scholarly journals Genotyping of Porcine Circovirus 2 (PCV-2) in Vaccinated Pigs Suffering from PCV-2-Systemic Disease between 2009 and 2020 in Spain

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1016
Author(s):  
Marina Sibila ◽  
Caterina Rocco ◽  
Giovanni Franzo ◽  
Eva Huerta ◽  
Mariano Domingo ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Temporal Distribution ◽  
Gene Region ◽  
Porcine Circovirus ◽  
The World ◽  
Porcine Circovirus 2 ◽  
Over Time ◽  
Vaccine Immunity

Vaccination against porcine circovirus 2 (PCV-2) is a common practice all over the world. Vaccines can prevent PCV-2-systemic disease (PCV-2-SD) outbreaks but not PCV-2 infection, which can be detectable in a percentage of vaccinated animals. Occasionally, PCV-2-SD is diagnosed in vaccinated farms. The objective of this study was to genotype the PCV-2 strains detected in vaccinated animals diagnosed with PCV-2-SD. Additionally, the evolution of the frequency of PCV-2 genotype detection at Spanish, European, and world levels was assessed. Fifty cases diagnosed as PCV-2-SD between 2009 and 2020 were included in this study. PCV-2 genotype was determined by sequencing the Cap gene region. Among them, only PCV-2b (23/50, 46%) and PCV-2d (27/50, 54%) genotypes were detected. Although the frequency of detection of these two genotypes was similar, their temporal distribution was different. Whereas most PCV-2b sequences (17/23, 74%) were detected between 2009 and 2012, PCV-2d sequences were obtained from 2013 to 2020. Indeed, a predominance of the PCV-2d genotype was observed from 2013 onwards, a trend also noticed at European and world levels. The results suggest that detection of particular genotypes in vaccinated animals probably reflects the general prevalence of the genotypes over time rather than genotype-specific vaccine-immunity escaping.

scholarly journals Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

2020 ◽  
Vol 25 (32) ◽  
Author(s):  
Erik Alm ◽  
Eeva K Broberg ◽  
Thomas Connor ◽  
Emma B Hodcroft ◽  
Andrey B Komissarov ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Data Dissemination ◽  
Sequence Data ◽  
Temporal Distribution ◽  
World Health ◽  
European Region ◽  
The World ◽  
Health Organization ◽  
Over Time

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.

scholarly journals Tripping over emerging pathogens around the world: A phylogeographical approach for determining the epidemiology of Porcine circovirus-2 (PCV-2), considering global trading

2012 ◽  
Vol 163 (1) ◽  
pp. 320-327 ◽  
Author(s):  
Pedro M.P. Vidigal ◽  
Claudio L. Mafra ◽  
Fernanda M.F. Silva ◽  
Juliana L.R. Fietto ◽  
Abelardo Silva Júnior ◽  
...  
Keyword(s):  
Porcine Circovirus ◽  
Emerging Pathogens ◽  
The World ◽  
Porcine Circovirus 2

scholarly journals Modelling and predicting the spatio-temporal spread of COVID-19 in Italy

2020 ◽  
Author(s):  
Diego Giuliani ◽  
Maria Michela Dickson ◽  
Giuseppe Espa ◽  
Flavio Santi
Keyword(s):  
Spatial Interaction ◽  
Local Level ◽  
National Level ◽  
Temporal Distribution ◽  
Control Measures ◽  
Disease Evolution ◽  
The World ◽  
The Usa ◽  
Spatio Temporal ◽  
Over Time

Abstract Background: Severe acute respiratory syndrome Coronavirus 2019 (COVID-19) has been firstly detected in China at the end of 2019 and it spread in few months all over the world. Italy is the second country in the World for number of cases, and the diffusion of COVID-19 has followed a peculiar spatial pattern. However, the interest of scientific community has been devoted almost exclusively to the prediction of the disease evolution over time so far. Methods: Official freely available data about the number of infected at the finest possible level of spatial areal aggregation (Italian provinces) are used to model the spatio-temporal distribution of COVID-19 infections at local level. An endemic-epidemic time-series mixed-effects generalized linear model for areal disease counts has been implemented to understand and predict spatio-temporal diffusion of the phenomenon. Results: Three subcomponents characterize the fitted model. The first describes the transmission of the illness within provinces; the second accounts for the transmission between nearby provinces; the third is related to the evolution of the disease over time. At the local level, the provinces first concerned by containment measures are those that are not affected by the effects of spatial neighbours. On the other hand, the component accounting for the spatial interaction with surrounding areas is prevalent for provinces that are strongly involved by contagions. Moreover, the proposed model provides good forecasts of the number of infections at local level while controlling for delayed reporting. Conclusions: A strong evidence is found that strict control measures implemented in some provinces efficiently break contagions and limit the spread to nearby areas. While containment policies may potentially be more effective if planned considering the peculiarities of local territories, the effective and homogeneous enforcement of control measures at national level is needed to prevent the disease control being delayed or missed as a whole. This may also apply at international level where, as it is for the EU or the USA, the internal border checks among states have largely been abolished.

scholarly journals Porcine circovirus 2 (PCV2) population study in experimentally infected pigs developing PCV2-systemic disease or a subclinical infection

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Florencia Correa-Fiz ◽  
Giovanni Franzo ◽  
Anna Llorens ◽  
Eva Huerta ◽  
Marina Sibila ◽  
...  
Keyword(s):  
Immune System ◽  
Systemic Disease ◽  
Clinical Signs ◽  
Porcine Circovirus ◽  
Host Immune System ◽  
Coding Region ◽  
Dna Viruses ◽  
Enveloped Virus ◽  
Porcine Circovirus 2 ◽  
Large Heterogeneity

Abstract Porcine circovirus 2 (PCV2) is a single stranded DNA virus with one of the highest mutation rates among DNA viruses. This ability allows it to generate a cloud of mutants constantly providing new opportunities to adapt and evade the immune system. This pig pathogen is associated to many diseases, globally called porcine circovirus diseases (PCVD) and has been a threat to pig industry since its discovery in the early 90’s. Although 11 ORFs have been predicted from its genome, only two main proteins have been deeply characterized, i.e. Rep and Cap. The structural Cap protein possesses the majority of the epitopic determinants of this non-enveloped virus. The evolution of PCV2 is affected by both natural and vaccine-induced immune responses, which enhances the genetic variability, especially in the most immunogenic Cap region. Intra-host variability has been also demonstrated in infected animals where long-lasting infections can take place. However, the association between this intra-host variability and pathogenesis has never been studied for this virus. Here, the within-host PCV2 variability was monitored over time by next generation sequencing during an experimental infection, demonstrating the presence of large heterogeneity. Remarkably, the level of quasispecies diversity, affecting particularly the Cap coding region, was statistically different depending on viremia levels and clinical signs detected after infection. Moreover, we proved the existence of hyper mutant subjects harboring a remarkably higher number of genetic variants. Altogether, these results suggest an interaction between genetic diversity, host immune system and disease severity.

Globalization and interconfessional communications

2001 ◽  
pp. 13-17
Author(s):  
Serhii Viktorovych Svystunov
Keyword(s):  
21St Century ◽  
Global Economy ◽  
Modern World ◽  
The World ◽  
Target Set ◽  
Almost All ◽  
Over Time ◽  
Rapid Appearance

In the 21st century, the world became a sign of globalization: global conflicts, global disasters, global economy, global Internet, etc. The Polish researcher Casimir Zhigulsky defines globalization as a kind of process, that is, the target set of characteristic changes that develop over time and occur in the modern world. These changes in general are reduced to mutual rapprochement, reduction of distances, the rapid appearance of a large number of different connections, contacts, exchanges, and to increase the dependence of society in almost all spheres of his life from what is happening in other, often very remote regions of the world.

The Values and Norms of Islam

2010 ◽  
Vol 1 (1) ◽  
pp. 1-19
Author(s):  
Ahmed Akgunduz
Keyword(s):  
Islamic Law ◽  
Legal Theory ◽  
The Other ◽  
Moral Norms ◽  
Simple Fact ◽  
Value System ◽  
Legal Norms ◽  
Islamic Legal Theory ◽  
The World ◽  
Over Time

AbstractIslamic Law is one of the broadest and most comprehensive systems of legislation in the world. It was applied, through various schools of thought, from one end of the Muslim world to the other. It also had a great impact on other nations and cultures. We will focus in this article on values and norms in Islamic law. The value system of Islam is immutable and does not tolerate change over time for the simple fact that human nature does not change. The basic values and needs (which can be called maṣlaḥa) are classified hierarchically into three levels: (1) necessities (Ḍarūriyyāt), (2) convenience (Ḥājiyyāt), and (3) refinements (Kamāliyyāt=Taḥsīniyyāt). In Islamic legal theory (Uṣūl al‐fiqh) the general aim of legislation is to realize values through protecting and guaranteeing their necessities (al-Ḍarūriyyāt) as well as stressing their importance (al‐ Ḥājiyyāt) and their refinements (taḥsīniyyāt).In the second part of this article we will draw attention to Islamic norms. Islam has paid great attention to norms that protect basic values. We cannot explain all the Islamic norms that relate to basic values, but we will classify them categorically. We will focus on four kinds of norms: 1) norms (rules) concerned with belief (I’tiqādiyyāt), 2) norms (rules) concerned with law (ʿAmaliyyāt); 3) general legal norms (Qawā‘id al‐ Kulliyya al‐Fiqhiyya); 4) norms (rules) concerned with ethics (Wijdāniyyāt = Aḵlāqiyyāt = Ādāb = social and moral norms).

Use of Phosphatidylcholine in the Treatment of Localized Fat Deposits. Results and expectations

2017 ◽  
Vol 68 (7) ◽  
pp. 1438-1441 ◽  
Author(s):  
Sorin Berbece ◽  
Dan Iliescu ◽  
Valeriu Ardeleanu ◽  
Alexandru Nicolau ◽  
Radu Cristian Jecan
Keyword(s):  
World Health Organisation ◽  
Normal Weight ◽  
World Health ◽  
Basic Substance ◽  
Physical Exercises ◽  
Fat Deposits ◽  
The World ◽  
The Common ◽  
Global Health Problem ◽  
Over Time

Obesity represents a global health problem. According to the latest studies released by the World Health Organisation (WHO), 1.7 billion currently in excess of normal weight individuals, of which approx. 75% are overweight (body mass index - BMI 25 to 30). The common form of excess adipose tissue manifestation in overweight individuals is localized fat deposits with high (abdominal) or low (buttocks and thighs) disposition. Although the overweight can be corrected relatively easy by changing behavioral habits or food, a constant physical exercises program or following a diet food are not accessible to all through the efforts of will, financial and time involved. Several methods have been studied and tested over time to eliminate more or less invasive fat deposits with varying efficacy and adverse effects. Chemical lipolysis using phosphatidylcholine as the basic substance was initially used in hypercholesterolemia and its complications and was rapidly adopted in mesotherapy techniques for the treatment of fat deposits. This study reveals the results obtained using Dermastabilon on a sample of 16 patients, the time allocated to treatment and discomfort being minimal, and rapid and notable results. There were no side effects.

The Staging of Large Wastewater Treatment Plants - A “Modular” Approach

1992 ◽  
Vol 25 (4-5) ◽  
pp. 67-73
Author(s):  
H. Fleckseder ◽  
L. Prendl ◽  
H. Meulenbroek
Keyword(s):  
Wastewater Treatment ◽  
Driving Force ◽  
Wastewater Treatment Plants ◽  
Aeration Tank ◽  
Modular Approach ◽  
Central European ◽  
Plant Hydraulics ◽  
The World ◽  
Whole Life Cycle ◽  
Over Time

The primary driving force for re-investments in wastewater treatment plants in Austria - and also other countries in Central Europe - is at present not an increase in load to treatment but a marked increase in effluent requirements to be fulfilled. (The re-investments necessary for sludge handling and treatment remain outside this paper.) Within a period of 20 years, the load specific requirements on aeration tank volume rose five- to tenfold, when Lv = 2.0 kg BOD5/(m3d) was the starting value, and roughly doubled for final clarifiers. In addition, the importance of the application and expansion of primary sedimentation decreased as well. This development over time in Central European countries as well as the need to utilize previous investments as long as possible - 35 to 60 years for civil works are common as periods of depreciation - indicate that investments in new plant at any location in the world have to consider the possible whole life cycle of a plant and that plant hydraulics becomes the “key hook” for expandability.

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