scholarly journals Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 725
Author(s):  
Saeyeong Jeon ◽  
Youjin Lee ◽  
Daeho Ryu ◽  
Yoon Kyung Cho ◽  
Yena Lee ◽  
...  
Keyword(s):  
Light Emitting Diode ◽  
Neural Recording ◽  
Electrophysiological Recording ◽  
Light Emitting ◽  
Technological Advances ◽  
Neuroscience Research ◽  
Cell Type Specific ◽  
Novel Design

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

scholarly journals Light-emitting diode-based transcranial photoacoustic measurement of sagittal sinus oxyhemoglobin saturation in hypoxic neonatal piglets

2020 ◽  
Author(s):  
Jeeun Kang ◽  
Raymond C. Koehler ◽  
Shawn Adams ◽  
Ernest M. Graham ◽  
Emad M. Boctor
Keyword(s):  
Mean Squared Error ◽  
Light Emitting Diode ◽  
Cost Effective ◽  
Preclinical Study ◽  
Light Emitting ◽  
Neonatal Piglets ◽  
Sagittal Sinus ◽  
Photoacoustic Measurement

AbstractWe present a light-emitting diode (LED)-based transcranial photoacoustic measurement (LED-trPA) of oxyhemoglobin (HbO2) saturation at superior sagittal sinus (SSS) in hypoxic neonatal piglets. The optimal LED imaging wavelengths and frame averaging scheme were determined based on in vivo characterization of transcranial sensitivity. Based on the framework (690/850 nm with >20 frame averaging), graded hypoxia was successfully identified in neonatal piglets in vivo with less than 10.0 % of root mean squared error (RMSE). This preclinical study suggests the feasibility of a rapid, cost-effective, and safe LED-trPA monitoring of perinatal hypoxia-ischemia and prompt interventions for clinical use.

scholarly journals Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

2019 ◽  
Vol 116 (43) ◽  
pp. 21427-21437 ◽  
Author(s):  
Yi Zhang ◽  
Daniel C. Castro ◽  
Yuan Han ◽  
Yixin Wu ◽  
Hexia Guo ◽  
...  
Keyword(s):  
Large Scale ◽  
Light Emitting Diode ◽  
Single Experiment ◽  
Light Emitting ◽  
3 Dimensional ◽  
Neuronal Populations ◽  
Neuroscience Research ◽  
Wide Range ◽  
Temporal Profiles

Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation.

Characterization and Elimination of Forward Snapback Defects in GaAs Light Emitting Diodes

1996 ◽  
Author(s):  
J. Zimmer ◽  
D. Nielsen ◽  
T.A. Anderson ◽  
M. Schade ◽  
N. Saha ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Light Emitting Diode ◽  
Elevated Concentration ◽  
Forward Voltage ◽  
Light Emitting ◽  
Intermittent Yield ◽  
Si Doped ◽  
Secondary Ion ◽  
Furnace Pressure

Abstract The p-n junction of a GaAs light emitting diode is fabricated using liquid phase epitaxy (LPE). The junction is grown on a Si doped (~1018/cm3) GaAs substrate. Intermittent yield loss due to forward voltage snapback was observed. Historically, out of specification forward voltage (Vf) parameters have been correlated to abnormalities in the junction formation. Scanning electron (SEM) and optical microscopy of cleaved and stained samples revealed a continuous layer of material approximately 2.5 to 3.0 urn thick at the n-epi/substrate interface. Characterization of a defective wafer via secondary ion mass spectroscopy (SIMS) revealed an elevated concentration of O throughout the region containing the defect. X-ray Photoelectron Spectroscopy (XPS) and Auger Electron Spectroscopy (AES) data taken from a wafer prior to growth of the epi layers did not reveal any unusual oxidation or contamination. Extensive review of the processing data suggested LPE furnace pressure was the obvious source of variability. Processing wafers through the LPE furnace with a slight positive H2 gas pressure has greatly reduced the occurrence of this defect.

scholarly journals In vitro and in vivo Efficacy of New Blue Light Emitting Diode Phototherapy Compared to Conventional Halogen Quartz Phototherapy for Neonatal Jaundice

2005 ◽  
Vol 20 (1) ◽  
pp. 61 ◽  
Author(s):  
Yun Sil Chang ◽  
Jong Hee Hwang ◽  
Hyuk Nam Kwon ◽  
Chang Won Choi ◽  
Sun Young Ko ◽  
...  
Keyword(s):  
Blue Light ◽  
Neonatal Jaundice ◽  
Light Emitting Diode ◽  
In Vivo Efficacy ◽  
Light Emitting

Retinal damage related to high-intensity light-emitting diode exposure: An in vivo study

2021 ◽  
Author(s):  
Marcela Emílio de Araújo ◽  
Marina Bozzini Paies ◽  
Ana Beatriz Arrais ◽  
Fernando Ladd Lobo ◽  
Ruthnaldo Rodrigues Melo de Lima ◽  
...  
Keyword(s):  
High Intensity ◽  
Light Emitting Diode ◽  
In Vivo Study ◽  
Retinal Damage ◽  
Light Emitting ◽  
High Intensity Light

Design, Measurements and Characterization of Smart Electronic Board for PV Streetlight based on LED and High Intensity Discharge Lamps

2013 ◽  
pp. 153-165
Author(s):  
Paolo Visconti ◽  
Daniele Romanello ◽  
Giovanni Zizzari ◽  
Vito Ventura ◽  
Giorgio Cavalera
Keyword(s):  
Rural Areas ◽  
High Intensity ◽  
Light Emitting Diode ◽  
Light Emitting ◽  
Electronic Board ◽  
Lighting Systems ◽  
And Control ◽  
Near Future ◽  
Hid Lamps

This work presents an electronic board for driving and control of High Intensity Discharge (HID) lamps and Light Emitting Diode (LED) lamps. The proposed electronic board is able to drive HID or LED lamps by means of a reconfigurable output. This feature allows using the ballast in lighting systems that currently use traditional discharge lamps, as well as keeping the same ballast when discharge lamps are replaced by LED modules in the near future, when LED street lighting systems will be more affordable. Additionally, since the lighting system is designed to be used in rural areas where there is no public electricity, each lighting point incorporates a system to convert solar energy into continuous voltage by means of photovoltaic panels. In this work, energy saving issues are taken into account.

scholarly journals Fabrication and Characterization of Light Emitting Diode Based on n-ZnO Nanorods Grown Via a Low-Temperature

2020 ◽  
Vol 1535 ◽  
pp. 012009
Author(s):  
Sabah M. Mohammad ◽  
Nabeel M. Abd-Alghafour ◽  
Z. Hassan ◽  
Naser M. Ahmed ◽  
Amal Mohamed Ahmed Ali ◽  
...  
Keyword(s):  
Low Temperature ◽  
Light Emitting Diode ◽  
Zno Nanorods ◽  
Light Emitting ◽  
Fabrication And Characterization
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