Faculty Opinions recommendation of Mutationally altered signal output in the Nart (NarX-Tar) hybrid chemoreceptor.

Ultrasensitive and turn-on homogeneous Hg2+ sensing based on target-triggered isothermal cycling reaction and dsDNA-templated copper nanoparticles

Analytical Methods ◽

10.1039/d1ay00880c ◽

2021 ◽

Author(s):

Qingli Chai ◽

Yuqi Wan ◽

Yanyun Zou ◽

Ting Zhu ◽

Ningxing Li ◽

...

Keyword(s):

Copper Nanoparticles ◽

Label Free ◽

Turn On ◽

Signal Output

In this work, an ultrasensitive and turn-on sensor for homogeneous Hg2+ detection has been constructed based on target-triggered isothermal cycling reaction and rapid label-free signal output with dsDNA-templated copper nanoparticles...

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Quantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy

Nature Communications ◽

10.1038/s41467-021-22678-z ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Qingqing Yin ◽

Anni Pan ◽

Binlong Chen ◽

Zenghui Wang ◽

Mingmei Tang ◽

...

Keyword(s):

Quantitative Imaging ◽

Tumour Mass ◽

Nanoparticle Exposure ◽

Imaging Tool ◽

Intracellular Compartments ◽

Signal Output ◽

Extracellular Microenvironment ◽

Intracellular Targets ◽

Ph Variations ◽

Therapeutic Responses

AbstractNanoparticle internalisation is crucial for the precise delivery of drug/genes to its intracellular targets. Conventional quantification strategies can provide the overall profiling of nanoparticle biodistribution, but fail to unambiguously differentiate the intracellularly bioavailable particles from those in tumour intravascular and extracellular microenvironment. Herein, we develop a binary ratiometric nanoreporter (BiRN) that can specifically convert subtle pH variations involved in the endocytic events into digitised signal output, enabling the accurately quantifying of cellular internalisation without introducing extracellular contributions. Using BiRN technology, we find only 10.7–28.2% of accumulated nanoparticles are internalised into intracellular compartments with high heterogeneity within and between different tumour types. We demonstrate the therapeutic responses of nanomedicines are successfully predicted based on intracellular nanoparticle exposure rather than the overall accumulation in tumour mass. This nonlinear optical nanotechnology offers a valuable imaging tool to evaluate the tumour targeting of new nanomedicines and stratify patients for personalised cancer therapy.

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Oblique-incident evaporated Co-O film with high signal output

IEEE Transactions on Magnetics ◽

10.1109/20.278934 ◽

1991 ◽

Vol 27 (6) ◽

pp. 4745-4747 ◽

Cited By ~ 1

Author(s):

K. Momono ◽

M. Matsumoto ◽

Y. Ikuta ◽

H. Kawamura ◽

Y. Ota ◽

...

Keyword(s):

High Signal ◽

Signal Output

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A bifunctional immunosensor based on the Osmium nano-hydrangeas as a catalytic chromogenic and tinctorial signal output for folic acid detection

The Analyst ◽

10.1039/d1an01432c ◽

2021 ◽

Author(s):

Junkang Pan ◽

Qiyi He ◽

Zhiting Lao ◽

Jingyi Su ◽

Yikui Zou ◽

...

Keyword(s):

Folic Acid ◽

Platinum Group Elements ◽

The Earth ◽

Signal Output ◽

Platinum Group

As a neglected member of the platinum group elements, osmium, the metal with the highest density in the earth, is very suitable for the preparation of a peroxidase with high...

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Learning Neural Circuit by AC Operation and Frequency Signal Output

Computer and Information Science - Studies in Computational Intelligence ◽

10.1007/978-3-030-25213-7_2 ◽

2019 ◽

pp. 15-30

Author(s):

Masashi Kawaguchi ◽

Naohiro Ishii ◽

Masayoshi Umeno

Keyword(s):

Neural Circuit ◽

Frequency Signal ◽

Signal Output

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Surgical wound monitoring by MRI with a metamaterial-based implanted local coil

EPJ Applied Metamaterials ◽

10.1051/epjam/2018001 ◽

2018 ◽

Vol 5 ◽

pp. 5 ◽

Cited By ~ 1

Author(s):

Hanan Kamel ◽

Richard R.A. Syms ◽

Evdokia M. Kardoulaki ◽

Marc Rea

Keyword(s):

Signal To Noise Ratio ◽

Electrical Response ◽

Field Of View ◽

Ring Resonators ◽

Resonance Imaging ◽

Surgical Wound ◽

Agar Gel ◽

Surgical Wounds ◽

Signal Output ◽

Implantable Sensor

An implantable sensor for monitoring surgical wounds after bowel reconstruction is proposed. The sensor consists of a coupled pair of 8-element magneto-inductive ring resonators, designed for mounting on a biofragmentable anastomosis ring to give a local increase in signal-to-noise ratio near an annular wound during 1H magnetic resonance imaging. Operation on an anti-symmetric spatial mode is used to avoid coupling to the B1 field during excitation, and a single wired connection is used for MRI signal output. The electrical response and field-of-view are estimated theoretically. Prototypes are constructed from flexible elements designed for operation at 1.5 T, electrical responses are characterized and local SNR enhancement is confirmed using agar gel phantoms.

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Integrated Balanced BPSK Modulator for Millimeter Wave Systems

Active and Passive Electronic Components ◽

10.1155/2007/69515 ◽

2007 ◽

Vol 2007 ◽

pp. 1-4

Author(s):

Ashok Mittal ◽

Asok De

Keyword(s):

Millimeter Wave ◽

Incident Wave ◽

Insertion Loss ◽

Pulse Width ◽

Coplanar Line ◽

Phase Switching ◽

High Isolation ◽

Average Loss ◽

Hybrid Junction ◽

Signal Output

This paper details the design of integrated balanced PSK modulator using finline coplanar line hybrid junction. The PSK signal output is in suspended stripline with incident wave carrier in finline. Schottky barrier Diode MA4E2037 has been used for modulation. The balanced configuration offers high isolation between the carrier input port and the modulated carrier output port and thus the pulse width variations and amplitude deviations are suppressed. An insertion loss imbalance of±1.5 dB with an average loss of 2 dB in the two switching states has been achieved over 38.9 to 40 GHz. The phase imbalance is±10 degrees with phase switching from 180 to 199 degrees As the PSK output signal is in suspended stripline, two BPSK modulators can be easily combined together to work as QPSK modulator.

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Perancangan Prototipe Transmitter Beacon Black Box Locator Acoustic 37.5 kHz Pingers

ELKOMIKA Jurnal Teknik Energi Elektrik Teknik Telekomunikasi & Teknik Elektronika ◽

10.26760/elkomika.v4i2.170 ◽

2018 ◽

Vol 4 (2) ◽

pp. 170

Author(s):

RUSTAMAJI RUSTAMAJI ◽

KANIA SAWITRI ◽

RUDI GUNAWAN

Keyword(s):

Pulse Width ◽

Black Box ◽

Pulse Repetition ◽

Acoustic Vibrations ◽

Colpitts Oscillator ◽

Amplifier Circuit ◽

Oscillator Circuit ◽

Signal Output ◽

Transmitted Signal ◽

Repetition Interval

ABSTRAKPingers transmitter berfungsi untuk memancarkan sinyal atau getaran pulsa akustik pada black box. Frekuensi sinyal yang dipancarkan sebesar 37,5 kHz yang dimodulasikan oleh pulsa dengan durasi 10 ms setiap interval 1 second. Modulasi yang digunakan adalah modulasi on off keying. Dalam penelitian ini dibuat perancangan pingers transmitter yang tersusun atas rangkaian osilator, timer, inverter, switch dan rangkaian amplifier. Frekuensi 37,5 kHz tersebut dibangkitkan oleh rangkaian osilator colpitts, sedangkan lebar pulsa dengan durasi 10 ms dan pengulangan pulsa setiap interval 1 second dibangkitkan oleh rangkaian timer. Berdasarkan perancangan yang telah dibuat, output sinyal yang dihasilkan oleh prototipe pingers transmitter tersebut sebesar 37,69 kHz dengan lebar pulsa 9,8 ms setiap interval 1 second.Kata kunci: Black box, pingers transmitter, on off keying. ABSTRACTPingers transmitter is used to emits a signal or pulse of acoustic vibrations in black box. The frequency of the transmitted signal is 37.5 kHz which is modulated by pulses with a duration of 10 ms every interval 1 second. The modulation that used this research is on off keying modulation. In this research, made the design of pingers transmitter which arrange of the oscillator circuit,timer, inverter, switch, and amplifier circuit. The 37.5 kHz frequency is generated by the colpitts oscillator circuit, while the pulse width with a duration of 10 ms,and each pulse repetition interval of 1 second generated by timer circuit. Based on the design that have made, signal output from the pingers transmitter prototype is 37.69 kHz, with the pulse width 9.8 ms every 1 second interval.Keywords: Black box, pingers transmitter, on off keying.

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