scholarly journals Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms

Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 542
Author(s):  
Thomas Eckert ◽  
Mahena Jährling-Butkus ◽  
Helen Louton ◽  
Monika Burg-Roderfeld ◽  
Ruiyan Zhang ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Treatment Options ◽  
Clinical Parameter ◽  
Food Supplement ◽  
Marine Organisms ◽  
Early Osteoarthritis ◽  
German Shepherd ◽  
Collagen Hydrolysate ◽  
Beneficial Effects ◽  
Collagen Hydrolysates

Osteoarthritis belongs to the most common joint diseases in humans and animals and shows increased incidence in older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study of 52 dogs as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen hydrolysates as well as sulfated glucosamine residues from marine organisms were strongly supported by both an animal model and molecular modeling of intermolecular interactions. Molecular modeling of predicted interaction dynamics was evaluated for the receptor proteins MMP-3 and ADAMTS-5. These proteins play a prominent role in the maintenance of cartilage health as well as innate and adapted immunity. Nutraceutical data were generated in a veterinary clinical study focusing on mobility and agility. Specifically, key clinical parameter (MMP-3 and TIMP-1) were obtained from blood probes of German shepherd dogs with early osteoarthritis symptoms fed with collagen hydrolysates. Collagen hydrolysate, a chondroprotective food supplement was examined by high resolution NMR experiments. Molecular modeling simulations were used to further characterize the interaction potency of collagen fragments and glucosamines with protein receptor structures. Potential beneficial effects of collagen hydrolysates, sulfated glycans (i.e., sulfated glucosamine from crabs and mussels) and lipids, especially, eicosapentaenoic acid (extracted from fish oil) on biochemical and physiological processes are discussed here in the context of human and veterinary medicine.

scholarly journals Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements

2021 ◽  
Author(s):  
Thomas Eckert ◽  
Mahena Jährling-Butkus ◽  
Helen Louton ◽  
Monika Burg-Roderfeld ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Fish Oil ◽  
Treatment Options ◽  
Food Supplement ◽  
Marine Organisms ◽  
Early Osteoarthritis ◽  
German Shepherd ◽  
Collagen Hydrolysate ◽  
Beneficial Effects ◽  
Collagen Hydrolysates

The bioactivities of collagen-hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen-hydrolysates as well as sulfated glucosamine residues from marine organisms were strongly supported by both an animal model and molecular modeling of intermolecular interactions. Molecular modeling of predicted interaction dynamics were evaluated for the receptor proteins MMP-3 and ADAMTS-5. These proteins play a prominent role in the maintenance of cartilage health as well as innate and adapted immunity. Nutraceuticals data were generated in a veterinary clinical study focusing on mobility and agility. Specifically, key clinical parameters were obtained from blood probes of German shepherd dogs with early osteoarthritis symptoms fed with collagen-hydrolysates or sulfated glucosamines. Collagen-hydrolysate, a chondroprotective food supplement was examined by high resolution NMR experiments. Molecular modeling simulations were used to further characterize the interaction potency of collagen-fragments and glucosamines with protein receptor structures. Potential beneficial effects of collagen-hydrolysates, sulfated glycans (i.e. sulfated glucosamine from crabs and mussels) and lipids, especially, eicosapentaenoic acid (extracted from fish oil) on biochemical and physiological processes are discussed here in the context of human and veterinary medicine.

scholarly journals Collagen Isolation from Arctic Marine Organisms and Their Industrial Processing Wastes

2020 ◽  
Author(s):  
Andrey Baryshnikov ◽  
Svetlana Derkach ◽  
Nadezhda Shumskaya ◽  
Kira Rysakova ◽  
Ivan Lyzhov ◽  
...  
Keyword(s):  
Gadus Morhua ◽  
Marine Organism ◽  
Raw Materials ◽  
Marine Organisms ◽  
Water Soluble ◽  
Insoluble Residue ◽  
Collagen Hydrolysate ◽  
Industrial Processing ◽  
Soluble Collagen ◽  
Collagen Hydrolysates

The results of the isolation of collagen hydrolysates from tissues of two Arctic marine organisms are presented. Extraction and use of marine organism collagen is a part of complex waste less processing of sea catches. Possible ways of preparing water-soluble collagen hydrolysates from different sources were studied. It is established that for preparing soluble collagen hydrolysate from skin of cod Gadus morhua acid hydrolysis in 0.3% acetic acid is suitable. Purification of solution by means of ultrafiltration gives a pure collagen hydrolysate with mass fraction of the main substance about 98%. Collagen of muscular skin bag of holothuria Molpadia borealis is almost insoluble in acid and alkali solutions. The major mass of collagen remains in an insoluble residue. The analysis of infrared spectrum transmission and chemical analysis of the general carbohydrates and collagen in different fractions showed that as a result of acid and alkaline processing of raw materials the glycosaminoglycans (GAG) and some quantity of collagen are extracted, their main quantity was determined in alkaline extracts. For extraction of soluble collagen from insoluble residue it is required enzymatic by pepsin in acidic medium. Properties of holothurian collagen and fish collagen are different. The preparation of water-soluble collagen derivatives requires using enzymatic hydrolysis.

scholarly journals Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate—A Randomized Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1064 ◽  
Author(s):  
Kathrine Skov ◽  
Mikkel Oxfeldt ◽  
Rebekka Thøgersen ◽  
Mette Hansen ◽  
Hanne Christine Bertram
Keyword(s):  
Enzymatic Hydrolysis ◽  
Absorption Rate ◽  
Controlled Trial ◽  
Plasma Concentrations ◽  
Collagen Hydrolysate ◽  
Beneficial Effects ◽  
Hydrolyzed Collagen ◽  
Collagen Protein ◽  
Collagen Hydrolysates ◽  
The Impact

Collagen is characterized by its high content of glycine, proline and hydroxyproline, and is found to exert beneficial effects on joint pain related to activity and osteoarthritis. However, to exert any beneficial effects it is essential that collagen is optimally absorbed. This study aimed to investigate the postprandial absorption of collagen and elucidate the impact of an exogenous enzymatic hydrolysis on absorption rate and bioavailability. A randomized, blinded, cross-over study was conducted where ten healthy male subjects received either 35 g enzymatically hydrolyzed collagen protein (EHC), 35 g non-enzymatically hydrolyzed collagen protein (NC) or placebo (250 mL water) on three nonconsecutive days. Blood samples were drawn before, and up to 240 min following, ingestion and the blood metabolome was characterized by nuclear magnetic resonance (NMR)-based metabolomics. A significant increase in the plasma concentration of nearly all amino acids (AAs) was observed over a 240 min period for both EHC and NC. In addition, the absorption rate and bioavailability of glycine, proline and hydroxyproline were significantly higher for EHC (p < 0.05). In conclusion, ingestion of collagen hydrolysates increases postprandial plasma concentrations of AAs over a period of 240 min, and an enzymatic hydrolysis increases the absorption rate and bioavailability of the collagen-rich AAs glycine, proline and hydroxyproline.

scholarly journals Evaluation of a Food Supplement with Collagen Hydrolysate and Micronutrients on Skin Appearance and Beauty Effects: A Randomized, Double-Blind, PlaceboControlled Clinical Study with Healthy Subjects

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Modinger Y ◽  
Schon C ◽  
Vogel K ◽  
Brandt M ◽  
Bielfeldt S ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Natural Aging ◽  
Food Supplement ◽  
Collagen Structure ◽  
Collagen Network ◽  
Double Blind ◽  
Collagen Hydrolysate ◽  
Beneficial Effects ◽  
Collagen Peptides ◽  
Hydrolyzed Collagen

Objective: Skin health, skin appearance and skin beauty are influenced by collagen composition of the dermis. Natural aging affects the structural integrity of the collagen network, resulting in drier skin, wrinkle formation and reduced skin elasticity. Orally ingested hydrolyzed collagen reaches the skin tissue and exerts beneficial effects on human skin from within. However, not only collagen peptides, but also micronutrients can beneficially affect skin appearance. Thus, dietary supplements for cosmetic and beauty effects containing combinations of collagen peptides and selected micronutrients are in demand. Aim of this study was to investigate the effect of a food supplement with collagen hydrolysate and micronutrients on skin beauty. The test product was assessed for its capability to reduce wrinkles and to improve skin hydration and collagen structure.

scholarly journals Salvia Officinalis Protects Pancreatic Beta-cells Against Streptozotocin-Induced Damage; A Stereological Study

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Soheil Ashkani-Esfahani ◽  
Ali Noorafshan ◽  
Alireza Ebrahimi ◽  
Maryam Bahmani-Jahromi ◽  
Mohammad-Hossein Imanieh ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Pancreatic Injury ◽  
Food Supplement ◽  
Salvia Officinalis ◽  
Diabetic Group ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Beneficial Effects ◽  
Patients With Diabetes

Background: Diabetes mellitus (DM) is a chronic disease, progressing due to inadequate secretion of insulin by pancreas. Salvia officinalis (SVO) has anti-inflammatory and anti-oxidative potentials, which may be beneficial in regulating underlying causes of DM. Objectives: In this study, we aimed to estimate the protective effects of SVO against Streptozotocin (STZ)-induced pancreatic injury in rat models of DM. Methods: Forty-eight male Sprague-Dawley rats were randomly divided into four groups (n = 12); C1: normal group with no treatment, C2: diabetic group with no treatment, E1: diabetic group treated with 200 mg/kg of the SVO extract, and E2: diabetic group treated with 400 mg/kg of the SVO extract. All groups received a single dose of STZ on day 7 except C1. Pancreas volume, shrinkage, volume densities of the islets, numerical densities, and volume of the beta cells were measured using stereological methods. Results: Blood sugar (BS) levels were significantly lower in SVO-treated groups comparing to C2 group. Also, volume densities and total number of islets and beta cells in E1 and E2 groups were higher than C2 (P < 0.05), but lower than C1 (P < 0.05). Volume densities of the islets and beta cells, and total number of beta cells in E1, and volume densities of the islets and beta cells in E2 groups were considerably higher than C2 group (P < 0.05). Conclusions: Our result showed the beneficial effects of SVO extract regarding pancreatic damage. We concluded that SVO might be prescribed as a therapeutic food supplement for patients with diabetes.

scholarly journals Precision medicine applications for severe asthma

2019 ◽  
Vol 6 (4) ◽  
pp. 117-135
Author(s):  
Orit Gourgy Hacohen ◽  
Shai Cohen
Keyword(s):  
Precision Medicine ◽  
Severe Asthma ◽  
Oral Corticosteroid ◽  
Treatment Options ◽  
Current Evidence ◽  
Blood Eosinophil ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma ◽  
Beneficial Effects ◽  
New Treatment

Asthma is a heterogeneous condition in which multiple pathological pathways manifest with similar symptoms. Severe asthma (SA) is challenging to manage and comprises a significant health and economic burden. Many studies have been conducted in an attempt to define different clinical phenotypes that translate into biological endotypes, with the goal of tailoring treatment based on precision medicine. This review summarizes the current evidence for the treatments of SA, and in particular, the biologic treatments that are currently available: omalizumab, mepolizumab, reslizumab, benralizumab and dupilumab. We found only limited high-quality direct evidence regarding treatment with anti-IgE (omalizumab) in SA patients. Data regarding anti-interleukin (IL)-5 (mepolizumab, reslizumab and benralizumab) showed beneficial effects in severe eosinophilic asthma (SEA) with different levels of blood eosinophils used in clinical trials. Dupilumab, anti-IL-4/IL-13, was shown to be effective in SEA and is the only agent currently FDA-approved for the indication of oral corticosteroid dependent asthma, regardless of the blood eosinophil level. This review also summarizes the existing knowledge regarding the characteristics of the patient who may respond to the different therapies. As of today, more studies are needed to better understand the diverse mechanisms that underlie SA phenotypes. We have not yet adequately reached the goal of precision medicine. Additional studies are necessary in order to find novel surrogate markers that can predict the response to a specific biologic therapy, especially in patients who are oral corticosteroid dependent. In addition, efforts must be invested into research looking for new treatment options for patients with non-type-2 inflammation SA. Statement of novelty: we review the current evidence regarding tailored treatment therapies in SA, with a particular focus on the knowledge regarding patient selection for specific biologic treatments.

scholarly journals Coating of Seeds with Collagen Hydrolysates from Leather Waste

2019 ◽  
Vol 27 (4(136)) ◽  
pp. 59-64 ◽  
Author(s):  
Katarzyna Ławińska ◽  
Magdalena Lasoń-Rydel ◽  
Dorota Gendaszewska ◽  
Edyta Grzesiak ◽  
Katarzyna Sieczyńska ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Growth And Yield ◽  
Collagen Hydrolysate ◽  
Drought Conditions ◽  
Different Types ◽  
Mineral Additive ◽  
Encapsulation Process ◽  
The Subject ◽  
Collagen Hydrolysates ◽  
The Impact

The subject of this paper is improvement in the growth and yield of three different types of legumes and rape in drought conditions by coating seeds with hydrolysed collagen from tanning waste. In addition, the impact of various additives in the seed shell on the growth of the plant was investigated. The encapsulation process of seeds was conducted on a disc granulator. A centrally placed seed was first coated with a layer of fungicides. The next layer was collagen hydrolysate, collagen hydrolysate with latex or a solution of yellow dextrin and polyvinyl alcohol. The outer layer was a mineral additive e.g. dolomite or kaolin. After the end of the encapsulation process on the disk granulator, all of the seeds tested were sown into soils. Seeds without coating were also sown as control seeds. Seedlings were maintained for 29 days with cultivation without irrigation. The length of the seedlings was analysed for all of the seeds sown. Higher seedling growth values were obtained for seeds coated with collagen hydrolysate in comparison with control seeds (without coating). The use of collagen hydrolysate gave slightly better results than in the case of a solution of dextrin with polyvinyl alcohol.

Comparative quality of life in patients randomized contemporaneously to docetaxel or abiraterone in the STAMPEDE trial.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 14-14 ◽  
Author(s):  
Hannah L. Rush ◽  
Adrian David Cook ◽  
Christopher D. Brawley ◽  
Laura Murphy ◽  
Archie Macnair ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Repeated Measures ◽  
Treatment Options ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Clinical Parameter ◽  
Cross Sectional ◽  
Multi Stage ◽  
Eortc Qlq

14 Background: Docetaxel (DOC) and abiraterone (ABI) both improve overall survival (OS) in men with locally advanced or metastatic hormone-sensitive prostate cancer (HSPC) but no head to head trials compare the 2 agents. STAMPEDE, a multi-arm multi-stage platform trial, recruited patients (pts) to treatments including DOC or ABI between Nov-11 and Mar-13. There was no evidence OS differed between DOC or ABI, thus quality of life (QOL) may increasingly inform treatment options. Methods: QOL scores were analysed in pts contemporaneously randomised to receive DOC or ABI, in addition to standard of care treatment. Self-assessment QOL questionnaires EORTC QLQ C30 and PR25 were completed during treatment and follow-up. These analyses focus on average global QOL over the first 2 years after randomisation, using repeated measures analysis, plus cross-sectional analyses at 3, 6, 12 and 24 months. A score difference of ≥4 points was pre-defined as clinically meaningful. Results: 173 men randomised to DOC and 342 men randomised to ABI participated in the QOL sub-study and contributed to this analysis. Baseline characteristics and proportion of missing data were similar between groups. Baseline global QOL scores were similar (mean (sd): DOC 77.8 (20) and ABI 78.0 (19.3)). Average global QOL over 2 years was higher in pts randomised to ABI than DOC, although the difference was statistically significant it did not meet the pre-defined clinical parameter (+3.9, 95%CI 0.6 to 7.1, p=0.021). Cross-sectional analyses showed clinically meaningful superior QOL in the ABI group at 3 and 6 months (+6.6, 95%CI 2.6 to 10.7, p=0.001; +8.0, 95%CI 3.6 to 12.3, p<0.001), but not at 1 or 2 years (+1.3, 95%CI -3.0 to 5.6, p=0.545; +4.5, 95%CI -0.25 to 9.2, p=0.063). An exploratory analysis indicated average QOL for pts with metastatic disease (n=207) was better in the ABI group (+4.44, 95%CI 0.2 to 8.6, p=0.036). Conclusion: Global QOL was significantly higher in the first 2 years of treatment for the ABI group compared to the DOC group, though did not meet the pre-defined clinically meaningful threshold. The majority of difference was seen in the first year of treatment. This should be considered when discussing treatment options with pts. Clinical trial information: NCT00268476.

The effect of collagen hydrolysates from silver carp (Hypophthalmichthys molitrix) skin on UV-induced photoaging in mice: molecular weight affects skin repair

2017 ◽  
Vol 8 (4) ◽  
pp. 1538-1546 ◽  
Author(s):  
Hongdong Song ◽  
Mengfei Meng ◽  
Xiaofeng Cheng ◽  
Bo Li ◽  
Chengtao Wang
Keyword(s):  
Molecular Weight ◽  
Silver Carp ◽  
Hypophthalmichthys Molitrix ◽  
Beneficial Effects ◽  
Skin Repair ◽  
Collagen Hydrolysates

LMCH exerted stronger beneficial effects on photoaging skin than HMCH and gelatin.

scholarly journals Clinical Effects of Topical Tacrolimus on Fox-Fordyce Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Hilal Kaya Erdoğan ◽  
Işıl Bulur ◽  
Zeliha Kaya
Keyword(s):  
Carbon Dioxide Laser ◽  
Treatment Options ◽  
Sweat Glands ◽  
Therapeutic Effects ◽  
Inflammatory Disorder ◽  
Clinical Effects ◽  
Apocrine Glands ◽  
Topical Tacrolimus ◽  
Beneficial Effects ◽  
Fractional Carbon Dioxide Laser

Fox-Fordyce Disease (FFD) is a rare, chronic, pruritic, inflammatory disorder of apocrine glands. It is characterized by dome-shaped, firm, discrete, skin-colored, and monomorphic perifollicular papules. The most common sites of involvement are axillae and anogenital and periareolar regions which are rich in apocrine sweat glands. Treatment is difficult. Topical, intralesional steroids, topical tretinoin, adapalene, clindamycin, benzoyl peroxide, oral contraceptives, isotretinoin, phototherapy, electrocauterisation, excision-liposuction and curettage, and fractional carbon dioxide laser are among the treatment options. In the literature, there are articles reporting beneficial effects of pimecrolimus in FFD. Nevertheless, there have not been any reports about the use of tacrolimus in FFD. We report two patients diagnosed with FFD by clinical and histopathologic examination and discussed therapeutic effects of topical tacrolimus on FFD in the light of literature.

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