scholarly journals Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 124
Author(s):  
Mundeep K. Kainth ◽  
Joanna S. Fishbein ◽  
Teresa Aydillo ◽  
Alba Escalera ◽  
Rachael Odusanya ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Normal Weight ◽  
Antibody Responses ◽  
Chi Square ◽  
Exact Test ◽  
Metabolic Phenotypes ◽  
Vaccine Responses ◽  
Metabolic Dysregulation ◽  
Influenza Prevention ◽  
Relationship Of

The most effective intervention for influenza prevention is vaccination. However, there are conflicting data on influenza vaccine antibody responses in obese children. Cardio-metabolic parameters such as waist circumference, cholesterol, insulin sensitivity, and blood pressure are used to subdivide individuals with overweight or obese BMI into ‘healthy’ (MHOO) or ‘unhealthy’ (MUOO) metabolic phenotypes. The ever-evolving metabolic phenotypes in children may be elucidated by using vaccine stimulation to characterize cytokine responses. We conducted a prospective cohort study evaluating influenza vaccine responses in children. Participants were identified as either normal-weight children (NWC) or overweight/obese using BMI. Children with obesity were then characterized using metabolic health metrics. These metrics consisted of changes in serum cytokine and chemokine concentrations measured via multiplex assay at baseline and repeated at one month following vaccination. Changes in NWC, MHOO and MUOO were compared using Chi-square/Fisher’s exact test for antibody responses and Kruskal–Wallis test for cytokines. Differences in influenza antibody responses in normal, MHOO and MUOO children were statistically indistinguishable. IL-13 was decreased in MUOO children compared to NWC and MHOO children (p = 0.04). IL-10 approached a statistically significant decrease in MUOO compared to MHOO and NWC (p = 0.07). Influenza vaccination does not provoke different responses in NCW, MHOO, or MUOO children, suggesting that obesity, whether metabolically healthy or unhealthy, does not alter the efficacy of vaccination. IL-13 levels in MUO children were significantly different from levels in normal and MHOO children, indicating that the metabolically unhealthy phenotypes may be associated with an altered inflammatory response. A larger sample size with greater numbers of metabolically unhealthy children may lend more insight into the relationship of chronic inflammation secondary to obesity with vaccine immunity.

HUBUNGAN PENGETAHUAN IBU TENTANG IMUNISASI DENGAN KELENGKAPAN PEMBERIAN IMUNISASI DASAR PADA BAYI DI POSYANDU KELURAHAN PANIKI WILAYAH KERJA PUSKESMAS ONDONG KABUPATEN KEPULAUAN SIAU TAGULANDANG BIARO

e-NERS ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Martha Revy Sarame ◽  
A. Y. Ismanto ◽  
Abram Babakal
Keyword(s):  
Significant Relationship ◽  
The Body ◽  
Fisher Exact Test ◽  
Maternal Knowledge ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Chi Square Test ◽  
Relationship Of ◽  
The Relationship

Abstract: Immunization is the vaccine into the body in the form of weakened germs that cause the body to produce antibodies but not cause disease, even children become immune.  The research objective was to determine the relationship of maternal knowledge about immunization with complete basic immunization in infants at IHC Health Center Village Paniki working area Ondong Tagulandang Biaro Siau Islands District . The study design was cross sectional method and using Chi-Square test on the value of the Fisher Exact Test. The study was conducted on 32 mothers of infants aged 9-12 months. Sampling with a total sampling instrument in the form of a questionnaire study to determine the motherʾs knowledge and KMS (Card Towards Health) to determine the completeness of immunization. The analysis shows there is a significant relationship between maternal knowledge about immunization with complete basic immunization in infants (p = 0,000). Conclusion that mothers with a good knowledge of immunization will do complete basic immunization in children compared to mothers with less knowledge about immunization. Keywords: Knowledge mother, Completed Basic Immunization.   Abstrak: Imunisasi  adalah pemberian vaksin ke dalam tubuh berupa bibit penykit  yang  dilemahkan yang menyebabkan tubuh memproduksi antibodi tetapi tidak menimbulkan penyakit, bahkan anak menjadi kebal. Tujuan penelitian adalah untuk mengetahui  hubungan pengetahuan ibu tentang imunisasi dengan kelengkapan pemberian imunisasi dasar pada bayi di Posyandu Kelurahan Paniki wilayah kerja Puskesmas Ondong Kabupaten Kepulauan Siau Tagulandang Biaro. Desain penelitian ini menggunakan metode Cross Sectional dan menggunakan  uji Chi-Square pada nilai Fisher Exact Test. Penelitian dilakukan pada 32 ibu yang memiliki bayi berusia 9-12 bulan. Pengambilan sampel secara total sampling dengan instrument penelitian berupa kuesioner untuk mengetahui pengetahuan ibu dan KMS (Kartu Menuju Sehat) untuk mengetahui kelengkapan imunisasi. Hasil analisis menunjukkan  terdapat hubungan bermakna antara pengetahuan ibu tentang imunisasi dengan kelengkapan pemberian imunisasi dasar pada bayi (p=0.000). Kesimpulan yaitu ibu dengan pengetahuan tentang imunisasi yang baik akan melakukan pemberian imunisasi dasar lengkap pada anaknya dibandingkan ibu dengan  pengetahuan tentang imunisasi yang kurang. Kata kunci: Pengetahuan ibu, Kelengkapan Imunisasi Dasar.

scholarly journals Relationship of Flamm Geiger Scores with Success Vaginal Delivery

2021 ◽  
Vol 1 (1) ◽  
pp. 24-33
Author(s):  
Laksmita Chandra Dewi ◽  
Amir Fauzi ◽  
Tri Suciati
Keyword(s):  
General Hospital ◽  
Vaginal Delivery ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Chi Square Test ◽  
History Of ◽  
Alternative Test ◽  
Cross Sectional Design ◽  
Relationship Of

Association Between Flamm Geiger Score And The Success Of Vaginal Delivery. Vaginal Birth After Cesarean (VBAC) is vaginal delivery on woman with history of cesarean delivery. A statement by Cragin (1916),  “Once a cesarean, always a cesarean”, has been a growing paradigm in the community which makes VBAC not a common practice. Flamm Geiger Scoring System is used to predict the likelihood of success in VBAC. The purpose of this research was to find out the association between Flamm Geiger score and the success of vaginal delivery. This research was an analytic observational study with cross sectional design. The population of this research were all patients that underwent delivery in dr. Mohammad Hoesin General Hospital Palembang from January to December  2014 and  the sample were all delivering patient with history of cesarean delivery.The data were taken from patient’s medical record and analyzed using Chi Square test or its alternative test (Fisher’s Exact Test). From 92 samples, there were 25 patients (27,2%) succeeded in undergoing VBAC and 67 patients (72,8%) delivered with repeated cesarean. There was an increasing probability for a successful VBAC ranging from 0% in samples with a score of 0-2 to 100% in samples with a score of 8-10. The result showed that there was an association between Flamm Geiger score and the success of vaginal delivery (p=0,000). There is association between Flamm Geiger score and the success of vaginal delivery in dr. Mohammad Hoesin General Hospital Palembang from January to December  2014.

scholarly journals RELATIONSHIP OF AGE, MENOPAUSE STATUS, AND BMI WITH THE EVENT OF BACTERIAL VAGINOSIS IN NEW PATIENTS OF PELVIC ORGAN PROLAPSE

2021 ◽  
Vol 4 (2) ◽  
pp. 109
Author(s):  
Atmi Marmiati ◽  
Pungky Mulawardhana ◽  
Zakiyatul Faizah
Keyword(s):  
Logistic Regression ◽  
Pelvic Organ Prolapse ◽  
Maternal Age ◽  
Menopausal Status ◽  
Pelvic Organ ◽  
P Value ◽  
Multiple Logistic Regression ◽  
Chi Square ◽  
Exact Test ◽  
Relationship Of

AbstractBackground and Purpose : The prevalence of Bacterial Vaginosis (BV) among Asian women in India and Indonesia is 32% while in the case of BV in 2018 the obstetric clinic of Dr. Soetomo Regional Hospital is 181 BV sufferers. The impact of BV on Pelvic Organ Prolapse (POP) patients, namely the delay in POP treatment such as BV pessaries can be influenced by age, menopausal status, and BMI. This study aims to analyze the relationship of age, menopausal status, and BMI with the incidence of BV in POP patients. Methods: This study used observational analytics with a retrospective and cross sectional approach. The number of samples used was 86 patients. Samoel taking technique with total sampling. The independent variable is the incidence of BV, while the dependent variable is age, menopause status, BMI. Bivariate data analysis using chi square, fisher's exact test and multivariate test using multiple logistic regression tests. Results: The results showed a positive BV prevalence of 76.7% with the majority of patients aged over 60 years at 44.2%, having menopause at 81.4%, and having a BMI of 18.5-24.5 at 47.7%. Fisher's exact test analysis test showed p value of maternal age = 0.003 (RR = 6.398) and p value of BMI = 0.767 (p> 0.005). Chi square analysis test showed p value of menopause status = 0.009 (RR = 4.833). The multiple logistic regression analysis test showed that maternal age was the most dominant factor with a value of p = 0.006 (OR = 6.398 (1,711-23,929)). Conclusion: There is a relationship between age and menopausal status with the incidence of BV. Age is the most dominant independent factor in the incidence of BV.

scholarly journals Food supplement consumption does not related to self-reported symptoms of covid-19 among students in Binawan University

2020 ◽  
Vol 5 (2) ◽  
pp. 203
Author(s):  
Mia Srimiati ◽  
Adhila Fayasari ◽  
Angga Rizqiawan ◽  
Lina Agestika
Keyword(s):  
Statistical Analysis ◽  
Food Supplement ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Distribution Phase ◽  
Relationship Of ◽  
The Relationship ◽  
Supplement Intake ◽  
Fischer Exact Test

The world is facing a pandemic of COVID-19. Multivitamin and other supplement is already known can improve immunity and prevent infected by the virus. The purpose of this study was to determine the relationship of multivitamin/supplement intake with the appearance of COVID-19 symptoms. The method of this study was analytic surveys with cross-sectional designs. The questionnaire was distributed twice, the first distribution phase involved 423 respondents to determine the consumption habits of supplements and the appearance of COVID-19 symptoms. Then, from the respondents who consumed supplements, the second questionnaire was sent again, to find out the type of supplements consumed, and only 127 respondents returned completely. As a respondent, we involved students of Binawan University, Jakarta, Indonesia. We used Pearson Chi-Square and Fischer exact test for statistical analysis. The results of this study noted that 67.7% of respondents consumed supplements/multivitamin, 94.8% of respondents did not show symptoms of COVID-19. The type of supplement consumed by most respondents was vitamin C (51.2%), while multivitamins / other vitamins were 20.1%. In conclusion, based on statistical analysis, there was no significant relationship between supplement consumption with the appearance of COVID-19 and conditions in carrying out daily activities on respondents who show COVID-19 symptoms

Low Pressure Low Frequency Jet Ventilation: Techniques, Safety and Complications

2022 ◽  
pp. 000348942110726
Author(s):  
Calvin W. Myint ◽  
Stephanie E. Teng ◽  
Jennifer J. Butler ◽  
Jacline V. Griffeth ◽  
Mark A. Fritz ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Case Series ◽  
Low Frequency ◽  
Low Pressure ◽  
Normal Weight ◽  
Morbidly Obese ◽  
Fisher Exact Test ◽  
Jet Ventilation ◽  
Chi Square ◽  
Exact Test

Objective: Manual jet ventilation is a specialized oxygenation and ventilation technique that is not available in all facilities due to lack of technical familiarity and fear of complications. The objective is to review our center’s 15 year experience with low pressure low frequency jet ventilation (LPLFJV). Methods: Retrospective review of procedures utilizing LPLFJV from 2005 to 2019 were performed collecting patient demographic, surgery type and complications. Fisher exact test, Chi square, and t-test were used to determine statistical significance. Results: Four hundred fifty-seven patients underwent a total of 891 microlaryngeal surgeries—279 cases for voice disorders, 179 for lesions, and 433 for airway stenosis. The peak jet pressure for all cases did not exceed 20 psi and average peak pressure for the last 100 procedures in this case series was 14.9 ± 4.6 psi. The average lowest oxygen saturation for all cases was 95% ± 0.6%. Brief intubation was required in 154 cases (17%). Surgical duration was significantly longer for cases requiring intubation P < .001. The need for intubation was not associated with smoking or cardiopulmonary disease, but was strongly associated with body mass index (BMI). Intubation rates were 7% for normal weight (BMI < 25, N = 216), 13% for overweight (BMI 25-30, N = 282), 24% for obese (BMI 30-40, N = 342), and 37% for morbidly obese (BMI > 40, N = 52) patients. Three patients developed respiratory distress in the recovery unit and 2 patients required intubation. Conclusion: LPLFJV assisted by intermittent endotracheal intubation is an exceedingly safe and effective intraoperative oxygenation and ventilationmodality for a broad variety of laryngeal procedure.

Venous Thromboembolism and High Grade Gliomas

1993 ◽  
Vol 70 (03) ◽  
pp. 393-396 ◽  
Author(s):  
Mandeep S Dhami ◽  
Robert D Bona ◽  
John A Calogero ◽  
Richard M Hellman
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Medical Center ◽  
Significant Risk ◽  
Bleeding Complications ◽  
Fisher Exact Test ◽  
High Grade ◽  
Chi Square ◽  
Exact Test ◽  
High Grade Gliomas

SummaryA retrospective study was done to determine the incidence of and the risk factors predisposing to clinical venous thromboembolism (VTE) in patients treated for high grade gliomas. Medical records of 68 consecutive patients diagnosed and treated at Saint Francis Hospital and Medical Center from January 1986 to June 1991 were reviewed. The follow up was to time of death or at least 6 months (up to December 1991). All clinically suspected episodes of VTE were confirmed by objective tests. Sixteen episodes of VTE were detected in 13 patients for an overall episode rate of 23.5%. Administration of chemotherapy (p = 0.027, two tailed Fisher exact test) and presence of paresis (p = 0.031, two tailed Fisher exact test) were statistically significant risk factors for the development of VTE. Thrombotic events were more likely to occur in the paretic limb and this difference was statistically significant (p = 0.00049, chi square test, with Yates correction). No major bleeding complications were seen in the nine episodes treated with long term anticoagulation.We conclude that venous thromboembolic complications are frequently encountered in patients being treated for high grade gliomas and the presence of paresis and the administration of chemotherapy increases the risk of such complications.

Hubungan Sikap dan Karakteristik Pasangan Usia Subur (PUS) dengan Keikutsertaan dalam Program KB di Wilayah Kerja UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur

2020 ◽  
Vol 8 (2) ◽  
pp. 105-114
Author(s):  
Ainul Mardhiah ◽  
Nova Hasbani Prima Dewi ◽  
Aminy Aminy
Keyword(s):  
Family Planning ◽  
Family Planning Program ◽  
The Elderly ◽  
P Value ◽  
Planning Program ◽  
Elderly Age ◽  
Chi Square ◽  
Cross Sectional ◽  
The Family ◽  
Relationship Of

The family planning program also aims to improve the quality of the family in order to generate a sense of security, peace and hope of a better future in realizing the prosperity of birth and inner happiness. Allegedly the factor causing EFA participation in the family planning program is characteristic. The purpose of this research is to know the relationship of attitude and characteristic of Elderly Age Couple (PUS) with participation in family planning program at UPT Puskesmas Sungai Raya Sungai Raya District, East Aceh regency 2018. The research design used was analytic survey with cross sectional design. The population of this study is all Pairs Age of Fertile located in Work Area UPT Sungai Raya Public Health Service Center in January to December 2017 which amounted to 1897 people. Sampling using Slovin formula, obtained as many as 95 samples. The study was conducted from 7-17 July 2018 using questionnaires by interview. Statistical test using chi-square test. Result of research indicate that majority of fertile couple couples (PUS) participate in family planning program as much as 67 respondents (70,5%). Statistically there is relationship of attitude and characteristic of Elderly Age Couple (EFA) with non participation in family planning program in Working Area of UPT Puskesmas Sungai Raya Sungai Raya District of East Aceh Regency 2018 with p value <0,1. It is recommended that the family planning program holders in UPT Puskesmas Sungai Raya Sungai Raya District of East Aceh District to invite cross-sectoral figures to hold meetings to create mini workshop plans at least once a month to increase the participation of the Elderly Age Couple (PUS) in family planning programs. Keyword : Family Planning Program, Attitudes, CharacteristicsABSTRAKProgram KB juga bertujuan untuk meningkatkan kualitas keluarga agar dapat timbul rasa aman, tentram, dan harapan masa depan yang lebih baik dalam mewujudkan kesejahteraan lahir dan kebahagiaan batin. Diduga faktor yang menyebabkan ketidakikutsertaan PUS dalam program KB adalah karakteristik. Tujuan penelitian ini untuk mengetahui hubungan sikap dan karakteristik Pasangan Usia Subur (PUS) dengan keikutsertaan dalam program KB di Wilayah Kerja UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur tahun 2018. Desain penelitian yang digunakan adalah survei analitik dengan rancangan bedah lintang. Populasi dari penelitian ini adalah seluruh Pasangan Usia Subur yang berada di Wilayah Kerja UPT Puskesmas Sungai Raya pada bulan Januari sampai dengan Desember tahun 2017 yang berjumlah 1.897 orang. Pengambilan sampel menggunakan rumus Slovin, didapatkan sebanyak 95 sampel. Penelitian dilaksanakan dari tanggal 7-17 Juli tahun 2018 menggunakan kuesioner dengan cara wawancara. Uji statistik menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa mayoritas Pasangan Usia Subur (PUS) ikut serta dalam program KB yaitu sebanyak 67 responden (70,5%). Secara statistik ada hubungan sikap dan karakteristik Pasangan Usia Subur (PUS) dengan ketidakikutsertaan dalam program KB di Wilayah Kerja UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur tahun 2018 dengan p value < 0,1. Sebaiknya pemegang program KB di UPT Puskesmas Sungai Raya Kecamatan Sungai Raya Kabupaten Aceh Timur agar mengajak tokoh lintas sektor agar mengadakan pertemuan untuk membuat rencana loka karya mini setidaknya satu bulan sekali untuk meningkatkan keikutsertaan Pasangan Usia Subur (PUS) dalam program KB.Kata Kunci : Program KB, Sikap, Karakteristik

Variable relationship of fat mass and bone with pubertal staging in obese and normal weight Indian children and adolescents

2013 ◽  
Author(s):  
Khadilkar Anuradha ◽  
Ekbote Veena ◽  
Pandit Deepa ◽  
Chiplonkar Shashi ◽  
Zulf Mughal M ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Fat Mass ◽  
Normal Weight ◽  
Indian Children ◽  
Relationship Of

Usia Resiko Tinggi dan Perdarahan Post Partum

2018 ◽  
Vol 3 (2) ◽  
pp. 91
Author(s):  
Ani Media Harumi ◽  
Kasiati Kasiati
Keyword(s):  
High Risk ◽  
Post Partum ◽  
Chi Square ◽  
Sample Number ◽  
Chi Square Test ◽  
Study Population ◽  
Relationship Of ◽  
The Relationship

Abstract: The purpose of this study is to analyze the relationship of age high risk with the incidence ofbleeding post partum in dr. M. Soewandhie Surabaya hospital. This research is analytic with an approachof a sectional cross. The study population was all post partum mothers in the Dr. M. Soewandhie Surabayahospital in January 2016 to March 2017, which amounts to an average of 1840respondents while theresearch sample number 182. Measuring collection sheet data obtained by systematic random sampling.The Study was conducted Chi-Square test obtained mean count X2 (0,00) is less than á (0.05) thenH0 is rejected and H1 accepted it means that there is a relationship between the age of high risk withbleeding post partum. Conclusion, there is a relationship between the age of high risk with the incidenceof bleeding post partum in the Spaceof the Maternity room Dr. Moch. Soewandhie Surabayahospital.

Use of SAMe-TT₂R₂ Score to Predict the Quality of Anticoagulation Control in Patients with Atrial Fibrillation Receiving Warfarin in Thailand

2020 ◽  
Vol 103 (6) ◽  
pp. 548-552
Keyword(s):  
Atrial Fibrillation ◽  
Therapeutic Range ◽  
Statistical Significance ◽  
Discrimination Performance ◽  
Poor Quality ◽  
Chi Square ◽  
Exact Test ◽  
Time In Therapeutic Range ◽  
Anticoagulation Control

Objective: To predict the quality of anticoagulation control in patients with atrial fibrillation (AF) receiving warfarin in Thailand. Materials and Methods: The present study retrospectively recruited Thai AF patients receiving warfarin for three months or longer between June 2012 and December 2017 in Central Chest Institute of Thailand. The patients were classified into those with SAMe-TT₂R₂ of 2 or less, and 3 or more. The Chi-square test or Fisher’s exact test was used to compare the proportion of the patients with poor time in therapeutic range (TTR) between the two groups of SAMe-TT₂R₂ score. The discrimination performance of SAMe-TT₂R₂ score was demonstrated with c-statistics. Results: Ninety AF patients were enrolled. An average age was 69.89±10.04 years. Most patients were persistent AF. An average CHA₂DS₂-VASc, SAMe-TT₂R₂, and HAS-BLED score were 3.68±1.51, 3.26±0.88, and 1.98±0.85, respectively. The present study showed the increased proportion of AF patients with poor TTR with higher SAMe-TT₂R₂ score. The AF patients with SAMe-TT₂R₂ score of 3 or more had a larger proportion of patients with poor TTR than those with SAMe-TT₂R₂ score of 2 or less with statistical significance when TTR was below 70% (p=0.03) and 65% (p=0.04), respectively. The discrimination performance of SAMe-TT₂R₂ score was demonstrated with c-statistics of 0.60, 0.59, and 0.55 when TTR was below 70%, 65% and 60%, respectively. Conclusion: Thai AF patients receiving warfarin had a larger proportion of patients with poor TTR when the SAMe-TT₂R₂ score was higher. The score of 3 or more could predict poor quality of anticoagulation control in those patients. Keywords: Time in therapeutic range, Poor quality of anticoagulation control, Warfarin, SAMe-TT₂R₂, Labile INR

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