Faculty Opinions recommendation of Premature ageing in mice expressing defective mitochondrial DNA polymerase.

2004 ◽  
Author(s):  
David Rand
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Premature Ageing ◽  
Mitochondrial Dna Polymerase

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Nature ◽  
2004 ◽  
Vol 429 (6990) ◽  
pp. 417-423 ◽  
Author(s):  
Aleksandra Trifunovic ◽  
Anna Wredenberg ◽  
Maria Falkenberg ◽  
Johannes N. Spelbrink ◽  
Anja T. Rovio ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Premature Ageing ◽  
Mitochondrial Dna Polymerase

scholarly journals The tamas Gene, Identified as a Mutation That Disrupts Larval Behavior in Drosophila melanogaster, Codes for the Mitochondrial DNA Polymerase Catalytic Subunit (DNApol-γ125)

Genetics ◽  
1999 ◽  
Vol 153 (4) ◽  
pp. 1809-1824 ◽  
Author(s):  
Balaji Iyengar ◽  
John Roote ◽  
Ana Regina Campos
Keyword(s):  
Mitochondrial Dna ◽  
Drosophila Melanogaster ◽  
Mutant Strain ◽  
Dna Polymerase ◽  
Complementation Group ◽  
Behavioral Changes ◽  
Catalytic Subunit ◽  
Primary Deficit ◽  
Mitochondrial Dna Polymerase ◽  
Food Substrate

AbstractFrom a screen of pupal lethal lines of Drosophila melanogaster we identified a mutant strain that displayed a reproducible reduction in the larval response to light. Moreover, this mutant strain showed defects in the development of the adult visual system and failure to undergo behavioral changes characteristic of the wandering stage. The foraging third instar larvae remained in the food substrate for a prolonged period and died at or just before pupariation. Using a new assay for individual larval photobehavior we determined that the lack of response to light in these mutants was due to a primary deficit in locomotion. The mutation responsible for these phenotypes was mapped to the lethal complementation group l(2)34Dc, which we renamed tamas (translated from Sanskrit as “dark inertia”). Sequencing of mutant alleles demonstrated that tamas codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-γ125).

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization†

Biochemistry ◽  
2000 ◽  
Vol 39 (7) ◽  
pp. 1702-1708 ◽  
Author(s):  
Allison A. Johnson ◽  
Yu-chih Tsai ◽  
Steven W. Graves ◽  
Kenneth A. Johnson
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Human Mitochondrial Dna ◽  
Mitochondrial Dna Polymerase

The expanding clinical and pathologic spectrum of mitochondrial DNA polymerase gamma mutations

2007 ◽  
Vol 66 (5) ◽  
pp. 437
Author(s):  
Michael A. Farrell ◽  
Rachel Howley ◽  
Yazan Alderazi ◽  
Francesca Brett ◽  
Joan Moroney ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Mitochondrial Dna Polymerase

scholarly journals Mitochondrial DNA polymerase-γ and human disease

2006 ◽  
Vol 15 (suppl_2) ◽  
pp. R244-R252 ◽  
Author(s):  
Gavin Hudson ◽  
Patrick F. Chinnery
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Human Disease ◽  
Mitochondrial Dna Polymerase ◽  
Dna Polymerase Γ
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