques to classify images of folds and fold-thrust structures. Here we show that convolutional neural networks (CNNs) as supervised deep learning techniques provide excellent algorithms to discriminate between geological image datasets. Four different datasets of images have been used to train and test the machine learning models. These four datasets are a seismic character dataset with five classes (faults, folds, salt, flat layers and basement), folds types with three classes (buckle, chevron and conjugate), fault types with three classes (normal, reverse and thrust) and fold-thrust geometries with three classes (fault bend fold, fault propagation fold and detachment fold). These image datasets are used to investigate three machine learning models. One Feedforward linear neural network model and two convolutional neural networks models (Convolution 2d layer transforms sequential model and Residual block model (ResNet with 9, 34, and 50 layers)). Validation and testing datasets forms a critical part of testing the model’s performance accuracy. The ResNet model records the highest performance accuracy score, of the machine learning models tested. Our CNN image classification model analysis provides a framework for applying machine learning to increase structural interpretation efficiency, and shows that CNN classification models can be applied effectively to geoscience problems. The study provides a starting point to apply unsupervised machine learning approaches to sub-surface structural interpretation workflows.</p>


2019 ◽  
Vol 134 (1) ◽  
pp. 52-55 ◽  
Author(s):  
J Huang ◽  
A-R Habib ◽  
D Mendis ◽  
J Chong ◽  
M Smith ◽  
...  

AbstractObjectiveDeep learning using convolutional neural networks represents a form of artificial intelligence where computers recognise patterns and make predictions based upon provided datasets. This study aimed to determine if a convolutional neural network could be trained to differentiate the location of the anterior ethmoidal artery as either adhered to the skull base or within a bone ‘mesentery’ on sinus computed tomography scans.MethodsCoronal sinus computed tomography scans were reviewed by two otolaryngology residents for anterior ethmoidal artery location and used as data for the Google Inception-V3 convolutional neural network base. The classification layer of Inception-V3 was retrained in Python (programming language software) using a transfer learning method to interpret the computed tomography images.ResultsA total of 675 images from 388 patients were used to train the convolutional neural network. A further 197 unique images were used to test the algorithm; this yielded a total accuracy of 82.7 per cent (95 per cent confidence interval = 77.7–87.8), kappa statistic of 0.62 and area under the curve of 0.86.ConclusionConvolutional neural networks demonstrate promise in identifying clinically important structures in functional endoscopic sinus surgery, such as anterior ethmoidal artery location on pre-operative sinus computed tomography.


2020 ◽  
Vol 32 (7) ◽  
pp. 1057-1065 ◽  
Author(s):  
Atsuko Tamashiro ◽  
Toshiyuki Yoshio ◽  
Akiyoshi Ishiyama ◽  
Tomohiro Tsuchida ◽  
Kazunori Hijikata ◽  
...  

Electronics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 118
Author(s):  
Holly Burrows ◽  
Javad Zarrin ◽  
Lakshmi Babu-Saheer ◽  
Mahdi Maktab-Dar-Oghaz

It is becoming increasingly apparent that a significant amount of the population suffers from mental health problems, such as stress, depression, and anxiety. These issues are a result of a vast range of factors, such as genetic conditions, social circumstances, and lifestyle influences. A key cause, or contributor, for many people is their work; poor mental state can be exacerbated by jobs and a person’s working environment. Additionally, as the information age continues to burgeon, people are increasingly sedentary in their working lives, spending more of their days seated, and less time moving around. It is a well-known fact that a decrease in physical activity is detrimental to mental well-being. Therefore, the need for innovative research and development to combat negativity early is required. Implementing solutions using Artificial Intelligence has great potential in this field of research. This work proposes a solution to this problem domain, utilising two concepts of Artificial Intelligence, namely, Convolutional Neural Networks and Generative Adversarial Networks. A CNN is trained to accurately predict when an individual is experiencing negative emotions, achieving a top accuracy of 80.38% with a loss of 0.42. A GAN is trained to synthesise images from an input domain that can be attributed to evoking position emotions. A Graphical User Interface is created to display the generated media to users in order to boost mood and reduce feelings of stress. The work demonstrates the capability for using Deep Learning to identify stress and negative mood, and the strategies that can be implemented to reduce them.


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