scholarly journals Daylight Photodynamic Therapy: An Update

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5195
Author(s):  
Chaw-Ning Lee ◽  
Rosie Hsu ◽  
Hsuan Chen ◽  
Tak-Wah Wong
Keyword(s):  
Photodynamic Therapy ◽  
Skin Cancer ◽  
20Th Century ◽  
Actinic Keratosis ◽  
Skin Diseases ◽  
Aminolevulinic Acid ◽  
Review Article ◽  
Skin Cancers ◽  
Superficial Skin ◽  
Pros And Cons

Daylight photodynamic therapy (dPDT) uses sunlight as a light source to treat superficial skin cancer. Using sunlight as a therapeutic device has been present for centuries, forming the basis of photodynamic therapy in the 20th century. Compared to conventional PDT, dPDT can be a less painful, more convenient and an effective alternative. The first clinical uses of dPDT on skin cancers began in Copenhagen in 2008. Currently, aminolevulinic acid-mediated dPDT has been approved to treat actinic keratosis patients in Europe. In this review article, we introduce the history and mechanism of dPDT and focus on the pros and cons of dPDT in treating superficial skin cancers. The future applications of dPDT on other skin diseases are expected to expand as conventional PDT evolves.

5-Aminolevulinic acid photodynamic therapy with and without Er:YAG laser for actinic keratosis: Changes in immune infiltration

2019 ◽  
Vol 26 ◽  
pp. 270-276 ◽  
Author(s):  
Emese Gellén ◽  
Eszter Fidrus ◽  
Eszter Janka ◽  
Sándor Kollár ◽  
György Paragh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Actinic Keratosis ◽  
Aminolevulinic Acid ◽  
Er:Yag Laser ◽  
Immune Infiltration

scholarly journals 770Clinical results of photodynamic therapy for superficial skin malignancies or actinic keratosis using topical 5-aminolaevulinic acid

1996 ◽  
Vol 40 ◽  
pp. S196
Author(s):  
P.J.N. Meijnders ◽  
W.M. Star ◽  
R.S. de Bruijn ◽  
M.J.M. van Mierto ◽  
S.J.M. Wijthoff ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Actinic Keratosis ◽  
Aminolaevulinic Acid ◽  
Superficial Skin

scholarly journals Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases

2017 ◽  
Vol 9 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Virginia Garofalo ◽  
Alessandra Ventura ◽  
Sara Mazzilli ◽  
Laura Diluvio ◽  
Luca Bianchi ◽  
...  
Keyword(s):  
High Risk ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Medical Device ◽  
Actinic Keratosis ◽  
Organ Transplant ◽  
Cyclooxygenase Inhibitors ◽  
Organ Transplant Recipient ◽  
Skin Cancers ◽  
Melanoma Skin

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers. Topical application of cyclooxygenase inhibitors such as diclofenac and, more recently, piroxicam has shown to reduce AK lesions in immunocompetent subjects. A medical device containing piroxicam and SPF 50+ sunscreen filters (P+SS) has been demonstrated to be effective in reducing AK lesions and improving the field of cancerization. We report the effect of P+SS, applied for 16 weeks, in a case series of 10 OTR subjects with multiple AK lesions. P+SS treatment was associated with a relevant AK lesion reduction (>75%) in 7 patients (with a complete clearance in 3 subjects) with an improvement in the field of cancerization. This medical device could be considered a promising long-term curative and preventive treatment in OTR patients at high risk of non-melanoma skin cancers.

scholarly journals Techniques for fluorescence detection of protoporphyrin IX in skin cancers associated with photodynamic therapy

2013 ◽  
Vol 2 (4) ◽  
Author(s):  
Kishore R. Rollakanti ◽  
Stephen C. Kanick ◽  
Scott C. Davis ◽  
Brian W. Pogue ◽  
Edward V. Maytin
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Detection ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Skin Lesions ◽  
Wide Field ◽  
Detection Techniques ◽  
Current State ◽  
Therapeutic Outcomes ◽  
Skin Cancers

AbstractPhotodynamic therapy (PDT) is a treatment modality that uses a specific photosensitizing agent, molecular oxygen, and light of a particular wavelength to kill cells targeted by the therapy. Topically administered aminolevulinic acid (ALA) is widely used to effectively treat cancerous and precancerous skin lesions, resulting in targeted tissue damage and little to no scarring. The targeting aspect of the treatment arises from the fact that ALA is preferentially converted into protoporphyrin IX (PpIX) in neoplastic cells. To monitor the amount of PpIX in tissues, techniques have been developed to measure PpIX-specific fluorescence, which provides information useful for monitoring the abundance and location of the photosensitizer before and during the illumination phase of PDT. This review summarizes the current state of these fluorescence detection techniques. Non-invasive devices are available for point measurements, or for wide-field optical imaging, to enable monitoring of PpIX in superficial tissues. To gain access to information at greater tissue depths, multi-modal techniques are being developed which combine fluorescent measurements with ultrasound or optical coherence tomography, or with microscopic techniques such as confocal or multiphoton approaches. The tools available at present, and newer devices under development, offer the promise of better enabling clinicians to inform and guide PDT treatment planning, thereby optimizing therapeutic outcomes for patients.

scholarly journals Overview on Topical 5-ALA Photodynamic Therapy Use for Non Melanoma Skin Cancers

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Carmen Cantisani ◽  
Giovanni Paolino ◽  
Valentina Faina ◽  
Federica Frascani ◽  
Franca Cantoresi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Skin Diseases ◽  
Leisure Activities ◽  
Noninvasive Technique ◽  
Biological Damage ◽  
Skin Cancers ◽  
Wide Range ◽  
Health Significance ◽  
Cure Rates ◽  
Common Malignancy

Ultraviolet radiation (UV) contributes to a variety of skin diseases including inflammation, degenerative aging, and cancer. Historically, humans have been exposed to UV radiation mainly through occupational exposure; recreational UV exposure, however, has increased dramatically in recent years, because of outdoor leisure activities and to purposely tan for cosmetic purposes. Both UVB and UVA radiation have been shown to cause DNA damage and immunosuppression, the important forms of biological damage that lead to NMSC. Nonmelanoma skin cancer (NMSC) is the most common malignancy, whose public health significance is often unrecognized which continues to grow at an alarming rate, becoming an occupational disease. Available treatments alternative to surgery include photodynamic therapy, electrochemotherapy, cryotherapy, ablative lasers, 5-fluorouracil, imiquimod, ingenol mebutate, and diclofenac. Among these, photodynamic therapy is a noninvasive technique with excellent cosmetic outcome and good curative results, when used in initial stages of skin cancers for superficial lesions. It is administered under numerous and significantly varied regimens and there are a wide range of cure rates reported, permitting treatment of large and multiple lesions with excellent cosmetic results. This is an overview of photodynamic applications especially for the treatment of NMSC, with a short focus on daylight modality.

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