scholarly journals The Past, Present and Future of Cannabis sativa Tissue Culture

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 185
Author(s):  
Adrian S. Monthony ◽  
Serena R. Page ◽  
Mohsen Hesami ◽  
Andrew Maxwell P. Jones
Keyword(s):  
Tissue Culture ◽  
Disease Virus ◽  
Cannabis Sativa ◽  
Clonal Plants ◽  
Future Directions ◽  
The Past ◽  
Recent Developments ◽  
History Of ◽  
Drug Type

The recent legalization of Cannabis sativa L. in many regions has revealed a need for effective propagation and biotechnologies for the species. Micropropagation affords researchers and producers methods to rapidly propagate insect-/disease-/virus-free clonal plants and store germplasm and forms the basis for other biotechnologies. Despite this need, research in the area is limited due to the long history of prohibitions and restrictions. Existing literature has multiple limitations: many publications use hemp as a proxy for drug-type Cannabis when it is well established that there is significant genotype specificity; studies using drug-type cultivars are predominantly optimized using a single cultivar; most protocols have not been replicated by independent groups, and some attempts demonstrate a lack of reproducibility across genotypes. Due to culture decline and other problems, the multiplication phase of micropropagation (Stage 2) has not been fully developed in many reports. This review will provide a brief background on the history and botany of Cannabis as well as a comprehensive and critical summary of Cannabis tissue culture. Special attention will be paid to current challenges faced by researchers, the limitations of existing Cannabis micropropagation studies, and recent developments and future directions of Cannabis tissue culture technologies.

scholarly journals The Past, Present and Future of Cannabis sativa Tissue Culture

2020 ◽  
Author(s):  
Adrian S. Monthony ◽  
Serena R. Page ◽  
Mohsen Hesami ◽  
Andrew Maxwell P. Jones
Keyword(s):  
Tissue Culture ◽  
Disease Virus ◽  
Cannabis Sativa ◽  
Clonal Plants ◽  
Future Directions ◽  
The Past ◽  
Recent Developments ◽  
Drug Type

The recent legalization of Cannabis sativa L. in many regions has revealed a need for effective propagation and biotechnologies for the species. Micropropagation affords researchers and producers methods to rapidly propagate insect/disease/virus free clonal plants, store germplasm, and forms the basis for other biotechnologies. Despite this need, research in the area is limited due to the long history or prohibitions and restrictions. Existing literature has multiple limitation: many publications use hemp as a proxy for drug-type Cannabis when it is well established that there is significant genotype specificity, studies using drug-type cultivars are predominantly op-timized using a single cultivar, most protocols have not been replicated by independent groups, and some attempts demonstrate a lack of reproducibility across genotypes. Due to culture decline and other problems the multiplication phase of micropropagation (stage 2) has not been fully developed in many reports. This review will provide a brief background on the history and botany of Cannabis as well as a comprehensive and critical summary of Cannabis tissue culture. Special attention will be paid to current challenges faced by researchers, the limitations of existing Cannabis micropropagation studies, and recent developments and future directions of Cannabis tissue culture technologies.

Reflections on Thirty Years of Muqarnas

2014 ◽  
Vol 30 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Gülru Necipoğlu
Keyword(s):  
Board Members ◽  
Islamic Art ◽  
Future Directions ◽  
The Past ◽  
Advisory Boards ◽  
Current State ◽  
Thirtieth Anniversary ◽  
History Of ◽  
Art And Architecture ◽  
State Of The Field

In this volume marking the thirtieth anniversary of Muqarnas, the Editor reflects on the evolution of the journal over the years. To that end, the members of the Editorial and Advisory Boards were sent a questionnaire, asking them to comment on the contributions of Muqarnas and its Supplements series to the field of Islamic art and architecture studies over the past three decades, and to provide suggestions for future directions. Their observations, thoughts, and hopes for Muqarnas have been anonymously incorporated into this essay, which, in conversation with their comments, looks back on the history of the publication and offers some possibilities for the path it might take going forward.
The goal here is neither to assess the historiography nor to examine the current state of the field thirty years after the opening essay of volume 1. Instead, the focus is on the development and impact of both Muqarnas and the Supplements series in a highly specialized field with relatively few and short-lived or sporadic journals, before turning to the successes and shortcomings of these publications, as outlined by some of the board members. 


Women in the history of linguistics

2020 ◽  
pp. 1-30
Author(s):  
Wendy Ayres-Bennett ◽  
Helena Sanson
Keyword(s):  
Language Acquisition ◽  
Central Section ◽  
Future Directions ◽  
The Past ◽  
Early Stages ◽  
Challenges And Opportunities ◽  
History Of Linguistics ◽  
History Of ◽  
Role Of Women

This Introduction outlines the need for a ‘true history’ (Lerner 1976) of the role of women in the history of linguistics, which considers them on their own terms, and challenges categories and concepts devised for traditional male-dominated accounts. We start by considering what research has already been conducted in the field, before exploring some of the reasons for the relative dearth of studies. We outline some of the challenges and opportunities encountered by women who wished to study the nature of language and languages in the past. The geographical and chronological scope of this volume is then discussed. In a central section we examine some of the major recurring themes in the volume. These include attitudes towards women’s language, both positive and negative; women and language acquisition and teaching; and women as creators of new languages and scripts. We further explore women as authors, dedicatees, or intended readers of metalinguistic texts, as interpreters and translators, and as contributors to the linguistic documentation and maintenance. We consider how women supported male relatives and colleagues in their endeavours, sometimes in invisible ways, before reviewing the early stages of their entry into institutionalized contexts. The chapter concludes with a brief section on future directions for research.

scholarly journals CCD Time-Series Photometry of Astronomical Sources

1995 ◽  
Vol 167 ◽  
pp. 167-172
Author(s):  
Steve B. Howell
Keyword(s):  
Time Series ◽  
Photometric Data ◽  
Two Dimensional ◽  
Future Directions ◽  
Recent Developments ◽  
History Of

CCDs are essentially the only instrument available today for photometry at most observatories; they are also becoming more readily available to amateurs as well. Thus, obtaining good photometric data with these two-dimensional devices is something we all need to understand. The history of and recent developments in CCD time-series photometry will be reviewed with some comments on future directions.

scholarly journals Foreign language attrition

2012 ◽  
Vol 1 (1) ◽  
pp. 102-124 ◽  
Author(s):  
Monika S. Schmid ◽  
Teodora Mehotcheva
Keyword(s):  
Foreign Language ◽  
Theoretical Models ◽  
Foreign Languages ◽  
Language Attrition ◽  
Present Contribution ◽  
Future Directions ◽  
Second Languages ◽  
History Of Research ◽  
Recent Developments ◽  
History Of

The present contribution discusses recent developments and future directions in the attrition of instructed foreign languages, arguing for a distinction between this type of attrition and attrition involving second languages acquired implicitly in an immersion setting. An overview of the history of research in the field and the most prominent findings is provided, followed by a discussion of theoretical models and methodologically problematic issues. We conclude by outlining some future directions for the field.

scholarly journals Newcastle Disease Virus as a Vaccine Vector for 20 Years: A Focus on Maternally Derived Antibody Interference

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 222 ◽  
Author(s):  
Zenglei Hu ◽  
Jie Ni ◽  
Yongzhong Cao ◽  
Xiufan Liu
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Research Work ◽  
Vaccine Vector ◽  
The Past ◽  
Protective Antigens ◽  
Recent Advances ◽  
History Of ◽  
Remarkable Progress

It has been 20 years since Newcastle disease virus (NDV) was first used as a vector. The past two decades have witnessed remarkable progress in vaccine generation based on the NDV vector and optimization of the vector. Protective antigens of a variety of pathogens have been expressed in the NDV vector to generate novel vaccines for animals and humans, highlighting a great potential of NDV as a vaccine vector. More importantly, the research work also unveils a major problem restraining the NDV vector vaccines in poultry, i.e., the interference from maternally derived antibody (MDA). Although many efforts have been taken to overcome MDA interference, a lack of understanding of the mechanism of vaccination inhibition by MDA in poultry still hinders vaccine improvement. In this review, we outline the history of NDV as a vaccine vector by highlighting some milestones. The recent advances in the development of NDV-vectored vaccines or therapeutics for animals and humans are discussed. Particularly, we focus on the mechanisms and hypotheses of vaccination inhibition by MDA and the efforts to circumvent MDA interference with the NDV vector vaccines. Perspectives to fill the gap of understanding concerning the mechanism of MDA interference in poultry and to improve the NDV vector vaccines are also proposed.

Marine Safety Regulation in Transport Canada: The Winds of Change

1996 ◽  
Vol 33 (03) ◽  
pp. 211-217
Author(s):  
John Grinstead
Keyword(s):  
Coast Guard ◽  
Safety Regulation ◽  
Organizational Changes ◽  
Future Directions ◽  
The Past ◽  
History Of ◽  
External Forces ◽  
Marine Safety

The paper traces the history of marine regulation in Canada from pre-Confederation days to the present. It addresses a number of the external forces which have impacted the regulatory scene over the past few years and outlines in some detail the recent organizational changes which have taken place within the Canadian Coast Guard with respect to marine regulation. The paper concludes with a few comments concerning future directions.

scholarly journals Recent Developments in Liposome-Based Veterinary Therapeutics

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Hassan Sadozai ◽  
Dorsa Saeidi
Keyword(s):  
Veterinary Medicine ◽  
Research Interest ◽  
Circulation Time ◽  
Phospholipid Vesicles ◽  
Future Directions ◽  
Ongoing Research ◽  
The Past ◽  
Wide Range ◽  
Recent Developments

Recent advances in nanomedicine have been studied in the veterinary field and have found a wide variety of applications. The past decade has witnessed a massive surge of research interest in liposomes for delivery of therapeutic substances in animals. Liposomes are nanosized phospholipid vesicles that can serve as delivery platforms for a wide range of substances. Liposomes are easily formulated, highly modifiable, and easily administered delivery platforms. They are biodegradable and nontoxic and have long in vivo circulation time. This review focuses on recent and ongoing research that may have relevance for veterinary medicine. By examining the recent developments in liposome-based therapeutics in animal cancers, vaccines, and analgesia, this review depicts the current significance and future directions of liposome-based delivery in veterinary medicine.

scholarly journals A tutorial survey of architectures, algorithms, and applications for deep learning

2014 ◽  
Vol 3 ◽  
Author(s):  
Li Deng
Keyword(s):  
Deep Learning ◽  
Information Processing ◽  
Language Processing ◽  
Feature Learning ◽  
Representation Learning ◽  
Machine Learning Techniques ◽  
Major Work ◽  
Future Directions ◽  
Recent Developments ◽  
History Of

In this invited paper, my overview material on the same topic as presented in the plenary overview session of APSIPA-2011 and the tutorial material presented in the same conference [1] are expanded and updated to include more recent developments in deep learning. The previous and the updated materials cover both theory and applications, and analyze its future directions. The goal of this tutorial survey is to introduce the emerging area of deep learning or hierarchical learning to the APSIPA community. Deep learning refers to a class of machine learning techniques, developed largely since 2006, where many stages of non-linear information processing in hierarchical architectures are exploited for pattern classification and for feature learning. In the more recent literature, it is also connected to representation learning, which involves a hierarchy of features or concepts where higher-level concepts are defined from lower-level ones and where the same lower-level concepts help to define higher-level ones. In this tutorial survey, a brief history of deep learning research is discussed first. Then, a classificatory scheme is developed to analyze and summarize major work reported in the recent deep learning literature. Using this scheme, I provide a taxonomy-oriented survey on the existing deep architectures and algorithms in the literature, and categorize them into three classes: generative, discriminative, and hybrid. Three representative deep architectures – deep autoencoders, deep stacking networks with their generalization to the temporal domain (recurrent networks), and deep neural networks (pretrained with deep belief networks) – one in each of the three classes, are presented in more detail. Next, selected applications of deep learning are reviewed in broad areas of signal and information processing including audio/speech, image/vision, multimodality, language modeling, natural language processing, and information retrieval. Finally, future directions of deep learning are discussed and analyzed.

scholarly journals New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics

2013 ◽  
Vol 2013 ◽  
pp. 1-25 ◽  
Author(s):  
Si-Yuan Pan ◽  
Shu-Feng Zhou ◽  
Si-Hua Gao ◽  
Zhi-Ling Yu ◽  
Shuo-Feng Zhang ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Success Rate ◽  
Capital Investment ◽  
Herbal Medicines ◽  
Future Directions ◽  
The Past ◽  
Daunting Task ◽  
History Of ◽  
Synthetic Drug ◽  
Herbal Medicinal

With tens of thousands of plant species on earth, we are endowed with an enormous wealth of medicinal remedies from Mother Nature. Natural products and their derivatives represent more than 50% of all the drugs in modern therapeutics. Because of the low success rate and huge capital investment need, the research and development of conventional drugs are very costly and difficult. Over the past few decades, researchers have focused on drug discovery from herbal medicines or botanical sources, an important group of complementary and alternative medicine (CAM) therapy. With a long history of herbal usage for the clinical management of a variety of diseases in indigenous cultures, the success rate of developing a new drug from herbal medicinal preparations should, in theory, be higher than that from chemical synthesis. While the endeavor for drug discovery from herbal medicines is “experience driven,” the search for a therapeutically useful synthetic drug, like “looking for a needle in a haystack,” is a daunting task. In this paper, we first illustrated various approaches of drug discovery from herbal medicines. Typical examples of successful drug discovery from botanical sources were given. In addition, problems in drug discovery from herbal medicines were described and possible solutions were proposed. The prospect of drug discovery from herbal medicines in the postgenomic era was made with the provision of future directions in this area of drug development.

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