scholarly journals 3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1096
Author(s):  
Christos S. Katsiotis ◽  
Michelle Åhlén ◽  
Maria Strømme ◽  
Ken Welch
Keyword(s):  
Drug Release ◽  
Mesoporous Materials ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Great Promise ◽  
Poorly Soluble Drugs ◽  
Drug Concentrations ◽  
Poorly Soluble ◽  
3D Printed ◽  
Oral Dosage Forms

Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms. In the present study, mesoporous materials were incorporated into a thermoplastic filament produced via hot-melt extrusion and used to produce oral dosage forms via FDM. Mesoporous materials are known to be highly effective for the amorphization and stabilization of poorly soluble drugs, and were therefore studied in order to determine their ability to enhance the drug-release properties in 3D-printed tablets. Celecoxib was selected as the model poorly soluble drug, and was loaded into mesoporous silica (MCM-41) or mesoporous magnesium carbonate. In vitro drug release tests showed that the printed tablets produced up to 3.6 and 1.5 times higher drug concentrations, and up to 4.4 and 1.9 times higher release percentages, compared to the crystalline drug or the corresponding plain drug-loaded mesoporous materials, respectively. This novel approach utilizing drug-loaded mesoporous materials in a printed tablet via FDM shows great promise in achieving personalized oral dosage forms for poorly soluble drugs.

Toward quality assessment of 3D printed oral dosage forms

2018 ◽  
Vol 2 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Daniel Markl ◽  
Axel Zeitler ◽  
Thomas Rades ◽  
Jukka Rantanen ◽  
Johan Bøtker
Keyword(s):  
Quality Assessment ◽  
Dosage Forms ◽  
Oral Dosage ◽  
3D Printed ◽  
Oral Dosage Forms

scholarly journals Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms

2018 ◽  
Vol 128 ◽  
pp. 282-289 ◽  
Author(s):  
Basel Arafat ◽  
Nidal Qinna ◽  
Milena Cieszynska ◽  
Robert T. Forbes ◽  
Mohamed A. Alhnan
Keyword(s):  
Dosage Forms ◽  
Oral Dosage ◽  
In Vivo Evaluation ◽  
On Demand ◽  
3D Printed ◽  
Oral Dosage Forms

Process of Drug Release with Oral Dosage Forms with a Lipidic Gelucire Matrix

1997 ◽  
Vol 17 (3) ◽  
Author(s):  
A. Ainaoui ◽  
E.M. Ouriemchi ◽  
D. Bidah ◽  
M.K. El Amrani ◽  
J.M. Vergnaud
Keyword(s):  
Drug Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Dosage Forms

Immediate Drug Release from Solid Oral Dosage Forms

2005 ◽  
Vol 94 (1) ◽  
pp. 120-133 ◽  
Author(s):  
Thomas Schreiner ◽  
Ulrich F. Schaefer ◽  
Helmut Loth
Keyword(s):  
Drug Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

scholarly journals Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 645 ◽  
Author(s):  
Andrew V. Healy ◽  
Evert Fuenmayor ◽  
Patrick Doran ◽  
Luke M. Geever ◽  
Clement L. Higginbotham ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Pharmaceutical Dosage Forms ◽  
Glycol Diacrylate ◽  
Drug Concentrations ◽  
Poly Ethylene ◽  
Print Process ◽  
Oral Dosage Forms ◽  
Poly Caprolactone

The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug concentrations, namely 2.50% and 5.00%, were fabricated via stereolithography (SLA) using a novel photopolymerizable resin formulation based on a monomer mixture that, to date, has not been reported in the literature, with paracetamol and aspirin selected as model drugs. In order to produce the dosage forms, the ratio of poly(ethylene glycol) diacrylate (PEGDA) to poly(caprolactone) triol was varied with diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Irgacure TPO) utilized as the photoinitiator. The fabrication of 28 dosages in one print process was possible and the printed dosage forms were characterized for their drug release properties. It was established that both drugs displayed a sustained release over a 24-h period. The physical properties were also investigated, illustrating that SLA affords accurate printing of dosages with some statistically significant differences observed from the targeted dimensional range, indicating an area for future process improvement. The work presented in this paper demonstrates that SLA has the ability to produce small, individualized batches which may be tailored to meet patients’ specific needs or provide for the localized production of pharmaceutical dosage forms.

Sign in / Sign up

Export Citation Format

Share Document