scholarly journals Kabirimine, a New Cyclic Imine from an Okinawan Dinoflagellate

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 353 ◽  
Author(s):  
Idam Hermawan ◽  
Mikako Higa ◽  
Philipus Uli Basa Hutabarat ◽  
Takeshi Fujiwara ◽  
Kiyotaka Akiyama ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Antiviral Activity ◽  
Spectroscopic Analysis ◽  
Computational Study ◽  
Bioactive Molecules ◽  
Chiral Derivatization ◽  
The Absolute ◽  
Syncytial Virus ◽  
Absolute Stereochemistry

On our quest for new bioactive molecules from marine sources, two cyclic imines (1, 2) were isolated from a dinoflagellate extract, inhibiting the growth of the respiratory syncytial virus (RSV). Compound 1 was identified as a known molecule portimine, while 2 was elucidated to be a new cyclic imine, named kabirimine. The absolute stereochemistry of 1 was determined by crystallographic work and chiral derivatization, whereas the structure of 2 was elucidated by means of spectroscopic analysis and computational study on all the possible isomers. Compound 1 showed potent cytotoxicity (CC50 < 0.097 µM) against HEp2 cells, while 2 exhibited moderate antiviral activity against RSV with IC50 = 4.20 µM (95% CI 3.31–5.33).

CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats

1998 ◽  
Vol 38 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Philip R Wyde ◽  
Donna K Moore-Poveda ◽  
Bryan O’Hara ◽  
Wei-Dong Ding ◽  
Boris Mitsner ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Respiratory Syncytial Virus ◽  
Antiviral Activity ◽  
Cotton Rats ◽  
Syncytial Virus

scholarly journals Matrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135970 ◽  
Author(s):  
Abdoulaye J. Dabo ◽  
Neville Cummins ◽  
Edward Eden ◽  
Patrick Geraghty
Keyword(s):  
Respiratory Syncytial Virus ◽  
Antiviral Activity ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Syncytial Virus ◽  
Metalloproteinase 9

scholarly journals Antiviral activity of carnosic acid against respiratory syncytial virus

2013 ◽  
Vol 10 (1) ◽  
pp. 303 ◽  
Author(s):  
Han-Bo Shin ◽  
Myung-Soo Choi ◽  
Byeol Ryu ◽  
Na-Rae Lee ◽  
Hye-In Kim ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Antiviral Activity ◽  
Carnosic Acid ◽  
Syncytial Virus

Beyond Polygodial: New Drimane Sesquiterpenes From a Southern Australian Marine Sponge, Dysidea sp.

1993 ◽  
Vol 46 (8) ◽  
pp. 1255 ◽  
Author(s):  
MS Butler ◽  
RJ Capon
Keyword(s):  
Marine Sponge ◽  
Structure Elucidation ◽  
Spectroscopic Analysis ◽  
Marine Metabolites ◽  
Ecological Relationship ◽  
Chemical Correlation ◽  
The Absolute ◽  
First Time ◽  
Absolute Stereochemistry

This report describes the isolation and structure elucidation of four new drimane sesquiterpenes (14)-(17) from a southern Australian marine sponge Dysidea sp. The structures for (14)-(17) were secured by detailed spectroscopic analysis, chemical interconversion and derivatization. Also reported are the known metabolites (+)- euryfuran (7), dihydropallescensin-2 (18), (-)- pallescensin-A (19) and (-)-7-deacetoxyolepupane (6). The rare co-occurrence of two antipodes, (7) and (19), in the same specimen highlights the dangers in assigning absolute stereochemistry based on 'unproven' biosynthetic relationships. The absolute stereochemistry for (6) has been unambiguously established for the first time by chemical interconversion to (7). Furthermore, the absolute stereochemistry of the new marine metabolites listed above, (14)-(17), were determined by chemical correlation to (6). A biosynthetic and ecological relationship is proposed between the metabolites from Dysidea sp. with the known marine and terrestrial antifeedant polygodial (8). Chemical investigations are reported that support this proposition.

Antiviral activity of polysaccharide extract from Laminaria japonica against respiratory syncytial virus

2016 ◽  
Vol 84 ◽  
pp. 1705-1710 ◽  
Author(s):  
Yin-guang Cao ◽  
Yu Hao ◽  
Zhi-hui Li ◽  
Shun-tao Liu ◽  
Le-xin Wang
Keyword(s):  
Respiratory Syncytial Virus ◽  
Antiviral Activity ◽  
Laminaria Japonica ◽  
Syncytial Virus

scholarly journals Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

2009 ◽  
Vol 179 (2) ◽  
pp. 138-150 ◽  
Author(s):  
Hye-Youn Cho ◽  
Farhad Imani ◽  
Laura Miller-DeGraff ◽  
Dianne Walters ◽  
Guillermina A. Melendi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Antiviral Activity ◽  
Murine Model ◽  
Virus Disease ◽  
Respiratory Syncytial Virus Disease ◽  
Syncytial Virus
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