Study the value of lung low dose computed tomography in early detection the malignant pulmonary nodule

2020 ◽  
pp. 7-15
Author(s):  
Ha Hoang ◽  
Tien Doan Dung ◽  
Khoan Le Trong
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Early Detection ◽  
Pulmonary Nodule ◽  
Pulmonary Nodules ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Solitary Pulmonary Nodules ◽  
Cross Sectional ◽  
The Right

Background: Early diagnosis of the malignant pulmonary nodules plays an important role in decreasing the mortality, increasing the lifetime and considering as early detection of lung cancer. Objectives: To describe the characteristics and diagnostic value of the malignant suspected signs of pulmonary nodule. Materials and methods: A descriptive cross-sectional study on 33 patients with localized pulmonary nodule which has indications of biopsy or surgery at Hospital of Hue University of Medicine and Pharmacy from 05/2017 to 08/2018. Results: A majority of pulmonary nodules were found in the right upper lobe with 42.4%; solitary pulmonary nodules made up the majority of 75.8%. (Nodules > 21.5 mm: 57.6%; nodules ≤ 21.5 mm: 42.4%; solid nodules: 97% and mixed nodules: 3%, round shape: 42.4% and polygons: 57.6%; irregular margin: 78.8%; regular margin: 21.2%; eccentric and stippled calcification: 18.2%; non-calcification: 81.8%; air-bronchogram in nodules: 39.4%; air-bronchogram (-): 60.6%; fat containing pulmonary nodules: 6.1%, malignant and benign confirmed by biopsy: 39.3% and 60.7% respectively. The sensitivity and specificity of features included size > 21.5 mm; air-bronchogram in nodules, polygons for malignant nodules diagnosis are 81.6%; 92.3%; 76.9% and 60%, 65%, 85% respectively. Conclusions: Three features of nodules: Size ≥ 21.5 mm; air-bronchogram and polygons are suggestive malignant characteristics. The combination of two or more characteristics have the sensitive 92.3% and specific 80% Keywords: pulmonary nodule, thoracic computed tomography, lung cancer.

scholarly journals Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
George Tsaknis ◽  
Muhammad Naeem ◽  
Advitya Singh ◽  
Siddharth Vijayakumar
Keyword(s):  
Lung Cancer ◽  
Malignant Melanoma ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Past History ◽  
White Male ◽  
Pulmonary Nodules ◽  
Metastatic Malignant Melanoma ◽  
Unknown Primary ◽  
Solitary Pulmonary Nodules

Abstract Background Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Case presentation A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later. Conclusions Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.

scholarly journals Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules

2021 ◽  
Vol 10 (20) ◽  
pp. 4795
Author(s):  
Jan F. Gielis ◽  
Lawek Berzenji ◽  
Vasiliki Siozopoulou ◽  
Marloes Luijks ◽  
Paul E. Y. Van Schil
Keyword(s):  
Differential Diagnosis ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Lower Lobe ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Pulmonary Surgery ◽  
Pubmed Database ◽  
Post Mortem Findings ◽  
The Right

Pulmonary ossifications have often been regarded as rare, post-mortem findings without any clinical significance. We have investigated the occurrence of pulmonary ossifications in patients undergoing thoracic procedures, and how this may affect the differential diagnosis of solitary pulmonary nodules. In addition, we have performed a literature search on the occurrence and possible pathogenesis of these ossifications. From January 2008 until August 2019, we identified pulmonary ossifications in 34 patients who underwent elective pulmonary surgery. Pre-operative imaging was unable to differentiate these ossifications from solid tumors. A definitive diagnosis was made by an experienced pathologist (VS, ML). The PubMed database was researched in December 2019 with the search terms “pulmonary ossifications”; “heterotopic ossifications”; and “solitary pulmonary nodule”. In total, 27 patients were male, with a mean age of 63 ± 12 years (age 41 to 82 on diagnosis). All lesions were identified on thoracic CT and marked for resection by a multidisciplinary team. A total of 17 patients were diagnosed with malignancy concurrent with ossifications. There was a clear predilection for the right lower lobe (12 cases, 35.3%) and most ossifications had a nodular form (70.6%). We could not identify a clear association with any other pathology, either cancerous or non-cancerous in origin. Oncologic or pulmonary comorbidities did not influence patient survival. Pulmonary ossifications are not as seldom as thought and are not just a curiosity finding by pathologists. These formations may be mistaken for a malignant space-occupying lesion, both pre-and perioperatively, as they are indistinguishable in imaging. We propose these ossifications as an underestimated addition to the differential diagnosis of a solitary pulmonary nodule.

scholarly journals Diagnosis and outcome of resected solitary pulmonary nodules after liver transplantation

2019 ◽  
Author(s):  
Mari Tone ◽  
Nobuyasu Awano ◽  
Takehiro Izumo ◽  
Hanako Yoshimura ◽  
Tatsunori Jo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Liver Transplantation ◽  
Early Stage ◽  
Lung Resection ◽  
Invasive Pulmonary Aspergillosis ◽  
Primary Lung Cancer ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Computed Tomography Scans

Abstract Objective Solitary pulmonary nodules after liver transplantation are challenging clinical problems. Herein, we report the causes and clinical courses of resected solitary pulmonary nodules in patients who underwent liver transplantation. Methods We retrospectively obtained medical records of 68 patients who underwent liver transplantation between March 2009 and June 2016. This study mainly focused on patients with solitary pulmonary nodules observed on computed tomography scans during follow-ups that were conducted until their deaths or February 2019. Results Computed tomography scans revealed solitary pulmonary nodules in 7 of the 68 patients. Definitive diagnoses were obtained using video-assisted lung resection in all seven patients. None experienced major postoperative complications. The final pathologic diagnoses were primary lung cancer in three patients, pulmonary metastases from hepatocellular carcinoma in one patient, invasive pulmonary aspergillosis in one patient, post-transplant lymphoproliferative disorder in one patient, and hemorrhagic infarction in one patient. The three patients with lung cancer were subsequently treated with standard curative resection. Conclusions Solitary pulmonary nodules present in several serious but potentially curable diseases, such as early-stage lung cancer. Patients who present with solitary pulmonary nodules after liver transplantation should be evaluated by standard diagnostic procedures, including surgical biopsy if necessary.

scholarly journals Metabolic Syndrome Components and the Risk of Pulmonary Nodules: A Cross‐sectional Study in Northern China

2021 ◽  
Author(s):  
Chengshui Chen ◽  
Mingyang Zhu ◽  
Xueyu Chen ◽  
Yong Zhou ◽  
Xiaocheng Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Metabolic Syndrome ◽  
Pulmonary Nodules ◽  
Heart Association ◽  
Northern China ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Increased Risk

Abstract Objective: The components of metabolic syndrome have been shown to be associated with lung cancer. Pulmonary nodules (PNs), early predictors of lung cancer, have become common incidental findings with the widespread use of low-dose computed tomography (LDCT) but few epidemiological studies have been performed. The present study aimed to determine the association between MetS and/or its components with PNs in Chinese adults.Methods:A total of 3,340 participants (51.4% women) aged 18 years or older were included from the Jidong communities. MetS was defined by the criteria from the American Heart Association, and National Heart, Lung, and Blood Institute (AHA/NHLBI). PNs were detected using LDCT. Results:The prevalence rate of PNs was 19.2% in participants with MetS, while 12.8% in healthy controls (P<0.001). The odds ratio (OR) and 95% confidence internal (CI) for PNs in participants with elevated blood pressure (≥130/85 mmHg or on drugs for treatment of hypertension) was OR = 1.23, 95% CI: 1.01–1.51. Compared to individuals without MetS components, the ORs (95% CI) for PNs development among those with 1, 2, and ≥3 MetS components were 1.25 (0.94–1.67), 1.10 (0.82–1.48), and 1.43 (1.08–1.89), respectively (P for trend =0.04). Moreover, individuals with MetS had an approximately 30% increased risk of PNs than those who did not meet the MetS diagnostic criteria (number of MetS components<3) ( OR = 1.29, 95% CI: 1.03–1.61). Conclusion:The present study suggested that PNs was associated with abnormal MetS components in Chinese adults. Individuals with MetS might have a higher PNs risk than those without MetS.

scholarly journals Assessment of diagnostic value of different methods (culture, PCR and biopsy) for the diagnosis of tuberculosis in patients with bronchial anthracosis

2020 ◽  
Vol 6 (2) ◽  
pp. e24-e24
Author(s):  
Seyed Shahabedin Mohammad Makki ◽  
Fariba Ghorbani ◽  
Katayoun Najafizadeh ◽  
Shadi Shafaghi ◽  
Hamid Reza Khoddami Vishteh
Keyword(s):  
Diagnostic Accuracy ◽  
Biopsy Specimen ◽  
Incidental Finding ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Bronchial Biopsy ◽  
Pathologic Examination ◽  
Cross Sectional ◽  
The Right ◽  
Sensitivity Specificity

Introduction: Although several studies have shown the relationship between tuberculosis (TB) and anthracosis, few studies have investigated the diagnostic value of various methods of diagnosis of TB in these patients. Objectives: This study was conducted to investigate the diagnostic value of different methods including smear, culture and polymerase chain reaction (PCR) of bronchoalveolar lavage (BAL) sample and bronchial biopsy specimens in the diagnosis of TB in patients with bronchial anthracosis. Patients and Methods: This descriptive cross-sectional study was performed on 67 patients referring for bronchoscopy, and bronchial anthracosis was an incidental finding. The BAL sample and patients’ bronchial biopsies were examined for TB infection. Results: The most affected areas by anthracosis were the right and the left upper lobes. The BAL smear and its culture were positive in 12 (20%) and 10 patients (17%), respectively. The PCR of BAL sample was positive in 37%. Non-specific chronic inflammation followed by bronchial anthracosis was the most common pathologic findings. According to pathological examinations, nine patients (13%) had TB. Sensitivity and specificity of the PCR versus culture were 90% and 70%, respectively, with a diagnostic accuracy of 74%. Sensitivity, specificity and diagnostic accuracy of the pathologic examination of biopsy specimen were 33%, 85% and 74%, respectively. Conclusion: Findings of this study showed that nearly one fifth of patients with bronchial anthracosis suffer from TB simultaneously. In these patients, PCR of the BAL and pathologic examination of the biopsy specimen had the same diagnostic accuracy, but the sensitivity of PCR was three times higher. However, application of PCR and pathologic examination does not seem to have more diagnostic advantages than BAL culture for the diagnosis of TB, although the results by PCR may help to diagnose the disease sooner.

scholarly journals Prevalence and variables associated with solitary pulmonary nodules in a routine clinic-based population: a cross-sectional study

2014 ◽  
Vol 24 (9) ◽  
pp. 2174-2182 ◽  
Author(s):  
N. Gómez-Sáez ◽  
I. González-Álvarez ◽  
J. Vilar ◽  
I. Hernández-Aguado ◽  
M. L. Domingo ◽  
...  
Keyword(s):  
Pulmonary Nodules ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Solitary Pulmonary Nodules ◽  
Cross Sectional

Application “Lung Nodule" Software With Lungrads On Early Detection And Follow Up The Pulmonary Nodules By Lung Low Dose CT Findings

2020 ◽  
Author(s):  
Ha Hoang Thi Ngoc
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Pulmonary Nodule ◽  
Low Dose ◽  
False Negative ◽  
Lung Nodule ◽  
Pulmonary Nodules ◽  
Lung Cancer Mortality ◽  
Smoking History ◽  
Low Dose Ct

Background: A pulmonary nodule is defined as a rounded or irregular opacity, well or poorly defined, measuring up to 3 cm in diameter. Early detection the malignancy of nodules has a significant role in decreasing the mortality, increasing the survival time and consider as early diagnosis lung cancer. Content: The main risk factors are those of current or former smokers, aged 55 to 74 years with a smoking history of at least 1 pack-day. Low dose CT: Screening individuals with high risk of lung cancer by low dose CT scans could reduce lung cancer mortality by 20 percent compared to chest X-ray. Radiation dose has to maximum reduced but respect the rule of ALARA (As Low as Resonably Archivable). ACR-LungRADS 2014: Classification of American College of Radiology, LungRADS, is a newly application but showed many advantages in comparison with others classification such as increasing positive predict value (PPV), no result of false negative and cost effectiveness. “Lung nodule” was applied as a smart phone application in order to have a quickly evaluation, especially the malignancy and management face on a pulmonary nodule.

scholarly journals An approach to the solitary pulmonary nodule

2016 ◽  
Vol 22 (3) ◽  
pp. 54 ◽  
Author(s):  
S Abraham ◽  
M J Vorster ◽  
S S Roy ◽  
C F N Koegelenberg
Keyword(s):  
Lung Cancer ◽  
South Africa ◽  
Risk Stratification ◽  
Current Literature ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Imaging Techniques ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Structured Approach

<p>Solitary pulmonary nodules may represent early lung cancer, which is potentially curable. The advent of improved imaging techniques, together with the worldwide implementation of screening programmes, has intensified the need for a structured approach to the management <br />of pulmonary nodules. We present an overview of the current literature on risk stratification, characteristics and management of pulmonary <br />nodules that are relevant to practitioners in South Africa.</p>

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