Faculty Opinions recommendation of Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation.

2012 ◽  
Author(s):  
Virginia Papaioannou
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Fate ◽  
Canonical Wnt Signaling ◽  
Stem Cell Fate ◽  
Body Formation ◽  
Cell Fate Decisions ◽  
Canonical Wnt

scholarly journals Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate

2020 ◽  
Author(s):  
Kira Allmeroth ◽  
Christine S. Kim ◽  
Andrea Annibal ◽  
Andromachi Pouikli ◽  
Carlos Andrés Chacón-Martínez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Fate ◽  
Protein Biosynthesis ◽  
Mrna Translation ◽  
Stem Cell Differentiation ◽  
List Type ◽  
Stem Cell Fate ◽  
Cell Fate Decisions ◽  
Hair Follicle Stem Cell

AbstractStem cell differentiation is accompanied by an increase in mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine, and spermine that are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous effectors of stem cell fate and whether they act through translational control remains obscure. Here, we investigated the function of polyamines in stem cell fate decisions using hair follicle stem cell (HFSC) organoids. HFSCs showed lower translation rates than progenitor cells, and a forced suppression of translation by direct targeting of the ribosome or through specific depletion of natural polyamines elevated stemness. In addition, we identified N1-acetylspermidine as a novel parallel regulator of cell fate decisions, increasing proliferation without reducing translation. Overall, this study delineates the diverse routes of polyamine metabolism-mediated regulation of stem cell fate decisions.Key PointsLow mRNA translation rates characterize hair follicle stem cell (HFSC) stateDepletion of natural polyamines enriches HFSCs via reduced translationN1-acetylspermidine promotes HFSC state without reducing translationN1-acetylspermidine expands the stem cell pool through elevated proliferation

scholarly journals A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Tao Peng ◽  
Linan Liu ◽  
Adam L MacLean ◽  
Chi Wut Wong ◽  
Weian Zhao ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Fate ◽  
Stem Cell Fate ◽  
Cell Fate Decisions ◽  
Mechanical Memory
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