scholarly journals Cordidepsine is A Potential New Anti-HIV Depsidone from Cordia millenii, Baker

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3202
Author(s):  
Rostanie Dongmo Zeukang ◽  
Xavier Siwe-Noundou ◽  
Maurice Tagatsing Fotsing ◽  
Turibio Tabopda Kuiate ◽  
Joseph Tanyi Mbafor ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
2D Nmr ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Hiv Integrase ◽  
Etoac Extract ◽  
X Ray Crystallography ◽  
Chemical Structures ◽  
First Time ◽  
Anti Hiv

Chemical investigation of Cordia millenii, Baker resulted in the isolation of a new depsidone, cordidepsine (1), along with twelve known compounds including cyclooctasulfur (2), lup-20(29)-en-3-triacontanoate (3), 1-(26-hydroxyhexacosanoyl)glycerol (4), glyceryl-1-hexacosanoate (5) betulinic acid (6), lupenone (7), β-amyrone (8), lupeol (9), β-amyrin (10), allantoin (11), 2′-(4-hydroxyphenyl)ethylpropanoate (12) and stigmasterol glycoside (13). Hemi-synthetic reactions were carried out on two isolated compounds (5 and 6) to afford two new derivatives, that is, cordicerol A (14) and cordicerol B (15), respectively. The chemical structures of all the compounds were established based on analysis and interpretation of spectroscopic data such as electron ionization mass spectrometry (EI–MS), high resolution electrospray ionization mass spectrometry (HR-ESI–MS), fast atom bombardment mass spectrometry (FAB–MS), one dimension and two dimension nuclear magnetic resonance (1D and 2D-NMR) spectral data as well as X-ray crystallography (XRC). Lupeol ester derivatives [Lup-20(29)-en-3-triacontanoate (3)], monoglycerol derivatives [1-(26-hydroxyhexacosanoyl)glycerol (4) and glyceryl-1 hexacosanoate (5)] were isolated for the first time from Cordia genus while sulfur allotrope [cyclooctasulfur (2)] was isolated for the first time from plant origin. Biological assays cordidepsine (1) exhibited significant anti-HIV integrase activity with IC50 = 4.65 μM; EtOAc extract of stem barks, EtOAc fraction of roots and leaves were not toxic against 3T3 cells.

scholarly journals Dolichols of the fern Matteucia struthiopteris.

2005 ◽  
Vol 52 (1) ◽  
pp. 255-259 ◽  
Author(s):  
Magdalena Wojtas ◽  
Tomasz Bieńkowski ◽  
Monika Zelman-Femiak ◽  
Seiji Tateyama ◽  
Hiroshi Sagami ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Plant Tissue ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Fresh Weight ◽  
Esi Ms ◽  
Fresh Plant ◽  
First Time

Dolichols isolated from leaves of the fern Matteucia struthiopteris were present as a mixture of prenologues composed of 14 up to 20 isoprene units with Dol-16 dominating. They comprised approximately 0.004% of the fresh weight of fresh plant tissue and were accompanied by traces of polyprenols (Pren-14 up to Pren-17, Pren-16 dominating). Their structure was confirmed by electropray ionization mass spectrometry (ESI-MS). This is the first time that dolichols have been reported as dominating polyisoprenoid alcohols in plant photosynthetic tissue.

Combined analysis of 1,3-benzodioxoles by crystalline sponge X-ray crystallography and laser desorption ionization mass spectrometry

The Analyst ◽  
2018 ◽  
Vol 143 (6) ◽  
pp. 1475-1481 ◽  
Author(s):  
Yukako Hayashi ◽  
Kazuaki Ohara ◽  
Rika Taki ◽  
Tomomi Saeki ◽  
Kentaro Yamaguchi
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Promising Method ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Combined Analysis ◽  
X Ray ◽  
X Ray Crystallography ◽  
Desorption Ionization

The combination of X-ray analysis and laser desorption ionization by using crystalline sponge will be a promising method to determine guest structures.

The in situ analysis of organic matter in soils

2001 ◽  
Vol 81 (3) ◽  
pp. 249-254 ◽  
Author(s):  
Morris Schnitzer
Keyword(s):  
Mass Spectrometry ◽  
Organic Matter ◽  
Solid State ◽  
In Situ Analysis ◽  
Ionization Mass Spectrometry ◽  
Field Ionization ◽  
Ionization Mass ◽  
Chemical Structures ◽  
C Nmr

Traditionally, studies on soil organic matter (SOM) begin with the extraction of SOM from soils, its fractionation into humic acid, fulvic acid, and humin, followed by de-ashing of each fraction. These are tedious, laborious and inefficient procedures that do not provide any chemical information on these materials. Instead, recently developed methods such as solid-state 13C NMR and pyrolysis – field ionization mass spectrometry (Py-FIMS) can now be used for the in situ analysis of SOM in soils. These methods identify the major chemical components of SOM without extractions and fractionations, and yield valuable information on the main chemical structures in these materials. A better knowledge of the structural chemistry of SOM will help SOM chemists and other soil scientists to better understand the complex chemical and biochemical reactions that occur in soils, and will enable them to develop practices that will improve soil management and soil productivity. Key words: Extraction, fractionation, solid state 13C NMR, pyrolysis-field ionization mass spectrometry, chemical composition

scholarly journals MASS SPECTROMETRY OF GLYCYRRETHENIC ACID COMPLEXES WITH STRIPTOMYCINES

2019 ◽  
pp. 119-126
Author(s):  
Елена (Elena) Владимировна (Vladimirovna) Ветрова (Vetrova) ◽  
Николай (Nikolay) Иванович (Ivanovich) Борисенко (Borisenko) ◽  
Анна (Anna) Владимировна (Vladimirovna) Лекарь (Lekar') ◽  
Елена (Elena) Владимировна (Vladimirovna) Максименко (Maksimenko) ◽  
Сергей (Sergey) Николаевич (Nikolaevich) Борисенко (Borisenko) ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Bathochromic Shift ◽  
Glycyrrhetinic Acid ◽  
Ionization Mass Spectrometry ◽  
Supramolecular Complexes ◽  
Ionization Mass ◽  
Molar Ratios ◽  
First Time

For the first time, complexes of glycyrrhetinic acid (GLA) with the antibiotic streptomycin (ST) have been studied. The complexes, obtained at different molar ratios of "host - GLA: guest - ST": 1 : 1, 2 : 1, 3 : 1 and 4 : 1, were studied using both spectrophotometry and electrospray ionization mass spectrometry. With increasing GLA concentration using spectrophotometry, the bathochromic shift of the maximum absorption of the MFR (203–210 nm) and the formation of an additional peak (260–273 nm) in the ST absorption spectrum are observed, indicating the formation of supramolecular complexes of different glycyrrhetinic acid stoichiometry with streptomycin antibiotic. Using electrospray ionization mass spectrometry, signals of nGLK-ST heterocomplexes containing GLA and CTP in the ratio of 1 : 1, 2 : 1, 3 : 1 and 4 : 1 were recorded, respectively. It has been shown that with increasing GLA concentration, the supramolecular structures are enlarged due to an increase in the number of GLA molecules in its composition. The presented data can be used in the development of a new dosage form of streptomycin based on supramolecular complexes with GLA.

Cytotoxic and Pro-apoptotic Activities of Diterpenoids from Zhumeria Majdae

2020 ◽  
Vol 17 ◽  
Author(s):  
Abolfazl Shakeri ◽  
Samira Navabi Nejad ◽  
Javad Asili ◽  
Milena Masullo ◽  
Mansoor Saeidi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cytotoxic Effect ◽  
Therapeutic Agent ◽  
2D Nmr ◽  
Etoac Extract ◽  
Chemical Structures ◽  
Ic50 Value ◽  
Cytotoxic Compounds ◽  
First Time ◽  
Mcf 7

Abstract:: Since the ethylacetate (EtOAc) extract of the roots of Zhumeria majdae had the potent cytotoxic effect (IC50 < 50 μg/ml) on three cancer cell lines; MCF-7, PC3 and MDA-MB-231, therefore the purpous of this study is to isolation of the responcible cytotoxic compounds from the plant. Isolation of the extract led to the identification of four diterpenoids named as lanugon Q (1), 12,16-dideoxy aegyptinone B (2), 12-deoxy-salvipisone (3) and manool (4). The chemical structures have been determined on the basis of 1D and 2D NMR experiments. Compound 1 is reported for the first time in the plants of Zhumeria genus. The results of cytotoxic and apoptotic evaluation revealed that compound 2 had the strong cytotoxic effect with the IC50 value of 15.90 μg/ml against MCF-7 cell lines. Sub-G1 peak in flow cytometry histogram of cells treated with EtOAc axtract and compound 2 showed the induction of apoptosis. Changes in the Bax/Bcl-2 ratio and cleavage of PARP were observed. It is to be noted that owing to strong cytotoxic effect, Z. majdae extract could be represented as therapeutic agent against cancer.

scholarly journals Probing surfaces of atmospherically relevant organic particles by easy ambient sonic-spray ionization mass spectrometry (EASI-MS)

2019 ◽  
Vol 10 (3) ◽  
pp. 884-897 ◽  
Author(s):  
L. M. Wingen ◽  
B. J. Finlayson-Pitts
Keyword(s):  
Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Promising Technique ◽  
Sonic Spray Ionization ◽  
Chemical Structures ◽  
Organic Particles ◽  
Atmospherically Relevant

EASI-MS is a promising technique for probing the chemical structures of inhomogeneous airborne organic particles.

Direct and fast detection of chlorothalonil in soil samples using laser desorption VUV single photon post-ionization mass spectrometry

2015 ◽  
Vol 7 (16) ◽  
pp. 6890-6895 ◽  
Author(s):  
Ping Liu ◽  
Yongjun Hu ◽  
Guichi Zhu ◽  
Qing Yang ◽  
Yanmin Tao
Keyword(s):  
Mass Spectrometry ◽  
Single Photon ◽  
Laser Desorption ◽  
Soil Samples ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Soil P ◽  
Fast Detection ◽  
First Time

A novel laser desorption VUV single photon post-ionization mass spectrometry (LDPI-MS) method has been applied for the first time for the direct and fast detection of chlorothalonil in soil.

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