Faculty Opinions recommendation of Semen quality in fertile US men in relation to geographical area and pesticide exposure.

Author(s):  
Jay Sandlow
2016 ◽  
Vol 36 (3) ◽  
pp. 218-226 ◽  
Author(s):  
A Ben Slima ◽  
Y Chtourou ◽  
M Barkallah ◽  
H Fetoui ◽  
T Boudawara ◽  
...  

Pesticide exposure may affect semen quality and male fertility in humans. The aim of the present work was to elucidate the adverse effects of deltamethrin (Delta), a synthetic pyrethroid, on exposed male mice and their offspring. Adult male Albino/Swiss mice received deltamethrin (5 mg/kg) daily for 35 days and mated with untreated females to produce offspring. Classical measurements of ejaculate and sperm quality and testicular histopathological changes were assessed. Deltamethrin treatment affects sperm quality and quantity in the ejaculated semen of mice that had also markedly impaired libido as measured by indices of mating and fertility and number of pregnant females housed with male mice exposed to this pesticide. Exposure mice to deltamethrin significantly decreased their testosterone and inhibin B levels and affected reproductive performance. Testes of exposed mice showed marked histopathological alterations as compared to the control group. The mice exposed to 5 mg/kg body weight/day of deltamethrin showed severe alterations of the seminiferous tubules, sloughing of the germ cells, the vacuolization of germ cell cytoplasm, and the disruption of spermatogenic cells compared to the control group. Altered pregnancy outcomes were directly attributed to damage of sperm of male mice exposed to deltamethrin compared to the control group. We concluded that exposure to deltamethrin affected the reproductive system of male mice explored by altered total sperm density, motility, and morphology in mice spermatozoa.


2000 ◽  
Vol 42 (10) ◽  
pp. 982-992 ◽  
Author(s):  
Chantana Padungtod ◽  
David A. Savitz ◽  
James W. Overstreet ◽  
David C. Christiani ◽  
Louise M. Ryan ◽  
...  

2013 ◽  
Vol 61 (4) ◽  
pp. 495-504
Author(s):  
Tomaz Snoj ◽  
Silvestra Kobal ◽  
Blanka Premrov Bajuk ◽  
Monika Zuzek ◽  
Nina Cebulj-Kadunc ◽  
...  

Decline in semen quality in humans and increased incidence of male reproductive problems could be caused by different factors, including pesticides that could mimic or block the action of endogenous hormones. If the decline in semen quality is real, and environmental chemicals are at least partially responsible for this decline, similar changes should be observed in animals that live in close connection with humans and are exposed to similar levels of pollutants. In the present study, the semen quality of bulls in the last 30 years was examined with respect to the year of birth. Furthermore, semen quality results were correlated to the total pesticide use in a limited geographical area. The results indicate a notable decrease in both ejaculate volume and total number of spermatozoa in ejaculates of bulls born in the late 1970s, while after that (until 2006) there was no obvious downward or upward trend either in ejaculate volume or in the total number of sperm cells. The amount of pesticides released into the environment increased about twofold in the given period, and linear regression analysis revealed a strong and statistically significant correlation between the amount of pesticides used and the total number of spermatozoa in the ejaculate.


2003 ◽  
Vol 111 (12) ◽  
pp. 1478-1484 ◽  
Author(s):  
Shanna H Swan ◽  
Robin L Kruse ◽  
Fan Liu ◽  
Dana B Barr ◽  
Erma Z Drobnis ◽  
...  

1999 ◽  
Vol 37 (3) ◽  
pp. 415-423 ◽  
Author(s):  
R. K. Juhler ◽  
S. B. Larsen ◽  
O. Meyer ◽  
N. D. Jensen ◽  
M. Spanò ◽  
...  

Epidemiology ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. S27
Author(s):  
C Padungtod ◽  
D A Saviu ◽  
J W Overstreet ◽  
D C Christiani ◽  
L Ryan ◽  
...  

2013 ◽  
Vol 33 (10) ◽  
pp. 1017-1039 ◽  
Author(s):  
Pallav Sengupta ◽  
Rajdeb Banerjee

This review comprehensively summarizes the effects of more than 15 mostly used pesticides on male reproductive physiology, as recent experimental and epidemiological research have indicated their alarming impact on overall human health. Mechanisms have described that pesticide exposure damages spermatozoa, alter Sertoli or Leydig cell function, both in vitro and in vivo and thus affects semen quality. But, the literature suggests a need for more intricate research in those pesticides that are defined as mutagens or carcinogens and directly affect the hypothalamic–pituitary–gonadal axis. This literature review also proposes specific solutions to overcome these health effects.


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