scholarly journals Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort

Toxics ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 26
Author(s):  
Manhai Long ◽  
Maria Wielsøe ◽  
Eva Cecilie Bonefeld-Jørgensen
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Serum Lipid ◽  
Normal Weight ◽  
Growth Indices ◽  
Serum Samples ◽  
Aryl Hydrocarbon ◽  
Median Level ◽  
Marine Food ◽  
Toxic Responses

Exposure to lipophilic persistent organic pollutants (lipPOPs) elicits a number of species- and tissue-specific toxic responses, many of which involve the aryl hydrocarbon receptor (AhR). This study aims to measure the combined serum dioxin-like activity of lipPOPs in Greenlandic Inuit pregnant women and the associations with fetal growth indices. The combined dioxin-like activity of serum lipPOPs extracts was determined using the AhR reporter gene bioassay and expressed as pico-gram (pg) TCDD equivalent (TEQ) per gram serum lipid [AhR-TEQ (pg/g lipid)]. Significant AhR-TEQ was found in > 87% of serum samples with the median level of 86.2 pg TEQ/g lipid. The AhR-TEQ level positively correlated with the marine food intake biomarker n-3/n-6 polyunsaturated fatty acids ratio, while negatively correlated with body mass index and parity. Women giving birth to infants with low birth weight (<2500 g) and length (<50 cm) had higher AhR-TEQ level compared to those with normal weight and length infants. For previous smokers, we found significant inverse associations between maternal AhR-TEQ level and fetal growth indices. In conclusion, exposure of Greenlandic Inuit pregnant women to dioxin-like compounds through traditional marine food can adversely influence the fetal growth via induced AhR activity. Smoking might have modifying effects.

scholarly journals BERAT BADAN IBU HAMIL TRIMESTER 3 DENGAN BERAT BADAN BAYI BARU LAHIR DI PUSKESMAS TANAH KALI KEDINDING SURABAYA

2019 ◽  
Vol 4 (2) ◽  
pp. 34
Author(s):  
Dewi Andriani
Keyword(s):  
Weight Gain ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Post Partum ◽  
Sampling Technique ◽  
Normal Weight ◽  
Maternal Weight Gain ◽  
Maternal Weight ◽  
Cross Sectional ◽  
Newborn Weight

ABSTRAK Kenaikan berat badan ibu hamil merupakan adanya adaptasi ibu terhadap pertumbuhan janin, sedangkan berat badan bayi baru lahir merupakan bagian dari hasil pertumbuhan janin yang dapat dipengaruhi oleh kenaikan berat badan ibu selama hamil. Tujuan penelitian ini adalah untuk mengetahui hubungan serta badan ibu hamil trimester 3 dengan berat badan bayi baru lahir di Puskesmas Tanah KaliKedinding Surabaya.Jenis penelitian ini adalah korelasi dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah ibu post partum yang melahirkan di Puskesmas Tanah KaliKedinding Surabaya dengan populasi 35 responden sampel sebanyak 32 responden. Teknik pengambilan sampling menggunakan Quota Sampling. Instrument penelitian ini menggunakan lembar observasi. Hasil yang didapat dari 32 responden terdapat berat badan ibu hamil yang normal sebanyak 17 orang (53,1%). Berat badan bayi baru lahir dengan berat sedang sebanyak 23 orang (71,9). Hasil analisis uji statistic Spierman Rho menunjukkan bahwa signifikan rho value sebesar 0,003 (α≤ 0,05) maka dengan ini H0 ditolak dan H1 diterima. Artinya terdapat Hubungan Berat Badan Ibu Hamil Trimester 3 Dengan Berat Badan Bayi Baru Lahir di Puskesmas Tanah KaliKedinding Surabaya. Pemantauan berat badan ibu hamil penting untuk mengetahui tumbuh kembang janin. ANC secara teratur merupakan upaya pemantauan yang efektif sehingga mengurangi resiko gangguan dalam persalinan.   Kata kunci :berat badan ibu hamil, berat badan bayi baru lahir, trimester 3   ABSTRACT Maternal weight gain is a maternal adaptation of fetal growth, while newborn weight is part of fetal growth that may be affected by maternal weight gain during pregnancy. The purpose of this study was to determine the relationship between body trimester pregnant mother 3 with newborn weight at Puskesmas Tanah KaliKedinding Surabaya. This research type is correlation with csoss sectional approach. The population in this research is post partum mother who gave birth at Puskesmas Tanah Kali Kedinding Surabaya with population of 35 sample respondents as many as 32 respondents. Sampling technique uses Sampling Quota. This research instrument uses observation sheet. Results obtained from 32 respondents had normal weight of pregnant women as many as 17 people (53.1%). Newborn weight with moderate weight as many as 23 people (71,9). The result of Spierman Rho statistic test shows that the significant rho value is 0,003 (α≤ 0,05) hence H0 is rejected and H1 accepted. This means that there is a Weight Pregnancy Trimester 3 Pregnant Wife With New Baby Weight Born in Puskesmas Tanah KaliKedinding Surabaya. Monitoring the weight of pregnant women is important to know the growth of fetal growth. ANCs are regularly an effective monitoring effort thus reducing the risk of impairment in labor.   Keywords: maternal weight, weight of newborn baby, trimester 3.

Dioxin-like activity in serum of Danish and Greenlandic Inuit pregnant women and fetal growth indices

2021 ◽  
Vol 350 ◽  
pp. S145-S146
Author(s):  
M Long ◽  
M. Wiels ◽  
E.C. Bonefeld-Jorgensen
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Growth Indices

scholarly journals Continuous Glucose Profiles in Obese and Normal-Weight Pregnant Women on a Controlled Diet: Metabolic determinants of fetal growth

Diabetes Care ◽  
2011 ◽  
Vol 34 (10) ◽  
pp. 2198-2204 ◽  
Author(s):  
K. A. Harmon ◽  
L. Gerard ◽  
D. R. Jensen ◽  
E. H. Kealey ◽  
T. L. Hernandez ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Normal Weight ◽  
Glucose Profiles

Exposure to Persistent Organic Pollutants in Danish pregnant women: hormone levels and fetal growth indices

2021 ◽  
Vol 350 ◽  
pp. S172-S173
Author(s):  
E.C. Bonefeld-Jørgensen ◽  
S.A.H. Boesen ◽  
M. Wielsøe ◽  
Þ.I. Halldórsson ◽  
M. Long
Keyword(s):  
Pregnant Women ◽  
Organic Pollutants ◽  
Fetal Growth ◽  
Persistent Organic Pollutants ◽  
Growth Indices ◽  
Hormone Levels

Elevated insulin sensitivity and β-cell function during pregnancy in mothers of growth-restricted newborns

2011 ◽  
Vol 301 (1) ◽  
pp. E25-E30 ◽  
Author(s):  
Maria Grazia Dalfrà ◽  
Giovanni Pacini ◽  
Elena Parretti ◽  
Eugenio Ragazzi ◽  
Giorgio Mello ◽  
...  
Keyword(s):  
Birth Weight ◽  
Insulin Sensitivity ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Cell Function ◽  
Normal Weight ◽  
Disposition Index ◽  
Insulinogenic Index ◽  
Β Cell ◽  
Β Cell Function

The “Barker hypothesis” suggests that low birth weight might predict future risk of developing obesity, cardiovascular disease, and type 2 diabetes. Identification of the causes of fetal growth restriction (FGR) is critical for preventive and management strategies. Some studies indicate that maternal carbohydrate metabolism might be involved in FGR development. We aimed to evaluate, in a large number of normotensive pregnant women with normal glucose tolerance, the effect of insulin sensitivity and β-cell function on unexplained fetal growth. A total of 1,814 Caucasian pregnant women with normal prepregnancy body mass index were tested with a 75-g, 2-h glucose load (24–28 gestation wk). Insulin sensitivity was evaluated with fasting (QUICKI) and dynamic index (OGIS) and β-cell function with a modified insulinogenic index as ΔAUCinsulin/ΔAUCglucose and disposition index. FGR was a birth weight below the 5th percentile for gestational age. FGR developed in 99 (5.5%) pregnant women that showed significantly higher QUICKI, OGIS, insulinogenic, and disposition index with respect to women with normal-weight babies ( P < 0.0001). By using multiple regression analysis in the FRG group, QUICKI and OGIS appeared as significant independent variables ( P < 0.0001 and P < 0.0366, respectively). We conclude that elevated insulin sensitivity seems to be one of the factors involved in determining unexplained fetal growth retardation; its assessment, even only in the fasting state, could be useful to guide any possible monitoring and therapeutic strategies to reduce fetal complications.

FETAL GROWTH RESTRICTION WITH EARLY AND LATE MANIFESTATION, PROGNOSTIC MARKERS

2020 ◽  
pp. 27-30
Author(s):  
Yakubova D.I.
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Prenatal Screening ◽  
Prognostic Markers ◽  
Growth Restriction ◽  
Late Manifestation ◽  
Late Form ◽  
Early Manifestation

Objective of the study: Comprehensive assessment of risk factors, the implementation of which leads to FGR with early and late manifestation. To evaluate the results of the first prenatal screening: PAPP-A, B-hCG, made at 11-13 weeks. Materials and Methods: A retrospective study included 110 pregnant women. There were 48 pregnant women with early manifestation of fetal growth restriction, 62 pregnant women with late manifestation among them. Results of the study: The risk factors for the formation of the FGR are established. Statistically significant differences in the indicators between groups were not established in the analyses of structures of extragenital pathology. According to I prenatal screening, there were no statistical differences in levels (PAPP-A, b-hCG) in the early and late form of FGR.

scholarly journals Dehydroepiandrosterone (DHEA) Serum Levels Indicate Cerebrospinal Fluid Levels of DHEA and Estradiol (E2) in Women at Term Pregnancy

2021 ◽  
Author(s):  
Pardes Habib ◽  
Joseph Neulen ◽  
Shahin Habib ◽  
Benjamin Rösing
Keyword(s):  
Pregnant Women ◽  
Strong Correlation ◽  
Serum Levels ◽  
Neuroactive Steroids ◽  
Term Pregnancy ◽  
Serum Samples ◽  
Functional Changes ◽  
The Central Nervous System ◽  
Csf Levels ◽  
Fluid Levels

AbstractNeuroactive steroids such as dehydroepiandrosterone (DHEA), estradiol (E2), and progesterone (P4) are associated with structural and functional changes in the central nervous system (CNS). Measurement of steroid levels in the CNS compartments is restricted in accessibility. Consequently, there is only limited human data on the distributional equilibrium for steroid levels between peripheral and central compartments. While some neuroactive steroids including DHEA and E2 have been reported to convey excitatory and proconvulsant properties, the opposite was demonstrated for P4. We aimed to elucidate the correlation between peripheral and central DHEA, E2, and P4 levels in women at term pregnancy. CSF and serum samples of 27 healthy pregnant women (22–39 years) at term pregnancy were collected simultaneously under combined spinal and epidural anesthesia and used for DHEA ELISA and E2, and P4 ECLIA. All three neuroactive steroids were detected at markedly lower levels in CSF compared to their corresponding serum concentrations (decrease, mean ± SD, 97.66 ± 0.83%). We found a strong correlation for DHEA between its serum and the corresponding CSF levels (r = 0.65, p = 0.003). Serum and CSF levels of E2 (r = 0.31, p = 0.12) appeared not to correlate in the investigated cohort. DHEA serum concentration correlated significantly with E2 (r = 0.58, p = 0.0016) in CSF. In addition, a strong correlation was found between DHEA and E2, both measured in CSF (r = 0.65, p = 0.0002). Peripheral DHEA levels might serve as an indicator for central nervous levels of the neuroactive steroids DHEA and E2 in pregnant women.

Fetal growth retardation and hemorheological predictors of oxygen delivery in hypertensive vs normotensive pregnant women

2019 ◽  
Vol 71 (4) ◽  
pp. 387-396
Author(s):  
Jean-Frédéric Brun ◽  
Emmanuelle Varlet-Marie ◽  
Pierre Boulot ◽  
Bénédicte Marion ◽  
Céline Roques ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Oxygen Delivery ◽  
Fetal Growth Retardation

scholarly journals Prevalence and clinical correlation of hepatitis E virus antibody in the patients’ serum samples from a tertiary care hospital in Thailand during 2015–2018

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Atiporn Boonyai ◽  
Anchalee Thongput ◽  
Thidarat Sisaeng ◽  
Parisut Phumchan ◽  
Navin Horthongkham ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Tertiary Care ◽  
Laboratory Data ◽  
Organ Transplant ◽  
Hospital Setting ◽  
Antibody Detection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
Serum Samples ◽  
Igm Antibodies

Abstract Background Prevalence and incidence of hepatitis caused by HEV infection are usually higher in developing countries. This study demonstrated the HEV seroprevalence and incidence of HEV infection in patients with clinical hepatitis in a tertiary hospital in Thailand. Methods A laboratory-based cross-sectional study was conducted using 1106 serum samples from patients suspected of HEV infection sent to the Serology laboratory, Siriraj Hospital, for detecting HEV antibodies during 2015–2018. Prevalence of anti-HEV IgG and IgM antibodies in general patients, including organ transplant recipients and pregnant women in a hospital setting, were determined using indirect enzyme-linked immunosorbent assay (ELISA) kits. Comparison of laboratory data between groups with different HEV serological statuses was performed. Results HEV IgG antibodies were detected in 40.82% of 904 serum samples, while HEV IgM antibodies were detected in 11.75% of 1081 serum samples. Similar IgG and IgM antibody detection rates were found in pregnant women. Interestingly, anti-HEV IgM antibodies were detected in 38.5% of patients who underwent organ transplantation. Patients who tested positive for anti-HEV IgM antibodies had higher alanine aminotransferase levels than those who had not. In contrast, patients who tested positive for anti-HEV IgG had more elevated levels of total bilirubin than those who tested negative. Conclusions HEV seroprevalence and incidence in patients with clinical hepatitis were relatively high in the Thai population, including the pregnancy and organ transplant subgroups. The results potentially benefit the clinicians in decision-making to investigate HEV antibodies and facilitating proper management for patients.

Sign in / Sign up

Export Citation Format

Share Document