scholarly journals Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3398
Author(s):  
Farid B. Cortés ◽  
Karol Zapata ◽  
Benjamín A. Rojano ◽  
Francisco Carrasco-Marín ◽  
Jaime Gallego ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Sol Gel ◽  
Desorption Kinetics ◽  
Type I ◽  
Carbon Xerogel ◽  
Batch Mode ◽  
Dual Purpose ◽  
Delayed Release ◽  
Kinetics Of

The main objective of this study is to develop a novel dual-purpose material based on carbon xerogel microspheres (CXMs) that permits the delayed release of cannabidiol (CBD) and the removal of aflatoxin. The CXMs were prepared by the sol-gel method and functionalized with phosphoric acid (CXMP) and melamine (CXMN). The support and the modified materials were characterized by scanning electronic microscopy (SEM), N2 adsorption at −196 °C, X-ray photoelectron spectroscopy (XPS), and zeta potential. For the loading of the cannabidiol (CBD) in the porous samples, batch–mode adsorption experiments at 25 °C were performed, varying the concentration of CBD. The desorption kinetics was performed at two conditions for simulating the gastric (pH of 2.1) and intestinal (pH of 7.4) conditions at 37 °C based on in vitro CBD release. Posteriorly, the samples obtained after desorption were used to study aflatoxin removal, which was evaluated through adsorption experiments at pH = 7.4 and 37 °C. The adsorption isotherms of CBD showed a type I(b) behavior, with the adsorbed uptake being higher for the support than for the modified materials with P and N. Meanwhile, the desorption kinetics of CBD at gastric conditions indicated release values lower than 8%, and the remaining amount was desorbed at pH = 7.4 in three hours until reaching 100% based on the in vitro experiments. The results for aflatoxin showed total removal in less than 30 min for all the materials evaluated. This study opens a broader landscape in which to develop dual-purpose materials for the delayed release of CBD, improving its bioavailability and allowing aflatoxin removal in gastric conditions.

scholarly journals Synthesis, characterization and in vitro cytotoxicity study of Co and Ni ferrite nanoparticles prepared by sol-gel method

2021 ◽  
Vol 3 (7) ◽  
Author(s):  
Alexandre Pancotti ◽  
Dener Pereira Santos ◽  
Dielly Oliveira Morais ◽  
Mauro Vinícius de Barros Souza ◽  
Débora R. Lima ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Sol Gel ◽  
Test Sample ◽  
In Vitro Cytotoxicity ◽  
Gel Method ◽  
X Ray ◽  
Sol Gel Method ◽  
Transmission Electron ◽  
Crystallite Sizes

AbstractIn this study, we report the synthesis and characterization of NiFe2O4 and CoFe2O4 nanoparticles (NPs) which are widely used in the biomedical area. There is still limited knowledge how the properties of these materials are influenced by different chemical routes. In this work, we investigated the effect of heat treatment over cytotoxicity of cobalt and niquel ferrites NPs synthesized by sol-gel method. Then the samples were studied using transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), Fourier Transform Infrared Spectroscopy Analysis (FTIR), and X-ray fluorescence (XRF). The average crystallite sizes of the particles were found to be in the range of 20–35 nm. The hemocompatibility (erythrocytes and leukocytes) was checked. Cytotoxicity results were similar to those of the control test sample, therefore suggesting hemocompatibility of the tested materials.

Adsorption–desorption kinetics of silica coated on textile fabrics by the sol–gel process

2019 ◽  
Vol 17 (2) ◽  
pp. 371-380 ◽  
Author(s):  
Mohamed El messoudi ◽  
Aicha Boukhriss ◽  
Omar Cherkaoui ◽  
M’hammed El kouali ◽  
Said Gmouh
Keyword(s):  
Sol Gel ◽  
Desorption Kinetics ◽  
Textile Fabrics ◽  
Sol Gel Process ◽  
Adsorption Desorption ◽  
Kinetics Of

scholarly journals SiO Desorption Kinetics of Si(111) Surface Oxidation Studied by Real-Time Photoelectron Spectroscopy

2013 ◽  
Vol 11 (0) ◽  
pp. 116-121 ◽  
Author(s):  
Jiayi Tang ◽  
Kiwamu Nishimoto ◽  
Shuichi Ogawa ◽  
Akitaka Yoshigoe ◽  
Shinji Ishidzuka ◽  
...  
Keyword(s):  
Real Time ◽  
Photoelectron Spectroscopy ◽  
Surface Oxidation ◽  
Desorption Kinetics ◽  
Kinetics Of

scholarly journals Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications

2013 ◽  
Vol 11 (10) ◽  
pp. 1657-1667 ◽  
Author(s):  
Georgeta Voicu ◽  
Alina Bădănoiu ◽  
Ecaterina Andronescu ◽  
Carmen Chifiruc
Keyword(s):  
Sol Gel ◽  
Mineral Trioxide Aggregate ◽  
Crystalline Lattice ◽  
Blue Staining ◽  
Starting Mixture ◽  
Induced Changes ◽  
Dental Applications ◽  
Kinetics Of ◽  
Mineralogical Phases

AbstractMaterials for dental applications, i.e., white mineral trioxide aggregate (WMTA) and partial stabilized cements (PSC) were obtained using the sol-gel method. The presence of ZnO or/and CaF2 additions in the starting mixture induced changes in the composition, morphology and grindability of PSCs as compared with WMTA. The presence of foreign elements (Zn or F) in the crystalline lattice of mineralogical phases, increased their grindability. Thermal analysis (TG&DTA) was used to assess the kinetics of hydration process in binding systems based on WMTA/PSCs. The presence of foreign elements in PSCs systems increases the reactivity vs. water of these materials and consequently, the compressive strength developed after 28 days of hardening at 37°C are higher as compared with WMTA. The in vitro bioevaluation results (trypan blue staining, eukaryotic cells cycle assay by flowcytometry) accounted for a high biocompatibilty of the obtained materials demonstrating their potential use for biomedical applications.

scholarly journals Novel antibacterial bioactive glass nanocomposite functionalized with tetracycline hydrochloride

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Josefina Rivadeneira ◽  
Gisela M. Luz ◽  
M. Carina Audisio ◽  
João F. Mano ◽  
Alejandro A. Gorustovich
Keyword(s):  
Bioactive Glass ◽  
Sol Gel ◽  
Inhibition Zone ◽  
Collagen Type I ◽  
Tetracycline Hydrochloride ◽  
Plate Count ◽  
Type I ◽  
Wound Infections ◽  
Chemical Route

AbstractTo prevent the high frequency of wound infections, anti-bacterial agents can be loaded onto composites. In the present study, the antibiotic tetracycline hydrochloride (TC)was incorporated, for the first time, in collagen type I membranes coated with nano-sized SiO2-CaOP2O5 bioactive glass (n-BG) obtained by a sol-gel chemical route. Collagen membranes coated with n-BG were immersed in simulated body fluid (SBF) containing 0.25, 0.75 or 1.25 mg mL−1 of TC for 48 h at 37∘C following a coprecipitation method. The antibiotic was released in distilledwater at 37∘C for up to 72 h. The antibacterial activity of the composites was evaluated in vitro by the inhibition zone test and plate count method. Two different Staphylococcus aureus strains, S. aureus ATCC29213 and S. aureus ATCC25923, were exposed to the biomaterials. The results showed that the incorporation but not the release of TC was dependent on the initial concentration of TC in SBF. The biomaterials inhibited S. aureus growth, although the efficacy was similar for all the concentrations. The results allow us to conclude that the new composite could have potential in the prevention of wound infections.

scholarly journals Organic/Inorganic bioactive materials Part II: in vitro bioactivity of Collagen-Calcium Phosphate Silicate/Wollastonite hybrids

2009 ◽  
Vol 7 (4) ◽  
pp. 711-720 ◽  
Author(s):  
Lachezar Radev ◽  
Vladimir Hristov ◽  
Bisserka Samuneva ◽  
Dimitrina Ivanova
Keyword(s):  
Calcium Phosphate ◽  
Sol Gel ◽  
Ceramic Powder ◽  
Red Shift ◽  
Type I ◽  
Carbonate Apatite ◽  
Bioactive Materials ◽  
Carboxylate Groups ◽  
Phosphate Silicate

AbstractIn the present study, novel hybrid materials of Collagen (C) and Calcium Phosphate Silicate/Wollastonite (CPS/W) were synthesized. The CPS/W ceramic was prepared via polystep sol-gel method. The dissolution test of CPS/W ceramic was filled with TRIS-HCl buffer. FTIR depicts that hydroxyl carbonate apatite (OHCO3HA) was observed after 3 days of immersion in TRIS-HCl buffer. Biohybrids of C-CPS/W were produced from diluted hydrochloric acid collagen type I and ceramic powder with different ratios of C and CPS/W equal to 25:75 and 75:25 wt.%. The synthesized hybrids were characterized by FTIR, XRD and SEM. FTIR depicts a “red shift” if amide I could be attributed to the fact that the collagen prefers to chelate Ca2+ from partial dissolution of CPS/W ceramic. The growth of B-type carbonate containing hydroxyapatite (B-CO3HA) on the C-CPS/W hybrids soaked in 1.5SBF was observed. The negatively charged carboxylate groups from the collagen may be responsible for hydroxyapatite (HA) deposition. This fact was confirmed by the “red shift” of carboxylate groups of collagen in FTIR spectra. The formation of HA was observed by FTIR, XRD and SEM.

scholarly journals Organic / inorganic bioactive materials Part I: Synthesis, structure and in vitro assessment of collagen/silicocarnotite biocoatings

2009 ◽  
Vol 7 (4) ◽  
pp. 702-710 ◽  
Author(s):  
Vladimir Hristov ◽  
Lachezar Radev ◽  
Bisserka Samuneva ◽  
Georgi Apostolov
Keyword(s):  
Type I Collagen ◽  
Sol Gel ◽  
Weight Ratio ◽  
Type I ◽  
Bioactive Materials ◽  
Organic Part ◽  
Carboxylate Groups ◽  
Cross Linkage ◽  
Collagen Molecules

AbstractThe silicocarnotite, as an inorganic part of the coatings, has been synthesized using a polystep sol-gel method. The chemical composition of the prepared silicocarnotite sol is described as 58.12 CaO, 29.42 P2O5, 12.45 SiO2 (wt%), where Ca/P+Si = 1,67. The acid soluble type I collagen, as an organic part of the obtained coatings, was mixed with silicocarnotite powder in a weight ratio of 25:75 and 75:25 weight ratio without cross-linkage. The acidity of the obtained mixture was readjust with 25% NH4OH to pH = 9.0. The mixture was then dried at 37°C for 12 h.The growth of B-type carbonate containing hydroxyapatite (B-type CO3HA) in which CO3 2+→PO4 3− on the surface of collagen/silicocarnotite coatings soaked in 1.5 simulated body fluid (1.5 SBF) was observed. The nucleation of B-type CO3HA was estimated on the obtained coatings after 3 days immersion in 1.5 SBF. The negatively charged carboxylate groups from the collagen surface may be responsible for the HA deposition. This was confirmed by the “red shift” of carboxylate groups of collagen molecules in the FTIR spectra. After soaking in 1.5 SBF, the morphology of prepared coatings and HA formation was observed by SEM.

Study on the Effects of Type I Collagen Combined with Noncollagenous Proteins on Hydroxyapatite Formation in vitro using SPM and GIXD

2009 ◽  
Vol 1238 ◽  
Author(s):  
Xiaolan Ba ◽  
Elaine DiMasi ◽  
Miriam H Rafailovich
Keyword(s):  
Type I Collagen ◽  
Early Stage ◽  
Cooperative Interaction ◽  
Type I ◽  
X Ray Diffraction ◽  
Noncollagenous Proteins ◽  
Force Microscopy ◽  
Kinetics Of

AbstractThe effects of the components of extracellular matrix on the bone formation and the kinetics of crystal growth of calcium phosphate have remained unknown. In this paper, we reported a method to investigate the role of Type I collagen and the interactions with other ECM proteins such as fibronectin and elastin during biomimic mineralization process in vitro. The early stage of mineralization was characterized by scanning probe microscopy (SPM) and shear modulation force microscopy (SMFM). The late stage of mineralization was investigated by synchrotron grazing incident x-ray diffraction (GIXD). The results demonstrate the cooperative interaction between type I collagen and noncollagenous proteins such as fibronectin or elastin could be essential for the biomineralization.

In Vitro Behavior of Magnesium Apatite Coatings in Organic Modified Simulated Body Fluid

2011 ◽  
Vol 299-300 ◽  
pp. 508-511
Author(s):  
Guo Chao Qi ◽  
Feng Jun Shan ◽  
Qiang Li ◽  
Jing Yuan Yu ◽  
Qu Kai Zhang
Keyword(s):  
Simulated Body Fluid ◽  
Photoelectron Spectroscopy ◽  
Body Fluid ◽  
Sol Gel ◽  
Dip Coating ◽  
X Ray ◽  
Coating Method ◽  
Sbf Solution ◽  
Dip Coating Method

Magnesium apatite (MA, (Ca9Mg)(PO4)6(OH)2) and Hydroxyapatite (HA) coatings were synthesized on Ti6Al4V substrates by a sol-gel dip coating method. Glucose and bovine serum albumin (BSA) were added to the standard simulated body fluid (SBF) separately to form organic-containing simulated body fluids. MA and HA coatings were immersed in standard and organic modified SBF for time periods of 4, 7, 14, 21 and 28 days at 37±1°C. The surface dissolution and deposition behavior of the coatings after soaking were examined with Scanning Electron Microscopy (SEM) and X-ray Photoelectron Spectroscopy (XPS). The results show that glucose in SBF has no apparent effect on the deposition of new apatite from the solution. BSA in SBF shows retardation effect on the deposition of apatite by forming a protein dominant globular layer. This layer inhibits the further deposition of apatite from SBF solution.

scholarly journals Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

Materials ◽  
2019 ◽  
Vol 12 (6) ◽  
pp. 847 ◽  
Author(s):  
Urban Ajdnik ◽  
Lidija Zemljič ◽  
Matej Bračič ◽  
Uroš Maver ◽  
Olivija Plohl ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Chitosan Nanoparticles ◽  
Antimicrobial Properties ◽  
Desorption Kinetics ◽  
Biofilm Inhibition ◽  
Tympanostomy Tubes ◽  
Potential Applications ◽  
Amoxicillin Clavulanic Acid ◽  
Pre Treatment

Silicones are widely used medical materials that are also applied for tympanostomy tubes with a trending goal to functionalise the surface of the latter to enhance the healing of ear inflammations and other ear diseases, where such medical care is required. This study focuses on silicone surface treatment with various antimicrobial coatings. Polysaccharide coatings in the form of chitosan nanoparticles alone, or with an embedded drug mixture composed of amoxicillin/clavulanic acid (co-amoxiclav) were prepared and applied onto silicone material. Plasma activation was also used as a pre-treatment for activation of the material’s surface for better adhesion of the coatings. The size of the nanoparticles was measured using the DLS method (Dynamic Light Scattering), stability of the dispersion was determined with zeta potential measurements, whilst the physicochemical properties of functionalised silicone materials were examined using the UV-Vis method (Ultraviolet-Visible Spectroscopy), SEM (Scanning Electron Microscopy), XPS (X-Ray Photoelectron Spectroscopy). Moreover, in vitro drug release testing was used to follow the desorption kinetics and antimicrobial properties were tested by a bacterial cell count reduction assay using the standard gram-positive bacteria Staphylococcus aureus. The results show silicone materials as suitable materials for tympanostomy tubes, with the coating developed in this study showing excellent antimicrobial and biofilm inhibition properties. This implies a potential for better healing of ear inflammation, making the newly developed approach for the preparation of functionalised tympanostomy tubes promising for further testing towards clinical applications.

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