scholarly journals Infrared Nanospectroscopy Reveals DNA Structural Modifications upon Immobilization onto Clay Nanotubes

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1103
Author(s):  
Federica Piccirilli ◽  
Franco Tardani ◽  
Annalisa D’Arco ◽  
Giovanni Birarda ◽  
Lisa Vaccari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Infrared Spectroscopy ◽  
Halloysite Nanotubes ◽  
Structural Modifications ◽  
Spatially Resolved ◽  
Naturally Occurring ◽  
Versatile Tool ◽  
Partial Covering ◽  
Clay Nanotubes ◽  
Absorption Measurements

The growing demand for innovative means in biomedical, therapeutic and diagnostic sciences has led to the development of nanomedicine. In this context, naturally occurring tubular nanostructures composed of rolled sheets of alumino-silicates, known as halloysite nanotubes, have found wide application. Halloysite nanotubes indeed have surface properties that favor the selective loading of biomolecules. Here, we present the first, to our knowledge, structural study of DNA-decorated halloysite nanotubes, carried out with nanometric spatially-resolved infrared spectroscopy. Single nanotube absorption measurements indicate a partial covering of halloysite by DNA molecules, which show significant structural modifications taking place upon loading. The present study highlights the constraints for the use of nanostructured clays as DNA carriers and demonstrates the power of super-resolved infrared spectroscopy as an effective and versatile tool for the evaluation of immobilization processes in the context of drug delivery and gene transfer.

Brain Drug Delivery: Overcoming the Blood-brain Barrier to Treat Tauopathies

2020 ◽  
Vol 26 (13) ◽  
pp. 1448-1465 ◽  
Author(s):  
Jozef Hanes ◽  
Eva Dobakova ◽  
Petra Majerova
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Neurodegenerative Disorders ◽  
Brain Barrier ◽  
Neuronal Function ◽  
Brain Drug Delivery ◽  
Naturally Occurring ◽  
Blood Brain ◽  
Traditional Approaches ◽  
The Brain

Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The application of potentially effective therapeutics for their successful treatment is hampered by the presence of a naturally occurring brain protection layer called the blood-brain barrier (BBB). BBB represents one of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders, where sufficient BBB penetration is inevitable. BBB is a heavily restricting barrier regulating the movement of molecules, ions, and cells between the blood and the CNS to secure proper neuronal function and protect the CNS from dangerous substances and processes. Yet, these natural functions possessed by BBB represent a great hurdle for brain drug delivery. This review is concentrated on summarizing the available methods and approaches for effective therapeutics’ delivery through the BBB to treat neurodegenerative disorders with a focus on tauopathies. It describes the traditional approaches but also new nanotechnology strategies emerging with advanced medical techniques. Their limitations and benefits are discussed.

Resin-based dental materials containing 3-aminopropyltriethoxysilane modified halloysite-clay nanotubes for extended drug delivery

2021 ◽  
Vol 37 (3) ◽  
pp. 508-515
Author(s):  
Ashley Karczewski ◽  
Sara Kalagi ◽  
Ítallo Emídio Lira Viana ◽  
Victor Mota Martins ◽  
Simone Duarte ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dental Materials ◽  
Clay Nanotubes

Smart H2O2-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers

2017 ◽  
Vol 9 (37) ◽  
pp. 31626-31633 ◽  
Author(s):  
Feng Liu ◽  
Libin Bai ◽  
Hailei Zhang ◽  
Hongzan Song ◽  
Liandong Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Halloysite Nanotubes ◽  
Carbohydrate Polymers

Magnetic halloysite nanotubes for yeast cell surface engineering

Clay Minerals ◽  
2016 ◽  
Vol 51 (3) ◽  
pp. 429-433 ◽  
Author(s):  
S.A. Konnova ◽  
Y.M. Lvov ◽  
R.F. Fakhrullin
Keyword(s):  
Surface Engineering ◽  
Halloysite Nanotubes ◽  
Yeast Cells ◽  
Biological Cells ◽  
Intrinsic Properties ◽  
Cell Surface Engineering ◽  
Yeast Cell Surface ◽  
Clay Nanotubes ◽  
Field Manipulation ◽  
Tube Shell

AbstractHalloysite clay nanotubes are safe and biocompatible nanomaterials and their application in biomaterials is very promising. The microencapsulation of yeast cells in the shell of clay nanotubes modifying their properties was demonstrated here. Each cell was coated with a 200–300 nm-thick tube shell and this coating was not harmful for these cells’ reproduction. Synthesis of magnetic nanoparticles on the surfaces of the nanotubes allowed for magnetic-field manipulation of the coated cells, including their separation. Providing nano-designed shells for biological cells is a step forward in development of ‘cyborg’ microorganisms combining their intrinsic properties with functions added through nano-engineering.

Nanosizing Noncrystalline and Porous Silica Material—Naturally Occurring Opal Shale for Systemic Tumor Targeting Drug Delivery

2018 ◽  
Vol 10 (31) ◽  
pp. 25994-26004 ◽  
Author(s):  
Qian Guo ◽  
Zengyan Chang ◽  
Naveed Ullah Khan ◽  
Tongtong Miao ◽  
Xiufeng Ju ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Porous Silica ◽  
Naturally Occurring ◽  
Silica Material

scholarly journals Surface Modification of Bacterial Cellulose for Biomedical Applications

2022 ◽  
Vol 23 (2) ◽  
pp. 610
Author(s):  
Teresa Aditya ◽  
Jean Paul Allain ◽  
Camilo Jaramillo ◽  
Andrea Mesa Restrepo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Human Tissues ◽  
Naturally Occurring ◽  
Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

scholarly journals Tissue Oximeter with Selectable Measurement Depth Using Spatially Resolved Near-Infrared Spectroscopy

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5573
Author(s):  
Masatsugu Niwayama ◽  
Naoki Unno
Keyword(s):  
Infrared Spectroscopy ◽  
Light Source ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Subcutaneous Tissue ◽  
Tissue Oxygen Saturation ◽  
Measurement Sensitivity ◽  
Phantom Experiment ◽  
Spatially Resolved ◽  
Measurement Depth

Tissue oxygenation sensing at a few millimeters deep is useful for surgical and postoperative management. However, the measurement sensitivity at each depth and the proper sensor combination have not been clarified. Here, the measurement characteristics of oximetry by spatially resolved near-infrared spectroscopy were analyzed using Monte Carlo simulation and phantom experiment. From summing the sensitivities of each depth, it was quantitatively found that the measurement sensitivity curve had a peak, and the measurement depth can be adjusted by combining the two distances between the light source and the detector. Furthermore, the gastric tissue was 10–20% smaller in terms of measurement depth than the skin-subcutaneous tissue. A miniaturized oximeter was prototyped so that it could be used in combination with an endoscope or laparoscope. The optical probes consisted of light emitting diodes with wavelengths of 770 nm and 830 nm and photodetectors located 3 to 30 mm from the light source. Phantom experiments using the probes demonstrated the tendency of theoretical analysis. These results suggest the possibility of measuring tissue oxygen saturation with a selectable measurement depth. This selectable method will be useful for obtaining oxygenation information at a depth of 2–5 mm, which is difficult to measure using only laparoscopic surface imaging.

Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities

2014 ◽  
Vol 96 ◽  
pp. 54-60 ◽  
Author(s):  
Anahí Philippart ◽  
Elena Boccardi ◽  
Lucia Pontiroli ◽  
Ana Maria Beltrán ◽  
Alexandra Inayat ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Simulated Body Fluid ◽  
Mesoporous Silica ◽  
Body Fluid ◽  
Glass Composition ◽  
Glass Structure ◽  
Sol Gel ◽  
Bioactive Glasses

Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.

Contactless Spatially Resolved Measurement of Bulk Free-Carrier Lifetime in Silicon Ingots

1986 ◽  
Vol 69 ◽  
Author(s):  
S. M. Johnson ◽  
L. G. Johnson ◽  
R. Hemphill
Keyword(s):  
Spatial Dependence ◽  
Polycrystalline Silicon ◽  
Carrier Lifetime ◽  
Transient Absorption ◽  
Free Carrier ◽  
Large Area ◽  
Spatially Resolved ◽  
Probe Transmission ◽  
Transmission Measurements ◽  
Absorption Measurements

AbstractA contactless spatially resolved measurement of bulk free-carrier lifetime in polycrystalline silicon ingots was accomplished using optically modulated free-carrier infrared absorption. Using a CW Nd:YAG laser (λ = 1.319 μm) for a probe and novel pulsed, tunable, infrared dye laser (λ = 1.10 to 1.13 μm) with photon energies near the Si bandgap, for a pump, the free-carrier lifetime was determined from transient absorption measurements to a maximum depth of 3.0 cm from the surface of an ingot. The spatial dependence of the free-carrier lifetime and the distribution of precipitates (determined from infrared probe transmission measurements) measured along the growth axis of an ingot were found to be strongly related to the spatial dependence of the I–V characteristics of large area solar cells fabricated from the subsequently wafered ingot.

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